Article ; Online: Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
The European respiratory journal
2018
Abstract: Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular (RV) remodelling.We ... ...
Abstract | Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular (RV) remodelling.We determined ROS in acute, chronic hypoxia and investigated the effect of the mitochondria-targeted antioxidant MitoQ under these conditions.The effect of MitoQ or its inactive carrier substance, decyltriphenylphosphonium (TPP |
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Language | English | ||||||||||
Publishing date | 2018-02-01 | ||||||||||
Publishing country | England | ||||||||||
Document type | Journal Article | ||||||||||
ZDB-ID | 639359-7 | ||||||||||
ISSN | 1399-3003 ; 0903-1936 | ||||||||||
ISSN (online) | 1399-3003 | ||||||||||
ISSN | 0903-1936 | ||||||||||
DOI | 10.1183/13993003.01024-2017 | ||||||||||
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Database | MEDical Literature Analysis and Retrieval System OnLINE |
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