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Article: SUPPLEMENT ARTICLE: Retinol: The Ideal Retinoid for Cosmetic Solutions.

Farris, Patricia

2022 Volume 21, Issue 7, Page(s) s4–s10

Abstract: Retinoids are a mainstay of dermatologic therapy. Although prescription retinoids are more potent than over the counter retinoids, when properly formulated cosmetic retinoids offer consumers an easily accessible, reasonably priced therapeutic option. ... ...

Abstract	Retinoids are a mainstay of dermatologic therapy. Although prescription retinoids are more potent than over the counter retinoids, when properly formulated cosmetic retinoids offer consumers an easily accessible, reasonably priced therapeutic option. Retinol has been shown to improve fine lines and wrinkles, hyperpigmentation, skin roughness, and the appearance of photoaged skin. The efficacy and tolerability of retinol makes it preferable to prescription retinoids as many patients are intolerant of these more potent forms. In this review, we will discuss the pharmacokinetics of retinol and the clinical studies confirming its efficacy, tolerability, and safety with long-term use. J Drugs Dermatol. 2022;21:7(Suppl):s4-10.
MeSH term(s)	Cosmetics/therapeutic use ; Humans ; Hyperpigmentation/drug therapy ; Retinoids/therapeutic use ; Skin ; Skin Aging ; Vitamin A/adverse effects
Chemical Substances	Cosmetics ; Retinoids ; Vitamin A (11103-57-4)
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.SO722
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Article ; Online: The Why, What, When, and How of Topical Antioxidants in Cosmeceuticals.

Farris, Patricia

Cutis

2021 Volume 107, Issue 3 Suppl, Page(s) 2–8

Language	English
Publishing date	2021-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0179
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Zs.B 1315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 44: Show issues

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Article ; Conference proceedings: Unusual access for biliary cholangioscopy with lithotripsy: every cloud has a silver lining

Marconato, E. / Farris, P. / Dequarti, A. / Antonelli, G. / Comberlato, M. / Desideri, F.

Endoscopy

2024 Volume 56, Issue S 02

Event/congress	ESGE Days 2024, Berlin, Germany, 2024-04-25
Language	English
Publishing date	2024-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0044-1783466
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Rural research capacity: a co-created model for research success.

Farris, Paige / Crist, Rachel / Miller, Sylvia / Shannon, Jackilen

Health research policy and systems

2023 Volume 21, Issue 1, Page(s) 76

Abstract: Purpose: The United States' National Institutes of Health (NIH) have long challenged academia to improve clinical trial enrollment, especially in underrepresented populations; inclusive of geography, age, disability status, racial and ethnic minorities. ...

Abstract	Purpose: The United States' National Institutes of Health (NIH) have long challenged academia to improve clinical trial enrollment, especially in underrepresented populations; inclusive of geography, age, disability status, racial and ethnic minorities. It has been shown that rural and urban residents enrolled in clinical trials have similar outcomes, yet, rural healthcare systems struggle to provide opportunities to rural residents to participate in clinical trials when infrastructure is limited or unsupportive of research programs and/or research staffing levels are insufficient. To fully address the barriers to clinical trial access in rural areas, it is not adequate to simply open more trials. Community receptivity of research as well as organizational and community capacity must be considered. This project was determined by the Oregon Health and Science University's Institutional Review Board to be generalizable research across the chosen counties and was approved to operate under a waiver of written consent. Participants received a cash incentive in appreciation for their time and verbally agreed to participate after reviewing a project information sheet. Methods: The research team co-created a community-responsive approach to the receipt, review, and acceptance of clinical trials in a rural community setting. An adapted 5 step Implementation Mapping approach was used to develop a systematic strategy intended to increase the success, and therefore, the number of clinical trials offered in a rural community. Results: The research team and participating rural community members pilot-tested the implementation of a co-designed research review strategy, inclusive of a Regional Cultural Landscape and three co-created project submission and feasibility review forms, with a cancer early detection clinical trial. The proposed clinical trial required engagement from primary care and oncology. Utilizing the research review strategy demonstrated strong researcher-community stakeholder communication and negotiation, which resulted in early identification and resolution of potential barriers, hiring a local clinical research coordinator, and timely trial opening. Conclusion: To the knowledge of the research team, the work described is the first to use a community-engaged approach for creating a clinical trial implementation strategy directly supportive of rural-sitting community stakeholders in receiving, reviewing, and approving cancer-related clinical trials in their community. Participating community members and leaders had the chance to negotiate research protocol changes or considerations directly with researchers interested in conducting a cancer clinical trial in their rural setting.
MeSH term(s)	Humans ; Community Participation ; Rural Population ; Stakeholder Participation ; Delivery of Health Care ; Neoplasms
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2101196-5
ISSN	1478-4505 ; 1478-4505
ISSN (online)	1478-4505
ISSN	1478-4505
DOI	10.1186/s12961-023-01030-5
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Article ; Online: Research News: Nurses as Heroes.

Farris, Pam / Stewart, Mary W

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2021 Volume 36, Issue 3, Page(s) 317–318

MeSH term(s)	Humans ; Nurses ; Nursing Research
Language	English
Publishing date	2021-06-11
Publishing country	United States
Document type	News
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2021.03.007
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Zs.A 2458: Show issues

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Article ; Online: Community paramedicine in Central Oregon: A promising model to reduce non-urgent emergency department utilization among medically complex Medicaid beneficiaries.

Currier, Jessica / Wallace, Neal / Bigler, Keshia / O'Connor, Maggie / Farris, Paige / Shannon, Jackilen

Journal of the American College of Emergency Physicians open

2023 Volume 4, Issue 3, Page(s) e12988

Abstract: Background: Community paramedicine has emerged as a promising model to redirect persons with nonmedically emergent conditions to more appropriate and less expensive community-based health care settings. Outreach through community paramedicine to ... ...

Abstract	Background: Community paramedicine has emerged as a promising model to redirect persons with nonmedically emergent conditions to more appropriate and less expensive community-based health care settings. Outreach through community paramedicine to patients with a history of high hospital emergency department (ED) use and chronic health conditions has been found to reduce ED use. This study examined the effect of community paramedicine implemented in 2 rural counties in reducing nonemergent ED use among a sample of Medicaid beneficiaries with complex medical conditions and a history of high ED utilization. Methods: A cluster randomized trial approach with a stepped wedge design was used to test the effect of the community paramedicine intervention. ED utilization for non-urgent care was measured by emergency medicine ED visits and avoidable ED visits. Results: The community paramedicine intervention reduced ED utilization among a sample of 102 medically complex Medicaid beneficiaries with a history of high ED utilization. In the unadjusted models, emergency medical ED visits decreased by 13.9% (incidence rate ratio [IRR], 0.86; 95% confidence interval [CI], 0.76-0.98) or 6.1 visits saved for every 100 people. Avoidable emergency department visits decreased by 38.9% (IRR, 0.61; 95% CI, 0.44-0.84) or 2.3 visits saved for every 100 people. Conclusion: Our results suggest community paramedicine is a promising model to achieve a reduction in ED utilization among medically complex patients by managing complex health conditions in a home-based setting.
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Journal Article
ISSN	2688-1152
ISSN (online)	2688-1152
DOI	10.1002/emp2.12988
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Article: Novel Facial Treatment Regimen Improves Aging Skin Appearance.

Farris, Patricia / Draelos, Zoe Diana / Felipe de Oliveira Stehling, Luiz

Journal of drugs in dermatology : JDD

2021 Volume 20, Issue 3, Page(s) 274–278

Abstract: Background: Skin care regimens with multiple active ingredients offer a multimodal approach to anti-aging treatments.: Objective: The objective of this research was to investigate the efficacy of a multimodal skincare regimen on facial skin ... ...

Abstract	Background: Skin care regimens with multiple active ingredients offer a multimodal approach to anti-aging treatments. Objective: The objective of this research was to investigate the efficacy of a multimodal skincare regimen on facial skin appearance after 12 weeks of twice daily use as compared to baseline. Method: 35 healthy female subjects 35–65 years of age of Fitzpatrick skin types I–III with mild to moderate facial photoaging characterized by hyperpigmentation were enrolled. Subjects were seen at baseline, week 6, and week 12, and underwent subject and investigator assessments along with noninvasive evaluations (elasticity, corneometry, dermaspectrophotometer) and photography. Results: Most notable at week 12 was a 60% improvement in smoothness, 82% improvement in dryness, 30% improvement in fine lines, and 24% improvement in crow’s feet. There was an 8% reduction in macule hyperpigmentation (P<0.001) at week 12, supporting excellent pigment lightening qualities for the regimen. There was a statistically significant increase in skin firmness (decrease in elasticity) as early as week 6 of 6% with further improvement observed at week 12 of 16% (P=0.002). Summary: A multimodal skincare regimen with antioxidants, retinol, hydrolyzed pearl, caviar extract, peptides, and growth factors including EGF and TGF-β results in an improvement in the appearance of photoaged skin after 12 weeks of twice daily use. J Drugs Dermatol. 2021;20(3):274-278. doi:10.36849/JDD.5791.
MeSH term(s)	Administration, Cutaneous ; Adult ; Aged ; Cosmeceuticals/administration & dosage ; Face/diagnostic imaging ; Facial Dermatoses/diagnosis ; Facial Dermatoses/therapy ; Female ; Healthy Volunteers ; Humans ; Hyperpigmentation/diagnosis ; Hyperpigmentation/therapy ; Middle Aged ; Photography ; Skin Aging/drug effects ; Skin Aging/physiology ; Skin Care/methods ; Treatment Outcome
Chemical Substances	Cosmeceuticals
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.5791
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Article: Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.

Farris, Patricia / Berson, Diane / Bhatia, Neal / Goldberg, David / Lain, Edward / Mariwalla, Kavita / Zeichner, Joshua / Miller, Dara / McGuire, Tony / Kizoulis, Menas

Journal of drugs in dermatology : JDD

2024 Volume 23, Issue 4, Page(s) 209–215

Abstract: Introduction: Chronic exposure to ultraviolet light photoages skin. Retinol, a precursor molecule to retinoic acid that causes less irritation, is available as a nonprescription, cosmetic retinoid and improves collagen production, skin elasticity, and ... ...

Abstract	Introduction: Chronic exposure to ultraviolet light photoages skin. Retinol, a precursor molecule to retinoic acid that causes less irritation, is available as a nonprescription, cosmetic retinoid and improves collagen production, skin elasticity, and signs of photoaging. Advances in formulation science have allowed the production of stabilized bioactive retinol formulations. This integrated analysis aims to build on previous studies and further examine the comprehensive efficacy and tolerability of topical 0.1% stabilized bioactive retinol. Methods: This analysis included 6 vehicle-controlled studies of 0.1% stabilized bioactive retinol in women with mild-to-moderate signs of photodamage. Across all studies, the same dermatologist investigator assessed overall photodamage; wrinkles on the forehead, cheeks, and undereye area; crow’s feet wrinkles and fine lines; lack of even skin tone; and brown spots at baseline and weeks 4, 8, and 12 on a numerical scale. Tolerability was also assessed. Results: Participants (retinol, N=237; vehicle, N=234) had a mean (SD) age of 47.4 (6.6) years. Retinol induced greater improvements from baseline in all signs of photoaging vs vehicle as early as week 4 and through 12 weeks of application. Few participants experienced irritation; all events were mild to moderate and transient. The most common signs of irritation were erythema (n=2) and skin scaling/peeling (n=5). Conclusions: This pooled analysis of 6 vehicle-controlled clinical studies provides new evidence for the efficacy of 0.1% stabilized bioactive retinol in improving signs of photoaging without causing major irritation. Topical 0.1% stabilized bioactive retinol was well tolerated with only a few reported cases of skin irritation. J Drugs Dermatol. 2024;23(4): doi:10.36849/JDD.8124.
MeSH term(s)	Female ; Humans ; Middle Aged ; Vitamin A ; Skin Aging ; Tretinoin/adverse effects ; Retinoids ; Double-Blind Method ; Treatment Outcome ; Administration, Cutaneous
Chemical Substances	Vitamin A (11103-57-4) ; Tretinoin (5688UTC01R) ; Retinoids
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.8124
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Article ; Online: Atmospheric skin aging-Contributors and inhibitors.

McDaniel, David / Farris, Patricia / Valacchi, Giuseppe

Journal of cosmetic dermatology

2018 Volume 17, Issue 2, Page(s) 124–137

Abstract: Cutaneous aging is a complex biological process consisting of 2 elements: intrinsic aging, which is primarily determined by genetics, and extrinsic aging, which is largely caused by atmospheric factors, such as exposure to sunlight and air pollution, and ...

Abstract	Cutaneous aging is a complex biological process consisting of 2 elements: intrinsic aging, which is primarily determined by genetics, and extrinsic aging, which is largely caused by atmospheric factors, such as exposure to sunlight and air pollution, and lifestyle choices, such as diet and smoking. The role of the solar spectrum, comprised of ultraviolet light, specifically UVB (290-320 nm) and UVA (320-400) in causing skin damage, including skin cancers, has been well documented. In recent years, the contribution of visible light (400-700 nm) and infrared radiation (above 800 nm) in causing skin damage, similar to the photodamage caused by UV light, is also being elucidated. In addition, other atmospheric factors such as air pollution (smog, ozone, particulate matter, etc.) have been implicated in premature skin aging. The skin damage caused by environmental exposure is largely attributable to a complex cascade of reactions inside the skin initiated by the generation of reactive oxygen species (ROS), which causes oxidative damage to cellular components such as proteins, lipids, and nucleic acids. These damaged skin cells initiate inflammatory responses leading to the eventual damage manifested in chronically exposed skin. Novel therapeutic strategies to combat ROS species generation are being developed to prevent the skin damage caused by atmospheric factors. In addition to protecting skin from solar radiation using sunscreens, other approaches using topically applied ingredients, particularly antioxidants that penetrate the skin and protect the skin from within, have also been well documented. This review summarizes current knowledge of atmospheric aggressors, including UVA, UVB, visible light, infrared radiation (IR), and ozone on skin damage, and proposes new avenues for future research in the prevention and treatment of premature skin aging caused by such atmospheric factors. New therapeutic modalities currently being developed are also discussed.
MeSH term(s)	Air Pollutants/adverse effects ; Antioxidants/therapeutic use ; Hot Temperature/adverse effects ; Humans ; Infrared Rays/adverse effects ; Ozone/adverse effects ; Skin/drug effects ; Skin/metabolism ; Skin/radiation effects ; Skin Aging/drug effects ; Skin Aging/physiology ; Skin Aging/radiation effects ; Smog/adverse effects ; Ultraviolet Rays/adverse effects
Chemical Substances	Air Pollutants ; Antioxidants ; Smog ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2018-07-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.12518
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Article ; Online: Idebenone, green tea, and Coffeeberry extract: new and innovative antioxidants.

Farris, Patricia

Dermatologic therapy

2007 Volume 20, Issue 5, Page(s) 322–329

Abstract: The use of topical antioxidants is gaining favor among dermatologists because of their broad biologic activity. Many are not only antioxidants but also have antiinflammatory and anticarcinogenic activities. Thus for dermatologists these cosmeceuticals ... ...

Abstract	The use of topical antioxidants is gaining favor among dermatologists because of their broad biologic activity. Many are not only antioxidants but also have antiinflammatory and anticarcinogenic activities. Thus for dermatologists these cosmeceuticals have many potential applications. In general, topical antioxidants exert their effects by down-regulating free radical mediated pathways that damage skin. The present study will describe the science behind some of the newest topical antioxidants and outline how they can be used as part of a comprehensive skin care regimen.
MeSH term(s)	Administration, Topical ; Antioxidants/administration & dosage ; Benzoquinones/administration & dosage ; Coffee/chemistry ; Cosmetics/therapeutic use ; Esthetics ; Female ; Humans ; Oxidation-Reduction ; Patient Satisfaction ; Plant Extracts/pharmacology ; Skin Aging/drug effects ; Skin Aging/physiology ; Skin Care/methods ; Sunburn/drug therapy ; Sunburn/prevention & control ; Tea/chemistry ; Ubiquinone/analogs & derivatives
Chemical Substances	Antioxidants ; Benzoquinones ; Coffee ; Cosmetics ; Plant Extracts ; Tea ; Ubiquinone (1339-63-5) ; idebenone (HB6PN45W4J)
Language	English
Publishing date	2007-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/j.1529-8019.2007.00146.x
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