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  1. Book: The Milan System for Reporting Salivary Gland Cytopathology

    Faquin, William C. / Rossi, Esther Diana / Baloch, Zubair / Vielh, Philippe / Foschini, Maria Pia / Kurtycz, Daniel F. I. / Pusztaszeri, Marc P. / Barkan, Güliz A.

    2023  

    Author's details Dr. William C. Faquin is the Chief of Otolaryngologic Pathology at the Massachusetts Eye and Ear and a subspecialist in Head and Neck Pathology & Cytopathology at the Massachusetts General Hospital in Boston. He is a Professor of Pathology at Harvard Medical School, and is recognized for his contributions to the study of thyroid, salivary gland, and HPV-related cancers of the head and neck. He has authored over 350 peer-reviewed publications, and has co-authored several books on head and neck cytohistology, salivary gland cytopathology, and thyroid cytopathology. Dr. Faquin is the Editor-in-Chief for Cancer Cytopathology which is one of the 3 journals of the American Cancer Society, he is an author of the upcoming ARP Fascicle for Upper Aerodigestive Tract Tumors, co-author of the Bethesda System for Reporting Thyroid Cytopathology, co-chair of the College of American Pathologists Evidence-Based Guidelines Committee for the testing ofhead and neck squamous cell carcinomas for high
    Keywords Cystic salivary gland lesions ; FNA specimen adequacy criteria ; salivary gland neoplasms ; Secondary tumors of the salivary gland ; Milan Reporting System
    Language English
    Size 260 p.
    Edition 2
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_21
    Format 155 x 235 x 14
    ISBN 9783031266614 ; 3031266617
    Database PDA

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  2. Article ; Online: The current state of sinonasal malignancies and recent management updates.

    Ababneh, Emad I / Faquin, William C

    Cancer cytopathology

    2023  Volume 131, Issue 10, Page(s) 605–608

    MeSH term(s) Humans ; Paranasal Sinus Neoplasms/therapy ; Paranasal Sinus Neoplasms/pathology
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22711
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  3. Article ; Online: Refining the Milan System for Reporting Salivary Gland Cytopathology.

    Faquin, William C

    Cancer cytopathology

    2020  Volume 129, Issue 1, Page(s) 22–23

    MeSH term(s) Biopsy, Fine-Needle ; Humans ; Salivary Gland Neoplasms/pathology ; Salivary Glands/pathology
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22340
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  4. Article ; Online: Cancer Cytopathology 2020: Keeping the field of cytopathology strong.

    Faquin, William C

    Cancer cytopathology

    2020  Volume 128, Issue 1, Page(s) 12–13

    MeSH term(s) Biomarkers, Tumor/analysis ; Cytodiagnosis ; Humans ; Journal Impact Factor ; Neoplasms/diagnosis ; Neoplasms/pathology ; Pathology, Clinical/methods
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-01-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22227
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  5. Article ; Online: The state of cytopathology laboratories during the COVID-19 pandemic.

    Faquin, William C

    Cancer cytopathology

    2020  Volume 128, Issue 12, Page(s) 881–882

    MeSH term(s) Asia ; COVID-19 ; Humans ; Laboratories ; Pandemics ; SARS-CoV-2 ; Surveys and Questionnaires
    Language English
    Publishing date 2020-12-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22393
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  6. Book ; Online ; E-Book: The Milan system for reporting salivary gland cytopathology

    Faquin, William C. / Rossi, Esther Diana / Baloch, Zubair W. / Barkan, Güliz A. / Foschini, Maria P. / Kurtycz, Daniel F.I. / Pusztaszeri, Marc / Vielh, Philippe

    2018  

    Author's details William C. Faquin, Esther Diana Rossi editors ; Zubair Baloch, Güliz A. Barkan, Maria P. Foschini, Daniel F.I. Kurtycz, Marc Pusztaszeri, Philippe Vielh associate editors
    Keywords Medicine ; Oncology ; Otorhinolaryngology ; Pathology
    Subject code 616.07
    Language English
    Size 1 Online-Ressource (xix, 182 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019621261
    ISBN 978-3-319-71285-7 ; 9783319712840 ; 3-319-71285-3 ; 3319712845
    DOI 10.1007/978-3-319-71285-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book: Thyroid cytopathology

    Clark, Douglas P. / Faquin, William C.

    (Essential in cytopathology ; 8)

    2010  

    Author's details Douglas P. Clark ; William C. Faquin
    Series title Essential in cytopathology ; 8
    Essentials in cytopathology series
    Collection Essentials in cytopathology series
    Keywords Thyroid Nodule / diagnosis ; Thyroid Nodule / physiopathology ; Biopsy, Fine-Needle / methods ; Thyroid Gland / pathology
    Language English
    Size IX, 200 S. : zahlr. Ill., 203 mm x 127 mm
    Edition 2. ed.
    Publisher Springer Science+Business Media
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016463588
    ISBN 978-1-441-95952-2 ; 9781441959546 ; 1-441-95952-1 ; 1441959548
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 4061 order for loan Magazin

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  8. Article ; Online: The Milan System classification of Warthin tumor: A large institutional study of 124 cases highlighting cytologic features that limit definitive interpretation.

    Torous, Vanda F / Faquin, William C

    Cancer cytopathology

    2022  Volume 130, Issue 9, Page(s) 714–725

    Abstract: Background: Fine-needle aspiration (FNA) is highly accurate for the diagnosis of Warthin tumor (WT). However, there is a minor subset of WT cases that are more challenging to interpret. The goal of this study is to identify factors that limit definitive ...

    Abstract Background: Fine-needle aspiration (FNA) is highly accurate for the diagnosis of Warthin tumor (WT). However, there is a minor subset of WT cases that are more challenging to interpret. The goal of this study is to identify factors that limit definitive diagnosis of WT on FNA.
    Methods: All WT surgical specimens diagnosed during a 6.5-year study period were retrospectively identified and the preceding cytologic specimen diagnostic categories were analyzed. Of particular interest were WT cases with indeterminate or malignant interpretations. Cases that noted squamous or mucinous change in either the surgical or cytologic reports were also reviewed.
    Results: A total of 157 WT surgical specimens were identified, with 124 (79.0%) having prior FNAs. The distribution of cytologic diagnostic categories was 12 (9.7%) nondiagnostic, 10 (8.1%) nonneoplastic, 13 (10.5%) atypia of undetermined significance (AUS), 82 (66.1%) neoplasm: benign, 4 (3.2%) salivary gland neoplasm of uncertain malignant potential (SUMP), 2 (1.6%) suspicious for malignancy, and 1 (0.8%) malignant. Of the 20 cases in indeterminate/malignant categories, a majority noted either squamoid (9 of 20) or mucinous (2 of 20) changes. The remainder noted scant cellularity as a limiting factor to interpretation. Additionally, 27 cases mentioned squamous or mucinous change in the surgical or cytology report, with a wide spectrum of cytologic categorization including 2 (7.4%) nondiagnostic, 2 (7.4%) nonneoplastic, 7 (25.9%) AUS, 8 (29.6%) neoplasm: benign, 4 (14.8%) SUMP, 2 (7.4%) suspicious for malignancy, and 1 (3.7%) malignant.
    Conclusions: This study identified 2 key causes for indeterminate or misclassification of WT on FNA: specimen hypocellularity and metaplastic changes. Recognition of the potential for squamous and mucinous metaplastic changes combined with observance of some helpful diagnostic clues such as the presence of crystalloids may aid in preventing diagnostic pitfalls.
    MeSH term(s) Adenolymphoma/diagnosis ; Adenolymphoma/pathology ; Carcinoma, Squamous Cell/pathology ; Humans ; Precancerous Conditions/diagnosis ; Retrospective Studies ; Salivary Gland Neoplasms/pathology ; Salivary Glands/pathology
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22588
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  9. Article: Expanding Our Knowledge of

    Riascos, Maria Cristina / Huynh, Anh / Faquin, William C / Nosé, Vania

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Mutations ... ...

    Abstract Mutations in
    Language English
    Publishing date 2024-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020347
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  10. Article ; Online: Our 2018 Cancer Cytopathology Young Investigator.

    Faquin, William C

    Cancer cytopathology

    2019  Volume 127, Issue 4, Page(s) 218–221

    Abstract: Background: The Paris System for Urine Cytopathology (the Paris System) has succeeded in making the analysis of liquid-based urine preparations more reproducible. Any algorithm seeking to automate this system must accurately estimate the nuclear-to- ... ...

    Abstract Background: The Paris System for Urine Cytopathology (the Paris System) has succeeded in making the analysis of liquid-based urine preparations more reproducible. Any algorithm seeking to automate this system must accurately estimate the nuclear-to-cytoplasmic (N:C) ratio and produce a qualitative "atypia score." The authors propose a hybrid deep-learning and morphometric model that reliably automates the Paris System.
    Methods: Whole-slide images (WSI) of liquid-based urine cytology specimens were extracted from 51 negative, 60 atypical, 52 suspicious, and 54 positive cases. Morphometric algorithms were applied to decompose images to their component parts; and statistics, including the NC ratio, were tabulated using segmentation algorithms to create organized data structures, dubbed rich information matrices (RIMs). These RIM objects were enhanced using deep-learning algorithms to include qualitative measures. The augmented RIM objects were then used to reconstruct WSIs with filtering criteria and to generate pancellular statistical information.
    Results: The described system was used to calculate the N:C ratio for all cells, generate object classifications (atypical urothelial cell, squamous cell, crystal, etc), filter the original WSI to remove unwanted objects, rearrange the WSI to an efficient, condensed-grid format, and generate pancellular statistics containing quantitative/qualitative data for every cell in a WSI. In addition to developing novel techniques for managing WSIs, a system capable of automatically tabulating the Paris System criteria also was generated.
    Conclusions: A hybrid deep-learning and morphometric algorithm was developed for the analysis of urine cytology specimens that could reliably automate the Paris System and provide many avenues for increasing the efficiency of digital screening for urine WSIs and other cytology preparations.
    MeSH term(s) Algorithms ; Cytodiagnosis/instrumentation ; Cytodiagnosis/methods ; Humans ; Neoplasms/diagnosis ; Research Personnel/statistics & numerical data ; Urinalysis/instrumentation ; Urinalysis/methods
    Language English
    Publishing date 2019-04-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2594979-2
    ISSN 1934-6638 ; 1934-662X
    ISSN (online) 1934-6638
    ISSN 1934-662X
    DOI 10.1002/cncy.22116
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