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  1. Article ; Online: Fentanyl and its derivatives, xylazine, and benzodiazepines: new sources of risk for acute poisonings.

    Cárdenas-Quesada, Jose / Torrens, Marta / Farré, Magí

    Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

    2023  Volume 35, Issue 5, Page(s) 400

    Title translation Fentanilos, xilacina y benzodiacepinas: un nuevo riesgo para las emergencias.
    MeSH term(s) Humans ; Fentanyl/adverse effects ; Benzodiazepines/adverse effects ; Xylazine/adverse effects
    Chemical Substances Fentanyl (UF599785JZ) ; Benzodiazepines (12794-10-4) ; Xylazine (2KFG9TP5V8)
    Language English
    Publishing date 2023-06-30
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2127173-2
    ISSN 2386-5857 ; 2386-5857
    ISSN (online) 2386-5857
    ISSN 2386-5857
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  2. Article ; Online: Thalidomide, the story goes on.

    Papaseit, Esther / Farré, Magí / Garcia-Algar, Óscar

    Anales de pediatria

    2023  Volume 98, Issue 6, Page(s) 490–491

    MeSH term(s) Thalidomide/adverse effects
    Chemical Substances Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2023-05-08
    Publishing country Spain
    Document type Letter
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2023.03.007
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  3. Article ; Online: La nueva moda de consumo de algunos inhalantes: riesgos y alerta por la falsa inocuidad.

    Cárdenas-Quesada, Jose / Pérez-Mañá, Clara / Papaseit, Esther / Farré, Magí

    Medicina clinica

    2023  Volume 161, Issue 12, Page(s) 543–546

    Title translation The new trend of some inhalant use: Risks and warnings of false harmlessness.
    Language Spanish
    Publishing date 2023-07-28
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.07.001
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    Ua VI Zs.279: Show issues Location:
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  4. Article ; Online: Heterologous COVID-19 Vaccination in Spain: A Case Study of Individual Autonomy in the Real World.

    Dal-Ré, Rafael / Farré, Magí / Lucena, M Isabel

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2022  Volume 25, Issue 5, Page(s) 770–772

    Abstract: In Spain, 1.5 million essential < 60-year-old workers were vaccinated with a first AstraZeneca vaccine dose. After assessing the cases of thrombosis with thrombocytopenia associated to this vaccine, the European Medicines Agency (EMA) supported the ... ...

    Abstract In Spain, 1.5 million essential < 60-year-old workers were vaccinated with a first AstraZeneca vaccine dose. After assessing the cases of thrombosis with thrombocytopenia associated to this vaccine, the European Medicines Agency (EMA) supported the administration of 2 doses of the AstraZeneca vaccine with no age restrictions. Nevertheless, Spain decided not to administer the second dose of this vaccine to < 60-year-olds. The government sponsored a clinical trial (CombiVacS) to assess the immunogenicity response to a Pfizer/BioNTech vaccine dose in adults primed with the AstraZeneca vaccine. The positive results backed the Public Health Commission and the Spanish Ministry of Health to offer the Pfizer/BioNTech vaccine as the booster. Nevertheless, regional public health authorities-responsible for administering vaccines-believed that, following the EMA's decision, an AstraZeneca booster dose should be given. The public confrontation of these 2 positions forced the Spanish Health Ministry to request the signature of an informed consent form to those individuals willing to receive the AstraZeneca vaccine booster and rejecting the Pfizer/BioNTech vaccine dose. Eventually, it was decided that these essential workers could choose the vaccine but signing an informed consent form. All relevant information was posted on the Ministry of Health and regional health authorities' websites and provided to potential vaccine recipients at vaccination sites. Most individuals (≥ 75%) chose the AstraZeneca vaccine: perhaps because they likely trusted the EMA more than the CombiVacS results. This unprecedented and massive exercise of individual autonomy about the choice of COVID-19 vaccines from 2 different platforms has shown that adequately informed persons can autonomously weigh their options, regardless of government decisions. Exercising individual autonomy may contribute to the success of future COVID-19 booster vaccination campaigns.
    MeSH term(s) Adult ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Middle Aged ; Spain ; Vaccination ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2021.12.011
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    Zs.A 5904: Show issues Location:
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  5. Article: Drug-Related Deaths in a Tertiary Hospital: Characteristics of Spontaneously Reported Cases and Comparison to Cases Detected from a Retrospective Study.

    Arellano, Ana Lucía / Alcubilla, Pau / Farré, Magí / Montané, Eva

    Journal of clinical medicine

    2021  Volume 10, Issue 18

    Abstract: Drug-related deaths (DRDs) are a common cause of hospital death. Pharmacovigilance, either as spontaneous reporting or active surveillance, plays a key role in the detection and reporting of suspected adverse drug reactions (ADRs). We conducted a ... ...

    Abstract Drug-related deaths (DRDs) are a common cause of hospital death. Pharmacovigilance, either as spontaneous reporting or active surveillance, plays a key role in the detection and reporting of suspected adverse drug reactions (ADRs). We conducted a retrospective analysis of all DRDs spontaneously reported to a pharmacovigilance program of a tertiary hospital, by health care professionals. We compared these results to those of a previous retrospective study conducted in the same hospital from the hospital's mortality registry. From 1460 spontaneous reported ADRs in a 10-year period, 73 (5%) were DRDs. The median age of DRD was 75 years (range 1 month-94) and 60.3% were men. The most frequent DRDs were hemorrhages (41.1%), followed by infections (17.8%). The most frequently involved drugs were anticoagulants and/or antithrombotic (30%), and antineoplastics (26.3%). When comparing both studies, spontaneous reporting detected more type B reactions (
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10184053
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  6. Article: Restorative Retelling for Processing Psychedelic Experiences: Rationale and Case Study of Complicated Grief.

    González, Débora / Aixalà, Marc B / Neimeyer, Robert A / Cantillo, Jordi / Nicolson, Donald / Farré, Magi

    Frontiers in psychology

    2022  Volume 13, Page(s) 832879

    Abstract: Rationale: Many psychedelic experiences are meaningful, but ineffable. Engaging in meaning-making regarding emerging symbolic content and changing previous schemas have been proposed as mechanisms of change in psychedelic therapy.: Objective: Firstly, ...

    Abstract Rationale: Many psychedelic experiences are meaningful, but ineffable. Engaging in meaning-making regarding emerging symbolic content and changing previous schemas have been proposed as mechanisms of change in psychedelic therapy.
    Objective: Firstly, we suggest the implementation of a Restorative Retelling (RR) technique to process and integrate the psychedelic experience into autobiographical memory, in a way that fosters meaning-making. We also show how ayahuasca has the potential to evoke key psychological content in survivors, during the process of grief adjustment following the death of a loved one.
    Methods: The rationale for the implementation of RR to process psychedelic experiences and a case study of a woman suffering from Complicated Grief (CG) after her mother's suicide are presented.
    Results: Evaluations conducted before the ayahuasca experience and after RR suggest the effectiveness of ayahuasca and RR in reducing symptoms of CG and psychopathology.
    Conclusion: This case report illustrates an effective adaptation of the RR technique for processing the psychedelic experience. The significance of the study and its limitations are discussed.
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.832879
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  7. Article ; Online: Nocebo Response in Attention Deficit Hyperactivity Disorder: Meta-Analysis and Meta-Regression of 105 Randomized Clinical Trials.

    Ramírez-Saco, David / Barcheni, Maghie / Cunill, Ruth / Sáez, Marc / Farré, Magí / Castells, Xavier

    Journal of attention disorders

    2022  Volume 26, Issue 11, Page(s) 1412–1421

    Abstract: Objective: To determine nocebo response in ADHD, identify covariates modifying nocebo response, and study the relationship between nocebo response and drug safety.: Method: Systematic review of randomized, double-blind, placebo-controlled clinical ... ...

    Abstract Objective: To determine nocebo response in ADHD, identify covariates modifying nocebo response, and study the relationship between nocebo response and drug safety.
    Method: Systematic review of randomized, double-blind, placebo-controlled clinical trials (RCT) investigating the efficacy and safety of pharmacological interventions for ADHD patients. The influence of covariates was studied using meta-regression.
    Results: A total of 105 studies with 8,743 patients in placebo arms were included. Slightly over half (55.5%) of the patients experienced adverse events (AE) while receiving placebo. Nocebo response was associated positively with age, treatment length and method for collecting AEs. Studies with the largest nocebo response showcased the greatest drug response and the best outcome for drug safety.
    Conclusion: Nocebo response in ADHD RCTs is remarkable, showing a positive relationship with drug response, and a negative relationship with drug safety.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/drug therapy ; Double-Blind Method ; Humans ; Nocebo Effect ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547221075845
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5196: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Metabolic profile of N-ethylhexedrone, N-ethylpentedrone, and 4-chloromethcathinone in urine samples by UHPLC-QTOF-HRMS.

    Massano, Marta / Nuñez-Montero, Melani / Papaseit, Esther / Hladun, Olga / Pérez-Maña, Clara / Ventura, Mireia / Marchei, Emilia / Alladio, Eugenio / Gerace, Enrico / Pichini, Simona / Farrè, Magi / Salomone, Alberto

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 241, Page(s) 115994

    Abstract: Forensic laboratories are constantly required to identify new drugs and their metabolites. N-ethylhexedrone (NEH, HEXEN), N-Ethylpentedrone (NEP), and 4-Chloromethcathinone (4-CMC, clephedrone) are synthetic substances structurally related to natural ... ...

    Abstract Forensic laboratories are constantly required to identify new drugs and their metabolites. N-ethylhexedrone (NEH, HEXEN), N-Ethylpentedrone (NEP), and 4-Chloromethcathinone (4-CMC, clephedrone) are synthetic substances structurally related to natural cathinone, alkaloid present in the leaves of the Catha edulis (Khat) plant. These synthetic cathinones (SC) are members of the heterogenous family of new psychoactive substances (NPS) that raised major concerns in scientific and forensic communities over the past years due to their widespread consumption. In this context, we investigated their metabolic profile using of UHPLC-QTOF-HRMS to elucidate the distribution of the parent drug and its metabolites in urine samples over time. Initially, both male and female volunteers were divided into three groups and eight subjects of each group were administered intranasally or orally with one SC (20-40 mg of NEH or NEP intranasal, 100-150 mg of 4-CMC oral). Urine samples were collected at 0-2 and 2-4 or 2-5 h. Urine (50 μL) was diluted 1:2 with acetonitrile/methanol (95:5) and injected into the UHPLC-QTOF-HRMS. Phase-I and phase-II metabolites were identified on the basis of fragmentation patterns and exact masses. Several phase-I and glucuronide-phase-II metabolites were identified in urine samples. Keto group reduction, hydroxylation and dealkylation were the common metabolic pathways identified for all cathinones and the presence of NEH-glucuronide, NEP-glucuronide and 4-CMC-glucuronide was also relevant. Significant is the slower metabolite formation for 4-CMC, which was detected at high concentrations in its original form even 5 h after administration, due to its long half-life and low intrinsic clearance compared to the other SCs. UHPLC-QTOF-HRMS demonstrated a considerable capability to semi-quantify the three synthetic cathinones and identify the target metabolites with high reliability. The introduction of new target compounds improves the efficiency of toxicological screening analysis on real samples and extends the window of detection of the SCs in biological matrices.
    MeSH term(s) Humans ; Chromatography, High Pressure Liquid ; Synthetic Cathinone ; Reproducibility of Results ; Glucuronides ; Metabolome ; Methylamines ; Propiophenones
    Chemical Substances clephedrone (PTAYYYZMMT) ; Synthetic Cathinone ; Glucuronides ; Methylamines ; Propiophenones
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2024.115994
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  9. Article ; Online: UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers.

    Pellegrini, Manuela / Marchei, Emilia / Papaseit, Esther / Farré, Magí / Zaami, Simona

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 8

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Illicit Drugs/urine ; Indoles/urine ; Naphthalenes/urine ; Reproducibility of Results
    Chemical Substances (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone ; 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone ; Illicit Drugs ; Indoles ; Naphthalenes ; (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone (44147RI31X)
    Language English
    Publishing date 2020-08-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56080408
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    Zs.A 6270: Show issues Location:
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  10. Article ; Online: Reply.

    Poyatos, Lourdes / Farré, Magí / López, Anna

    Medicina clinica

    2018  Volume 152, Issue 2, Page(s) 79–80

    Title translation Respuesta.
    Language Spanish
    Publishing date 2018-06-07
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2018.05.004
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    Ua VI Zs.279: Show issues Location:
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