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Article ; Online: Investigation of Clinical Features and Surgical Results in Patients with Thyroid Nodules Referred to the Endocrinology Clinic in Hamadan City

Fatemeh Yaghoubi / Ali Reza Soltanian / Shiva Borzouei

پزشکی بالینی ابن سینا, Vol 30, Iss 1, Pp 52-

2023 Volume 58

Abstract: Background and Objective: Considering the high prevalence of thyroid nodules and the increased incidence of malignancy of this gland, the present study aimed to assess the clinical characteristics and pathology results following surgery in patients with ... ...

Abstract	Background and Objective: Considering the high prevalence of thyroid nodules and the increased incidence of malignancy of this gland, the present study aimed to assess the clinical characteristics and pathology results following surgery in patients with nodular goiter and referred to the endocrinology clinic in Hamadan, Iran. Materials and Methods: This study was conducted as case series from 2011 to 2021. All patients diagnosed with thyroid nodules who underwent thyroidectomy according to the indication and whose pathology was benign or malignant were included in the study. The patients' information was collected by reviewing the files, which included demographic, clinical, and pathology results. The data was analyzed in SPSS software (version 26), and the significance level was considered less than 0.05. Results: Among the 507 patients studied, 88.2% were female, and 11.8% were male. The mean age of the patients was 41.93 years. Pathology result was malignant in 57% of cases and benign in 43% of subjects. Most patients with malignant pathology were under 35 years of age, and those with benign pathology were older (P<0.001). Most patients were in stage I of the disease; nonetheless, males compared to females were significantly in more advanced stages of the disease (P<0.001). Conclusion: Thyroid nodules are very common, and their incidence is increasing. Considering the nature of malignancy, the good prognosis of these nodules, and effective treatment, early diagnosis of malignancy assumes critical importance.
Keywords	pathology ; thyroid nodules ; thyroid surgery ; Medicine ; R
Subject code	610
Language	Persian
Publishing date	2023-06-01T00:00:00Z
Publisher	Hamadan University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relapsing anemia associated with parvovirus B19 infection in a kidney transplant recipient

Fatemeh Yaghoubi / Davood Dalil / Farnaz Tavakoli / Seyyed Mohammad Hosseini

Clinical Case Reports, Vol 11, Iss 9, Pp n/a-n/a (2023)

A case report and review of the literature

2023

Abstract: Key clinical message PB19 infection should be considered an uncommon cause of posttransplant anemia in renal transplant recipients, particularly those whose anemia is not associated with common etiologies. IVIG treatment and reduced immunosuppression ... ...

Abstract	Key clinical message PB19 infection should be considered an uncommon cause of posttransplant anemia in renal transplant recipients, particularly those whose anemia is not associated with common etiologies. IVIG treatment and reduced immunosuppression could be beneficial. Abstract Parvovirus B19‐associated relapsing anemia is rare in kidney transplant recipients. Herein, we report a case of relapsed anemia due to parvovirus B19 infection in a 53‐year‐old woman 18 months after kidney transplantation. The patient presented with palpitations, shortness of breath, dizziness, weakness, and lethargy. Early laboratory findings showed a WBC count of 6.000/μL, RBC count of 1.89/μL, hemoglobin (Hb) 3.5 g/dL, hematocrit (Hct) 15%, platelet count 266.000/μL, MCV 89, reticulocyte count 0.8%, and serum iron 221 μg/dL. Upon further evaluation, the RT‐PCR test for BK polyomavirus and cytomegalovirus (CMV) was negative, while the parvovirus B19 RT‐PCR was positive. The patient was treated with blood transfusion and IVIG 25 g daily for 5 days. Two months after discharge, the patient presented, complaining of palpitation, shortness of breath, and dizziness, with RBC 2.7/μL, Hb 6.5 g/dL, Hct 25%, and MCV 85. Again, the CMV RT‐PCR was negative, while the parvovirus B19 RT‐PCR was positive. Tacrolimus and mycophenolic acid were stopped, and IVIG 25 g daily for 5 days was administered. Consequently, her Hb level increased to 9 g/dL, and the patient was discharged with prednisolone 5 mg daily and cyclosporine 50 mg daily instead of tacrolimus. Viral infection, particularly PB19 infection, should be considered in the differential diagnosis of posttransplantation anemia in KTRs. IVIG treatment and modification of immunosuppressive medications are suggested standard therapies for such patients. The function of transplanted kidneys should be carefully monitored during treatment.
Keywords	anemia ; ESRD ; kidney transplant ; parvovirus B19 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparing Gait Variability Between Deaf and Normal-Hearing Children After Proprioception Training

Fatemeh Yaghoubi Hamraz / Mahdi Majlesi

Biyumikānīk-i varzishī, Vol 5, Iss 4, Pp 262-

2020 Volume 271

Abstract: Objective: Gait variability is an important feature in clinical treatment of people with walking problems. Since the gait variability has not been yet evaluated among deaf people, the purpose of this study was to evaluate the gait variability in deaf ... ...

Abstract	Objective: Gait variability is an important feature in clinical treatment of people with walking problems. Since the gait variability has not been yet evaluated among deaf people, the purpose of this study was to evaluate the gait variability in deaf children and compare it with normal-hearing peers. Methods: The study population consists of deaf and normal-hearing children living in Hamedan, Iran. Of these, 10 deaf (aged 8-14 years) and 10 with normal hearing matched for age and anthropometric characteristics volunteered to participate in the study. The 3D Vicon motion analysis system was used to measure the kinematic gait parameters in subjects. Paired sample t-test was used for within-group comparison and independent sample t-test for between-group comparison. Statistical analysis was performed in SPSS software by considering a significance level of P<0.05. Results: The gait variability after proprioception training decreased in deaf children, but this change was not statistically significant (P>0.05). There was no significant difference between the two groups before and after the training (P>0.05). Conclusion: It is suggested that balance exercise with an emphasis on proprioception training be included in the physical education program of deaf children.
Keywords	gait ; deafness ; spatio-temporal variables ; Sports medicine ; RC1200-1245
Subject code	796
Language	Persian
Publishing date	2020-02-01T00:00:00Z
Publisher	Islamic Azad University, Hamedan Branch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the Relationship between Troponin T Level and Prognosis of Preterm Neonates Admitted to Neonatal Intensive Care Unit of Fatemieh Hospital in Hamadan

Asadolah Tanasan / Mohammad Kazem Sabzehei / Pegah Ameri / Ali Amri / Fatemeh Yaghoubi / Hossein Ariana

پزشکی بالینی ابن سینا, Vol 29, Iss 2, Pp 88-

2022 Volume 93

Abstract: Background and Objective: Due to the prevalence of myocardial dysfunction and Patent Ductus Arteriosus (PDA) in a large number of preterm neonates, the prognosis of these infants is highly related to their early diagnosis and treatment. In this regard, ... ...

Abstract	Background and Objective: Due to the prevalence of myocardial dysfunction and Patent Ductus Arteriosus (PDA) in a large number of preterm neonates, the prognosis of these infants is highly related to their early diagnosis and treatment. In this regard, the present study aimed to determine the relationship between troponin T level and the prognosis of premature neonates admitted to the Neonatal Intensive Care Unit (NICU) of Fatemieh Hospital in Hamadan. Materials and Methods: In this cross-sectional study, a certain number of infants who underwent serum levels of troponin T from 72 hours to one week after birth were assessed for demographic information, length of hospital stay, complications during hospitalization, acidosis, inotropic agents, recovery, and mortality, as well as their relationship with troponin level. Results: Out of 61 neonates, 22 patients had large PDA with a troponin level of 436±50.2 pg/ml, 14 patients had a small PDA with a troponin level of 260.5±89.8 pg/ml, and 25 patients were without PDA with a troponin level of 277.1±229.7 pg /ml (P = 0.203). There was no statistically significant difference between the three groups. The mean levels of troponin were 423±521 and 274±154 pg/ml in deceased and surviving neonates, respectively (P=0.194). Inotropic was significantly higher in deceased patients (P=0.003), and troponin T level was statistically significant (P=0.008). The relationship between troponin level and severe acidosis (P=0.051) was not significant, with a small difference that could be clinically valuable. Conclusion: Serum troponin T level was higher in preterm neonates with large PDA and deceased ones who received inotropic agents due to hemodynamic disorders and severe acidosis.
Keywords	premature neonate ; prognosis ; troponin t ; Medicine ; R
Subject code	610
Language	Persian
Publishing date	2022-09-01T00:00:00Z
Publisher	Hamadan University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Dark Chocolate on C-Reactive Protein Level

Fatemeh Yaghoubi / Zahra Darabi / Azam Ahmadi Vasmehjani / Zohreh Sadat Sangsefidi / Mahdieh Hosseinzadeh

Journal of Nutrition and Food Security, Vol 7, Iss 4, Pp 562-

A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

2022 Volume 574

Abstract: Background: This systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted to determine the effect of dark chocolate on C-Reactive Protein (CRP) levels as one of the inflammatory factors. Methods: A literature search was ... ...

Abstract	Background: This systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted to determine the effect of dark chocolate on C-Reactive Protein (CRP) levels as one of the inflammatory factors. Methods: A literature search was conducted in PubMed, ISI Web of Science, Scopus, and Google Scholar up to April of 2020. The registration number of study in PROSPERO was CRD4202020072, which was conducted over 5 eligible RCTs containing a total of 330 participants. The weighted mean difference (WMD) with 95% confidence intervals was calculated for the pool effect size of CRP. The heterogeneity of studies was examined by Cochran's Q test and I-squared (I2) statistic. Results: Effect sizes from 330 participants based on random effect model showed no effect between consumption of dark chocolate on CRP levels compared to the control group (WMD: 0.01 mg/dl; 95% CI: −0.19, 0.22 mg/dl; P = 0.89; Cochran's Q test, Q statistic = 21.97; P < 0.001; I2 = 81.80%). The results of subgroup analysis based on intervention duration and dosage showed no significant effect on CRP levels (WMD = 0.05 mg/dl, 95% CI: −0.30, 0.42 mg/dl; P = 0.76). Meta-regression for the intervention duration (slope: −0.0033, 95% CI: −0.0089, 0.0022; P = 0.24) and dosage (slope: 0.00006, 95% CI: −0.0036, 0.0037; P = 0.97) indicated no significant relationship with the mean difference of CRP. Conclusion: The results of the present meta-analysis showed that consuming dark chocolate had no significant effect on the CRP level. More clinical trials are required with higher quality and bigger sample sizes to verify the positive impact of dark chocolate on the reduction CRP level.
Keywords	dark chocolate ; crp ; inflammation ; Agriculture ; S ; Nutrition. Foods and food supply ; TX341-641
Subject code	310 ; 150
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences and Health Services
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effect of quercetin on stress The Effect of Quercetin on Stress Oxidative Markers

Azam Ahmadi Vasmehjani / Fatemeh Yaghoubi / Zahra Darabi / Nooshin Abdollahi / Zohreh Sadat Sangsefidi / Mahdieh Hosseinzadeh

Journal of Nutrition and Food Security, Vol 7, Iss 4, Pp 548-

A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trialsers; A systematic review and meta-analysis of randomized controlled clinical trials

2022 Volume 561

Abstract: Background: Quercetin is one of the main flavonoids, overall distributed in plants. The antioxidant capacity of quercetin is several times vitamin E and glutathione. This systematic review and meta‐analysis of randomized controlled trials were performed ... ...

Abstract	Background: Quercetin is one of the main flavonoids, overall distributed in plants. The antioxidant capacity of quercetin is several times vitamin E and glutathione. This systematic review and meta‐analysis of randomized controlled trials were performed to determine the effect of quercetin on oxidative stress (OS) markers. Methods: A literature search was conducted in PubMed, ISI Web of Science, Scopus, and Google Scholar to February of 2021. Meta-analysis was conducted on 8 eligible RCTs containing a total of 668 participants. The weighted mean difference (WMD) with 95% confidence intervals (CIs) was calculated for a pool effect size of Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), and Ferric Reducing Ability of Plasma (FRAP). Subgroup analyses were performed based on intervention duration and dosage. The heterogeneity of studies was examined by Cochran's Q test and I-squared (I2) statistic. Results: Effect sizes from 668 participants based on the random effect model showed that quercetin supplementation had no significant effect on TAC and MDA compared to the control group. The analysis illustrated that quercetin supplementation significantly increased FRAP in adults (WMD = -0.159 mmol/l, 95% confidence interval (CI):-0.178, -0.141, P ≤ 0.001). Conclusions: The finding of the current study showed that quercetin supplementation had no significant effect on TAC levels, although it significantly increased FRAP levels in adults. Also, MDA level did not markedly change. It has needed to conduct clinical trials with more quality and bigger sample sizes to verify the positive impact of quercetin on stress oxidative marker.
Keywords	quercetin ; oxidative stress ; malondialdehyde ; total antioxidant capacity ; ferric reducing ability of plasma ; Agriculture ; S ; Nutrition. Foods and food supply ; TX341-641
Subject code	150
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences and Health Services
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigation and comparison of laser and ultrasound effects on the temperature increasing of the solutions containing graphene oxide nanoparticles for thermal treatment of osteosarcoma cancer cells

Najmeh Sadat Hosseini Motlagh / Elyas Sharifi / Bibi Fatemeh Hghiralsadat / Mohsen Sardari Zarchi / Fatemeh Yaghoubi / Fatemeh Oroojalian

Nanomedicine Journal, Vol 10, Iss 4, Pp 313-

2023 Volume 322

Abstract: Objective(s): The waves of ultrasound and laser in the presence of nanoparticles are introduced as desirable candidates for the thermal treatment of cancer due to having fewer side effects, more speed, and superior treatment efficiency. Here, 2D Graphene ...

Abstract	Objective(s): The waves of ultrasound and laser in the presence of nanoparticles are introduced as desirable candidates for the thermal treatment of cancer due to having fewer side effects, more speed, and superior treatment efficiency. Here, 2D Graphene oxide nanoparticle is used as a thermal nano-convertor for increasing the yield of thermal cancer therapy.Materials and Methods: The temperature of GO (in 0.2 and 0.4 mg/ml concentrations) and deionized water regarding heater, bath sonicate, probe sonicate (at a power range of 2-3.5 W), and laser properties at 808 nm with continuous wave (at a power of 0-2 W) in 10 min are investigated. Based on the experimental results, the effect of laser and ultrasound radiation on the temperature is simulated using a data mining approach.Results: Experimental and simulation results show that GO nanoparticle in this form is unsuitable for converting ultrasound waves into heat. But it is a strong absorber for electromagnetic waves at 808 nm and can raise the temperature to 85 °C. The results indicate that the laser + GO enhances the mortality percentage and treatment yield of MG63 cancerous cells by up to 85%. Also, GO uptake is analyzed by fluorescent microscopic images.Conclusion: This analysis confirmed that GO is important when laser radiation is used but not when Ultrasound is employed. Also, GO is an excellent photothermal nanoparticle for localized thermal therapy of osteosarcoma cancer cells by laser at 808 nm with low side effects.
Keywords	cancer ; graphene oxide ; laser ; thermal therapy ; ultrasound ; Medicine (General) ; R5-920
Subject code	620
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adherence to low carbohydrate diets and non-alcoholic fatty liver disease

Fatemeh Yaghoubi / Mina Darand / Aazam Ahmadi Vasmehjani / Zahra Darabi / Nasir Talenezhad / Farhang Mirzavandi / Mahdieh Hosseinzadeh

BMC Nutrition, Vol 8, Iss 1, Pp 1-

a case control study

2022 Volume 8

Abstract: Abstract Background Non-alcoholic fatty liver disease (NAFLD) is defined as the excessive accumulation of fat in the liver cells of people who do not drink alcohol. The aim of study is investigated the association between low carbohydrate diets (LCDs) ... ...

Abstract	Abstract Background Non-alcoholic fatty liver disease (NAFLD) is defined as the excessive accumulation of fat in the liver cells of people who do not drink alcohol. The aim of study is investigated the association between low carbohydrate diets (LCDs) and NAFLD. Methods This age and gender-matched case–control study was conducted on 120 patients newly diagnosed with NAFLD and 120 adults without NAFLD. Diagnosis of NAFLD based on laboratory tests and abdominal ultrasound. Low carbohydrate diets score calculated on the percentage of energy as carbohydrate, fat, and protein. Participants in the highest rank intake of fat and protein and lowest intake of carbohydrate received 10 points. Multivariable logistic odds ratio was used for examine the relation between LCDs and NAFLD. Results This study showed subjects in the highest tertile of LCD has more intake of zinc and vitamin B12 compare to lowest. Also, intake of protein (p = 0.02) carbohydrate (p < 0.02) and cholesterol (p = 0.02) were significantly higher in patient with NAFLD compare to control subjects. There was no significant association between LCD and risk of NAFLD (OR: 1.36; 95% CI: 0.97–1.92; P-trend = 0.13) in crude and adjusted (OR: 1.31; 95% CI: 0.84–2.04; P-trend = 0.23) model. Conclusion However, we showed that intake of protein, carbohydrate and cholesterol are higher in NAFLD, but our results of study showed that LCDs with higher proportion intakes of protein and fat was not associated with NAFLD. Further prospective studies are required for confirm these associations.
Keywords	Diet ; Carbohydrate-Restricted ; Fatty Liver ; Non-alcoholic fatty liver disease ; Nutrition. Foods and food supply ; TX341-641 ; Food processing and manufacture ; TP368-456 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A functionalized graphene oxide with improved cytocompatibility for stimuli-responsive co-delivery of curcumin and doxorubicin in cancer treatment

Fatemeh Yaghoubi / Najmeh Sadat Hosseini Motlagh / Seyed Morteza Naghib / Fateme Haghiralsadat / Hossein Zarei Jaliani / Ali Moradi

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 18

Abstract: Abstract Nowadays, the usage of nanoparticles in various fields such as drug delivery, attracts the attention of many researchers in the treatment of cancers. Graphene oxide (GO) is one of the novel drug delivery systems which is used broadly owing to ... ...

Abstract	Abstract Nowadays, the usage of nanoparticles in various fields such as drug delivery, attracts the attention of many researchers in the treatment of cancers. Graphene oxide (GO) is one of the novel drug delivery systems which is used broadly owing to its unique features. In this survey, doxorubicin (DOX) was accompanied by natural medicine, curcumin (CUR), to diminish its side effects and enhance its efficiency. Cytotoxicity assay in human gastric cancer (AGS), prostate cancer (PC3), and ovarian cancer (A2780), was evaluated. Also, the uptake of DOX and CUR into cells, was assessed using a fluorescence microscope. Moreover, real-time PCR was applied for the evaluation of the expression of RB1 and CDK2 genes, which were involved in the cell cycle. In both separate and simultaneous forms, DOX and CUR were loaded with high efficiency and the release behavior of both drugs was pH-sensitive. The higher release rate was attained at pH 5.5 and 42 °C for DOX (80.23%) and CUR (13.06), respectively. The intensity of fluorescence in the free form of the drugs, was higher than the loaded form. In the same concentration, the free form of CUR and DOX were more toxic than the loaded form in all cell lines. Also, free drugs showed more impact on the expression of RB1 and CDK2 genes. Co-delivery of CUR and DOX into the mentioned cell lines, was more effective than the free form of CUR and DOX due to its lower toxicity to normal cells.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Edible Coating Containing Plant Extract on Inhibiting the Growth of Aflatoxin in Nuts

mehrnoosh shirdeli / Maryam Sadat Shahidi / Matthew Shirani / ameneh marzban / Fatemeh Yaghoubi

Journal of Community Health Research, Vol 9, Iss 3, Pp 139-

2020 Volume 140

Abstract: There is no abstract. ...

Abstract	There is no abstract.
Keywords	edible coating ; aflatoxin ; nuts ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Shahid Sadoughi University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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