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Article ; Online: Test-Retest Reproducibility of Reduced-Field-of-View Density-Weighted CRT MRSI at 3T.

Farley, Nicholas / Susnjar, Antonia / Chiew, Mark / Emir, Uzay E

Tomography (Ann Arbor, Mich.)

2024 Volume 10, Issue 4, Page(s) 493–503

Abstract: Quantifying an imaging modality's ability to reproduce results is important for establishing its utility. In magnetic resonance spectroscopic imaging (MRSI), new acquisition protocols are regularly introduced which improve upon their precursors with ... ...

Abstract	Quantifying an imaging modality's ability to reproduce results is important for establishing its utility. In magnetic resonance spectroscopic imaging (MRSI), new acquisition protocols are regularly introduced which improve upon their precursors with respect to signal-to-noise ratio (SNR), total acquisition duration, and nominal voxel resolution. This study has quantified the within-subject and between-subject reproducibility of one such new protocol (reduced-field-of-view density-weighted concentric ring trajectory (rFOV-DW-CRT) MRSI) by calculating the coefficient of variance of data acquired from a test-retest experiment. The posterior cingulate cortex (PCC) and the right superior corona radiata (SCR) were selected as the regions of interest (ROIs) for grey matter (GM) and white matter (WM), respectively. CVs for between-subject and within-subject were consistently around or below 15% for Glx, tCho, and Myo-Ins, and below 5% for tNAA and tCr.
MeSH term(s)	Humans ; Reproducibility of Results ; Male ; Female ; Adult ; Magnetic Resonance Imaging/methods ; Gray Matter/diagnostic imaging ; Signal-To-Noise Ratio ; Magnetic Resonance Spectroscopy/methods ; Brain/diagnostic imaging ; White Matter/diagnostic imaging ; Young Adult
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography10040038
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Article ; Online: Renal artery occlusion in a young woman - a tale of mysterious thrombosis.

Farley, Ned / Faraj, Joseph / Fernando, Malindu / Singh, Tejas / Powell, Aaron / Kumar, Senthil

Vascular

2024 , Page(s) 17085381241247906

Abstract: Background: Renal artery thrombosis is rare and limited reports exist in the young population. The most common aetiology is thromboembolic disease or abdominal trauma in this population and isolated occurrences are extremely rare. We present the case of ...

Abstract	Background: Renal artery thrombosis is rare and limited reports exist in the young population. The most common aetiology is thromboembolic disease or abdominal trauma in this population and isolated occurrences are extremely rare. We present the case of an 18-year-old woman with spontaneous unilateral renal artery thrombosis and infarction for whom reperfusion was achieved through endovascular intervention. The aetiology of her thrombosis remains unclear and is under investigation with differential diagnoses being fibromuscular dysplasia, large and medium vessel vasculitis, and thromboembolic causes. Objective: To demonstrate the value in attempting salvage of an ischaemic kidney in a young patient with an unexplained spontaneous renal thrombosis. Method: JM is an 18-year-old woman who presented to a large regional tertiary hospital with 3 days of right flank pain. She had no infective symptoms and no urinary or bowel changes before admission. She was not pregnant, and her only medication was the oral contraceptive pill commenced 3 months prior. A CT angiogram demonstrated right renal artery thrombosis with renal infarction. The kidney was deemed potentially salvageable, and ultrasound defined adequate vessel calibre to access for thrombectomy in the context of a negative coagulopathy screen. Results: The patient underwent thrombolysis, thrombectomy and balloon angioplasty. Intraoperatively, a thin segment of distal stenosis was identified, and angiogram reperfusion was achieved with subsequent improvement in renal function. Conclusion: Renal artery thrombosis in young people is extremely rare and presents a diagnostic and management challenge requiring input from multiple teams including nephrology, rheumatology, paediatrics and vascular surgery. Systemic coagulopathy and vasculitis are differentials against anatomical aetiologies such as fibromuscular dysplasia. Our case adds to the limited literature regarding this in the young population. Renal artery thrombosis with occlusion in young people is very rare and is most often associated with a systemic coagulopathic disorder, such as antiphospholipid syndrome or structural pathology of the renal vasculature such as fibromuscular dysplasia. The work-up of a young female presenting with renal artery thrombosis without any previous medical history screens for a wide range of pathological processes.
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381241247906
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Zs.A 4277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 590: Show issues

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Article ; Online: Anatomical and biochemical evidence for Treponema pallidum in a 19th to early twentieth century skeletal cadaver.

Henkel, James S / Davis, Joel / Farley, Ned

Forensic science, medicine, and pathology

2020 Volume 16, Issue 3, Page(s) 557–561

Abstract: This report summarizes findings relating to the biochemical and skeletal evidence for Treponema pallidum in an unusually old case of congenital syphilis. In 1951, the Milwaukee Public Museum acquired skeletal remains from the Surgical School of Marquette ...

Abstract	This report summarizes findings relating to the biochemical and skeletal evidence for Treponema pallidum in an unusually old case of congenital syphilis. In 1951, the Milwaukee Public Museum acquired skeletal remains from the Surgical School of Marquette University. The male was identified as a 60-65-year-old, that was suffering from congenital syphilis. His remains are now part of the anthropological collections of Wisconsin Lutheran College (Milwaukee, Wisconsin). Venereal Disease Research Laboratory (VDRL) and Rapid Plasma Reagin (RPR) tests were used to verify the presence of the bacteria-generated antibodies, while mass spectrometry testing provided indirect evidence for the historical treatment of the disease. Notably, antibody detection in human remains of this age is rare. These initial results support what is known of syphilis and its treatment prior to the wide scale, clinical use of penicillin therapy, and describe evidence for long-term skeletal symptoms of congenital syphilis in century-old human remains.
MeSH term(s)	Aged ; Anodontia/pathology ; Antibodies, Bacterial/analysis ; Bone Resorption ; Bone and Bones/pathology ; Cadaver ; Craniosynostoses/pathology ; Edema/pathology ; Facial Bones/abnormalities ; History, 20th Century ; Humans ; Joints/pathology ; Male ; Malnutrition/pathology ; Mass Spectrometry ; Mercury/analysis ; Middle Aged ; Osteophyte/pathology ; Syphilis, Congenital/pathology ; Treponema pallidum
Chemical Substances	Antibodies, Bacterial ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2020-05-11
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	2195904-3
ISSN	1556-2891 ; 1547-769X
ISSN (online)	1556-2891
ISSN	1547-769X
DOI	10.1007/s12024-020-00243-2
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Article ; Online: Delayed diagnosis of Crohn's disease-associated liver abscesses and enteric fistulas due to COVID-19.

Farley, Ned / Hindmarch, Jake / Quah, Gaik Si / Iannuzzi, Aniello / Di Re, Angelina

ANZ journal of surgery

2022 Volume 93, Issue 3, Page(s) 773–774

MeSH term(s)	Humans ; Crohn Disease/complications ; Crohn Disease/diagnosis ; Delayed Diagnosis ; COVID-19 ; Liver Abscess ; Intestinal Fistula/diagnostic imaging ; Intestinal Fistula/etiology ; Rectal Fistula ; COVID-19 Testing
Language	English
Publishing date	2022-09-02
Publishing country	Australia
Document type	Case Reports
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.18019
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Zs.A 180: Show issues

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Article ; Online: Assessment of Porites microatolls for paleothermometry

Farley, Nicholas / Antonioli, Guillaume / Hallmann, Nadine / Camoin, Gilbert / Eisenhauer, Anton / Vella, Claude / Milne, Glenn A. / Samankassou, Elias

Calibration for French Polynesia

2024

Abstract: Highlights • Investigation into the potential of Porites microatolls for SST reconstruction. • Comparison between recent and more conventional coral paleoclimatology methods. • Application of Srsingle bondU and Li/Mg paleothermometer. • Accuracy and ... ...

Abstract	Highlights • Investigation into the potential of Porites microatolls for SST reconstruction. • Comparison between recent and more conventional coral paleoclimatology methods. • Application of Srsingle bondU and Li/Mg paleothermometer. • Accuracy and reproducibility of Sr/Ca proved to be the most suitable proxy for SST reconstruction. Abstract Massive dome-shaped coral Porites are the predominant choice for paleoclimate studies due to their consistent and reliable growth. When growing close to sea level, they become limited in their vertical growth and form so-called ‘microatolls’. Microatolls have not yet been extensively explored for paleoclimate reconstruction. Here, we investigate how reliable modern Porites microatolls are against empirical sea-surface temperature using Sr/Ca, δ18O, Li/Mg and Srsingle bondU paleothermometry methods on samples from the Society Islands, French Polynesia. Our results show Sr/Ca ratios have the lowest Standard Error of the Inverse Prediction (SEIP) at 0.415 °C (N = 41) with a calibration of Sr/Ca (mmol mol−1) = −0.082 ± 0.006 SST (°C) + 11.256 ± 0.170 and with high reproducibility across multiple corals. The reproducibility of δ18O was less good, with SEIP increasing to 0.829 °C (N = 41). Considering methods directly from the literature, Li/Mg ratio empirically corrected for Sr/Ca had the best balance between bias and precision where no local calibration could be available. This study independently evaluates and confirms the suitability of Porites microatolls from well-flushed environments for paleoclimate studies. Fossil dome-shaped Porites grow anywhere between near-surface and roughly 20 m depths which inherently incorporates uncertainty into any sea surface temperature reconstruction. This uncertainty is significantly reduced for microatolls due to their well-constrained bathymetry. The study represents a fundamental step in paleoclimate research targeting consistently near the water-air interface bringing reliability and, especially when combined with their ability to ...
Subject code	551
Language	English
Publisher	Elsevier
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optical Coherence Tomography Angiography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopathy.

Farley, Nathan / Pellegrini, Marco / Marlow, Elizabeth / Ruby, Alan / Randhawa, Sandeep

Journal of vitreoretinal diseases

2020 Volume 4, Issue 6, Page(s) 515–521

Abstract: Purpose: Acute syphilitic posterior placoid chorioretinopathy (ASPPC) is an uncommon and distinct manifestation of ocular syphilis necessitating immediate treatment. ASPPC is attributed to disruption of the choriocapillaris, retinal pigment epithelium, ... ...

Abstract	Purpose: Acute syphilitic posterior placoid chorioretinopathy (ASPPC) is an uncommon and distinct manifestation of ocular syphilis necessitating immediate treatment. ASPPC is attributed to disruption of the choriocapillaris, retinal pigment epithelium, and photoreceptors. Optical coherence tomography angiography (OCTA) can evaluate choriocapillaris vascular flow and may provide further information about ASPPC's disease process. Methods: OCTA images from 7 eyes of 4 patients with ASPPC were compared before and after treatment when available. Results: All eyes demonstrated increased choriocapillaris vascular flow voids in the distribution of the ASPPC lesions at initial testing. Following treatment, decreased placoid lesion size was associated with decreased flow voids on OCTA along with improved ellipsoid zone integrity in 2 patients. Conclusions: Disruption of choriocapillaris vascular flow in ASPPC that causes outer retinal changes can improve following treatment as suggested by OCTA imaging. Some cases may continue to demonstrate decreased flow even after appropriate therapy.
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Case Reports
ISSN	2474-1272
ISSN (online)	2474-1272
DOI	10.1177/2474126420936193
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Article ; Online: Paraneoplastic ocular sarcoidosis in the setting of recurrent rectal carcinoid tumor diagnosed by F

Marlow, Elizabeth D / Faia, Lisa J / Wu, Dafang / Farley, Nathan / Randhawa, Sandeep

American journal of ophthalmology case reports

2020 Volume 20, Page(s) 100887

Abstract: Purpose: Nuclear medicine imaging can provide a noninvasive means of distinguishing inflammatory mass lesions from oncologic intraocular tumors.: Observation: We report a case of paraneoplastic ocular sarcoidosis with choroidal mass lesions that was ... ...

Abstract	Purpose: Nuclear medicine imaging can provide a noninvasive means of distinguishing inflammatory mass lesions from oncologic intraocular tumors. Observation: We report a case of paraneoplastic ocular sarcoidosis with choroidal mass lesions that was initially concerning for choroidal metastasis of a primary carcinoid tumor. PET CT was utilized with two different tracers to characterize the choroidal mass as being FDG-avid, consistent with a sarcoid-like lesion, and lacking the Gallium (Ga-68) DOTATAE uptake of carcinoid tumor metastases. Conclusions and importance: Functional imaging is valuable to distinguish clinically similar inflammatory verses oncologic intraocular pathology.
Language	English
Publishing date	2020-08-20
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2020.100887
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Book: Living in paradox

Farley, Ned

the theory and practice of contextual existentialism

2008

Author's details	Ned Farley
MeSH term(s)	Existentialism ; Psychotherapy/methods
Language	English
Size	xii, 114 p. ;, 23 cm.
Publisher	University Press Of America
Publishing place	Lanham, MD
Document type	Book
ISBN	9780761841517 ; 0761841512 ; 9780761842651 ; 0761842659
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Concordance between physiotherapists and physicians for care of patients with musculoskeletal disorders presenting to the emergency department.

Matifat, E / Perreault, K / Roy, J-S / Aiken, A / Gagnon, E / Mequignon, M / Lowry, V / Décary, S / Hamelin, B / Ambrosio, M / Farley, N / Pelletier, D / Carlesso, L / Desmeules, F

BMC emergency medicine

2019 Volume 19, Issue 1, Page(s) 67

Abstract: Background: Overcrowding in emergency departments (ED) is a major concern worldwide. To answer increasing health care demands, new models of care including advanced practice physiotherapists (APP) have been implemented in EDs. The purpose of this study ... ...

Abstract	Background: Overcrowding in emergency departments (ED) is a major concern worldwide. To answer increasing health care demands, new models of care including advanced practice physiotherapists (APP) have been implemented in EDs. The purpose of this study was to assess diagnostic, treatment and discharge plan concordance between APPs and ED physicians for patients consulting to the ED for minor musculoskeletal disorders (MSKD). Methods: Patients presenting to two EDs in Montréal (Canada) with a minor MSKD were recruited and independently assessed by an APP and ED physician. Both providers had to formulate diagnosis, treatment and discharge plans. Cohen's kappa (κ) and Prevalence and Bias Adjusted Kappas (PABAK) with associated 95%CI were calculated. Chi Square and t-tests were used to compare treatment, discharge plan modalities and patient satisfaction between providers. Results: One hundred and thirteen participants were recruited, mean age was 50.3 ± 17.4 years old and 51.3% had an atraumatic MSKD. Diagnostic inter-rater agreement between providers was very good (κ = 0.81; 95% CI: 0.72-0.90). In terms of treatment plan, APPs referred significantly more participants to physiotherapy care than ED physicians (κ = 0.27; PABAK = 0.27; 95% CI: 0.07-0.45; p = 0.003). There was a moderate inter-rater agreement (κ = 0.46; PABAK = 0.64; 95% CI: 0.46-0.77) for discharge plans. High patient satisfaction was reported with no significant differences between providers (p = 0.57). Conclusion: There was significant agreement between APPs and ED physicians in terms of diagnosis and discharge plans, but more discrepancies regarding treatment plans. These results tend to support the integration of APPs in ED settings, but further prospective evaluation of the efficiency of these types of models is warranted.
MeSH term(s)	Adult ; Aged ; Canada ; Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/standards ; Female ; Humans ; Male ; Middle Aged ; Musculoskeletal Diseases ; Patient Care Planning/organization & administration ; Patient Care Planning/standards ; Patient Satisfaction ; Physical Therapists/standards ; Physicians/standards
Language	English
Publishing date	2019-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-227X
ISSN (online)	1471-227X
DOI	10.1186/s12873-019-0277-7
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Article ; Online: ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in "double hit" lymphoma cells.

Johnson-Farley, Nadine / Veliz, Jonny / Bhagavathi, S / Bertino, Joseph R

Leukemia & lymphoma

2015 Volume 56, Issue 7, Page(s) 2146–2152

Abstract: Double hit lymphoma (DHL) is a recently recognized lymphoma with a survival of less than 2 years. Both ABT-737, a Bcl-2/Bcl-XL inhibitor, and ABT-199, which selectively targets Bcl-2, were potently cytotoxic against DHL cell lines Sc-1 and OcI-LY18, the ... ...

Abstract	Double hit lymphoma (DHL) is a recently recognized lymphoma with a survival of less than 2 years. Both ABT-737, a Bcl-2/Bcl-XL inhibitor, and ABT-199, which selectively targets Bcl-2, were potently cytotoxic against DHL cell lines Sc-1 and OcI-LY18, the RL cell line and primary human DHL cells, but not Ramos cells, which lack Bcl-2 expression. ABT-199 was more potent than ABT-737, and is the most promising of the BH3 mimetics to date. The DHL cell lines were also sensitive (< 200 nM) to doxorubicin, methotrexate, cytarabine and the proteosome inhibitor, bortezomib. The combination of chemotherapy with ABT-199 and doxorubicin or cytarabine, bortezomib, YM-155 and JQ1 produced synergistic cell kill against the DHL cell lines. Cells from a patient with DHL were also sensitive to JQ1 and bortezomib, providing a rationale for a clinical trial of these combinations in patients with relapsed DHL.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis/drug effects ; Azepines/administration & dosage ; Biomimetics ; Blotting, Western ; Bortezomib/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Cell Proliferation/drug effects ; Drug Synergism ; Humans ; Lymphoma/drug therapy ; Lymphoma/metabolism ; Lymphoma/pathology ; Peptide Fragments/administration & dosage ; Proto-Oncogene Proteins/administration & dosage ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Sulfonamides/administration & dosage ; Triazoles/administration & dosage ; Tumor Cells, Cultured
Chemical Substances	(+)-JQ1 compound ; Azepines ; Bax protein (53-86) ; Bridged Bicyclo Compounds, Heterocyclic ; Peptide Fragments ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; Triazoles ; Bortezomib (69G8BD63PP) ; venetoclax (N54AIC43PW)
Language	English
Publishing date	2015-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2014.981172
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Zs.A 2997: Show issues

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