Article: An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in
bioRxiv : the preprint server for biology
2024
Abstract: Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe ... ...
| Abstract | Throughout history, humans have relied on plants as a source of medication, flavoring, and food. Plants synthesize large chemical libraries and release many of these compounds into the rhizosphere and atmosphere where they affect animal and microbe behavior. To survive, nematodes must have evolved the sensory capacity to distinguish plant-made small molecules (SMs) that are harmful and must be avoided from those that are beneficial and should be sought. This ability to classify chemical cues as a function of their value is fundamental to olfaction, and represents a capacity shared by many animals, including humans. Here, we present an efficient platform based on multi-well plates, liquid handling instrumentation, inexpensive optical scanners, and bespoke software that can efficiently determine the valence (attraction or repulsion) of single SMs in the model nematode, |
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| Language | English |
| Publishing date | 2024-04-03 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.06.02.542933 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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