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Article ; Online: Efficient Synthesis of Dihydropyrimidines Using a Highly Ordered Mesoporous Functionalized Pyridinium Organosilica

Fatemeh Rajabi / Mika Sillanpää / Christophe Len / Rafael Luque

Catalysts, Vol 12, Iss 350, p

2022 Volume 350

Abstract: A Brönsted acidic ionic solid pyridinium-functionalized organosilica network (PMO-Py-IL) was demonstrated to efficiently catalyse one-pot Biginelli condensation reaction. The green synthesis of 3,4-dihydro-2(H)-pyrimidinones (DHPMs) with high yield was ... ...

Abstract	A Brönsted acidic ionic solid pyridinium-functionalized organosilica network (PMO-Py-IL) was demonstrated to efficiently catalyse one-pot Biginelli condensation reaction. The green synthesis of 3,4-dihydro-2(H)-pyrimidinones (DHPMs) with high yield was carried out via one-pot three component condensation of β- dicarbonyls, aldehydes, and urea in the presence of a catalytic amount of PMO-Py-IL nanomaterial as an efficient nanocatalyst under solvent free conditions. Furthermore, the catalyst showed outstanding stability and could be easily separated and reused for at least ten reaction runs without significant loss of activity and product selectivity. The green protocol features simple set-up, cost-effectiveness, easy work-up, eco-friendly and mild reaction conditions.
Keywords	biginelli reaction ; dihydropyrimidines ; pyridinium-functionalized organosilica ; reusable nanocatalyst ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Challenges and policy recommendations for IT governance in the University of Medical Sciences

Hamid Esmailzadeh / Shiva Mafimoradi / Ali Reza Hemmati / Fatemeh Rajabi

مدیریت سلامت, Vol 25, Iss 3, Pp 9-

a case study

2022 Volume 29

Abstract: Introduction: “Information and Communication Technology (ICT) governance” was introduced in developed countries in the late 1990s and replaced ICT management. In addition to the separation of the ICT responsibilities between different units/levels, ICT ... ...

Abstract	Introduction: “Information and Communication Technology (ICT) governance” was introduced in developed countries in the late 1990s and replaced ICT management. In addition to the separation of the ICT responsibilities between different units/levels, ICT governance allowed universities to develop mechanisms for monitoring ICT decisions in line with the University's vision, mission, and strategic goals through the distribution of the decision-making rights to various stakeholders. This study aimed to investigate the ICT management challenges in the university under study and explore the need for ICT governance. Methods: This is a qualitative-descriptive case study conducted in the three stages of preparation, identification, and analysis and prescription in one of the universities of medical sciences in Tehran (from November to December 2021). Semi-structured interviews based on judgmental purposeful sampling and FGDs were used for data collection, and qualitative content analysis in ATLAS-ti software was used for data analysis. Results: Structurally, the only macro-policymaking body in the ICT field is the ICT council, which is inefficient in providing general direction and standards. In terms of processes, it lacks a mission and a long-term plan, and it has failed to integrate the university and ICT decisions, as well as steering decisions toward the university's goals. In terms of relational mechanisms, it hasn't been able to create a unified procedure in the implementation of ICT policies by creating a common language between ICT and the owners of the main processes in the university. Conclusion: To get out of the current situation, the university needs serious changes in the ICT structure and the university users’ approach to ICT. These changes require the adoption of an indigenous ICT governance model tailored to the current and future problems and needs of the university toward full integration.
Keywords	challenge ; ict management ; policy recommendations ; ict governance ; university of medical sciences ; Medicine (General) ; R5-920
Subject code	306
Language	Persian
Publishing date	2022-12-01T00:00:00Z
Publisher	Iran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Formation of Geometric Patterns in the Architectural Decoration

Fatemeh Rajabi / Molood Khosravi

Tarih Kültür ve Sanat Araştırmaları Dergisi, Vol 8, Iss 3, Pp 330-

An Investigation on the Ilkhanids’ Period

2019 Volume 352

Abstract: The Ilkhanids made considerable changes in their ancestors’ legacy after capturing Iran caused the creation of complex geometric patterns. Exhaustive research has been undertaken about the features of decoration of this era; however, the raised question ... ...

Abstract	The Ilkhanids made considerable changes in their ancestors’ legacy after capturing Iran caused the creation of complex geometric patterns. Exhaustive research has been undertaken about the features of decoration of this era; however, the raised question is how this progress could have happened in spite of slaughtering or secluding the artists. The purpose of this study is to point out the role of the most effective factors in the formation of the decorations with complex geometric patterns during the Ilkhanids’ era. This study implements a descriptive-historical approach with reference to written library sources. The analysis of the observations shows that Iranian rulers and scholars, especially Nasir al-Din Tosi, have played a key role in this development. This includes especially Nasir al-Din Tosi who is the composer of several fields including astronomy, ethics, history, logic, jurisprudence, mathematics, medicine, poetry, and philosophy as well he translated from the Greek geometry books. His success influenced Mongols. Eventually, he was appointed in several administration positions. His position influenced the promotion and progress of the geometry and math and their application in architecture and engineering. In fact, it can be said that the interaction of architects and mathematicians, which was Tosi’s brainchild, brought about a turning point in the Ilkhanids’ art and architecture, especially geometric decorations.
Keywords	geometric pattern ; decoration ; architecture ; the ilkhanids ; nasir al-din tosi ; islamic art ; History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H ; Social sciences (General) ; H1-99
Subject code	720
Language	Arabic
Publishing date	2019-10-01T00:00:00Z
Publisher	Karabuk University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Examining the Relationship between Sleep Quality and Academic Performance with the Degree of Dependence on Smartphone during the Coronavirus Pandemic

Elham Alinezhad / Samira Moradi / Zeynab Nemati / Fatemeh Mohammadi Golestani / Fatemeh Rajabi / Mansoor Alimehdi

Journal of Sleep Sciences, Vol 7, Iss 1-

2023 Volume 2

Abstract: Background and Objective: After the outbreak of the coronavirus disease 2019 (COVID-19) pandemic in Iran, to pre-vent the spread of coronavirus, it was decided for classes to be held virtually. Even though this decision reduced the spread of the virus, ... ...

Abstract	Background and Objective: After the outbreak of the coronavirus disease 2019 (COVID-19) pandemic in Iran, to pre-vent the spread of coronavirus, it was decided for classes to be held virtually. Even though this decision reduced the spread of the virus, the students were exposed to smartphone addiction, which is believed to have high comorbidity with psychological problems. The current study aims to examine the relationship between sleep quality and academic per-formance with the degree of dependence on smartphone during the COVID-19 pandemic. Materials and Methods: The current research was a cross-sectional study with 254 adolescent students participating in virtual classes. This study was conducted in 2020-2021. The participants filled out the following questionnaires online: Pittsburgh Sleep Quality Index (PSQI), smartphone addiction scale (SAS), and Educational Performance Test (EPT). The data were analyzed using SPSS software, descriptive statistics [frequency, pearson correlation, mean, standard deviation (SD)], and inferential statistics (simultaneous regression) (P < 0.05). Results: There was a significant correlation between components of addiction to the Internet and the study’s variables. The results of correlation analysis showed that there was a significant correlation between Internet addiction and academic performance (Pearson correlation = -0.57, P = 0.01) and between Internet addiction and sleep quality (Pearson correlation = 0.47, P = 0.01). Conclusion: According to the results, it can be concluded that after the COVID-19 pandemic and virtual education, Internet addiction could be a risk factor for decreasing sleep quality and academic performance in students.
Keywords	Internet addiction disorder ; Sleep quality ; Academic performance ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evidence-informed health policy making

Fatemeh Rajabi

International Journal of Preventive Medicine, Vol 3, Iss 9, Pp 596-

The role of policy brief

2012 Volume 598

Keywords	Medicine ; R
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interventions to increase participation of NGOs in preventive care

Haniye Sadat Sajadi / Laleh Ghadirian / Fatemeh Rajabi / Azadeh Sayarifard / Narges Rostamigooran / Reza Majdzadeh

Health Science Reports, Vol 5, Iss 5, Pp n/a-n/a (2022)

A scoping review

2022

Abstract: Abstract Background and Aims Nongovernmental organizations (NGOs) have enormous potential to effectively prevent and manage diseases; however, little research is available on interventions used to improve NGOs' participation in this area. A scoping ... ...

Abstract	Abstract Background and Aims Nongovernmental organizations (NGOs) have enormous potential to effectively prevent and manage diseases; however, little research is available on interventions used to improve NGOs' participation in this area. A scoping review was conducted to identify options proposed or implemented to improve the participation of the NGOs in preventive care. Methods Pubmed, Web of Science, and ProQuest were extensively searched. Google Scholar was also searched to find potential studies related to the subject. Relevant keywords were used in the English language. The reference list of relevant studies was also scanned. Studies were screened with defined inclusion and exclusion criteria. Relevant data were then extracted. Two individuals independently screened and extracted studies. The interventions implemented or proposed to promote the participation of the NGOs in the implementation of preventive interventions were deductively identified and classified. Results Eighteen articles were included in our review. We identified 31 interventions and categorized them into 11 strategies, including (1) building strong collaboration among NGOs and with governments; (2) expanding networks and sustained relations among NGOs; (3) evaluating the NGOs' performance; (4) increasing intersectoral collaboration; (5) advocating for the role of NGOs; (6) supporting NGOs from the side of government; (7) empowering the abilities and capabilities of NGOs; (8) defining the precise roles and responsibilities of the parties; (9) strengthening the health system governance; (10) increasing the health literacy of the community; and (11) developing required regulations, rules, and policies. None of the interventions identified had evidence of its effectiveness. Conclusion The current evidence on effective interventions to strengthen NGOs' participation in implementing health care is scanty. It means there is an information gap in the effect of interventions to improve NGOs' participation in health.
Keywords	health ; nongovernmental organizations ; participation ; prevention ; Medicine ; R
Subject code	360 ; 306
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identifying the non-governmental organizations' activities and challenges in response to the COVID-19 pandemic in Iran

Azadeh Sayarifard / Maryam Nazari / Fatemeh Rajabi / Laleh Ghadirian / Haniye Sadat Sajadi

BMC Public Health, Vol 22, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Background The spread and severity of the COVID-19 pandemic have been to such an extent that to shape an effective, collective response, governments need the participation of society and the cooperation of a wide range of civil society ... ...

Abstract	Abstract Background The spread and severity of the COVID-19 pandemic have been to such an extent that to shape an effective, collective response, governments need the participation of society and the cooperation of a wide range of civil society organizations and institutions. The objective of this study was to identify the activities of non-governmental organizations (NGOs) in response to the covid-19 pandemic in Iran and the challenges they confronted. Methods We conducted a qualitative analysis based on twenty-two individual, virtual, and semi-structured interviews. Interviewees were selected through purposeful and snowball sampling. All interviews were performed with active health-related NGO representatives willing to participate in the study and continued until data saturation. Data analysis was performed using qualitative content analysis. Results The activities and challenges raised by NGO representatives were identified in 6 main categories, including the need for the participation of NGOs in the fight against pandemics, response to the COVID-19 crisis in the society, challenges in providing services to the target group in the COVID-19 crisis, NGOs challenges in interacting with governmental and non-governmental institutions, information sources used by NGOs in the COVID-19 crisis and strategies to support NGOs in their efforts. Conclusion Considering the crucial challenges for their participation, such as the NGO access to the target groups, lack of communication network, and constructive interaction between government institutions and the NGOs, it is recommended to increase the capacity of these institutions and intervene to establish a constructive and long-term relationship with the government.
Keywords	Health system ; Public participation ; Non-governmental organizations ; Covid-19 ; Iran ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pro-tumorigenic role of lnc-ZNF30-3 as a sponge counteracting miR-145-5p in prostate cancer

Matthieu Le Hars / Luis Jaime Castro-Vega / Fatemeh Rajabi / David Tabatadze / Martha Romero / Marina Pinskaya / Irina Groisman

Biology Direct, Vol 18, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background Prostate cancer remains one of the deadliest neoplasms in developed countries. Identification of new molecular markers that predict the onset and progression of the disease could improve its clinical management. Low miR-145-5p ... ...

Abstract	Abstract Background Prostate cancer remains one of the deadliest neoplasms in developed countries. Identification of new molecular markers that predict the onset and progression of the disease could improve its clinical management. Low miR-145-5p expression is consistently found in primary tumors and metastases, but the regulatory mechanisms governing its functions remain largely unknown. Methods Bioinformatics analysis was conducted to identify [1] a set of novel potential competing endogenous lncRNAs for sponging of miRNA-145-5p in prostate cancer and [2] miR-145-5p and other EMT-related miRNAs response elements in lnc-ZNF30-3. Quantification of miR-145-5p, lnc-ZNF30-3, and TWIST1 expression levels in tumor tissues in RNA sequencing datasets of our and TCGA PRAD cohorts revealed a correlation with clinical outcome of prostate cancer patients. Biochemical and cell biology approaches, such as RNA pull-down, western blot, immunostaining, and wound healing assays were used for evaluation of the impact of TWIST1/miR-145/ lnc-ZNF30-3 interactions in prostate cancer cells altered in miRNA and lncRNA expression. Results We identified a few potential lncRNA sponges of miR-145-5p, including lnc-ZNF30-3. It contains five response elements for miR-145-5p, but also other miRNAs targeting EMT transcription factors. Lnc-ZNF30-3 is significantly upregulated in prostate cancer cell lines and tumor tissues, and its high expression is correlated with poor patient prognosis. We demonstrated that lnc-ZNF30-3 is associated with AGO2 and specifically interacts with the miR-145-5p seed region. Knockdown of lnc-ZNF30-3 results in decreased migration of prostate cancer cells and downregulation of EMT drivers such as TWIST1 and ZEB1 at both the RNA and protein levels. These phenotypic and molecular features of lnc-ZNF30-3-depleted cells are partially rescued by miR-145-5p inhibition. Conclusions Collectively, our results point to lnc-ZNF30-3 as a novel competing endogenous lncRNA for miR-145-5p and other miRNAs that target TWIST1 as ...
Keywords	Prostate cancer ; miR-145 ; lnc-ZNF30-3 ; EMT ; TWIST1 ; Biology (General) ; QH301-705.5
Subject code	610 ; 570
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Saffron for the management of premenstrual dysphoric disorder

Fatemeh Rajabi / Marjan Rahimi / Mohammad Reza Sharbafchizadeh / Mohammad Javad Tarrahi

Advanced Biomedical Research, Vol 9, Iss 1, Pp 60-

A randomized controlled trial

2020 Volume 60

Abstract: Background: Selective serotonin reuptake inhibitors are among the most common agents have been used for the treatment of the premenstrual dysphoric disorder (PMDD); however, due to the diversity in the outcomes and adverse effects, efforts are in ... ...

Abstract	Background: Selective serotonin reuptake inhibitors are among the most common agents have been used for the treatment of the premenstrual dysphoric disorder (PMDD); however, due to the diversity in the outcomes and adverse effects, efforts are in progress to find an agent with maximal efficacy and minimal adverse effects. Saffron is an herbal agent consisted of ingredients shown to act as an antidepressant, pain tranquilizer, and antioxidant. In the current study, it is aimed to assess the efficacy of saffron on PMDD treatment. Materials and Methods: In the current randomized controlled trial, 120 females with the diagnosis of PMDD were randomly allocated to three groups of treatment with fluoxetine (20 mg, twice daily), saffron (15 mg, twice daily) or placebo for 2 weeks in the luteal phase of two menstruation cycles. Daily record of severity of problems (DRSP) and Hamilton questionnaires had been filled before the interventions and then following the treatment cessation. The questionnaires' scores and drug-related adverse effects were compared among the studied groups. Results: Post-intervention assessment of three groups revealed significant improvement in all of the treatment approaches in terms of DRSP and Hamilton assessments (P < 0.001). Although DRSP assessments showed remarkable superiority of saffron to placebo (P = 0.027), Hamilton evaluations showed insignificant differences among the three interventions (P > 0.05). Fluoxetine posed a significantly higher rate of adverse effects as compared to the other agents (P = 0.01). Conclusion: Based on the findings of this study, saffron was an efficacious herbal agent for the treatment of PMDD with minimal adverse effects.
Keywords	crocus ; dsm-v ; fluoxetine ; premenstrual dysphoric disorder ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cytosine Palladium Complex Supported on Ordered Mesoporous Silica as Highly Efficient and Reusable Nanocatalyst for One-Pot Oxidative Esterification of Aldehydes

Fatemeh Rajabi / Chin Hua Chia / Mika Sillanpää / Leonid G. Voskressensky / Rafael Luque

Catalysts, Vol 11, Iss 1482, p

2021 Volume 1482

Abstract: The synthesis of esters is one of the most fundamental and significant subjects in organic chemistry and chemical industry because they are used in high-value products such as cosmetics, biofuel, pharmaceuticals, surfactants, and food ingredients. In ... ...

Abstract	The synthesis of esters is one of the most fundamental and significant subjects in organic chemistry and chemical industry because they are used in high-value products such as cosmetics, biofuel, pharmaceuticals, surfactants, and food ingredients. In this study, an efficient, economic, sustainable, and green protocol for oxidative esterification reaction has been developed. A one-pot direct transformation of aliphatic, aromatic, and unsaturated aldehydes into esters in the presence of oxygen has been carried out over mesoporous organosilica-supported palladium nanocatalyst (Pd-Cyt@SBA-15) under ambient conditions. Pd-Cyt@SBA-15 efficiently catalyzed selectively large-scale conversion of aldehydes into esters in high yields and large turnover numbers (TON = 98,000). Pd-Cyt@SBA-15 nanocatalyst demonstrated excellent reusability and stability and could be recycled up to ten times without loss of significant reactivity. ICP-AES analysis showed that no leaching of active palladium species occurred during the recycling process of the heterogeneous Pd-Cyt@SBA-15 nanocatalyst.
Keywords	oxidative esterification ; palladium nanocatalyst ; aldehydes ; aerobic ; SBA-15 ; heterogeneous ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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