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  1. Article ; Online: Climbing the STAIRs to SPAN the Clinical Translation Gap: Recent Advances in Multicenter Preclinical Stroke Trials.

    Turner, Renée J / Farr, Tracy D

    Stroke

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.124.045998
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 448: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke.

    Nowak, Thaddeus S / Farr, Tracy D

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2023  Volume 44, Issue 1, Page(s) 3–5

    Abstract: Functional ultrasound (FUS) has emerged as a novel imaging method to reliably assess relative cerebral blood volume (rCBV) and infer perfusion, with good spatiotemporal resolution. Brunner and colleagues provide what appears to be its first application ... ...

    Abstract Functional ultrasound (FUS) has emerged as a novel imaging method to reliably assess relative cerebral blood volume (rCBV) and infer perfusion, with good spatiotemporal resolution. Brunner and colleagues provide what appears to be its first application to characterize peri-infarct spreading depolarizations (SDs) in experimental stroke through recording of transient hyperemic events. They also report incomplete overlap between acute perfusion deficits and subsequent infarct distribution, specifically noting a rostral expansion to involve penumbral territory from which propagating depolarizations had preferentially originated. This observation would not be straightforward using other methodologies. Other strengths and limitations of the study are considered.
    MeSH term(s) Humans ; Ischemic Stroke ; Cortical Spreading Depression/physiology ; Brain/diagnostic imaging ; Stroke/diagnostic imaging ; Brain Ischemia/diagnostic imaging ; Ultrasonography ; Hemodynamics/physiology ; Cerebrovascular Circulation/physiology ; Infarction
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X231207182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Functional Connectivity Change in Response to Stroke Is Comparable Across Species: From Mouse to Man.

    Hall, Gerard R / Kaiser, Marcus / Farr, Tracy D

    Stroke

    2021  Volume 52, Issue 9, Page(s) 2961–2963

    MeSH term(s) Animals ; Connectome ; Mice ; Stroke
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.034097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel targets, treatments, and advanced models for intracerebral haemorrhage.

    Zille, Marietta / Farr, Tracy D / Keep, Richard F / Römer, Christine / Xi, Guohua / Boltze, Johannes

    EBioMedicine

    2022  Volume 76, Page(s) 103880

    Abstract: Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major cause of mortality and disability worldwide. Despite advances in surgical interventions and acute ICH management, there is currently no effective therapy to improve ... ...

    Abstract Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major cause of mortality and disability worldwide. Despite advances in surgical interventions and acute ICH management, there is currently no effective therapy to improve functional outcomes in patients. Recently, there has been tremendous progress uncovering new pathophysiological mechanisms underlying ICH that may pave the way for the development of therapeutic interventions. Here, we highlight emerging targets, but also existing gaps in preclinical animal modelling that prevent their exploitation. We particularly focus on (1) ICH aetiology, (2) the haematoma, (3) inflammation, and (4) post-ICH pathology. It is important to recognize that beyond neurons and the brain, other cell types and organs are crucially involved in ICH pathophysiology and successful interventions likely will need to address the entire organism. This review will spur the development of successful therapeutic interventions for ICH and advanced animal models that better reflect its aetiology and pathophysiology.
    MeSH term(s) Animals ; Brain/pathology ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/pathology ; Cerebral Hemorrhage/therapy ; Hematoma/etiology ; Hematoma/pathology ; Hematoma/therapy ; Humans ; Inflammation/pathology ; Stroke/pathology
    Language English
    Publishing date 2022-02-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.103880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  5. Article ; Online: Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells.

    Ogrodzinski, Lydia / Platt, Simon / Goulding, Joelle / Alexander, Cameron / Farr, Tracy D / Woolard, Jeanette / Hill, Stephen J / Kilpatrick, Laura E

    iScience

    2023  Volume 26, Issue 7, Page(s) 107232

    Abstract: E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in living cells. ...

    Abstract E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been hampered by lack of experimental approaches to monitor expression in real time in living cells. Here, NanoLuc Binary Technology (NanoBiT) in conjunction with CRISPR-Cas9 genome editing was used to tag endogenous E-selectin in human umbilical vein endothelial cells (HUVECs) with the 11 amino acid nanoluciferase fragment HiBiT. Addition of the membrane-impermeable complementary fragment LgBiT allowed detection of cell surface expression. This allowed the effect of inflammatory mediators on E-selectin expression to be monitored in real time in living endothelial cells. NanoBiT combined with CRISPR-Cas9 gene editing allows sensitive monitoring of real-time changes in cell surface expression of E-selectin and offers a powerful tool for future drug discovery efforts aimed at this important inflammatory protein.
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: NK1 tachykinin receptor antagonist treatment reduces cerebral edema and intracranial pressure in an ovine model of ischemic stroke.

    Sorby-Adams, Annabel J / Marian, Oana C / Bilecki, Isabella M / Elms, Levi E / Yassi, Nawaf / Hood, Rebecca J / Coller, Janet K / Stuckey, Shannon M / Kimberly, W Taylor / Farr, Tracy D / Leonard, Anna V / Thornton, Emma / Vink, Robert / Turner, Renée J

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2024  , Page(s) 271678X241241907

    Abstract: Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 ... ...

    Abstract Following ischemic stroke, substance P (SP)-mediated neurogenic inflammation is associated with profound blood-brain barrier (BBB) dysfunction, cerebral edema, and elevated intracranial pressure (ICP). SP elicits its effects by binding the neurokinin 1 tachykinin receptor (NK1-R), with administration of an NK1-R antagonist shown to ameliorate BBB dysfunction and cerebral edema in rodent and permanent ovine stroke models. Given the importance of reperfusion in clinical stroke, this study examined the efficacy of NK1-R antagonist treatment in reducing cerebral edema and ICP in an ovine model of transient middle cerebral artery occlusion (tMCAo). Anesthetized sheep (
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X241241907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
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  7. Book ; Online ; Thesis: Influence of the extracellular matrix protein Tenascin-C in the immune response, glial scar formation and ECM reorganization following cerebral ischemia in mice

    Manrique-Castaño, Daniel [Verfasser] / Hermann, Dirk Matthias [Gutachter] / Krieger, Patrik [Gutachter] / Farr, Tracy D. [Gutachter]

    2020  

    Author's details Daniel Manrique-Castaño ; Gutachter: Dirk Matthias Hermann, Patrik Krieger, Tracy D. Farr ; International Graduate School of Neuroscience
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence.

    Farr, Tracy D / Wegener, Susanne

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2010  Volume 30, Issue 4, Page(s) 703–717

    Abstract: Despite promising results in preclinical stroke research, translation of experimental data into clinical therapy has been difficult. One reason is the heterogeneity of the disease with outcomes ranging from complete recovery to continued decline. A ... ...

    Abstract Despite promising results in preclinical stroke research, translation of experimental data into clinical therapy has been difficult. One reason is the heterogeneity of the disease with outcomes ranging from complete recovery to continued decline. A successful treatment in one situation may be ineffective, or even harmful, in another. To overcome this, treatment must be tailored according to the individual based on identification of the risk of damage and estimation of potential recovery. Neuroimaging, particularly magnetic resonance imaging (MRI), could be the tool for a rapid comprehensive assessment in acute stroke with the potential to guide treatment decisions for a better clinical outcome. This review describes current MRI techniques used to characterize stroke in a preclinical research setting, as well as in the clinic. Furthermore, we will discuss current developments and the future potential of neuroimaging for stroke outcome prediction.
    MeSH term(s) Animals ; Brain/anatomy & histology ; Brain/pathology ; Brain/physiology ; Diffusion Tensor Imaging ; Fibrinolytic Agents/therapeutic use ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging/methods ; Neuropsychological Tests ; Outcome Assessment, Health Care/methods ; Recovery of Function ; Stroke/pathology ; Stroke/therapy ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2010-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1038/jcbfm.2010.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1663: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features.

    Hall, Gerard R / Boehm-Sturm, Philipp / Dirnagl, Ulrich / Finke, Carsten / Foddis, Marco / Harms, Christoph / Koch, Stefan Paul / Kuchling, Joseph / Madan, Christopher R / Mueller, Susanne / Sassi, Celeste / Sotiropoulos, Stamatios N / Trueman, Rebecca C / Wallis, Marcus D / Yildirim, Ferah / Farr, Tracy D

    Stroke

    2022  Volume 53, Issue 5, Page(s) 1735–1745

    Abstract: Background: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, but ... ...

    Abstract Background: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, but connectivity approaches are currently lagging in the rodent.
    Methods: We present a pipeline adapted for structural and functional connectivity analysis of the mouse brain, and we tested it in a mouse model of vascular dementia.
    Results: We observed lacunar infarctions, microbleeds, and progressive white matter change across 6 months. For the first time, we report that default mode network activity is disrupted in the mouse model. We also identified specific functional circuitry that was vulnerable to vascular stress, including perturbations in a sensorimotor, visual resting state network that were accompanied by deficits in visual and spatial memory tasks.
    Conclusions: These findings advance our understanding of the mouse connectome and provide insight into how it can be altered by vascular insufficiency.
    MeSH term(s) Animals ; Brain/diagnostic imaging ; Connectome/methods ; Dementia, Vascular/diagnostic imaging ; Disease Models, Animal ; Humans ; Magnetic Resonance Imaging/methods ; Mice ; Nerve Net
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.036997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Brief Review of Edema-Adjusted Infarct Volume Measurement Techniques for Rodent Focal Cerebral Ischemia Models with Practical Recommendations.

    Nouraee, Cyrus / Fisher, Marc / Di Napoli, Mario / Salazar, Pascal / Farr, Tracy D / Jafarli, Alibay / Divani, Afshin A

    Journal of vascular and interventional neurology

    2019  Volume 10, Issue 3, Page(s) 38–45

    Abstract: Background: Determining cerebral infarction volume is an important part of preclinical studies to determine the benefit of potential therapies on stroke outcome. A well-known problem in determining the actual infarction volume of rodent models is the ... ...

    Abstract Background: Determining cerebral infarction volume is an important part of preclinical studies to determine the benefit of potential therapies on stroke outcome. A well-known problem in determining the actual infarction volume of rodent models is the presence of edema. Because of this, algorithms must be utilized to obtain the edema-adjusted (
    Materials and methods: Simulated models of infarction and corresponding swelling were employed to determine which absolute method of calculation (Lin et al., Reglodi et al., or Belayev et al.) is the most accurate in calculating the absolute
    Results: The Reglodi and Belayev methods were statistically more accurate in measuring
    Conclusion: We recommend that Reglodi's method, that is
    Language English
    Publishing date 2019-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627963-0
    ISSN 1944-141X ; 1941-5893
    ISSN (online) 1944-141X
    ISSN 1941-5893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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