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  1. AU="Farshad Moradi Kashkooli"
  2. AU="Doaa Ebrahim"
  3. AU="Rangarajan, Amith"
  4. AU="Alonso-Sánchez, Jesús"
  5. AU="Zhuo, J C"
  6. AU="Pazurek, Angelica" AU="Pazurek, Angelica"
  7. AU=Sundararaman T
  8. AU="Singla, Amit Kumar"
  9. AU="Shu, Ran"
  10. AU="Kim, Jiha"
  11. AU="MacDonald, Suzanne E."
  12. AU="Heather Limburg"
  13. AU="Gross, Boris"
  14. AU="Perkins, George H"
  15. AU="Jormanainen, J"
  16. AU="Pichardo-González, Priamo A"
  17. AU="Cannegieter, Suzanne"
  18. AU="Trocino, Giuseppe"
  19. AU="Emiliano, Thais Moura"
  20. AU=Sinelli Mariateresa
  21. AU="De-guo LÜ"
  22. AU="Benoit-Pilven, Clara"
  23. AU="Lanza, Stefania"
  24. AU="Chilingarian, A"
  25. AU="Baldovini, Nicolas"
  26. AU="López Rodríguez, David"
  27. AU="Alexander König"
  28. AU="Jakobsen, Henrik L"
  29. AU="Yong-Zhao Dai"
  30. AU="Tara L. Pukala"
  31. AU="Addo‐Danso, Shalom D."
  32. AU=Ficheux Q.
  33. AU="Tomoyo Sawada"
  34. AU="Mohammad Kawsar Sharif Siam"
  35. AU=Kushnareva Yulia
  36. AU="Canova, Christopher T"
  37. AU="Hasnaoui, Naoual"
  38. AU="Maradana, Jhansi"
  39. AU="Raggini, Elisa"
  40. AU="Baxter, A."
  41. AU="Jackson, Shirnae"
  42. AU="Schenzle, Lisa"
  43. AU="Veronica Phillips"
  44. AU="Braun, Jörg"
  45. AU="Cassandra E. Holbert"
  46. AU="Trevisan Alexandra"

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  1. Artikel ; Online: Evaluation of solid tumor response to sequential treatment cycles via a new computational hybrid approach

    Farshad Moradi Kashkooli / M. Soltani

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 15

    Abstract: Abstract The development of an in silico approach that evaluates and identifies appropriate treatment protocols for individuals could help grow personalized treatment and increase cancer patient lifespans. With this motivation, the present study ... ...

    Abstract Abstract The development of an in silico approach that evaluates and identifies appropriate treatment protocols for individuals could help grow personalized treatment and increase cancer patient lifespans. With this motivation, the present study introduces a novel approach for sequential treatment cycles based on simultaneously examining drug delivery, tumor growth, and chemotherapy efficacy. This model incorporates the physical conditions of tumor geometry, including tumor, capillary network, and normal tissue assuming real circumstances, as well as the intravascular and interstitial fluid flow, drug concentration, chemotherapy efficacy, and tumor recurrence. Three treatment approaches—maximum tolerated dose (MTD), metronomic chemotherapy (MC), and chemo-switching (CS)—as well as different chemotherapy schedules are investigated on a real tumor geometry extracted from image. Additionally, a sensitivity analysis of effective parameters of drug is carried out to evaluate the potential of using different other drugs in cancer treatment. The main findings are: (i) CS, MC, and MTD have the best performance in reducing tumor cells, respectively; (ii) multiple doses raise the efficacy of drugs that have slower clearance, higher diffusivity, and lower to medium binding affinities; (iii) the suggested approach to eradicating tumors is to reduce their cells to a predetermined rate through chemotherapy and then apply adjunct therapy.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

    Mohammad Souri / Madjid Soltani / Farshad Moradi Kashkooli

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 12

    Abstract: Abstract For the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical ... ...

    Abstract Abstract For the first time, inspired by magnetic resonance imaging-guidance high intensity focused ultrasound (MR-HIFU) technology, i.e., medication therapy and thermal ablation in one session, in a preclinical setting based on a developed mathematical model, the performance of doxorubicin (Dox) and its encapsulation have been investigated in this study. Five different treatment methods, that combine medication therapy with mild hyperthermia by MRI contrast ( $$\gamma -{Fe}_{2}{O}_{3}$$ γ - Fe 2 O 3 ) and thermal ablation via HIFU, are investigated in detail. A comparison between classical chemotherapy and thermochemistry shows that temperature can improve the therapeutic outcome by stimulating biological properties. On the other hand, the intravascular release of ThermoDox increases the concentration of free drug by 2.6 times compared to classical chemotherapy. The transport of drug in interstitium relies mainly on the diffusion mechanism to be able to penetrate deeper and reach the cancer cells in the inner regions of the tumor. Due to the low drug penetration into the tumor center, thermal ablation has been used for necrosis of the central areas before thermochemotherapy and ThermoDox therapy. Perfusion of the region around the necrotic zone is found to be damaged, while cells in the region are alive and not affected by medication therapy; so, there is a risk of tumor recurrence. Therefore, it is recommended that ablation be performed after the medication therapy. Our model describes a comprehensive assessment of MR-HIFU technology, taking into account many effective details, which can be a reliable guide towards the optimal use of drug delivery systems.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Effects of hypoxia and nanocarrier size on pH-responsive nano-delivery system to solid tumors

    M. Soltani / Mohammad Souri / Farshad Moradi Kashkooli

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 12

    Abstract: Abstract One of the special features of solid tumors is the acidity of the tumor microenvironment, which is mainly due to the presence of hypoxic regions. Therefore, pH-responsive drug delivery systems have recently been highly welcomed. In the present ... ...

    Abstract Abstract One of the special features of solid tumors is the acidity of the tumor microenvironment, which is mainly due to the presence of hypoxic regions. Therefore, pH-responsive drug delivery systems have recently been highly welcomed. In the present study, a comprehensive mathematical model is presented based on extravascular drug release paradigm. Accordingly, drug delivery system using pH-responsive nanocarriers is taken into account to examine the impacts of hypoxic regions as well as the size of nanocarriers for cancerous cell-death. The extent of hypoxic regions is controlled by vascular density. This means that regions with very low vascular density represent regions of hypoxia. Using this mathematical model, it is possible to simulate the extracellular and intracellular concentrations of drug by considering the association/disassociation of the free drug to the cell-surface receptors and cellular uptake. Results show that nanocarriers with smaller sizes are more effective due to higher accumulation in the tumor tissue interstitium. The small size of the nanocarriers also allows them to penetrate deeper, so they can expose a larger portion of the tumor to the drug. Additionally, the presence of hypoxic regions in tumor reduces the fraction of killed cancer cells due to reduced penetration depth. The proposed model can be considered for optimizing and developing pH-sensitive delivery systems to reduce both cost and time of the process.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Kinetic modelling of ultrasound-triggered chemotherapeutic drug release from the surface of gold nanoparticles

    Tyler K. Hornsby / Farshad Moradi Kashkooli / Anshuman Jakhmola / Michael C. Kolios / Jahangir (Jahan) Tavakkoli

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Band 13

    Abstract: Abstract Therapeutic ultrasound can be used to trigger the on-demand release of chemotherapeutic drugs from gold nanoparticles (GNPs). In the previous work, our group achieved doxorubicin (DOX) release from the surface of GNPS under low-intensity pulsed ... ...

    Abstract Abstract Therapeutic ultrasound can be used to trigger the on-demand release of chemotherapeutic drugs from gold nanoparticles (GNPs). In the previous work, our group achieved doxorubicin (DOX) release from the surface of GNPS under low-intensity pulsed ultrasound (LIPUS) exposure. However, the specific release kinetics of ultrasound-triggered DOX release from GNPs is not known. Here, we present a release kinetics study of DOX from GNPs under ultrasound exposure for the first time. A novel dialysis membrane setup was designed to quantify DOX release from LIPUS-activated GNPs at 37.0 °C and 43.4 °C (hyperthermia temperature range). Contributions of thermal and non-thermal mechanisms of LIPUS-triggered DOX release were also quantified. Non-thermal mechanisms accounted for 40 ± 7% and 34 ± 5% of DOX release for 37.0 °C and 43.4 °C trials, respectively. DOX release under LIPUS exposure was found to follow Korsmeyer–Peppas (K–P) kinetics, suggesting a shift from a Fickian (static) to a non-Fickian (dynamic) release profile with the addition of non-thermal interactions. DOX release was attributed to an anomalous diffusion release mechanism from the GNP surface. A finite element model was also developed to quantify the acoustic radiation force, believed to be the driving force of non-thermal DOX release inside the dialysis bag.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 660 ; 500
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: A spatiotemporal multi-scale computational model for FDG PET imaging at different stages of tumor growth and angiogenesis

    Farshad Moradi Kashkooli / Mohammad Amin Abazari / M. Soltani / Mehran Akbarpour Ghazani / Arman Rahmim

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 16

    Abstract: Abstract A deeper understanding of the tumor microenvironment (TME) and its role in metabolic activity at different stages of vascularized tumors can provide useful insights into cancer progression and better support clinical assessments. In this study, ... ...

    Abstract Abstract A deeper understanding of the tumor microenvironment (TME) and its role in metabolic activity at different stages of vascularized tumors can provide useful insights into cancer progression and better support clinical assessments. In this study, a robust and comprehensive multi-scale computational model for spatiotemporal transport of F-18 fluorodeoxyglucose (FDG) is developed to incorporate important aspects of the TME, spanning subcellular-, cellular-, and tissue-level scales. Our mathematical model includes biophysiological details, such as radiopharmaceutical transport within interstitial space via convection and diffusion mechanisms, radiopharmaceutical exchange between intracellular and extracellular matrices by glucose transporters, cellular uptake of radiopharmaceutical, as well as its intracellular phosphorylation by the enzyme. Further, to examine the effects of tumor size by varying microvascular densities (MVDs) on FDG dynamics, four different capillary networks are generated by angiogenesis modeling. Results demonstrate that as tumor grows, its MVD increases, and hence, the spatiotemporal distribution of total FDG uptake by tumor tissue changes towards a more homogenous distribution. In addition, spatiotemporal distributions in tumor with lower MVD have relatively smaller magnitudes, due to the lower diffusion rate of FDG as well as lower local intravenous FDG release. Since mean standardized uptake value (SUVmean) differs at various stages of microvascular networks with different tumor sizes, it may be meaningful to normalize the measured values by tumor size and the MVD prior to routine clinical reporting. Overall, the present framework has the potential for more accurate investigation of biological phenomena within TME towards personalized medicine.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors

    Mohammad Kiani Shahvandi / M. Soltani / Farshad Moradi Kashkooli / Babak Saboury / Arman Rahmim

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 18

    Abstract: Abstract We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal distributions within vascularized solid tumors. The novelty of the presented model is at mathematical level. From the mathematical viewpoint, we provide a ... ...

    Abstract Abstract We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal distributions within vascularized solid tumors. The novelty of the presented model is at mathematical level. From the mathematical viewpoint, we provide a general modeling framework for the process of radiopharmaceutical distribution in the tumor microenvironment to enable an analysis of the effect of various tumor-related parameters on the distribution of different radiopharmaceuticals. We argue that partial differential equations (PDEs), beyond conventional methods, including ODE-based kinetic compartment modeling, can be used to evaluate radiopharmaceutical distribution in both time and space. In addition, we consider the spatially-variable dynamic structure of tumor microvascular networks to simulate blood flow distribution. To examine the robustness of the model, the effects of microvessel density (MVD) and tumor size, as two important factors in tumor prognosis, on the radiopharmaceutical distribution within the tumor are investigated over time (in the present work, we focus on the radiopharmaceutical [18F]FDG, yet the framework is broadly applicable to radiopharmaceuticals). Results demonstrate that the maximum total uptake of [18F]FDG at all time frames occurs in the tumor area due to the high capillary permeability and lack of a functional lymphatic system. As the MVD of networks increases, the mean total uptake in the tumor is also enhanced, where the rate of diffusion from vessel to tissue has the highest contribution and the rate of convection transport has the lowest contribution. The results of this study can be used to better investigate various phenomena and bridge a gap among cancer biology, mathematical oncology, medical physics, and radiology.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-08-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Numerical Methods in Studies of Liquid Crystal Elastomers

    Madjid Soltani / Kaamran Raahemifar / Arman Nokhosteen / Farshad Moradi Kashkooli / Elham L. Zoudani

    Polymers, Vol 13, Iss 1650, p

    2021  Band 1650

    Abstract: Liquid crystal elastomers (LCEs) are a type of material with specific features of polymers and of liquid crystals. They exhibit interesting behaviors, i.e., they are able to change their physical properties when met with external stimuli, including heat, ...

    Abstract Liquid crystal elastomers (LCEs) are a type of material with specific features of polymers and of liquid crystals. They exhibit interesting behaviors, i.e., they are able to change their physical properties when met with external stimuli, including heat, light, electric, and magnetic fields. This behavior makes LCEs a suitable candidate for a variety of applications, including, but not limited to, artificial muscles, optical devices, microscopy and imaging systems, biosensor devices, and optimization of solar energy collectors. Due to the wide range of applicability, numerical models are needed not only to further our understanding of the underlining mechanics governing LCE behavior, but also to enable the predictive modeling of their behavior under different circumstances for different applications. Given that several mainstream methods are used for LCE modeling, viz. finite element method, Monte Carlo and molecular dynamics, and the growing interest and reliance on computer modeling for predicting the opto-mechanical behavior of complex structures in real world applications, there is a need to gain a better understanding regarding their strengths and weaknesses so that the best method can be utilized for the specific application at hand. Therefore, this investigation aims to not only to present a multitude of examples on numerical studies conducted on LCEs, but also attempts at offering a concise categorization of different methods based on the desired application to act as a guide for current and future research in this field.
    Schlagwörter liquid crystal elastomer ; numerical methods ; finite element method ; Monte Carlo method ; molecular dynamics method ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Numerical Assessment of an Air Cleaner Device under Different Working Conditions in an Indoor Environment

    Farshad Moradi Kashkooli / Mostafa Sefidgar / M. Soltani / Shahab Anbari / Seyed-Amir Shahandashti / Bahram Zargar

    Sustainability, Vol 13, Iss 369, p

    2021  Band 369

    Abstract: Transmission and spread of exhaled contaminants in the air may cause many airborne infectious diseases. In addition to appropriate ventilation, air cleaner devices are used as one of the most common ways to improve the indoor air quality. Therefore, it ... ...

    Abstract Transmission and spread of exhaled contaminants in the air may cause many airborne infectious diseases. In addition to appropriate ventilation, air cleaner devices are used as one of the most common ways to improve the indoor air quality. Therefore, it is necessary to understand the performance of an air cleaner under different operating conditions. This study mainly concerns investigating the effect of presence or absence of furniture and its displacement on the removal rate of the particles leaving a person’s mouth while coughing in an isolated room. Moreover, the effect of air exit angle of the device on removal rate of contaminated particles and the pattern of their dispersion within a room was studied. To this aim, computational fluid dynamics were employed to examine the mentioned effects by using the Eulerian− Lagrangian method. As the results indicated, when the furniture was placed farther away from the device, more particles were removed by the device. Additionally, the air ejection angle of the air cleaner device significantly affects the removal of particles. Results of the present study could improve use of air cleaner devices for maximum reduction of particles in the indoor environment.
    Schlagwörter air cleaner device ; indoor environment ; computational fluid dynamics (CFD) ; clean air delivery rate (CADR) ; particle transport ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes-A computational approach.

    Masoud H H Tehrani / M Soltani / Farshad Moradi Kashkooli / Kaamran Raahemifar

    PLoS ONE, Vol 15, Iss 6, p e

    2020  Band 0233219

    Abstract: Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells ... ...

    Abstract Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs due to rapid heat dispersive tissues. In the present study, the effects of the shape and size of the tumor on MWA are investigated. To obtain the temperature gradient, coupled bio-heat and electromagnetic equations are solved using a three-dimensional finite element method (FEM). To extract cellular response at different temperatures and times, the three-state mathematical model was employed to achieve the ablation zone size. Results show that treatment of larger tumors is more difficult than that of smaller ones. By doubling the diameter of the tumor, the percentage of dead cancer cells is reduced by 20%. For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. The findings of this study can be used to choose the optimum frequency and the best antenna design according to the shape and size of the tumor.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Towards principled design of cancer nanomedicine to accelerate clinical translation

    Mohammad Souri / M. Soltani / Farshad Moradi Kashkooli / Mohammad Kiani Shahvandi / Mohsen Chiani / Fatemeh Sadat Shariati / Mohammad Reza Mehrabi / Lance L. Munn

    Materials Today Bio, Vol 13, Iss , Pp 100208- (2022)

    2022  

    Abstract: Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technology is ...

    Abstract Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technology is challenging. To create drug delivery systems with increased treatment efficacy for clinical translation, the physicochemical characteristics of nanoparticles such as size, shape, elasticity (flexibility/rigidity), surface chemistry, and surface charge can be specified to optimize efficiency for a given application. Consequently, interdisciplinary researchers have focused on producing biocompatible materials, production technologies, or new formulations for efficient loading, and high stability. The effects of design parameters can be studied in vitro, in vivo, or using computational models, with the goal of understanding how they affect nanoparticle biophysics and their interactions with cells. The present review summarizes the advances and technologies in the production and design of cancer nanomedicines to achieve clinical translation and commercialization. We also highlight existing challenges and opportunities in the field.
    Schlagwörter Tumor microenvironment ; Nanomedicine ; Drug delivery ; Nanoparticle design ; Drug loading ; Clinical translation ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Elsevier
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