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  1. Article ; Online: Burnout risks in Bangladeshi Physicians

    Farhana Rizwan / Forhad Monjur / Mamunur Rahman / Samiha Tamanna / Noor Muhammad Khan / Muhammad Rafiqul Islam / Samira Alam / Lamia Mariyam

    Heliyon, Vol 9, Iss 12, Pp e22386- (2023)

    A multicenter, cross-sectional study

    2023  

    Abstract: Physician burnout is a global concern that can lead to exhaustion, ineffectiveness, and poor health outcomes. Burnout has been linked to a variety of societal and professional variables worldwide. This cross-sectional, multi-centered study was conducted ... ...

    Abstract Physician burnout is a global concern that can lead to exhaustion, ineffectiveness, and poor health outcomes. Burnout has been linked to a variety of societal and professional variables worldwide. This cross-sectional, multi-centered study was conducted by face-to-face interviews between April 2019 and December 2021 at sixty-two (62) tertiary level hospitals to identify potential risk factors for burnout among Bangladeshi physicians, which is essential for preventing adverse impact on their well-being, improving overall quality of life, and facilitating measures to manage stress and maintain a healthy work-life balance. A simple random sampling technique in conjunction with a structured questionnaire was used to collect a total of 1434 responses, assuming 20 % of the sample as non-responsive. Univariate, bivariate, and multinomial logistic regression statistical analyses were performed to determine the risk factors and associate the level of severity. The distribution of burnout status differs significantly at distinct covariate levels, such as working place, working hour, prevalence of potential interpersonal conflicts (subsequent increase of adjusted odds ratios i.e.; 6.52, 8.82, 11.41, and 37.07 is observed for physicians having interpersonal conflicts with both co-workers & family members), job dissatisfaction, annoyed feeling while dealing with patients (adjusted odds ratios are 529.68, 518.26,983.87 and 849.57 respectively) and some other significant factors of the physicians. This study also reveals that the female physicians, physicians with age 40–49, physicians with additional liabilities, physicians with job dissatisfaction, less salary compared to the workload, less flexibility and security at the job sector as well as obese physicians are at high risk of burnout. These results are statistically significant with a p value ≤ 0.05. To reduce burnout of Bangladeshi physicians, it is necessary to address the risk factors, create supportive workplaces, maintain a healthy work-life balance, provide ...
    Keywords Burnout ; Bangladeshi physicians ; Workplace ; Burnout measure ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 300
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dataset concerning effects of stevia (Stevia rebaudiana bertoni), amlodipine, losartan, and valsartan on water consumption, blood glucose and heart tissue in gentamycin-induced nephrotoxicity in the rat model

    Farhana Rizwan / Saquiba Yesmine / Ishtiaque Ahmed Chowdhury / Sultana Gulshana Banu / Tapan Kumar Chatterjee

    Data in Brief, Vol 31, Iss , Pp 105965- (2020)

    2020  

    Abstract: This dataset indicates the effect of stevia (Stevia rebaudiana Bertoni); angiotensin-II type-1 receptor (AT1) blockers, losartan and valsartan; and a calcium (Ca2+) channel blocker, amlodipine; on water consumption, fasting blood glucose, and cardiac ... ...

    Abstract This dataset indicates the effect of stevia (Stevia rebaudiana Bertoni); angiotensin-II type-1 receptor (AT1) blockers, losartan and valsartan; and a calcium (Ca2+) channel blocker, amlodipine; on water consumption, fasting blood glucose, and cardiac histology in gentamycin-induced nephrotoxic rat model. Six groups of male Sprague-Dawley rats were selected as sham control group, gentamycin-induced nephrotoxic disease control group; gentamycin-induced disease control groups treated with stevia (200 mg/kg/day); amlodipine (4 mg/kg/day); losartan (15 mg/kg/day) and valsartan (5 mg/kg/day) respectively. Fasting blood glucose level and water consumption were recorded daily for the first week and then weekly for the rest of treatment period. Serum creatinine, blood urea, total protein and lipid profile were determined. Histological examination of the heart tissue was assessed to find out any alteration of cardiac muscle tissue following gentamycin-induced nephrotoxicity. This article provides additional data collected from the same animals previously reported [1] .
    Keywords Angiotensin-ii type-1 receptor (at1) blockers ; Calcium (ca2+) channel blocker ; Gentamycin-induced nephrotoxicity ; stevia ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Subject code 630
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Iron Overload and Breast Cancer

    Sufia Islam / Nazia Hoque / Nishat Nasrin / Mehnaz Hossain / Farhana Rizwan / Kushal Biswas / Muhammad Asaduzzaman / Sabera Rahman / David W. Hoskin / Saki Sultana / Christian Lehmann

    Life, Vol 12, Iss 7, p

    Iron Chelation as a Potential Therapeutic Approach

    2022  Volume 963

    Abstract: Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer ... ...

    Abstract Breast cancer has historically been one of the leading causes of death for women worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the most common type of cancer globally, representing an estimated 11.3% of all cancer diagnoses. A multidisciplinary approach is taken for the diagnosis and treatment of breast cancer that includes conventional and targeted treatments. However, current therapeutic approaches to treating breast cancer have limitations, necessitating the search for new treatment options. Cancer cells require adequate iron for their continuous and rapid proliferation. Excess iron saturates the iron-binding capacity of transferrin, resulting in non-transferrin-bound iron (NTBI) that can catalyze free-radical reactions and may lead to oxidant-mediated breast carcinogenesis. Moreover, excess iron and the disruption of iron metabolism by local estrogen in the breast leads to the generation of reactive oxygen species (ROS). Therefore, iron concentration reduction using an iron chelator can be a novel therapeutic strategy for countering breast cancer development and progression. This review focuses on the use of iron chelators to deplete iron levels in tumor cells, specifically in the breast, thereby preventing the generation of free radicals. The inhibition of DNA synthesis and promotion of cancer cell apoptosis are the targets of breast cancer treatment, which can be achieved by restricting the iron environment in the body. We hypothesize that the usage of iron chelators has the therapeutic potential to control intracellular iron levels and inhibit the breast tumor growth. In clinical settings, iron chelators can be used to reduce cancer cell growth and thus reduce the morbidity and mortality in breast cancer patients.
    Keywords breast cancer ; oxidative stress ; iron overload ; iron chelator ; estrogen ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Preliminary analysis of the effect of Stevia (Stevia rebaudiana) in patients with chronic kidney disease (stage I to stage III)

    Farhana Rizwan / Harun Ur Rashid / Saquiba Yesmine / Forhad Monjur / Tapan Kumar Chatterjee

    Contemporary Clinical Trials Communications, Vol 12, Iss , Pp 17-

    2018  Volume 25

    Abstract: Background: Stevia, Stevia rebaudiana (Bertoni), has become an important economic plant for its commercial use as a sweetener. Stevia plays a significant role in the healthcare practice of different cultures and in population. Previous animal and ... ...

    Abstract Background: Stevia, Stevia rebaudiana (Bertoni), has become an important economic plant for its commercial use as a sweetener. Stevia plays a significant role in the healthcare practice of different cultures and in population. Previous animal and clinical studies demonstrated the efficacy of Stevia against chronic diseases like diabetes and hypertension. This study aimed to investigate the beneficial effect of Stevia in chronic kidney disease (CKD) patients after three (3) months of treatment along with the conventional antihypertensive and anti diabetic medications. Methods: A prospective, interventional, randomized, single-blind, placebo-controlled trial has been done with 97 participants. Stevia capsule (250 mg) or matching placebo was given to the participants twice daily along with Angiotensin-II Receptor Blocker (ARB) and/or Ca2+ Channel Blocker (CCB). First follow up visits were done after 3 months of the interval. Blood and urine samples were collected for the biochemical tests. A structured questionnaire was used for the baseline assessment. Informed consent was taken from each participant. Results: Both hypertension and diabetes were found to be associated with CKD. Most of the participants (52.3%) of Stevia group were in CKD Stage II. Significant changes were found in Serum creatinine (p < 0.027), Serum Uric acid (p < 0.009), Fasting blood sugar (p < 0.041) and Postprandial blood sugar (p < 0.013) and Microalbumin (p < 0.041) level in the treatment group. Conclusion: The initial result demonstrated that Stevia has the potential for a significant improvement of some biochemical parameters in CKD patients. After completion of the nine (9) months clinical trial, the constructive effect of Stevia can be confirmed in this group of patients. Keywords: Stevia, Chronic kidney disease (CKD), Hypertension, Diabetes mellitus, Angiotensin-II receptor blocker (ARB), Ca2+ channel blocker (CCB)
    Keywords Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

    Apurba Sarker Apu / Mahmuda Sultana Liza / A.T.M. Jamaluddin / Md. Amran Howlader / Repon Kumer Saha / Farhana Rizwan / Nishat Nasrin

    Asian Pacific Journal of Tropical Biomedicine, Vol 2, Iss 9, Pp 673-

    2012  Volume 678

    Abstract: Objective: To investigate the bioactivities of crude n-hexane, ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn. (B. diffusa) and its phytochemical analysis. Methods: The identification of phytoconstituents and assay of ... ...

    Abstract Objective: To investigate the bioactivities of crude n-hexane, ethyl acetate and methanol extracts of aerial part of Boerhavia diffusa Linn. (B. diffusa) and its phytochemical analysis. Methods: The identification of phytoconstituents and assay of antioxidant, thrombolytic, cytotoxic, antimicrobial activities were conducted using specific standard in vitro procedures. Results: The results showed that the plant extracts were a rich source of phytoconstituents. Methanol extract showed higher antioxidant, thrombolytic activity and less cytotoxic activity than those of n-hexane and ethyl acetate extracts of B. diffusa. Among the bioactivities, antioxidant activity was the most notable compared to the positive control and thus could be a potential rich source of natural antioxidant. In case of antimicrobial screening, crude extracts of the plant showed remarkable antibacterial activity against tested microorganisms. All the extracts showed significant inhibitory activity against Candida albicuns, at a concentration of 1 000 μg/disc. Conclusions: The present findings suggest that, the plant widely available in Bangladesh, could be a prominent source of medicinally important natural compounds.
    Keywords Boerhavia diffusa ; Antioxidant ; Cytotoxic ; Thrombolytic ; Antimicrobial ; DPPH ; NO ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2012-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: In vitro Sensitivity of Different Brands of Antiamoebic Drugs (Metronidazole Tablets) Against Clinical Isolates of Entamoeba histolytica in Bangladesh

    Md. Mehedi Aziz Sarker / Farhana Rizwan / Rashidul Haque / Abdulllah Siddique / Seheli Parveen / Sufia Islam

    Journal of Biological Sciences, Vol 8, Iss 5, Pp 925-

    2008  Volume 929

    Abstract: The aim of the study was to evaluate in vitro sensitivity of different metronidazole tablets from Bangladeshi pharmaceuticals against clinical isolates of E. histolytica. Metronidazole tablets of 12 different brands were randomized from some big and ... ...

    Abstract The aim of the study was to evaluate in vitro sensitivity of different metronidazole tablets from Bangladeshi pharmaceuticals against clinical isolates of E. histolytica. Metronidazole tablets of 12 different brands were randomized from some big and small pharmaceuticals according to their business. The parasite count was adjusted to 3x10 6 parasites mL -1 in a medium. In vitro drug sensitivity assay of the samples was carried out by using microtiter plates after treatment with different concentrations of metronidazoles. The viable parasites were counted by haemocytometer. No statistical significance was observed in terms of viable parasites with the metronidazole tablets from three big pharmaceuticals at the concentration of 2.3, 3.5 and 4.6 μM when compared with the standard metronidazole. We conclude that brands from some big pharmaceuticals showed in vitro sensitivity against E. histolytica .
    Keywords Amoebiasis ; metronidazole ; Entamoeba histolytica ; drug resistance ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Asian Network for Scientific Information
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Antibiotic sensitivity pattern of causative organisms of neonatal septicemia in an urban hospital of Bangladesh

    Forhad Monjur / Farhana Rizwan / Muhammad Asaduzzaman / Nishat Nasrin / Nobo Krishna Ghosh / Apurba Sarker Apu / Fazlul Haque

    Indian Journal of Medical Sciences, Vol 64, Iss 6, Pp 265-

    2010  Volume 271

    Abstract: Background: The information of the sensitivity pattern of the causative organisms is very important for effective control of septicemia in neonates. OBJECTIVE: To determine the proportion and profile of pathogenic bacteria in the blood cultures of the ... ...

    Abstract Background: The information of the sensitivity pattern of the causative organisms is very important for effective control of septicemia in neonates. OBJECTIVE: To determine the proportion and profile of pathogenic bacteria in the blood cultures of the neonates with clinically suspected septicemia and their susceptibility pattern to antimicrobial agents for developing a unified antibiotic treatment protocol. Materials and Methods: A cross-sectional retrospective study was conducted over a period of 3 year and 4 months (39 months). The study included 1000 patients admitted in the selected hospital in Bangladesh. Blood samples for culture were taken aseptically before starting antibiotic therapy. Microorganisms were isolated and identified by standard microbiological processes which include colony morphology, Gram stain, and biochemical profiles. Antimicrobial sensitivity patterns were performed by Kirby-Bauer′s disc diffusion method against imipenem, ciprofloxacin, ceftazidime, chloramphenicol, netilmicin, gentamicin, ceftriaxone, aztreonam, cefotaxime, cephalexin, and ampicillin. Results: Among the patients, 633 (63.3%) were males and 367 (36.7%) were females. Blood cultures were found positive in 194 (19.4%) neonates. The organisms isolated were Pseudomonas spp. (31.4%), Klebsiella pneumoniae (23.2%), Staphylococcus aureus (12.4%), Escherichia coli (7.2%), Acinatobactor (5.7%), Gram-negative Bacilli (4.1%), Flavobacterium spp. (3.6%), Serratia spp. (5.7%), Citrobacter fruendi (3.1%), Streptococcus species (2.6%), and Enterobacter spp. (1.0%). A majority of the bacterial isolates in neonatal sepsis were found sensitive to imipenem (91.8%) and ciprofloxacin (57.2%) and resistant to commonly used antibiotics, eg. ampicillin (96.4%) and cephalexin (89.2%). Conclusion : The problem can be mitigated by careful selection and prudent use of available antibiotics.
    Keywords Antibiotics ; bacterial pathogen ; blood culture ; neonatal septicemia ; sensitivity ; Medicine (General) ; R5-920 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2010-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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