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Article ; Online: Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.

Pak, Oleg / Scheibe, Susan / Esfandiary, Azadeh / Gierhardt, Mareike / Sydykov, Akylbek / Logan, Angela / Fysikopoulos, Athanasios / Veit, Florian / Hecker, Matthias / Kroschel, Florian / Quanz, Karin / Erb, Alexandra / Schäfer, Katharina / Fassbinder, Mirja / Alebrahimdehkordi, Nasim / Ghofrani, Hossein A / Schermuly, Ralph T / Brandes, Ralf P / Seeger, Werner /
Murphy, Michael P / Weissmann, Norbert / Sommer, Natascha

The European respiratory journal

2018  

Abstract: Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular (RV) remodelling.We ... ...

Abstract Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular (RV) remodelling.We determined ROS in acute, chronic hypoxia and investigated the effect of the mitochondria-targeted antioxidant MitoQ under these conditions.The effect of MitoQ or its inactive carrier substance, decyltriphenylphosphonium (TPP
Language English
Publishing date 2018-02-01
Publishing country England
Document type Journal Article
ZDB-ID 639359-7
ISSN 1399-3003 ; 0903-1936
ISSN (online) 1399-3003
ISSN 0903-1936
DOI 10.1183/13993003.01024-2017
Shelf mark
Zs.A 2322: Show issues Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues
Database MEDical Literature Analysis and Retrieval System OnLINE

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