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  1. Article ; Online: The impact of a chemical reaction on the heat and mass transfer mechanisms in a dissipative and radiative nanofluid flow over a nonlinear stretching sheet.

    Abbas, W / Megahed, Ahmed M / Fares, Eman

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7712

    Abstract: This paper presents a numerical investigation of the flow of a non-Newtonian tangent hyperbolic nanofluid over a nonlinearly stretched surface, taking into account factors such as thermal radiation, prescribed surface temperature, and a chemical reaction ...

    Abstract This paper presents a numerical investigation of the flow of a non-Newtonian tangent hyperbolic nanofluid over a nonlinearly stretched surface, taking into account factors such as thermal radiation, prescribed surface temperature, and a chemical reaction mechanism. Furthermore, the analysis includes the consideration of both viscous dissipation and the influence of a magnetic field within a Darcy porous medium. A mathematical framework for addressing the issue, rooted in the principles of conserving momentum, energy, and mass. The MATHEMATICA tools were employed to apply the shooting technique in order to solve the modeled equations describing the temperature, velocity, and concentration fields of the proposed physical system. Graphs are used to illustrate how certain key parameters affect the profiles of concentration, velocity, and temperature. Data tables are utilized to display information pertaining to the local Nusselt number, local Sherwood number, and local skin friction coefficient. The present results have been confirmed through a comparison with previously published findings. This research holds significant importance as it focuses on the extensive utilization of tangent hyperbolic nanofluids in cooling electronic components that produce substantial heat during their operation. The observed pattern indicates that as the local Weisbsenberg number, magnetic number, local porous parameter, and power law index increase, there is a reduction in the boundary layer thickness. Conversely, in the instances of concentration and temperature distributions, an escalation in these parameters leads to an expansion of the boundary layer thickness.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57952-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genomic analysis of a Palestinian family with inherited cancer syndrome: a next-generation sequencing study.

    Fares, Eman / Thawabtah, Rua / Sallam, Husam / Khatib, Areej A H / Qutob, Nouar / Salah, Zaidoun

    Frontiers in genetics

    2023  Volume 14, Page(s) 1230241

    Abstract: Familial predisposition is a strong risk factor for different types of cancer and accounts for around 10% of the cases. In this study, we investigated cancer predisposition in a Palestinian family using whole-exome sequencing (WES) technologies. In this ... ...

    Abstract Familial predisposition is a strong risk factor for different types of cancer and accounts for around 10% of the cases. In this study, we investigated cancer predisposition in a Palestinian family using whole-exome sequencing (WES) technologies. In this study, we focused more on cutaneous melanoma (CM). Our analysis identified three heterozygous rare missense variants, WRN (p.L383F and p.A995T) and TYRP1 (p.T262M) and a pathogenic homozygous missense mutation in ERCC2 (p.R683Q). Although WRN and TYRP1 genes and their variations were correlated with different types of cancer, including melanoma, the currently identified WRN and TYRP1 variants were not reported previously in melanoma cases. The pathogenic mutation was segregated with the clinical phenotypes and found in the two affected brothers, one with CM and the other with brain tumor, and was confirmed by Sanger sequencing analysis. Segregation analysis of this mutation revealed that family members are either heterozygous or wild type. Our findings confirm that the homozygous ERCC2 (p.R683Q) mutation was responsible for causing melanoma and other cancer types in the family. Our work highlights the value to decipher the mutational background of familial cancers, especially CM, in the Palestinian population to guide diagnosis, prevention, and treatment of affected patients and their families.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1230241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Impact of Direct-Acting Antiviral Agents on Cytomegalovirus Reactivation in Chronic Hepatitis C Infection.

    Dawood, Reham M / Gomaa, Ahmed A / Abd El Meguid, Mai / Hassan, Essam A / Salum, Ghada M / Fares, Hany Mahmoud / El Awady, Mostafa K / Fares, Eman M / Esmat, Gamal

    Asian Pacific journal of cancer prevention : APJCP

    2022  Volume 23, Issue 4, Page(s) 1365–1372

    Abstract: Objective: The co-infection of HCV/CMV may accelerate the progression of liver diseases and worsen responsiveness to IFN treatment. The Direct-acting antiviral agents (DAAs), currently approved therapy for HCV, may cause a transient change in immune ... ...

    Abstract Objective: The co-infection of HCV/CMV may accelerate the progression of liver diseases and worsen responsiveness to IFN treatment. The Direct-acting antiviral agents (DAAs), currently approved therapy for HCV, may cause a transient change in immune status, favoring the reactivation of other viruses. The current study aims to evaluate the impact of DAAs treatment on the reactivation of latent CMV in HCV patients.
    Methods: The serological IgG, IgM Abs against CMV were detected by ELISA on192 HCV patients. The seronegative CMV IgM patients received (sofosbuvir/daclatasvir) regimen, then the CMV reactivation was examined by measuring the CMV IgM by ELISA and CMV DNA by real-time PCR.
    Results: The serological data revealed that all patients were positive for CMV IgG (100%) while (64%) patients were positive for CMV IgM. The seronegative CMV IgM (36%) received the DAAs protocol. The sustained virological response was monitored by measuring the HCV RNA viremia in the patient sera. The serological data revealed that 28.6% of patients had a reactivation of CMV, while 18.5% of patients had detectable CMV DNA viremia. Moreover, there was a significant improvement in liver function as well as a decrease in FIB-4 and APRI scores at EOT. SVR was reached 97.4% among the total studied patients (N= 192).
    Conclusion: CMV co-infection has no impact on the response rate to DAAs. However, the CMV reactivation might have occurred after the complete eradication of HCV by DAAs.
    MeSH term(s) Antiviral Agents/therapeutic use ; Coinfection/drug therapy ; Cytomegalovirus ; Cytomegalovirus Infections/drug therapy ; Graft vs Host Disease/drug therapy ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Viremia/chemically induced ; Viremia/drug therapy
    Chemical Substances Antiviral Agents ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2022-04-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2022.23.4.1365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The COVEG score to predict severity and mortality among hospitalized patients with COVID-19.

    El-Kassas, Mohamed / El Gaafary, Maha / Elbadry, Mohamed / Medhat, Mohamed Ahmed / Dabbous, Hany / Hassan, Essam Ali / Abdelmoaty, Ahmed / Karam-Allah, Haidi / Sayed, Hamdy / Abdalazeem, Amr / Sherief, Ahmed Fouad / Fares, Eman / Alsadik, Maha / Moustafa, Ehab / Anwar, Wagida / Abdelghaffar, Hossam / Abdelghaffar, Khaled

    Journal of infection in developing countries

    2022  Volume 16, Issue 7, Page(s) 1138–1147

    Abstract: Introduction: COVID-19 severity and mortality predictors could determine admission criteria and reduce mortality. We aimed to evaluate the clinical-laboratory features of hospitalized patients with COVID-19 to develop a novel score of severity and ... ...

    Abstract Introduction: COVID-19 severity and mortality predictors could determine admission criteria and reduce mortality. We aimed to evaluate the clinical-laboratory features of hospitalized patients with COVID-19 to develop a novel score of severity and mortality.
    Methodology: This retrospective cohort study was conducted using data from patients with COVID-19 who were admitted to five Egyptian university hospitals. Demographics, comorbidities, clinical manifestations, laboratory parameters, the duration of hospitalization, and disease outcome were analyzed, and a score to predict severity and mortality was developed.
    Results: A total of 1308 patients with COVID-19, with 996 (76.1%) being moderate and 312 (23.9%) being severe cases, were included. The mean age was 46.5 ± 17.1 years, and 61.6% were males. The overall mortality was 12.6%. Regression analysis determined significant predictors, and a ROC curve defined cut-off values. The COVEG severity score was defined by age ≥ 54, D-dimer ≥ 0.795, serum ferritin ≥ 406, C-reactive protein ≥ 30.1, and neutrophil: lymphocyte ratio ≥ 2.88. The COVEG mortality score was based on COVEG severity and the presence of cardiac diseases. Both COVEG scores had high predictive values (area under the curve 0.882 and 0.883, respectively).
    Conclusions: COVEG score predicts the severity and mortality of patients with COVID-19 accurately.
    MeSH term(s) Adult ; COVID-19 ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Prognosis ; ROC Curve ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2022-07-28
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.15984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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