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  1. Article ; Online: Acute Myelomonoblastic Leukemia (My1/De): A Preclinical Rat Model.

    Arató, Viktória / Képes, Zita / Szabó, Judit P / Farkasinszky, Gergely / Sass, Tamás / Dénes, Noémi / Kis, Adrienn / Opposits, Gábor / Jószai, István / Kálmán, Ferenc Krisztián / Hajdu, István / Trencsényi, György / Kertész, István

    In vivo (Athens, Greece)

    2024  Volume 38, Issue 3, Page(s) 1064–1073

    Abstract: Background/aim: Since acute myeloid leukemias still represent the most aggressive type of adult acute leukemias, the profound understanding of disease pathology is of paramount importance for diagnostic and therapeutic purposes. Hence, this study aimed ... ...

    Abstract Background/aim: Since acute myeloid leukemias still represent the most aggressive type of adult acute leukemias, the profound understanding of disease pathology is of paramount importance for diagnostic and therapeutic purposes. Hence, this study aimed to explore the real-time disease fate with the establishment of an experimental myelomonoblastic leukemia (My1/De) rat model using preclinical positron emission tomography (PET) and whole-body autoradiography.
    Materials and methods: In vitro [
    Results: The tracer accumulation in the My1/De culture cells exceeded that of both the tumorous and the healthy bone marrow suspensions (p<0.01). Based on in vivo imaging, the subrenally transplanted My1/De cells resulted in the development of leukemia in the abdominal organs, and metastasized to the mesenterial and thoracic parathymic lymph nodes (PTLNs). The lymphatic spread of metastasis was further confirmed by the significantly higher %ID/g values of the metastatic PTLNs (4.25±0.28) compared to the control (0.94±0.34). Cytochemical staining of the peripheral blood, autopsy findings, and wright-Giemsa-stained post-mortem histological sections proved the leukemic involvement of the assessed tissues/organs.
    Conclusion: The currently established My1/De model appears to be well-suited for further leukemia-related therapeutic and diagnostic investigations.
    MeSH term(s) Animals ; Rats ; Disease Models, Animal ; Fluorodeoxyglucose F18 ; Autoradiography ; Positron-Emission Tomography ; Cell Line, Tumor ; Tissue Distribution ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/diagnostic imaging ; Radiopharmaceuticals ; Male ; Humans
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2024-04-28
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: In Vivo Imaging of Acute Hindlimb Ischaemia in Rat Model: A Pre-Clinical PET Study.

    Farkasinszky, Gergely / Péliné, Judit Szabó / Károlyi, Péter / Rácz, Szilvia / Dénes, Noémi / Papp, Tamás / Király, József / Szabo, Zsuzsanna / Kertész, István / Mező, Gábor / Halmos, Gabor / Képes, Zita / Trencsényi, György

    Pharmaceutics

    2024  Volume 16, Issue 4

    Abstract: Background: To better understand ischaemia-related molecular alterations, temporal changes in angiogenic Aminopeptidase N (APN/CD13) expression and glucose metabolism were assessed with PET using a rat model of peripheral arterial disease (PAD).: ... ...

    Abstract Background: To better understand ischaemia-related molecular alterations, temporal changes in angiogenic Aminopeptidase N (APN/CD13) expression and glucose metabolism were assessed with PET using a rat model of peripheral arterial disease (PAD).
    Methods: The mechanical occlusion of the base of the left hindlimb triggered using a tourniquet was applied to establish the ischaemia/reperfusion injury model in Fischer-344 rats. 2-[
    Results: Due to a cellular adaptation to hypoxia, a gradual increase in [
    Conclusions: The PET-based longitudinal assessment of angiogenesis-associated APN/CD13 expression and glucose metabolism during ischaemia may continue to broaden our knowledge on the pathophysiology of PAD.
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16040542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Vivo

    Farkasinszky, Gergely / Dénes, Noémi / Rácz, Szilvia / Kis, Adrienn / Péliné, Judit Szabó / Opposits, Gábor / Veres, Gergő / Balkay, László / Kertész, István / Mező, Gábor / Hunyadi, János / Trencsényi, György

    In vivo (Athens, Greece)

    2022  Volume 36, Issue 2, Page(s) 657–666

    Abstract: Background/aim: Previous studies have already shown that : Materials and methods: Ischemia/reperfusion injury was initiated by surgical ligation of the left bulbus oculi of rats. In vivo PET imaging studies were performed after the surgery using : ... ...

    Abstract Background/aim: Previous studies have already shown that
    Materials and methods: Ischemia/reperfusion injury was initiated by surgical ligation of the left bulbus oculi of rats. In vivo PET imaging studies were performed after the surgery using
    Results: Significantly higher
    Conclusion: 68
    MeSH term(s) Animals ; CD13 Antigens/metabolism ; Cell Line, Tumor ; Gallium Radioisotopes ; Heterocyclic Compounds, 1-Ring ; Ischemia ; Positron-Emission Tomography/methods ; Rats ; Reperfusion
    Chemical Substances Gallium Radioisotopes ; Heterocyclic Compounds, 1-Ring ; 1,4,7-triazacyclononane-N,N',N''-triacetic acid (56491-86-2) ; CD13 Antigens (EC 3.4.11.2)
    Language English
    Publishing date 2022-03-03
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12750
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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