LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Search options

Article ; Online: Nutraceutical potential of olive pomace: insights from cell-based and clinical studies.

Monteiro, Camila Sant'Anna / Adedara, Isaac Adegboyega / Farombi, Ebenezer Olatunde / Emanuelli, Tatiana

Journal of the science of food and agriculture

2024 Volume 104, Issue 7, Page(s) 3807–3815

Abstract: Olive oil production yields a substantial volume of by-products, constituting up to 80% of the processed fruits. The olive pomace by-product represents a residue of significant interest due to the diverse bioactive compounds identified in it. However, a ... ...

Abstract	Olive oil production yields a substantial volume of by-products, constituting up to 80% of the processed fruits. The olive pomace by-product represents a residue of significant interest due to the diverse bioactive compounds identified in it. However, a thorough characterization and elucidation of the biological activities of olive pomace are imperative to redirect its application for functional food, nutraceutical, and pharmaceutical purposes both for animals and humans. In this review, we examine data from experimental models, including immortalized human vascular endothelial cells, human corneal and conjunctival epithelial cells, human colorectal adenocarcinoma cells, non-tumorigenic human hepatoma cells, and murine macrophages alongside clinical trials. These studies aim to validate the safety, nutritional value, and pharmacological effects of olive pomace. In vitro studies suggest that biophenols extracted from olive pomace possess antioxidant, anti-inflammatory, and antiproliferative properties that could be beneficial in mitigating cardiovascular disorders, particularly atherosclerosis, hepatosteatosis, and dry-eye disease. Protective effects against dry-eye disease were confirmed in a mouse model assay. Olive pomace used in the feed for fish and poultry has demonstrated the ability to enhance animals' immunity and improve nutritional quality of meat and eggs. Human clinical trials are scarce and have revealed minimal biological changes following the consumption of olive pomace-enriched foods. However, alterations in certain biomarkers tentatively suggest cardioprotective properties. The review underscores the value of olive pomace while addressing potential drawbacks and future perspectives, with a specific focus on the need for further investigation into the animal feed and human nutritional properties of olive pomace. © 2024 Society of Chemical Industry.
MeSH term(s)	Humans ; Animals ; Mice ; Olea/chemistry ; Endothelial Cells ; Olive Oil/chemistry ; Dietary Supplements ; Eye Diseases
Chemical Substances	Olive Oil
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13281
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 808: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: 6-Gingerol, an active constituent of ginger, attenuates lipopolysaccharide-induced oxidation, inflammation, cognitive deficits, neuroplasticity, and amyloidogenesis in rat.

Adetuyi, Babatunde Oluwafemi / Farombi, Ebenezer Olatunde

Journal of food biochemistry

2021 Volume 45, Issue 4, Page(s) e13660

Abstract: This study examined the protective effect of 6-Gingerol (6G) against lipopolysaccharide (LPS)-induced cognitive impairments, oxidative stress, neuroplasticity, amyloidogenesis, and inflammation. Male rats were allocated into six groups in this manner; ... ...

Abstract	This study examined the protective effect of 6-Gingerol (6G) against lipopolysaccharide (LPS)-induced cognitive impairments, oxidative stress, neuroplasticity, amyloidogenesis, and inflammation. Male rats were allocated into six groups in this manner; Group I placed on normal saline only. Group II was treated for 7 days with LPS alone intraperitoneally at 250 µg/kg body weight (bw). Group III received 6G alone at 50 mg/kg bw orally for 14 days. Groups IV and V received 6G at 20 and 50 mg/kg bw for 7 days, respectively, and LPS for another 7 days to induce neurotoxicity. Group VI received 5 mg/kg bw of donepezil for 7 days and LPS for 7 days. Pretreatment with 20 and 50 mg/kg bw of 6G protected against LPS-mediated learning and memory function, and also locomotor and motor deficits. Besides, 20 and 50 mg/kg bw 6G mitigated LPS-induced alteration in markers of oxidative stress. Furthermore, induction of amyloidogenesis associated with disruption of histoarchitecture and high expression of interleukin 1β, inducible nitric oxide synthase, amyloid precursor protein (APP), β-secretase 1, and brain-derived neurotrophic factor by LPS was mitigated by the two doses of 6G in the rat hippocampus and cerebral cortex region of the brain. 6G pretreatment at the two doses mitigated LPS-mediated histopathological changes in the hippocampus and cerebral cortex of rats. Overall, our results demonstrate that the protective effect of 6G is mediated through the reversal of neurobehavioral deficit, oxidative stress, inflammation, and amyloidogenesis, thus making 6G a possible chemoprophylactic agent against brain injury as a result of LPS exposure. PRACTICAL APPLICATIONS: In the search for a holistic prevention of inflammation-associated neurodegeneration, nutraceuticals are becoming prominent. Hence, this study presents 6G, an active constituent of ginger, as a chemoprotective, antioxidant, and anti-inflammatory agent, which is able to ameliorate cognitive impairments, oxidative stress, neuroplasticity, amyloidogenesis, and inflammation in LPS-induced rat model of neuroinflammation.
MeSH term(s)	Animals ; Catechols ; Cognition ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/drug therapy ; Fatty Alcohols ; Zingiber officinale ; Inflammation/chemically induced ; Inflammation/drug therapy ; Lipopolysaccharides/toxicity ; Male ; Neuronal Plasticity ; Rats
Chemical Substances	Catechols ; Fatty Alcohols ; Lipopolysaccharides ; gingerol (925QK2Z900)
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13660
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Pterocarpus mildbraedii (Harms) extract resolves propanil-induced hepatic injury via repression of inflammatory stress responses in Wistar rats.

Otuechere, Chiagoziem Anariochi / Farombi, Ebenezer Olatunde

Journal of food biochemistry

2020 Volume 44, Issue 12, Page(s) e13506

Abstract: Pterocarpus mildbraedii (PME) is a green leafy vegetable from the Papilionaceae family. This study evaluated the anti-inflammatory activity of PME in Wistar rats exposed to experimental hepatotoxicity using propanil (PRP), a post-emergent herbicide. ... ...

Abstract	Pterocarpus mildbraedii (PME) is a green leafy vegetable from the Papilionaceae family. This study evaluated the anti-inflammatory activity of PME in Wistar rats exposed to experimental hepatotoxicity using propanil (PRP), a post-emergent herbicide. Animals were grouped as control, PRP, PME, and PME + PRP. After 7 days, the levels of stress-activated protein kinases/c-Jun N-terminal kinase (SAPK/JNK), p38 mitogen-activated protein kinase (p38 MAPK), and signal transducer and activator of transcription (STAT-3) were measured in rat liver. Furthermore, myeloperoxidase (MPO) and nitric oxide (NO) levels, as well as protein expressions of nuclear factor-κB (NF-κB p65), inducible nitric oxide synthase (iNOS), and cyclo-oxygenase-2 (COX-2) were determined. Compared with PRP-treated rats, PME significantly reduced the hepatic MPO and NO levels. PME also diminished NFκB, iNOS, and COX-2 protein expressions in PRP-treated rats. This study showed that Pterocarpus mildbraedii leaves produce active principles with relevant anti-inflammatory potential. PRACTICAL APPLICATIONS: Previous studies have shown that bioactive principles contained in medicinal plants can offer protection against chemically induced inflammation. Pterocarpus mildbraedii leaves, with rich content of polyphenols, flavonoids, and essential fatty acids, could be exploited as a therapeutic agent against pesticide-induced oxidative stress and inflammation. This current study has also shown that the potential of PME as a functional food is boosted by the presence of α-linolenic acid, an omega-3-fatty acid known to possess anti-inflammatory activity. Here, we elucidated the cellular mechanisms of the anti-inflammatory action of PME.
MeSH term(s)	Animals ; Liver ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Propanil ; Pterocarpus ; Rats ; Rats, Wistar
Chemical Substances	Plant Extracts ; Propanil (709-98-8)
Language	English
Publishing date	2020-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13506
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: 6‐Gingerol, an active constituent of ginger, attenuates lipopolysaccharide‐induced oxidation, inflammation, cognitive deficits, neuroplasticity, and amyloidogenesis in rat

Adetuyi, Babatunde Oluwafemi / Farombi, Ebenezer Olatunde

Journal of food biochemistry. 2021 Apr., v. 45, no. 4

2021

Abstract: This study examined the protective effect of 6‐Gingerol (6G) against lipopolysaccharide (LPS)‐induced cognitive impairments, oxidative stress, neuroplasticity, amyloidogenesis, and inflammation. Male rats were allocated into six groups in this manner; ... ...

Abstract	This study examined the protective effect of 6‐Gingerol (6G) against lipopolysaccharide (LPS)‐induced cognitive impairments, oxidative stress, neuroplasticity, amyloidogenesis, and inflammation. Male rats were allocated into six groups in this manner; Group I placed on normal saline only. Group II was treated for 7 days with LPS alone intraperitoneally at 250 µg/kg body weight (bw). Group III received 6G alone at 50 mg/kg bw orally for 14 days. Groups IV and V received 6G at 20 and 50 mg/kg bw for 7 days, respectively, and LPS for another 7 days to induce neurotoxicity. Group VI received 5 mg/kg bw of donepezil for 7 days and LPS for 7 days. Pretreatment with 20 and 50 mg/kg bw of 6G protected against LPS‐mediated learning and memory function, and also locomotor and motor deficits. Besides, 20 and 50 mg/kg bw 6G mitigated LPS‐induced alteration in markers of oxidative stress. Furthermore, induction of amyloidogenesis associated with disruption of histoarchitecture and high expression of interleukin 1β, inducible nitric oxide synthase, amyloid precursor protein (APP), β‐secretase 1, and brain‐derived neurotrophic factor by LPS was mitigated by the two doses of 6G in the rat hippocampus and cerebral cortex region of the brain. 6G pretreatment at the two doses mitigated LPS‐mediated histopathological changes in the hippocampus and cerebral cortex of rats. Overall, our results demonstrate that the protective effect of 6G is mediated through the reversal of neurobehavioral deficit, oxidative stress, inflammation, and amyloidogenesis, thus making 6G a possible chemoprophylactic agent against brain injury as a result of LPS exposure. PRACTICAL APPLICATIONS: In the search for a holistic prevention of inflammation‐associated neurodegeneration, nutraceuticals are becoming prominent. Hence, this study presents 6G, an active constituent of ginger, as a chemoprotective, antioxidant, and anti‐inflammatory agent, which is able to ameliorate cognitive impairments, oxidative stress, neuroplasticity, amyloidogenesis, and inflammation in LPS‐induced rat model of neuroinflammation.
Keywords	amyloid ; animal models ; anti-inflammatory agents ; antioxidants ; body weight ; brain damage ; cerebral cortex ; cognition ; dietary supplements ; ginger ; hippocampus ; histopathology ; inducible nitric oxide synthase ; inflammation ; lipopolysaccharides ; males ; memory ; neurodegenerative diseases ; neuroplasticity ; neurotoxicity ; oxidation ; oxidative stress ; protective effect ; rats
Language	English
Dates of publication	2021-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13660
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat.

Asejeje, Folake / Etim, Sylvia / Asejeje, Gbolahan / Iwuoh, Benneth Chukwudi / Akintade, Sanmi Ibukunoluwa / Adedara, Isaac / Farombi, Ebenezer Olatunde

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria

2023 Volume 38, Issue 2, Page(s) 145–155

Abstract: Dimethyl nitrosamine (DMN), a potent hepatotoxin, exerts carcinogenic effects and induces hepatic necrosis in experimental animals via CYP2E1 metabolic activation, and generation of reactive oxygen species (ROS). Protocatechuic acid (PCA), a plant-based ... ...

Abstract	Dimethyl nitrosamine (DMN), a potent hepatotoxin, exerts carcinogenic effects and induces hepatic necrosis in experimental animals via CYP2E1 metabolic activation, and generation of reactive oxygen species (ROS). Protocatechuic acid (PCA), a plant-based simple phenolic compound and potent antioxidant, has been shown to affect the development of neoplasia in the rat liver and inhibit the initiation or progression phases of most cancers. In this study, the modulatory effects of PCA on DMN-induced hepatotoxicity, oxidative stress, inflammation, and selected phase I xenobiotic metabolizing enzymes were investigated in male Wistar rats. This study assessed biomarkers of hepatic injury (alanine transaminase, aspartate aminotransferase, alkaline phosphatase, and gamma- glutamyl transferase); oxidative stress (hydrogen peroxide concentration, lipid peroxidation, and reduced glutathione levels); measured activities of antioxidant enzymes (catalase, sodium dismutase, glutathione peroxidase, glutathione S-transferase); and inflammation (Tumor necrosis factor (TNF)-α, interleukin-1-Beta (IL-1β) and iNOS). The results of our investigation demonstrated that pretreatment with PCA at 50 and 100 mg/kg body weight p.o. reduced DMN (20 mg/kg bw) i.p. mediated hepatic injury, oxidative stress, and inflammation in a dose-dependent manner. In addition, the activities of phase I metabolizing enzymes were significantly induced except for aminopyrine-N-demethylase in the DMN-treated rats when compared with the DMN alone control group. This induction was also reversed by pre-treatment with PCA. The result of this study suggests that PCA is hepatoprotective against DMN-induced hepatic damage by its ability to suppress oxidative stress, inflammation, and modulate the activities of the selected phase I drug metabolizing enzymes. Thus, PCA may prove useful in combating DMN-induced hepatic damage.
MeSH term(s)	Animals ; Oxidative Stress/drug effects ; Rats, Wistar ; Hydroxybenzoates/pharmacology ; Male ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Rats ; Inflammation/metabolism ; Inflammation/drug therapy ; Dimethylnitrosamine/toxicity ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/prevention & control
Chemical Substances	Hydroxybenzoates ; protocatechuic acid (36R5QJ8L4B) ; Dimethylnitrosamine (M43H21IO8R) ; Antioxidants
Language	English
Publishing date	2023-12-31
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	2197951-0
ISSN	0794-859X
ISSN	0794-859X
DOI	10.54548/njps.v38i2.4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: 6‐ shogaol suppresses AOM/DSS‐mediated colorectal adenoma through its antioxidant and anti‐inflammatory effects in mice

Ajeigbe, Olufunke Florence / Maruf, Opeyemi Rabiat / Anyebe, Daniel Abu / Opafunso, Ifeoluwa Tobi / Ajayi, Babajide Oluwaseun / Farombi, Ebenezer Olatunde

Journal of Food Biochemistry. 2022 Dec., v. 46, no. 12 p.e14422-

2022

Abstract: Colorectal adenoma appears as benign lesions and is a precursor of colorectal adenocarcinoma. The effect of 6‐Shogaol (6‐[S]), a bioactive agent from ginger, in early colonic adenoma growth is unknown. As a result, this study examines the effect of 6‐[S] ...

Abstract	Colorectal adenoma appears as benign lesions and is a precursor of colorectal adenocarcinoma. The effect of 6‐Shogaol (6‐[S]), a bioactive agent from ginger, in early colonic adenoma growth is unknown. As a result, this study examines the effect of 6‐[S] in a mouse colorectal adenoma model induced by Azoxymethane (AOM) and dextran sulfate sodium (DSS). Adult male mice served as control in Group 1. Group 2 was treated orally with 6‐[S] extract (20 mg/kg BW). Group 3 was exposed to AOM (25 mg/kg BW, ip) and one cycle of DSS (2.5%) in drinking water alone while Group 4 was co‐treated with 6‐[S] for twenty‐one (21) days. The body weight gain, organ weight and length, oxidative stress indices, inflammatory markers and histological examination were estimated. Our findings show that 6‐[S] co‐treatment reversed AOM/DSS‐induced elevation in colon weight, colon length, nitric oxide (NO), myeloperoxidase (MPO), hydrogen peroxidase (H₂O₂), and tumor necrosis factor‐alpha (TNF‐α). However, the antioxidant enzyme activities measured namely catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and glutathione‐S‐transferase were significantly increased in 6‐[S] treated mice. Taken together, the protective effect of 6‐[S] on oxidative burden, inflammation, and histological aberration observed in the colon of the AOM/DSS model of adenoma growth in mice is mediated primarily owing to its anti‐inflammatory and anti‐oxidative properties. Thus, this study reveals 6‐[S] as a useful agent in the possible clinical intervention of colorectal adenoma. PRACTICAL APPLICATIONS: Certain spices have been reported to have numerous phytochemicals with numerous medicinal purposes. However, no studies have been conducted to investigate the role of 6‐[S], a phytochemical found in ginger, in the treatment of colorectal adenoma. The study's findings show that 6‐[S] is protective in early colonic cancer development, as it manages colorectal adenoma cancer models of AOM/DSS. As a result, 6‐[S]’s ability to reduce oxidative stress and inflammation in the colon may be a potential nutritional therapeutic adjuvant for colorectal adenoma.
Keywords	adenocarcinoma ; adenoma ; adjuvants ; adults ; antioxidant enzymes ; azoxymethane ; body weight changes ; carcinogenesis ; catalase ; colon ; dextran sulfate ; ginger ; glutathione ; glutathione transferase ; histology ; hydrogen ; inflammation ; males ; mice ; models ; myeloperoxidase ; nitric oxide ; oxidative stress ; peroxidase ; phytochemicals ; protective effect ; superoxide dismutase ; therapeutics ; tissue weight ; tumor necrosis factor-alpha
Language	English
Dates of publication	2022-12
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14422
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: D-Penicillamine prolongs survival and lessens copper-induced toxicity in

Abolaji, Amos Olalekan / Fasae, Kehinde Damilare / Iwezor, Chizim Elizabeth / Farombi, Ebenezer Olatunde

Toxicology research

2020 Volume 9, Issue 4, Page(s) 346–352

Abstract: D-penicillamine (DPA) is an amino-thiol that has been established as a copper chelating agent for the treatment of Wilson's disease. DPA reacts with metals to form complexes and/or chelates. Here, we investigated the survival rate extension capacity and ... ...

Abstract	D-penicillamine (DPA) is an amino-thiol that has been established as a copper chelating agent for the treatment of Wilson's disease. DPA reacts with metals to form complexes and/or chelates. Here, we investigated the survival rate extension capacity and modulatory role of DPA on Cu
Language	English
Publishing date	2020-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2684701-2
ISSN	2045-4538 ; 2045-452X
ISSN (online)	2045-4538
ISSN	2045-452X
DOI	10.1093/toxres/tfaa032
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Antioxidant and antiplasmodial activities of methanol leaf extract of Paullinia pinnata

Adeyemo-Salami, Oluwatoyin Adenike / Ademowo, Olusegun George / Farombi, Ebenezer Olatunde

Journal of herbs, spices & medicinal plants. 2020 July 02, v. 26, no. 3

2020

Abstract: The antiplasmodial effect of methanol extract of Paullinia pinnata leaves was investigated in mice to observe the outcome on oxidative stress and inflammation in the liver. Wistar mice of both sexes were used for the curative, prophylaxis, and ... ...

Abstract	The antiplasmodial effect of methanol extract of Paullinia pinnata leaves was investigated in mice to observe the outcome on oxidative stress and inflammation in the liver. Wistar mice of both sexes were used for the curative, prophylaxis, and suppressive tests by adopting standard procedures. In the curative test, the liver was processed for liver function, antioxidant, and anti-inflammatory assays and histology. Changes in percentage parasitemia was observed while the antioxidant and anti-inflammatory parameters were not affected. There was low suppressive activity, mildly moderate prophylactic potential, and curative property which were also reflected in the antioxidant and liver function test at higher dose while at a lower dose it showed weak curative activity with prophylactic and suppressive capacities.
Keywords	Paullinia pinnata ; antimalarials ; antioxidants ; disease prevention ; histology ; inflammation ; leaf extracts ; liver ; liver function ; methanol ; oxidative stress ; parasitemia
Language	English
Dates of publication	2020-0702
Size	p. 315-328.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1122804-0
ISSN	1540-3580 ; 1049-6475
ISSN (online)	1540-3580
ISSN	1049-6475
DOI	10.1080/10496475.2020.1740905
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 3868: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: 6- shogaol suppresses AOM/DSS-mediated colorectal adenoma through its antioxidant and anti-inflammatory effects in mice.

Ajeigbe, Olufunke Florence / Maruf, Opeyemi Rabiat / Anyebe, Daniel Abu / Opafunso, Ifeoluwa Tobi / Ajayi, Babajide Oluwaseun / Farombi, Ebenezer Olatunde

Journal of food biochemistry

2022 , Page(s) e14422

Abstract: Colorectal adenoma appears as benign lesions and is a precursor of colorectal adenocarcinoma. The effect of 6-Shogaol (6-[S]), a bioactive agent from ginger, in early colonic adenoma growth is unknown. As a result, this study examines the effect of 6-[S] ...

Abstract	Colorectal adenoma appears as benign lesions and is a precursor of colorectal adenocarcinoma. The effect of 6-Shogaol (6-[S]), a bioactive agent from ginger, in early colonic adenoma growth is unknown. As a result, this study examines the effect of 6-[S] in a mouse colorectal adenoma model induced by Azoxymethane (AOM) and dextran sulfate sodium (DSS). Adult male mice served as control in Group 1. Group 2 was treated orally with 6-[S] extract (20 mg/kg BW). Group 3 was exposed to AOM (25 mg/kg BW, ip) and one cycle of DSS (2.5%) in drinking water alone while Group 4 was co-treated with 6-[S] for twenty-one (21) days. The body weight gain, organ weight and length, oxidative stress indices, inflammatory markers and histological examination were estimated. Our findings show that 6-[S] co-treatment reversed AOM/DSS-induced elevation in colon weight, colon length, nitric oxide (NO), myeloperoxidase (MPO), hydrogen peroxidase (H
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14422
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3310: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Kolaviron and Garcinia kola Seed Extract Protect Against Ischaemia/Reperfusion Injury on Isolated Rat Heart.

Oyagbemi, Ademola Adetokunbo / Bester, Dirk / Esterhuyse, Johan / Farombi, Ebenezer Olatunde

Drug research

2018 Volume 68, Issue 5, Page(s) 286–295

Abstract: Background: The incidence of cardiovascular diseases and its associated complications have increased greatly in the past three decades. The purpose of this study was to evaluate the acute cardioprotective effects of Garcinia kola (GK) seed extract and ... ...

Abstract	Background: The incidence of cardiovascular diseases and its associated complications have increased greatly in the past three decades. The purpose of this study was to evaluate the acute cardioprotective effects of Garcinia kola (GK) seed extract and Kolaviron (KV) and determine mechanisms of action involving RISK signalling pathways. Methods: Male Wistar rats were used in this study. Hearts were excised and mounted on the Langendorff perfusion system. The control, group 1 was perfused with dimethyl sulfoxide (DMSO), group II with KV and group III with GK respectively. Western blot analyses were performed on frozen heart tissues. Results: Isolated rat hearts perfused with KV and GK attenuated apoptotic pathways with significant reduction in p38 MAPK protein phosphorylation, as well as reduction in total caspase 3, cleaved caspase 3 (Asp 175) and PARP cleavage. KV and GK also down-regulated p-JNK1 (Tyr 185) and p-JNK 2 (Thr 183) protein expression at the 10 min reperfusion time ponit. Cardioprotection was achieved in part, by enhancement of the reperfusion injury signalling kinase (RISK) pathway; as evidenced by significant increases in protein expresion of Akt/PKB and p-Akt/PKB (Ser 473) in KV and GK respectively. Conclusions: KV and GK supplementation led to significant increases in the expressions of survival proteins. It is noteworthy that both KV and GK supplementation offered cardioprotection in ischaemic/reperfusion injury rat heart model. In all, GK showed better cardioprotective effect that KV.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cardiotonic Agents/chemistry ; Cardiotonic Agents/pharmacology ; Flavonoids/pharmacology ; Garcinia kola/chemistry ; Heart/drug effects ; Isolated Heart Preparation ; Male ; Myocardial Reperfusion Injury/prevention & control ; Myocardium/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Protective Agents/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Seeds/chemistry ; Signal Transduction/drug effects
Chemical Substances	Cardiotonic Agents ; Flavonoids ; Plant Extracts ; Protective Agents ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; kolaviron (PX7M0YV62G)
Language	English
Publishing date	2018-01-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703847-6
ISSN	2194-9387 ; 2194-9379
ISSN (online)	2194-9387
ISSN	2194-9379
DOI	10.1055/s-0043-123686
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.151: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito