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  1. Article ; Online: The Importance of Explicit Change Management in Health Care: An Example from the Operating Room.

    Farrelly, James S

    Joint Commission journal on quality and patient safety

    2021  Volume 48, Issue 1, Page(s) 1–2

    MeSH term(s) Change Management ; Delivery of Health Care ; Health Facilities ; Humans ; Operating Rooms/organization & administration
    Language English
    Publishing date 2021-11-18
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
    DOI 10.1016/j.jcjq.2021.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complications in pediatric enteral and vascular access.

    Farrelly, James S / Stitelman, David H

    Seminars in pediatric surgery

    2016  Volume 25, Issue 6, Page(s) 371–379

    Abstract: Obtaining reliable enteral and vascular access constitutes a significant fraction of a pediatric surgeon׳s job. Multiple approaches are available. Given the complicated nature of this patient population multiple complications can also occur. This article ...

    Abstract Obtaining reliable enteral and vascular access constitutes a significant fraction of a pediatric surgeon׳s job. Multiple approaches are available. Given the complicated nature of this patient population multiple complications can also occur. This article discusses the various techniques and potential complications associated with short- and long-term enteral and vascular access.
    MeSH term(s) Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/instrumentation ; Catheterization, Central Venous/methods ; Catheterization, Peripheral/adverse effects ; Catheterization, Peripheral/instrumentation ; Catheterization, Peripheral/methods ; Child ; Device Removal/adverse effects ; Device Removal/methods ; Gastrostomy/adverse effects ; Gastrostomy/methods ; Humans ; Intubation, Gastrointestinal/adverse effects ; Intubation, Gastrointestinal/methods ; Jejunostomy/adverse effects ; Jejunostomy/methods ; Laparoscopy ; Pediatrics ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Specialties, Surgical
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1133381-9
    ISSN 1532-9453 ; 1055-8586
    ISSN (online) 1532-9453
    ISSN 1055-8586
    DOI 10.1053/j.sempedsurg.2016.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Current use of the National Surgical Quality Improvement Program surgical risk calculator in academic surgery: a mixed-methods study.

    Miller, Samuel M / Azar, Sara Abou / Farrelly, James S / Salzman, Garrett A / Broderick, Meaghan E / Sanders, Katherine M / Anto, Vincent P / Patel, Nathan / Cordova, Alfredo C / Schuster, Kevin M / Jones, Tyler J / Kodadek, Lisa M / Gross, Cary P / Morton, John M / Rosenthal, Ronnie A / Becher, Robert D

    Surgery in practice and science

    2023  Volume 13

    Abstract: Background: This study aims to quantitatively assess use of the NSQIP surgical risk calculator (NSRC) in contemporary surgical practice and to identify barriers to use and potential interventions that might increase use.: Materials and methods: We ... ...

    Abstract Background: This study aims to quantitatively assess use of the NSQIP surgical risk calculator (NSRC) in contemporary surgical practice and to identify barriers to use and potential interventions that might increase use.
    Materials and methods: We performed a cross-sectional study of surgeons at seven institutions. The primary outcomes were self-reported application of the calculator in general clinical practice and specific clinical scenarios as well as reported barriers to use.
    Results: In our sample of 99 surgeons (49.7% response rate), 73.7% reported use of the NSRC in the past month. Approximately half (51.9%) of respondents reported infrequent NSRC use (<20% of preoperative discussions), while 14.3% used it in ≥40% of preoperative assessments. Reported use was higher in nonelective cases (30.2% vs 11.1%) and in patients who were ≥65 years old (37.1% vs 13.0%), functionally dependent (41.2% vs 6.6%), or with surrogate consent (39.9% vs 20.4%). NSRC use was not associated with training status or years in practice. Respondents identified a lack of influence on the decision to pursue surgery as well as concerns regarding the calculator's accuracy as barriers to use. Surgeons suggested improving integration to workflow and better education as strategies to increase NSRC use.
    Conclusions: Many surgeons reported use of the NSRC, but few used it frequently. Surgeons reported more frequent use in nonelective cases and frail patients, suggesting the calculator is of greater utility for high-risk patients. Surgeons raised concerns about perceived accuracy and suggested additional education as well as integration of the calculator into the electronic health record.
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ISSN 2666-2620
    ISSN (online) 2666-2620
    DOI 10.1016/j.sipas.2023.100173
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  4. Article ; Online: Engineering alginate microparticles for optimized accumulation in fetal rat myelomeningocele.

    Freedman-Weiss, Mollie R / Wu, Douglas / Maassel, Nathan / Ullrich, Sarah J / Ahle, Samantha L / Roberts, Katherine / Farrelly, James S / Buzzelli, Gina / Saltzman, W Mark / Stitelman, David H

    Journal of pediatric surgery

    2021  Volume 57, Issue 3, Page(s) 544–550

    Abstract: Introduction: Intraamniotic microparticle injection is a novel technique for the treatment of myelomeningocele (MMC) in which microparticles are delivered in-utero in a minimally invasive fashion to bind to and protect the exposed spinal cord. This ... ...

    Abstract Introduction: Intraamniotic microparticle injection is a novel technique for the treatment of myelomeningocele (MMC) in which microparticles are delivered in-utero in a minimally invasive fashion to bind to and protect the exposed spinal cord. This technique could offer earlier intervention and greater access to prenatal treatment of MMC. Here we demonstrate progress on the engineering of the microparticles to promote binding to the MMC defect. We hypothesized that when the particle's surface charge was decreased and delivery concentration increased, particles would bind to the MMC defect more frequently and more specifically.
    Methods: Alginate microparticles underwent surface modification to alter the particle charge. Dye-loaded alginate, alginate- dextran sulfate, and alginate- chitosan were injected on e17 into the amnion of a rat model of MMC and the incidence of successful binding and specificity of particle binding to the MMC defect were calculated. Specificity of binding was described using a defect-to-skin brightness ratio based on specimen imaging. Comparisons were made with chi-square, p< 0.05 marked significance.
    Results: There was no difference in the incidence of successful binding at e17 with 0.6 mg/fetal kg between the three tested alginate particles. However, alginate- dextran sulfate bound most specifically to the defect (p< 0.05). Alginate-dextran sulfate also demonstrated more frequent binding at higher doses than lower doses (79% at 1.2 mg/kg vs 38% at 0.6 mg/kg and 24% at 0.8 mg/kg, p< 0.01 for both). Specificity was not sacrificed at higher dose injections: defect-to-skin brightness ratio of 5.4 at 1.2 mg/kg vs 1.8 at 0.6 mg/kg (p< 0.05) CONCLUSION: We demonstrate that the intraamniotic injection of alginate-dextran sulfate microparticles at high concentration bind more frequently and more specifically to MMC defects than the previously tested unmodified alginate microparticles.
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2021.03.060
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  5. Article ; Online: Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele.

    Farrelly, James S / Bianchi, Anthony H / Ricciardi, Adele S / Buzzelli, Gina L / Ahle, Samantha L / Freedman-Weiss, Mollie R / Luks, Valerie L / Saltzman, W Mark / Stitelman, David H

    Journal of pediatric surgery

    2018  Volume 54, Issue 1, Page(s) 80–85

    Abstract: Background/purpose: We sought to develop a minimally invasive intra-amniotic therapy for prenatal treatment of myelomeningocele (MMC) in an established rat model.: Methods: Time-dated pregnant rats were gavage-fed retinoic acid to induce MMC. Groups ... ...

    Abstract Background/purpose: We sought to develop a minimally invasive intra-amniotic therapy for prenatal treatment of myelomeningocele (MMC) in an established rat model.
    Methods: Time-dated pregnant rats were gavage-fed retinoic acid to induce MMC. Groups received intraamniotic injections at E17.5 with alginate particles loaded with fluorescent dye, basic fibroblast growth factor (Alg-HSA-bFGF), fluorescently tagged albumin (Alginate-BSA-TR), free bFGF, blank alginate particles (Alg-Blank), or PBS. Groups were analyzed at 3 h for specific particle binding or at term (E21) to determine MMC coverage.
    Results: Alginate microparticles demonstrated robust binding to the MMC defect 3 h after injection. Of those specimens analyzed at E21, 150 of 239 fetuses (62.8%) were viable. Moreover, 18 of 61 (30%) treated with Alg-HSA-bFGF showed evidence of soft tissue coverage compared to 0 of 24 noninjected (P = 0.0021), 0 of 13 PBS (P = 0.0297), and 0 of 42 free bFGF (P = P < 0.0001). Scaffolds of aggregated particles associated with disordered keratinized tissue were observed covering the defect in 2 of 18 (11%) Alg-BSA-TR and 3 of 19 (16%) Alg-Blank specimens.
    Conclusions: Injection of microparticles loaded with bFGF resulted in significant soft tissue coverage of the MMC defect compared to controls. Alginate microparticles without growth factors might result in scaffold development over the fetal MMC.
    Type of study: Basic science.
    Level of evidence: N/A.
    MeSH term(s) Alginates/pharmacology ; Amniotic Fluid ; Animals ; Biocompatible Materials/pharmacology ; Female ; Fetal Therapies/methods ; Fibroblast Growth Factor 2/pharmacology ; Meningomyelocele/therapy ; Minimally Invasive Surgical Procedures/methods ; Pregnancy ; Rats
    Chemical Substances Alginates ; Biocompatible Materials ; Fibroblast Growth Factor 2 (103107-01-3)
    Language English
    Publishing date 2018-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2018.10.031
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  6. Article ; Online: Surgical tray optimization as a simple means to decrease perioperative costs.

    Farrelly, James S / Clemons, Crystal / Witkins, Sherri / Hall, Walter / Christison-Lagay, Emily R / Ozgediz, Doruk E / Cowles, Robert A / Stitelman, David H / Caty, Michael G

    The Journal of surgical research

    2017  Volume 220, Page(s) 320–326

    Abstract: Background: Health care spending in the US remains excessively high. Aside from complicated, large-scale efforts at health care cost reduction, there are still relatively simple ways in which individual hospitals can cut unnecessary costs from everyday ... ...

    Abstract Background: Health care spending in the US remains excessively high. Aside from complicated, large-scale efforts at health care cost reduction, there are still relatively simple ways in which individual hospitals can cut unnecessary costs from everyday operations. Inspired by recent publications, our group sought to decrease the costs associated with surgical instrument processing at a large, multihospital academic center.
    Methods: This was a single-site observational study conducted at a large academic medical center. At the study start, all attending surgeons within the section of pediatric surgery agreed to standardize the pediatric surgery trays and to eliminate instruments that were deemed unnecessary from each tray. A multidisciplinary start-up meeting was held, and this meeting included stakeholders from central sterile processing, operating room nursing, scrub technicians, and materials management along with all five pediatric surgeons. Each tray was addressed individually. Instruments were eliminated from trays only if there was unanimous agreement among all the surgeons in the group. If no instruments in a given surgical tray were deemed necessary, the entire tray was eliminated from sterile processing rotation. Feedback questionnaires were drafted by the multidisciplinary team that participated in the start-up meeting. Surgeons were allowed to request for certain instruments to be placed back into the trays at any time, and the questionnaires also allowed for free-hand comments. Surgical kit preparation time was obtained from the institutional barcode scanning system. The cost per second of sterile processing labor was calculated using regional median salary for sterile processing technicians in the state of Connecticut. Using the pediatric surgery section as the model unit, this method was then applied to pediatric urology, neurosurgery, spine surgery, and orthopedics.
    Results: The pediatric surgery section eliminated an average of 59.5% of instruments per tray, resulting in an overall reduction of 1826 (39.5%) instruments from rotation, 45,856 fewer instruments processed per year, and nine trays eliminated completely from regular rotation. Processing time for six commonly used trays was reduced by an average of 28.7%. The urology section eliminated 18 trays from regular rotation and 179 (10.1%) instruments in total. Pediatric orthopedics, neurosurgery, and spine sections eliminated 708 (17.1%), 560 (92.7%), and 31 (32.2%) instruments, respectively, resulting in approximately 18,804 fewer instruments processed per year. Among all five surgical sections, annual instrument cost avoidance after tray optimization was estimated at $53,193 to $531,929 using average instrument life spans ranging from 1-10 y. Negative feedback and requests for instrument replacement were both minimal on feedback questionnaires.
    Conclusions: Surgical tray optimization represents a relatively simple microsystem improvement that could result in significant hospital cost reduction. Although difficult to quantify, other gains from surgical kit optimization include decreased weight per tray, decreased materials cost, and decreased labor required to count, decontaminate, and pack surgical trays.
    MeSH term(s) Cost Savings ; Perioperative Care/economics ; Surgical Instruments/economics
    Language English
    Publishing date 2017-08-12
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2017.06.029
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  7. Article ; Online: In utero nanoparticle delivery for site-specific genome editing.

    Ricciardi, Adele S / Bahal, Raman / Farrelly, James S / Quijano, Elias / Bianchi, Anthony H / Luks, Valerie L / Putman, Rachael / López-Giráldez, Francesc / Coşkun, Süleyman / Song, Eric / Liu, Yanfeng / Hsieh, Wei-Che / Ly, Danith H / Stitelman, David H / Glazer, Peter M / Saltzman, W Mark

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 2481

    Abstract: Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and mortality. Early intervention through intrauterine gene editing, however, could correct the genetic ...

    Abstract Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and mortality. Early intervention through intrauterine gene editing, however, could correct the genetic defect, potentially allowing for normal organ development, functional disease improvement, or cure. Here we demonstrate safe intravenous and intra-amniotic administration of polymeric nanoparticles to fetal mouse tissues at selected gestational ages with no effect on survival or postnatal growth. In utero introduction of nanoparticles containing peptide nucleic acids (PNAs) and donor DNAs corrects a disease-causing mutation in the β-globin gene in a mouse model of human β-thalassemia, yielding sustained postnatal elevation of blood hemoglobin levels into the normal range, reduced reticulocyte counts, reversal of splenomegaly, and improved survival, with no detected off-target mutations in partially homologous loci. This work may provide the basis for a safe and versatile method of fetal gene editing for human monogenic disorders.
    MeSH term(s) Animals ; DNA, Single-Stranded/administration & dosage ; DNA, Single-Stranded/genetics ; Disease Models, Animal ; Female ; Fetal Therapies/methods ; Gene Editing/methods ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/therapy ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Nanoparticles/administration & dosage ; Peptide Nucleic Acids/administration & dosage ; Peptide Nucleic Acids/genetics ; Pregnancy ; Safety ; Targeted Gene Repair/methods ; Uterus ; beta-Globins/genetics ; beta-Thalassemia/blood ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
    Chemical Substances DNA, Single-Stranded ; Peptide Nucleic Acids ; beta-Globins
    Language English
    Publishing date 2018-06-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-04894-2
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