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  1. AU="Farzaneh Ashrafi"
  2. AU="Mitamura, Yasuhito"
  3. AU="Mayfield, Margaret M"
  4. AU="Rebsomen, L"
  5. AU="Abtie Abebaw"
  6. AU="Treitz, Christian"
  7. AU=Abd-Elsayed Alaa
  8. AU="Vesajoki, Marja" AU="Vesajoki, Marja"
  9. AU=Lewiecki E Michael
  10. AU=von Bubnoff Nikolas
  11. AU="Tang, Walfred W C"
  12. AU=Hashitani Hikaru
  13. AU="Löw, Martina"
  14. AU="Robertson, Leon S"
  15. AU="Wright, Aaron T"
  16. AU="Jones, T. B."
  17. AU=Shirtliff Mark E.
  18. AU="Riis, Kamilla R"
  19. AU="Xu, Leyao"
  20. AU="Udayakumar, Karthikrajan Parasuraman"
  21. AU="Fry, Brian"

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  1. Artikel ; Online: The prevention of cisplatin-induced nephrotoxicity

    Farzaneh Ashrafi / Mojgan Mortazavi / Mehdi Nematbakhsh

    International Journal of Preventive Medicine, Vol 13, Iss 1, Pp 21-

    A general consensus statement of a group of oncologist-hematologists, adult and pediatric nephrologists, radiation oncologists, clinical pathologists, clinical pharmacologists, and renal physiologists on cisplatin therapy in cancer patients

    2022  Band 21

    Abstract: Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisplatin (CP) in clinic. However, the most side effect of CP is nephrotoxicity, which limits the treatment. The aim of study was to develop a general consensus ... ...

    Abstract Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisplatin (CP) in clinic. However, the most side effect of CP is nephrotoxicity, which limits the treatment. The aim of study was to develop a general consensus statement for CP therapy in clinic to limit the drug-induced nephrotoxicity. Methods: A total of 30 oncologist-hematologists, adult and pediatric nephrologists, radiation oncologists, clinical pathologist clinical pharmacologist, and renal physiologist participated in a workshop, and in order to reduce the incidence of CP-induced nephrotoxicity, a general consensus was developed. Results: The developed general consensus was focused on some items such as age, sex, female hormone, nonsteroidal anti-inflammatory drugs (NSAID), renin–angiotensin system inhibitor drugs, glomerular filtration rate, hydration methods, contrasts, antioxidants, dextrose, and magnesium. Conclusion: The agreement between participants for CP therapy in clinic was achieved, and this general consensus was announced to be implemented in the hospitals.
    Schlagwörter cisplatin ; consensus ; nephron ; toxicity ; Medicine ; R
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: A comparative study of the effects of multimedia training materials on mini CEX scores of internal medicine residents in Isfahan University of Medical Sciences

    Soheila Shokrollahi / Farzaneh Ashrafi / Bijan Iraj / Athar Omid / Vahid Mansouri

    Journal of Education and Health Promotion, Vol 11, Iss 1, Pp 322-

    2022  Band 322

    Abstract: BACKGROUND: Role of multimedia training materials on Mini-CEX scores of internal medicine residents. We aimed to assess the effect of multi multimedia training materials on Mini-CEX scores of internal medicine residents of Isfahan University of Medical ... ...

    Abstract BACKGROUND: Role of multimedia training materials on Mini-CEX scores of internal medicine residents. We aimed to assess the effect of multi multimedia training materials on Mini-CEX scores of internal medicine residents of Isfahan University of Medical Sciences. SETTINGS AND DESIGN: A quasi-experimental action research study on 1st, 2nd, and 3rd-year internal medicine residents were implemented. MATERIALS AND METHODS: The Mini-CEX test measures students' performance in six core skills necessary for medical practice. Mini-CEX scores of 135 internal medicine residents in 2017–2018 were compared before and after the training with prepared multimedia materials. We used repeated measured ANOVA and Mann–Whitney U test to compare the distribution of Mini-CEX scores across corresponding groups. Analysis was done using the SPSS software version 23 (IBM SPSS Statistics for Windows. Armonk, NY, USA: IBM Corp). RESULTS: The median Mini-CEX score (IQR) of students in preintervention and postintervention groups were 16.14 (5.19) and 19.62 (3.13), respectively. Findings of this study showed a significant increase in mini-CEX scores of the groups who used the multimedia learning material compared to those who did not use it (P < 0.001). CONCLUSIONS: Multimedia learning resources demonstrated a promising influence on internal residents' mini-CEX scores in this study. They demonstrate significantly greater performance after using multimedia learning materials compared to their same-year residents who did not benefit from it. This demonstrates the favorable effect of multimedia on the acquisition of practical skills such as obtaining a history or performing a physical examination.
    Schlagwörter education ; educational measurement ; internal medicine ; internship ; residency ; Special aspects of education ; LC8-6691 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Losartan risk for female in cisplatin-induced nephrotoxicity

    Mehdi Nematbakhsh / Farzaneh Ashrafi

    Journal of Research in Medical Sciences, Vol 24, Iss 1, Pp 4-

    2019  Band 4

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
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  4. Artikel ; Online: T-cell immunophenotyping in COVID-19 pneumonia

    Pardis Nematollahi / Farzaneh Ashrafi / Ali Darakhshandeh / Mehrzad Salmasi

    Journal of Research in Medical Sciences, Vol 26, Iss 1, Pp 81-

    2021  Band 81

    Abstract: The COVID-19 epidemic is currently a global threat that has affected many parts of the world. Some patients require intensive care unit admission due to severe symptoms in the course of the disease. The severity of symptoms in this disease varies from ... ...

    Abstract The COVID-19 epidemic is currently a global threat that has affected many parts of the world. Some patients require intensive care unit admission due to severe symptoms in the course of the disease. The severity of symptoms in this disease varies from person to person. The effectiveness of the immune response against viral infections depends on the number and activity of T-cells, which play an important role in eliminating virus-infected cells. In this study, we report two patients with COVID-19 pneumonia, one with moderate symptoms and the other with severe symptoms. Although a decrease of absolute lymphocyte count was seen in both patients, a more significant decline reported in the ICU-admitted patient. Expression of activated markers, HLA-DR, CD38, on CD8-positive T-cells was shown in a patient with more severe disease. On the other hand, partial loss of CD7 in the severe case was also observed. Hence, besides of the above parameters that already mentioned in other studies, loss of pan T-markers could be considered as a potentially valuable test for predicting disease severity. We suggest evaluating the predictability of these tests in COVID-19 in larger studies. This study was approved by the Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.MED.REC.1399.238).
    Schlagwörter covid-19 ; flowcytometry ; t cell immunophenotyping ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
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  5. Artikel ; Online: The Correlation between the Serum Level of Free Light Chain Ratio and Prognostic Factors among the Patients with Lymphoma

    Farzaneh Ashrafi / Seyyed Amirabbas Nekouei / Elham Moazzam

    مجله دانشکده پزشکی اصفهان, Vol 36, Iss 467, Pp 96-

    2018  Band 103

    Abstract: Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease. Methods: In a cross-sectional study, ... ...

    Abstract Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease. Methods: In a cross-sectional study, 59 patients with lymphoma who presented to Seyyed-al-Shohada hospital, Isfahan, Iran, were investigated. Subtype and stage of disease were specified via clinical exam and histologic and radiologic studies. Prognostic laboratory factors such as B2-microglobulin (B2MG), albumin, lactate dehydrogenase (LDH) and (ESR), in addition to serum free light chain (kappa and lambda) using nephelometry method were measured. The data were analyzed using SPSS software Findings: There was no relationship between the mean serum level of free light chains and B2-microglobulin (P = 0.193, r = 0.173, and P = 0.170, r = 0.181 for lambda and kappa chains, respectively). Mean serum level of lambda chain was higher among the patients with bone marrow involvement and B-symptoms (fever, night sweats, and weight loss) (P = 0.021), but the mean serum level of albumin was lower among these patients (P = 0.025). Conclusion: In patients with bone marrow involvement and presence of B-symptoms, only serum lambda levels were higher than those without it. There were no correlation between the level of serum free light chain ratio and age, and subtype and stage of disease.
    Schlagwörter Lymphoma ; Immunoglobulin light chains ; Immunoglobulin lambda-chains ; Prognosis ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616 ; 610
    Sprache Persisch
    Erscheinungsdatum 2018-04-01T00:00:00Z
    Verlag Vesnu Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Thalidomide for the treatment of COVID-19 pneumonia

    Babak Amra / Farzaneh Ashrafi / Mehdi Torki / Marzieh Hashemi / Mohamad Shirzadi / Forogh Soltaninejad / Somayeh Sadeghi / Mehrzad Salmasi / Ramin Sami / Ali Darakhshandeh / Maryam Nasirian / Samaneh Pourajam

    Advanced Biomedical Research, Vol 12, Iss 1, Pp 14-

    A randomized controlled clinical trial

    2023  Band 14

    Abstract: Background: Coronavirus disease 2019 has become a public health concern with a high number of fatalities. Thalidomide can target inflammatory mediators and decrease inflammation in SARS-CoV-2. Materials and Methods: An open-label, randomized controlled ... ...

    Abstract Background: Coronavirus disease 2019 has become a public health concern with a high number of fatalities. Thalidomide can target inflammatory mediators and decrease inflammation in SARS-CoV-2. Materials and Methods: An open-label, randomized controlled trial was conducted on patients with compatible lung high-resolution computed tomography scan for COVID-19 pneumonia and moderate involvement. Childbearing-age women were excluded. A total of 20 patients in the control group receiving usual treatment were compared with 26 patients in the case group who in addition to the same regimen also received thalidomide. The primary outcome was time for clinical recovery (TTCR) and intensive-care unit (ICU) admission. Results: From April 25 to August 8, 2020, based on the inclusion criteria, 47 patients were assigned to the study. Patients receiving thalidomide had a mean TTCR of days 5.5 (95% confidence interval [CI], 0.7–10.3), as compared with days 5.3 (95% CI, 1.7–8.9) with control (odds ratio 0.01; 95% CI, −1.58–1.59, P = 0.807). The incidence of ICU admission was 27% in the thalidomide group compared with 20% in the control group (odds ratio 3.89; 95% CI, 0.55–27.4, P = 0.425). The mean length of stay in hospital in both groups was 10 days. Progressive improvement in respiratory rate, fever, and O2 saturation during the study was seen in both groups without a significant difference between the thalidomide and control group (P > 0.05). Conclusion: This study investigated the effects of thalidomide to treat moderate COVID-19 clinical outcomes. The results established that this drug regimen did not add more effect to usual treatment for moderate COVID-19 pneumonia.
    Schlagwörter covid-19 ; intensive-care unit (icu) ; length of stay ; pneumonia ; thalidomide ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: Dextrose Hydration May Promote Cisplatin-induced Nephrotoxicity in Rats

    Farzaneh Karimi / Sayyedehnikta Kasaei / Azar Baradaran / Farzaneh Ashrafi / Ardeshir Talebi / Zahra Lak / Mehdi Nematbakhsh

    Indonesian Biomedical Journal, Vol 11, Iss 2, Pp 136-

    Gender-related Difference

    2019  Band 44

    Abstract: BACKGROUNDS: Cisplatin (CP) as an anticancer drug may affect the plasma glucose level while diabetic subjects are protected against CP-induced nephrotoxicity. In the current study, the role of dextrose hydration during CP therapy on CP-induced ... ...

    Abstract BACKGROUNDS: Cisplatin (CP) as an anticancer drug may affect the plasma glucose level while diabetic subjects are protected against CP-induced nephrotoxicity. In the current study, the role of dextrose hydration during CP therapy on CP-induced nephrotoxicity was evaluated. METHODS: Sixty-nine male and female rats were divided into 12 groups. The rats were hydrated with 15 mL/kg vehicle or different doses of 2%, 10% and 20% dextrose before and after 7.5 mg/kg CP administration. One week later, the biochemical and kidney function markers, and histology finding were determined. RESULTS: All the animals co-treated with CP and 20% dextrose, were dead during one week of the experiment. Administration of CP alone increased kidney tissue damage score (KTDS) and kidney weight (KW). It also elevated the blood urea nitrogen (BUN) and BUN-creatineine ratio (BUN/Cr) levels in the serum. In addition, CP decreased body weight and creatinine (Cr) clearance (ClCr) significantly in both male and female rats (p<0.05). However, 2% and 10% dextrose did not alter the mentioned parameters in male, but 10% dextrose supplement increased the serum levels of BUN, Cr and BUN/Cr ratio, KW and KTDS significantly in female rats (p<0.05). CONCLUSION: Our data suggest that not only do not support the nephro-protective role of dextrose hydration during CP therapy, the dextrose hydration can act as risk factor to promote CP-induced nephrotoxicity in female rats. Prohibition of high carbohydrate (glucose) diet during CP therapy is recommended. KEYWORDS: cisplatin, nephrotoxicity, dextrose, rat, gender
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag Secretariat of The Indonesian Biomedical Journal
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  8. Artikel ; Online: Outcome of rapamycin therapy for post-transplant-lymphoproliferative disorder after kidney transplantation

    Farzaneh Ashrafi / Shahrzad Shahidi / Zeinab Ebrahimi / Mojgan Mortazavi

    International Journal of Hematology-Oncology and Stem Cell Research, Vol 9, Iss 1, Pp 26-

    case series.

    2015  Band 32

    Abstract: Post-transplant lymphoproliferative disorders (PTLD) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as rapamycin have been explored.A detailed retrospective ... ...

    Abstract Post-transplant lymphoproliferative disorders (PTLD) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as rapamycin have been explored.A detailed retrospective analysis was performed according to data collected from 13 patients with PTLD. At the time of PTLD diagnosis, immunosuppressive therapy was decreased and rapamycin administered. Overall survival, disease-free survival of patients and graft survival were determined.Among 590 kidney transplant recipients, 13 adult patients with PTLD were included in this study. The mean age of the patients was 42.15 (range: 25-58) years at the time of PTLD diagnosis, and 9 patients were male. Histology was distributed in 9 diffuse large B cell, 1 Malt lymphoma, 1 Burkitt lymphoma, 2 Hodgkin-like PTLD. The response rate to rapamycin alone was 30.8%. The mean overall survival period was 23.38 months and 11 patients are still alive. In total, 10 patients (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) patients.Despite the retrospective focus and limited number of patients, this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to rapamycin for patients with PTLD.
    Schlagwörter Lymphoma Therapy ; Rapamycin ; Transplant ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2015-03-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Composite lymphoma in a patient with ulcerative colitis

    Farzaneh Ashrafi / Farid Kowsari / Ali Darakhshandeh / Peyman Adibi

    International Journal of Hematology-Oncology and Stem Cell Research, Vol 8, Iss 4, Pp 45-

    a case report.

    2014  Band 8

    Abstract: A 45-year-old female patient with a diagnosis of ulcerative colitis complicated with composite lymphoma in the spleen and para-aortic lymph node presented with a one-month history of malaise, weakness and fatigue. Only mesalamine kept ulcerative colitis ... ...

    Abstract A 45-year-old female patient with a diagnosis of ulcerative colitis complicated with composite lymphoma in the spleen and para-aortic lymph node presented with a one-month history of malaise, weakness and fatigue. Only mesalamine kept ulcerative colitis under control. In physical examination, splenomegaly was revealed and pancytopenia was obtained from laboratory data. Computed tomography scan revealed para-aortic mediastinal lymphadenopathy with splenomegaly. Splenectomy and excisional biopsy of abdominal lymph node were performed and disease was diagnosed as composite lymphoma, consisting of diffuse large B-cell lymphoma and nodular sclerosing Hodgkin lymphoma.
    Schlagwörter Composite lymphoma ; Diffuse large B-Cell lymphoma ; Inflammatory bowel disease ; Nodular sclerosing Hodgkin lymphoma ; Ulcerative colitis ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-12-01T00:00:00Z
    Verlag Tehran University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Electrical stimulation of acupuncture points for analgesia during bone marrow aspiration and biopsy

    Omid Shokrani / Mahmood Saghaei / Farzaneh Ashrafi / Alireza Sadeghi

    Advanced Biomedical Research, Vol 3, Iss 1, Pp 125-

    A randomized double-blind placebo-controlled trial

    2014  Band 125

    Abstract: Background: Bone marrow aspiration and biopsy (BMA/BMB) is a painful procedure mostly used in diagnosing and staging of a broad spectrum of hematological diseases. In spite of local anesthesia, the prevalence and intensity of the pain and patient ... ...

    Abstract Background: Bone marrow aspiration and biopsy (BMA/BMB) is a painful procedure mostly used in diagnosing and staging of a broad spectrum of hematological diseases. In spite of local anesthesia, the prevalence and intensity of the pain and patient discomfort caused by this procedure are considerable. The effect of acupuncture and electrical stimulation of acupoints (acupuncture points) in the treatment of many medical conditions, including pain, have been approved. The study is designed to evaluate the effect of electrical stimulation of acupoints to decrease the pain during BMA/BMB in adults. Materials and Methods: In a double-blind controlled clinical trial, 50 patients undergoing BMA/BMB were randomly allocated into two groups, to receive either true or placebo electrical stimulation of acupoints LI-4 (large intestine 4, Hegu) and LI-11 (large intestine 11, Quchi), bilaterally. Both groups received infiltrative local anesthesia. The pain level caused by BMA/BMB was measured using the Visual Analog Scale (VAS). Results: The means of the VAS in the case and control groups were 41.84 ± 20.54 and 69.40 ± 20.06 respectively (P < 0.001). The systolic and diastolic blood pressure and pulse rate rose significantly in both the groups compared to the basal values. The rise was lower in the acupuncture group compared to the placebo group regarding systolic blood pressure and pulse rate (P = 0.018 and P < 0.001, respectively). Conclusions: The results of this study show that the electrical stimulation of acupoints significantly decreases the pain caused by BMA/BMB and some of the complications of the pain.
    Schlagwörter Acupuncture ; bone marrow examination ; electrical stimulation ; pain ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
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