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Article: Primary non leukemic myeloid sarcoma of the ureteral wall: a case report of a rare disease.

Quaresima, Luigi / Polisini, Giordano / Fasanella, Daniela / Cammarata, Vanessa / Galosi, Andrea Benedetto / Giannubilo, Willy

Journal of surgical case reports

2023 Volume 2023, Issue 8, Page(s) rjad433

Abstract: Myeloid sarcoma (MS) is an extramedullary tumor mass causing proliferation of mature or immature blast cells of one or more myeloid lineages. Involvement of the genitourinary tract is rare. We present a case of MS of the ureteral wall. A 74-year-old man ... ...

Abstract	Myeloid sarcoma (MS) is an extramedullary tumor mass causing proliferation of mature or immature blast cells of one or more myeloid lineages. Involvement of the genitourinary tract is rare. We present a case of MS of the ureteral wall. A 74-year-old man was evaluated for left hydronephrosis and ipsilateral low back pain. A computed tomography scan showed a nodular formation in the pelvic ureter. Urinary cytology revealed cellular atypia, so ureteroscopy was performed showing a distal ureteral mass. The histological examination of the biopsy revealed to be malignant neoplasm. The patient underwent left laparoscopic nephroureterectomy with bladder cuff excision. Microscopic histological examination revealed a tumor compatible with MS. A postoperative positron emission tomography revealed residual hypercaptation of the bladder, pelvic muscle and iliac nodes, so the patient started chemotherapy. A multidisciplinary approach was required, taking into account the patient's age, the already poor renal function and the location of the neoplasm.
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjad433
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Article: Conservative approach for a giant prostatic hyperplasia of 1280 ml: a case report and literature review.

Quaresima, Luigi / Tramanzoli, Pietro / Fasanella, Daniela / Galosi, Andrea Benedetto / Giannubilo, Willy

Journal of surgical case reports

2023 Volume 2023, Issue 8, Page(s) rjad422

Abstract: Benign Prostatic Hypertrophy (BPH) affects at least one-third of men over 60 years. A giant prostatic hyperplasia (GPH) is a prostate enlargement that exceeds 500 g. We present a case of a 72-year-old man with a GPH volume of 1280 ml, referred to our ... ...

Abstract	Benign Prostatic Hypertrophy (BPH) affects at least one-third of men over 60 years. A giant prostatic hyperplasia (GPH) is a prostate enlargement that exceeds 500 g. We present a case of a 72-year-old man with a GPH volume of 1280 ml, referred to our hospital for a worsening of the lower urinary tract symptoms (LUTS), bilateral loin pain and kidney failure. Although the patient had a negligible post-void residual urine, he had bilateral hydronephrosis. The patient was managed conservatory because of a high anesthesiologic risk but a bilateral percutaneous nephrostomy was placed soon due to kidney function worsening. The presence of serious comorbidities and the resolution of the loin pain and the renal failure, achieved first with the nephrostomy and then with periodic replacement of ureteral stents, along with an improvement of the LUTS obtained with medical therapy, have oriented us towards a conservative management of the patient.
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjad422
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Article ; Online: A giant scrotal pendulous fibroma mimicking a supernumerary testis.

Quaresima, Luigi / Fave, Rocco Francesco Delle / Polisini, Giordano / Fasanella, Daniela / Giannubilo, Willy

Asian journal of andrology

2023

Language	English
Publishing date	2023-10-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202354
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Article: Neobladder "Function": Tips and Tricks for Surgery and Postoperative Management.

Fasanella, Daniela / Marchioni, Michele / Domanico, Luigi / Franzini, Claudia / Inferrera, Antonino / Schips, Luigi / Greco, Francesco

Life (Basel, Switzerland)

2022 Volume 12, Issue 8

Abstract: Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable ... ...

Abstract	Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable patients who do not prefer a stoma and are motivated to undergo adequate training of the neobladder. Careful patient selection, taking into account the absolute and relative contraindications for ONB as well as an adequate recovery protocol after surgery are integral to the success of this procedure and the oncological and functional outcomes. The objective of this review is to summarize the current data on RC with ONB in terms of patient selection, preoperative preparation, surgical techniques and functional (continence and sexual activity) and oncological outcomes, with particular attention to the management of complications and the impact on quality of life (QoL).
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12081193
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Article ; Online: Potential prognostic value of miRNAs as biomarker for progression and recurrence after nephrectomy in renal cell carcinoma: a literature review.

Fasanella, Daniela / Antonaci, Alessio / Esperto, Francesco / Scarpa, Roberto M / Ferro, Matteo / Schips, Luigi / Marchioni, Michele

Diagnosis (Berlin, Germany)

2021 Volume 9, Issue 2, Page(s) 157–165

Abstract: Objectives: We provide a systematic literature review on tissue miRNAs in patients with RCC to evaluate and summarize their usefulness as prognostic markers. We undertook a systematic search for articles in English using the PubMed-Medline database from ...

Abstract	Objectives: We provide a systematic literature review on tissue miRNAs in patients with RCC to evaluate and summarize their usefulness as prognostic markers. We undertook a systematic search for articles in English using the PubMed-Medline database from January 2010 to December 2020. Studies were identified and selected according to the PRISMA criteria and the PICO methodology. The population consisted of RCC patients undergoing nephrectomy and the main outcome of interest was recurrence-free survival (RFS). Only studies providing hazard ratios (HRs) from multivariate or univariate analyzes with corresponding 95% confidence intervals (CI) and/or area under the curve (AUC) were considered. Content: All nine included studies (1,541 patients) analyzed the relationship between tissue miRNA expression levels (up or downregulated) and RFS. Some of these found that the methylation status of miR-9-1, miR-9-3 and miR-124 was associated with a high risk of relapse. Moreover, miR-200b overexpression was associated with OS. MiR-210 overexpression indicated a shorter OS than those who were miR-210 negative. Finally, patients with high miR-125b expression had shorter cancer-specific survival (CSS) than those with low expression; similarly, patients with low miR-126 expression also had shorter CSS time. Summary and outlook: Several studies tested the usefulness of specific miRNAs to predict RCC recurrence. Some of them showed a fair accuracy and strong relationship between specific miRNA over or under-expression and survival outcomes. However, results from these studies are preliminary and miRNAs use in routine clinical practice is still far to come.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/surgery ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/surgery ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nephrectomy ; Prognosis
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2021-10-22
Publishing country	Germany
Document type	Journal Article ; Review ; Systematic Review
ISSN	2194-802X
ISSN (online)	2194-802X
DOI	10.1515/dx-2021-0080
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Article ; Online: Retroperitoneal extension of massive ulcerated testicular seminoma through the inguinal canal: A case report.

Antonaci, Alessio / Fasanella, Daniela / Galica, Vikiela / Tinari, Nicola / Giampietro, Jamara / Di Marino, Pietro / Delli Pizzi, Andrea / Basilico, Raffaella / Schips, Luigi / Marchioni, Michele

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2021 Volume 93, Issue 1, Page(s) 64–67

Abstract: Introduction: Testicular cancers represent about 5% of all urological malignancies and 1-1.5% of all male neoplasms. Most of the testicular cancers are localized (68%) at diagnosis. Bulky masses in the scrotum are rare. We present a rare case of bulky ... ...

Abstract	Introduction: Testicular cancers represent about 5% of all urological malignancies and 1-1.5% of all male neoplasms. Most of the testicular cancers are localized (68%) at diagnosis. Bulky masses in the scrotum are rare. We present a rare case of bulky testicular cancer with retroperitoneal spread through the inguinal canal. Case report: A 44-year-old man came to the emergency department referring weakness and the presence of a scrotal mass. At physical examination, a voluminous mass was found, with necrotic phenomena within the scrotum. Abdomen was tense and sore. Abdominal CT scan revealed a bulky testicular mass spreading to the retroperitoneal space through the inguinal canal with node enlargement. Patient underwent orchiectomy with excision of infiltrated scrotum skin. Histologic diagnosis confirmed a typical form seminoma. The patient was then treated with a cisplatin-based chemotherapy, with a partial response. The patient recently relapsed and he is being treated with a new line of chemotherapy and subsequent surgery with or without radiotherapy. Conclusions: We described a rare presentation of testicular cancer. This case highlights the importance of a multidisciplinary approach to rare testis tumour presentation and early diagnosis for testicular cancers.
MeSH term(s)	Adult ; Humans ; Inguinal Canal/pathology ; Male ; Neoplasm Invasiveness ; Retroperitoneal Neoplasms/complications ; Retroperitoneal Neoplasms/pathology ; Retroperitoneal Neoplasms/therapy ; Seminoma/complications ; Seminoma/pathology ; Seminoma/therapy ; Testicular Neoplasms/complications ; Testicular Neoplasms/pathology ; Testicular Neoplasms/therapy ; Ulcer/complications
Language	English
Publishing date	2021-03-19
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2021.1.64
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Article ; Online: The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives.

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 11

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Male ; Humans ; MicroRNAs/genetics ; Testicular Neoplasms/diagnosis ; Testicular Neoplasms/genetics ; Testicular Neoplasms/pathology ; Neoplasm Recurrence, Local ; Neoplasms, Germ Cell and Embryonal/diagnosis ; Neoplasms, Germ Cell and Embryonal/genetics ; Biomarkers, Tumor/genetics
Chemical Substances	MicroRNAs ; Biomarkers, Tumor
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59112033
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Book ; Online: The Analytical Method algorithm for trigger primitives generation at the LHC Drift Tubes detector

Abbiendi, G. / Maestre, J. Alcaraz / Fernández, A. Álvarez / González, B. Álvarez / Amapane, N. / Bachiller, I. / Barcellan, L. / Baldanza, C. / Battilana, C. / Bellato, M. / Bencze, G. / Benettoni, M. / Beni, N. / Benvenuti, A. / Bergnoli, A. / Ramos, L. C. Blanco / Borgonovi, L. / Bragagnolo, A. / Cafaro, V. /

Calderon, A. / Calvo, E. / Carlin, R. / Montoya, C. A. Carrillo / Cavallo, F. R. / Ruiz, J. M. Cela / Cepeda, M. / Cerrada, M. / Checchia, P. / Ciano, L. / Colino, N. / Corti, D. / Cotto, G. / Crupano, A. / Calzada, S. Cuadrado / Cuevas, J. / Cuffiani, M. / Dallavalle, G. M. / Dattola, D. / De La Cruz, B. / Rodríguez, C. I. de Lara / De Remigis, P. / Cid, C. Erice / Eliseev, D. / Fabbri, F. / Fanfani, A. / Fasanella, D. / Bedoya, C. F. / de Trocóniz, J. F. / del Val, D. Fernández / Menéndez, J. Fernández

2023

Abstract: The Compact Muon Solenoid (CMS) experiment prepares its Phase-2 upgrade for the high-luminosity era of the LHC operation (HL-LHC). Due to the increase of occupancy, trigger latency and rates, the full electronics of the CMS Drift Tube (DT) chambers will ... ...

Abstract	The Compact Muon Solenoid (CMS) experiment prepares its Phase-2 upgrade for the high-luminosity era of the LHC operation (HL-LHC). Due to the increase of occupancy, trigger latency and rates, the full electronics of the CMS Drift Tube (DT) chambers will need to be replaced. In the new design, the time bin for the digitisation of the chamber signals will be of around 1~ns, and the totality of the signals will be forwarded asynchronously to the service cavern at full resolution. The new backend system will be in charge of building the trigger primitives of each chamber. These trigger primitives contain the information at chamber level about the muon candidates position, direction, and collision time, and are used as input in the L1 CMS trigger. The added functionalities will improve the robustness of the system against ageing. An algorithm based on analytical solutions for reconstructing the DT trigger primitives, called Analytical Method, has been implemented both as a software C++ emulator and in firmware. Its performance has been estimated using the software emulator with simulated and real data samples, and through hardware implementation tests. Measured efficiencies are 96 to 98\% for all qualities and time and spatial resolutions are close to the ultimate performance of the DT chambers. A prototype chain of the HL-LHC electronics using the Analytical Method for trigger primitive generation has been installed during Long Shutdown 2 of the LHC and operated in CMS cosmic data taking campaigns in 2020 and 2021. Results from this validation step, the so-called Slice Test, are presented. Comment: 16 pages, 11 figures
Keywords	High Energy Physics - Experiment ; Physics - Instrumentation and Detectors
Subject code	621
Publishing date	2023-02-03
Publishing country	us
Document type	Book ; Online
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Article ; Online: Peak expiratory flow in bed? A comparison of 3 positions.

Wallace, Jessica L / George, Christa M / Tolley, Elizabeth A / Winton, John C / Fasanella, Dana / Finch, Christopher K / Self, Timothy H

Respiratory care

2013 Volume 58, Issue 3, Page(s) 494–497

Abstract: Background: Current guidelines for the correct peak expiratory flow (PEF) maneuver include standing. In the hospital setting, PEF values are often ordered to assess response to asthma therapy for exacerbations. We have observed that the PEF is sometimes ...

Abstract	Background: Current guidelines for the correct peak expiratory flow (PEF) maneuver include standing. In the hospital setting, PEF values are often ordered to assess response to asthma therapy for exacerbations. We have observed that the PEF is sometimes performed with the patient in bed. Methods: Healthy adults performed the PEF maneuver in random order, standing, lying back at an ~45° angle on pillows, and sitting, slumped forward ~10° with legs extended. PEF was recorded for 3 attempts in each of the 3 positions. Results: We enrolled 94 subjects (39 male, 55 female, mean age 24 y) in 2011. Mean PEF in the standing position (669 ± 42 L/min) was significantly higher than in the lying back (621 ± 42 L/min) (P < .001) and sitting (615 ± 42 L/min) positions in males (P < .001), and, similarly, in females, standing produced a significantly higher mean PEF (462 ± 42 L/min) than the lying back (422 ± 42 L/min) (P < .001) and sitting (447 ± 42 L/min) positions (P < .05). Conclusions: Clinicians should ensure that PEF is obtained with patients out of bed and in the standing position.
MeSH term(s)	Adult ; Asthma/physiopathology ; Beds ; Female ; Humans ; Male ; Peak Expiratory Flow Rate/physiology ; Posture/physiology ; Prospective Studies
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.01843
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Article: Comparison between ultrasound-guided and digital-guided anesthesia before prostatic biopsy.

D'Eramo, Giuseppe / Fasanella, Daniela / Di Quilio, Francesca / Molnar, Peter / Salciccia, Stefano / Sciarra, Alessandro / Gentile, Vincenzo

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2012 Volume 84, Issue 4, Page(s) 260–262

Abstract: Objective: Our target in this study is to evaluate the efficacy of ultrasound (US)-guided anesthesia in comparison it to the digital-guided one, considering pain and discomfort reduction, during prostate biopsy.: Materials and methods: We analyzed ... ...

Abstract	Objective: Our target in this study is to evaluate the efficacy of ultrasound (US)-guided anesthesia in comparison it to the digital-guided one, considering pain and discomfort reduction, during prostate biopsy. Materials and methods: We analyzed 150 patients that underwent prostate biopsy between March 2011 and January 2012; conditions to enter the sample were: elevated PSA levels and/or psa ratio free/total less than 15% and/or detection of alteration via ultrasound examination and/or a positive outcome of a digital rectal examination. Patients were randomized into two groups. In 75 patients (group A) was performed local US-guided anesthesia with a dose of 10 ml of mepivacaine 1%, in the other 75 patients (group B) a local digital-guided anesthesia was performed, again with an equal dose of 10 ml of mepivacaine 1%. After the biopsy patients were kept under observation for two hours, after that they were asked to provide description of the pain experienced during biopsy, using a 10-point visual analog scale (visual analogue scale; 0 for no pain, 10 for excruciating pain). Results: In group A, 49 patients scored a VAS value of zero, 23 a value of 1 and 2 a value of 3. On the other side, in group B, 9 patients scored a VAS value of 1, 36 a value of 2, 28 a value of 3 and 2 a value of 4. In comparison patients in group A scored VAS values statistically lower than patients in group B (t student test, p < 0.01). Conclusions: The ultrasound-guided prostatic anesthesia is preferable to the digital-guided, because it considerably reduce the pain related to this procedure.
MeSH term(s)	Anesthesia, Local/methods ; Biopsy/adverse effects ; Humans ; Intraoperative Complications/prevention & control ; Male ; Pain/etiology ; Pain/prevention & control ; Preoperative Care ; Prostate/pathology ; Ultrasonography, Interventional
Language	English
Publishing date	2012-12
Publishing country	Italy
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1124-3562 ; 1120-8538
ISSN (online)	2282-4197
ISSN	1124-3562 ; 1120-8538
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