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Article: Le innovazioni introdotte dal decreto legislative 3 agosto 2009, n. 106, in materia di valutazione dei rischi da stress lavoro-correlato.

Fantini, L

Giornale italiano di medicina del lavoro ed ergonomia

2010 Volume 32, Issue 4 Suppl, Page(s) 138–140

Title translation	Innovations introduced by the legislative decree of 3 August 2009, No. 106, related to the risk assessment of work-related stress.
MeSH term(s)	Humans ; Italy ; Occupational Diseases/diagnosis ; Occupational Diseases/epidemiology ; Risk Assessment/legislation & jurisprudence ; Stress, Psychological/diagnosis ; Stress, Psychological/epidemiology
Language	Italian
Publishing date	2010-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	603103-1
ISSN	1592-7830 ; 0391-9889
ISSN	1592-7830 ; 0391-9889
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Article ; Online: An intervention based on Well-Being Therapy to prevent alcohol use and other unhealthy lifestyle behaviors among students: a three-arm cluster randomized controlled trial.

Fantini, Luana / Gostoli, Sara / Artin, Michael G / Rafanelli, Chiara

Psychology, health & medicine

2023 , Page(s) 1–21

Abstract: Unhealthy lifestyle, such as alcohol use, and negative health outcomes have been associated with impairments in psychological well-being. The primary objective of the study was to test the efficacy of an intervention based on Well-Being Therapy to ... ...

Abstract	Unhealthy lifestyle, such as alcohol use, and negative health outcomes have been associated with impairments in psychological well-being. The primary objective of the study was to test the efficacy of an intervention based on Well-Being Therapy to prevent or stem alcohol use, binge drinking and other unhealthy lifestyle among Italian adolescents in school settings. A three-arm cluster randomized controlled trial including three test periods (baseline, post-test, six-month follow-up) was implemented. Seven classes (144 students) were randomly assigned to receive well-being intervention (WBI), lifestyle intervention (LI), or no intervention (NI). Primary outcomes were alcohol use (AUDIT-C), binge drinking and other unhealthy lifestyle behaviors (i.e. unhealthy diet, physical inactivity, tobacco and cannabis smoking, poor sleep and Internet addiction). Linear mixed models and mixed-effects logistic regression were used to test the efficacy of WBI in comparison with LI and NI. At six-month follow-up, AUDIT-C total score increased more in NI in comparison with WBI (
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1477841-5
ISSN	1465-3966 ; 1354-8506
ISSN (online)	1465-3966
ISSN	1354-8506
DOI	10.1080/13548506.2023.2235740
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Article: Elevation of transaminases associated with teriparatide treatment: a case report.

Pappalardo, Francesco / Fantini, Laura / Caruso, Vincenzo

European journal of hospital pharmacy : science and practice

2020 Volume 29, Issue 5, Page(s) 290–293

Abstract: This report describes the case of a 64-year-old Caucasian woman presenting with hypertransaminasemia during treatment with teriparatide for postmenopausal osteoporosis. The patient was also receiving food supplements containing red yeast rice (RYR) to ... ...

Abstract	This report describes the case of a 64-year-old Caucasian woman presenting with hypertransaminasemia during treatment with teriparatide for postmenopausal osteoporosis. The patient was also receiving food supplements containing red yeast rice (RYR) to lower her cholesterol levels. RYR has been reported to cause hepatoxicity because it contains monacolin K. According to the results of a causality assessment, carried out via several probability scales, teriparatide was defined as a 'possible' cause of the adverse drug reaction (ADR). Following progressive normalisation of the levels of transaminases after the teriparatide was discontinued, we therefore postulated that teriparatide was the main cause of the ADR. In addition to this, based on a literature review, we considered RYR as a concomitant agent in the aetiology of the ADR. Further post-marketing surveillance studies on teriparatide seem to be necessary.
MeSH term(s)	Dietary Supplements/analysis ; Female ; Humans ; Lovastatin/therapeutic use ; Middle Aged ; Teriparatide/adverse effects ; Transaminases
Chemical Substances	Teriparatide (10T9CSU89I) ; Lovastatin (9LHU78OQFD) ; Transaminases (EC 2.6.1.-)
Language	English
Publishing date	2020-11-16
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2020-002293
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Article ; Online: Decision making under uncertainty in Parkinson's disease with Rem sleep behavior disorder.

Marques, Ana / Pereira, Bruno / Figorilli, Michela / Vidal, Tiphaine / Deffarges, Paul / Durif, Franck / Fantini, Livia

Sleep medicine

2022 Volume 90, Page(s) 214–221

Abstract: Background: REM sleep behavior disorder (RBD) is associated with an increased risk to develop Impulse control disorders (ICDs) in Parkinson's disease (PD), however the mechanisms underlying this putative association are still poorly understood. Decision- ...

Abstract	Background: REM sleep behavior disorder (RBD) is associated with an increased risk to develop Impulse control disorders (ICDs) in Parkinson's disease (PD), however the mechanisms underlying this putative association are still poorly understood. Decision-making impairment, one major neuro-psychological dimension that may lead to ICDs, has been reported in idiopathic RBD, but has never been assessed in RBD associated with PD. Objective: We aimed to assess decision-making abilities under ambiguous situations associated with the presence of RBD in PD patients. Methods: In this cross-sectional study, 60 non-demented PD patients with (PD-RBD, n = 40) and without (PD-nRBD, n = 20) video polysomnography-confirmed RBD, and 20 healthy controls matched for gender and age were included. All subjects underwent neurological and neuropsychological examination, including Iowa Gambling task designed to asses decision-making under uncertainty. Results: IGT total score did not differ between groups (p = 0.851), however PD-RBD presented, more disadvantageous choices for the last blocks of IGT compared to PD-nRBD (p = 0.001) and to HC (p = 0.012). Progression of scores did not differ between HC and PD-nRBD. Multivariate analyses taking into account the value of scores at baseline, as well as the duration of PD, the duration of treatment, the presence of ICDs and MMSE confirmed those results. Conclusion: Decision making under uncertainty is impaired in PD-RBD compared to PD-nRBD and healthy controls, regardless to the duration of disease, treatment, cognitive status and the presence of ICDs. This could reflect an inability to learn from punishment or reward in PD-RBD, and could explain the increased risk to develop ICDs reported in those patients.
MeSH term(s)	Cross-Sectional Studies ; Disruptive, Impulse Control, and Conduct Disorders ; Humans ; Parkinson Disease/complications ; Parkinson Disease/psychology ; REM Sleep Behavior Disorder/complications ; REM Sleep Behavior Disorder/psychology ; Uncertainty
Language	English
Publishing date	2022-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2022.01.025
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Article ; Online: Clinical value of negative

Celli, M / De Giorgi, U / Caroli, P / Di Iorio, V / Fantini, L / Rossetti, V / Foca, F / Nicolini, S / Giganti, M / Paganelli, G / Matteucci, F

European journal of nuclear medicine and molecular imaging

2020 Volume 48, Issue 1, Page(s) 87–94

Abstract: Purpose: To evaluate the clinical value of : Methods: One hundred three BCR patients (median age, 70 years; median PSA, 0.47 ng/mL) with negative : Results: In 57 patients out of 103 (55.3%), CR was detected in the prostatic fossa (45.6%), nodes ( ... ...

Abstract	Purpose: To evaluate the clinical value of Methods: One hundred three BCR patients (median age, 70 years; median PSA, 0.47 ng/mL) with negative Results: In 57 patients out of 103 (55.3%), CR was detected in the prostatic fossa (45.6%), nodes (38.6%), and bone (15.8%). The median CRFS was 15.4 months (range, 12.1-20.5), with a CRFS at 12 months in 61.4% of cases (range, 50.9-70.4) whereas the 24-month CRFS was 34.8% (range, 24-45.8). ISUP subset 1 benefited from significantly longer CRFS compared to subset 2 and subset 3 (median CRFS, 20.5 months, 12.6 months, and 12.1 months, respectively). ISUP subset 3 had significantly poorer 24-month CRFS (9.3%) compared to subset 1 (47.8%) and subset 2 (33.5%). At the univariate and multivariate analyses, the ISUP subset was the only significant risk factor for clinical relapse; ISUP subset 3 and subset 2 patients held a higher risk of CR compared to subset 1 patients (HR of 2.75 [1.35-5.57] for subset 3 versus subset 1; HR of 2.08 [1.11-3.88] for subset 2 versus subset 1). Conclusion: 68
MeSH term(s)	Aged ; Edetic Acid/analogs & derivatives ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Oligopeptides ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Retrospective Studies
Chemical Substances	Gallium Isotopes ; Gallium Radioisotopes ; Oligopeptides ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2020-06-26
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-020-04914-8
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Article ; Online: Genome size of two cebus species (primates: platyrrhini) with a fertile hybrid and their quantitative genomic differences.

Fantini, L / Mudry, M D / Nieves, M

Cytogenetic and genome research

2011 Volume 135, Issue 1, Page(s) 33–41

Abstract: Genome size or C-value is defined as the total amount of DNA contained within a haploid chromosome set and is regarded as a species-specific constant. Speciation among neotropical primates seems to be accompanied by marked quantitative changes in DNA ... ...

Abstract	Genome size or C-value is defined as the total amount of DNA contained within a haploid chromosome set and is regarded as a species-specific constant. Speciation among neotropical primates seems to be accompanied by marked quantitative changes in DNA content. A direct correlation between genome size and the presence of heterochromatin has also been proposed. In this work, we analyzed the genome of a female fertile hybrid between Cebus libidinosus and C. nigritus using interspecies comparative genomic hybridization (iCGH), in order to detect quantitative differences between the hybrid and the parental genomes. We also estimated the genome sizes of C. libidinosus and C. nigritus. Both species, considered subspecies of C. apella until 2001, have a highly homologous karyotype but are easily distinguishable at the chromosomal level due to the noncentromeric heterochromatin block on C. libidinosus chromosome 11. Our findings on C-value quantification support the species status for C. libidinosus and C. nigritus, each having a different genome size. The iCGH analysis of the hybrid revealed quantitative differences in comparison to both parental species. The hybrid genome contains a greater amount of DNA in the heterochromatic blocks related to those in the genomes of both parental species. In view of observations in previous and the present work, some hypotheses about genome dynamics of neotropical primates are proposed and discussed.
MeSH term(s)	Animals ; Cebus/classification ; Cebus/genetics ; Chimera/genetics ; Chromosome Banding ; Chromosomes/chemistry ; Chromosomes/genetics ; Comparative Genomic Hybridization/methods ; Crosses, Genetic ; Cytogenetics/methods ; DNA/analysis ; DNA/genetics ; Female ; Genome ; Genomics/methods ; Heterochromatin/chemistry ; Heterochromatin/genetics ; Karyotyping ; Male ; Repetitive Sequences, Nucleic Acid ; Sample Size ; Species Specificity
Chemical Substances	Heterochromatin ; DNA (9007-49-2)
Language	English
Publishing date	2011
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2087824-2
ISSN	1424-859X ; 1424-8581
ISSN (online)	1424-859X
ISSN	1424-8581
DOI	10.1159/000330127
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Article ; Online: Non FDG PET.

Nanni, C / Fantini, L / Nicolini, S / Fanti, S

Clinical radiology

2010 Volume 65, Issue 7, Page(s) 536–548

Abstract: 2- [(18)F]-fluoro-2-deoxy-D-glucose (FDG) is the radiopharmaceutical most frequently used for clinical positron emission tomography (PET). However, FDG cannot be used for many oncological, cardiological, or neurological conditions, either because the ... ...

Abstract	2- [(18)F]-fluoro-2-deoxy-D-glucose (FDG) is the radiopharmaceutical most frequently used for clinical positron emission tomography (PET). However, FDG cannot be used for many oncological, cardiological, or neurological conditions, either because the abnormal tissue does not concentrate it, or because the tissues under investigation demonstrate high physiological glucose uptake. Consequently, alternative PET tracers have been produced and introduced into clinical practice. The most important compounds in routine practice are (11)C-choline and (18)F-choline, mainly for the evaluation of prostate cancer; (1)C-methionine for brain tumours; (118)F-DOPA ((18)F-deoxiphenilalanine) for neuroendocrine tumours and movement disorders; (68)Ga-DOTANOC (tetraazacyclododecanetetraacetic acid-[1-Nal3]-octreotide) and other somatostatin analogues for neuroendocrine tumours; 11C-acetate for prostate cancer and hepatic masses and 18F-FLT (3-deoxy-3-fluorothymidine) for a number of malignant tumours. Another impetus for the development of new tracers is to enable the investigation of biological processes in tumours other than glucose metabolism. This is especially important in the field of response assessment, where there are new agents that are targeted more specifically at angiogenesis, hypoxia, apoptosis and other processes.
MeSH term(s)	Choline ; Humans ; Methionine ; Neoplasm Staging ; Neoplasms/diagnostic imaging ; Positron-Emission Tomography/methods ; Practice Guidelines as Topic ; Radioisotopes ; Radiopharmaceuticals
Chemical Substances	Radioisotopes ; Radiopharmaceuticals ; Methionine (AE28F7PNPL) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2010-07
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2010.03.012
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Article ; Online: Multimodal Approach to Outcome Prediction in Metastatic Castration-Resistant Prostate Cancer by Integrating Functional Imaging and Plasma DNA Analysis.

Conteduca, Vincenza / Scarpi, Emanuela / Matteucci, Federica / Caroli, Paola / Ravaglia, Giorgia / Fantini, Lorenzo / Gurioli, Giorgia / Schepisi, Giuseppe / Wetterskog, Daniel / Menna, Cecilia / Burgio, Salvatore Luca / Lolli, Cristian / Paganelli, Giovanni / Attard, Gerhardt / De Giorgi, Ugo

JCO precision oncology

2022 Volume 3, Page(s) 1–13

Abstract: Purpose: Biomarkers for treatment personalization in metastatic castration-resistant prostate cancer (mCRPC) could help improve patient outcomes. Multiple tests on blood have reported associations with poorer outcome, including serum lactate ... ...

Abstract	Purpose: Biomarkers for treatment personalization in metastatic castration-resistant prostate cancer (mCRPC) could help improve patient outcomes. Multiple tests on blood have reported associations with poorer outcome, including serum lactate dehydrogenase (LDH), chromogranin A (CGA), neutrophil:lymphocyte ratio (NLR), and, recently, copy number (CN) of androgen receptor (AR) in plasma DNA. Biologic data suggest an association between choline uptake and AR signaling. We aimed to integrate 18 Materials and methods: We determined plasma Results: Plasma Conclusion: Our results indicate the potential usefulness of integrating functional imaging with plasma DNA analysis and other noninvasive biomarkers as a tool to improve treatment selection for CRPC. A larger prospective evaluation is warranted.
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.18.00302
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Article: Exploratory Analysis of

Fantini, Lorenzo / Belli, Maria Luisa / Azzali, Irene / Loi, Emiliano / Bettinelli, Andrea / Feliciani, Giacomo / Mezzenga, Emilio / Fedeli, Anna / Asioli, Silvia / Paganelli, Giovanni / Sarnelli, Anna / Matteucci, Federica

Frontiers in oncology

2021 Volume 11, Page(s) 601053

Abstract: Purpose: The objective of this study was to evaluate a set of radiomics-based advanced textural features extracted from : Materials and methods: Patients with operable (T2-T3, N0-N2, M0) or locally advanced (T4, N0-N2, M0) BC were enrolled. All ... ...

Abstract	Purpose: The objective of this study was to evaluate a set of radiomics-based advanced textural features extracted from Materials and methods: Patients with operable (T2-T3, N0-N2, M0) or locally advanced (T4, N0-N2, M0) BC were enrolled. All patients underwent chemotherapy (six cycles every 3 weeks). Surgery was performed within 4 weeks of the end of NCT. The MD Anderson Residual Cancer Burden calculator was used to evaluate the pathological response. Results: Twenty patients were included in the study. Lesions from 15 patients were evaluable and analyzed: 9 with pathological complete response (pCR) and 6 with pathological partial response (pPR). Concordance between PET response and histological examination was found in 13/15 patients. LASSO logistic modelling identified a combination of SUV Conclusions: Our study suggests the potential usefulness of FLT-PET for early monitoring of response to NCT. A model based on PET radiomic characteristics could have good discriminatory capacity of early response before the end of treatment.
Language	English
Publishing date	2021-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.601053
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Article ; Online: Growth curve of Nile tilapia from different families of the AquaAmérica variety.

Carvalho, J C / Corrêa Filho, R A C / Oliveira, C A L / Ribeiro, R P / Seraphim, G N / Silva, A L N / Kinjo Junior, G N / Laice, L M / Fantini, L E / Lopera-Barrero, N M / Povh, J A

Brazilian journal of biology = Revista brasleira de biologia

2021 Volume 82, Page(s) e243534

Abstract: Selection can affect growth, changing performance and asymptotic values. However, there is little information about the growth of families in fish breeding programs. The aim of this study was to evaluate the performance and growth of families of Nile ... ...

Abstract	Selection can affect growth, changing performance and asymptotic values. However, there is little information about the growth of families in fish breeding programs. The aim of this study was to evaluate the performance and growth of families of Nile tilapia AquaAmérica. Twenty AquaAmérica families cultivated in a net cage (13.5 m3) for 181 days were evaluated. The nonlinear Gompertz regression model was fitted to the data by the weighted least squares method, taking the inverse of the variance of weight in different families and at different ages as the weighting variable. The model was adjusted to describe the growth in weight and morphometric characteristics. Two families showed highest (P<0.05) weights at both 133 days (family AA10: 743.2 g; family AA16: 741.2 g) and 181 days (family AA10: 1,422.1 g; family AA16: 1,393.4 g) of the experiment. In both experimental periods, the males showed a heavier weight, with the greatest contrast between the sexes occurring at 181 days. The analysis of the three most contrasting families (AA1, AA9 and AA14) showed that the asymptotic value for weight was higher (P<0.05) in family AA9 (3,926.3 g) than in family AA14 (3,251.6 g), but specific growth rate and age at the inflection point did not differ significantly between families. In conclusion, two of the 20 families were superior; males exhibited a greater growth, mainly in the period of 181 days; and the growth curve differed between the families, especially for asymptotic weight.
MeSH term(s)	Animals ; Cichlids/genetics ; Male
Language	English
Publishing date	2021-06-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2036257-2
ISSN	1678-4375 ; 1519-6984
ISSN (online)	1678-4375
ISSN	1519-6984
DOI	10.1590/1519-6984.243534
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