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  1. Article: Myeloperoxidase: Indicator of cardiovascular disease in chronic kidney disease patients of tertiary care hospital of Karachi.

    Noor, Sabeela / Alam, Faiza / Fatima, Fasiha / Orakzai, Shehryar

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71, Issue 4, Page(s) 1128–1132

    Abstract: Objective: To estimate the levels of myeloperoxidase in various stages of chronic kidney disease, and to correlate them with an inflammatory marker and lipid profile.: Method: The cross-sectional study was conducted at the Biochemistry Department, ... ...

    Abstract Objective: To estimate the levels of myeloperoxidase in various stages of chronic kidney disease, and to correlate them with an inflammatory marker and lipid profile.
    Method: The cross-sectional study was conducted at the Biochemistry Department, Basic Medical Sciences Institute, in collaboration with the Nephrology Department, Jinnah Post Graduate Medical Centre, Karachi, from January 2013 to September 2014, and comprised chronic kidney disease patients and healthy controls. Serum cholesterol, triglycerides, high-density lipoprotein, C-reactive protein and myeloperoxidase levels were noted. Data was subjected to statistical analysis.
    Results: Of the 150 subjects, 84(56%) were cases and 66(44%) were controls. Weight, body mass index, triglycerides, very low-density lipoprotein, C-reactive protein and myeloperoxidase levels were significantly higher among the cases compared to the controls (p<0.05). Serum myeloperoxidase had a significantly positive association with C-reactive protein (p<0.01), cholesterol (p<0.01), triglycerides (p<0.01), low-density lipoprotein (p<0.01) and very low-density lipoprotein (p<0.01), and had a negative correlation with high-density lipoprotein (p<0.01).
    Conclusions: Myeloperoxidase concentration had association with lipid profile and C-reactive protein.
    MeSH term(s) Cardiovascular Diseases/epidemiology ; Cholesterol, HDL ; Cross-Sectional Studies ; Humans ; Peroxidase ; Renal Insufficiency, Chronic/epidemiology ; Tertiary Care Centers ; Triglycerides
    Chemical Substances Cholesterol, HDL ; Triglycerides ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2021-07-07
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.1056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  2. Article: Association of fetuin-A with dyslipidemia and insulin resistance in type-II Diabetics of Pakistani population.

    Fatima, Fasiha / Ahsan, Naveed / Nasim, Aliya / Alam, Faiza

    Pakistan journal of medical sciences

    2020  Volume 36, Issue 2, Page(s) 64–68

    Abstract: Background & objective: Fetuin-A, hepatokine is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Our objective was to investigate the relationship of fetuin-A with dyslipidemia and insulin resistance in type-II ... ...

    Abstract Background & objective: Fetuin-A, hepatokine is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Our objective was to investigate the relationship of fetuin-A with dyslipidemia and insulin resistance in type-II diabetics of Pakistani population.
    Methods: In this cross sectional study which was conducted at Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi between October 2013 to March 2014, a total of 330 participants were selected and divided into two groups. Group-A (n = 165) normal healthy individual and Group-B (n = 165) Type-II diabetes mellitus mellitus with no comorbidities. Serum fetuin-A and insulin levels were determined by commercially prepared ELISA kits while fasting blood glucose (FBG) and lipid profile were performed by enzymatic kit method. Employing independent t-test, comparison of groups was done and correlation was achieved by using spearman correlation.
    Results: The results demonstrate a significant difference in mean values of fetuin-A, lipid profile, glucose, insulin and Homoeostasis Model Assessment of Insulin resistance (HOMA-IR) in type-II diabetics when compared to normal healthy individuals (p<0.01). A positive correlation was found between serum fetuin-A levels and FBG(r= 0.495, p< 0.001), insulin(r= 0.227, p< 0.001), HOMA-IR(r= 0.336, p<0.001, triglycerides(r= 0.197, p< 0.001) and LDL-cholesterol(r= 0.170, p= 0.002), while negative correlation with HDL-cholesterol(r= -0.251, p< 0.001).
    Conclusion: The study concludes that fetuin-A might be accountable for dyslipidemia and insulin resistance in type-II diabetes mellitus mellitus. So the high levels of Fetuin-A responsible for insulin resistance might alters endothelium and causes inflammation, vasoconstriction and thrombosis and ultimately atherosclerosis.
    Language English
    Publishing date 2020-01-27
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.36.2.1106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: A Rare Case of Malignant Infantile Osteopetrosis Presenting as Frontal Lobe Hemorrhage.

    Ali, Aiman / Bin Arif, Taha / Khan, Sulhera / Bakhtawar Fatima, Fasiha / Abbasi, Rabia Sehar

    Cureus

    2020  Volume 12, Issue 7, Page(s) e9234

    Abstract: Osteopetrosis comprises a group of rare inherited disorders of the bones characterized by a common radiographic finding of increased bone thickness. The disorders vary genetically as well as clinically, and range in severity from mild manifestations to ... ...

    Abstract Osteopetrosis comprises a group of rare inherited disorders of the bones characterized by a common radiographic finding of increased bone thickness. The disorders vary genetically as well as clinically, and range in severity from mild manifestations to fatal complications based on the type of the disorder. Malignant infantile osteopetrosis (MIOP) is a less common, more severe form of the disease with most affected individuals surviving up to only the first few years of life if left untreated. We present a previously diagnosed case of the malignant infantile type who was brought to our attention for convulsions. Antiepileptic medications were started along with supportive therapy. CT scan revealed a large frontal lobe hemorrhage, which was suspected as a possible cause of the seizures, other than the progressively worsening hypocalcemia. Laboratory investigations also revealed pancytopenia and blood cultures positive for staphylococci, which were treated accordingly. Genetic testing and hematopoietic stem cell transplantation could not be performed due to financial constraints and the rapidly deteriorating condition of the patient. Unfortunately, the baby expired two weeks from the day of admission. This case highlights a rare and grave clinical manifestation of MIOP and brings to attention the significance of bone marrow transplantation as the only curative therapy of the disease.
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.9234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Elevated levels of ferritin and hs-CRP in type 2 diabetes.

    Alam, Faiza / Fatima, Fasiha / Orakzai, Shehryar / Iqbal, NajeehaTalat / Fatima, Syeda Sadia

    JPMA. The Journal of the Pakistan Medical Association

    2014  Volume 64, Issue 12, Page(s) 1389–1391

    Abstract: Objectives: To measure the levels of high-sensitivity C-reactive protein and ferritin in blood and to assess their association with inflammation in people with Type 2 diabetes.: Method: The case-control study was conducted between November 2012 to ... ...

    Abstract Objectives: To measure the levels of high-sensitivity C-reactive protein and ferritin in blood and to assess their association with inflammation in people with Type 2 diabetes.
    Method: The case-control study was conducted between November 2012 to November 2013 at the Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, and comprised randomly selected patients and healthy controls. Fasting blood samples were analysed for blood glucose, insulin, high-sensitivity C-reactive protein and iron status. SPSS 19 was used for statistical analysis.
    Results: Of the 210 subjects initially selected, 99(47%) were excluded owing to anaemia. The study population, as such, comprised 111(53%) with an overall mean age of 38.6±1.56 years and mean fasting blood sugar of 110.78±3.795 mg/dl. Group 1 had 44(39.6%) healthy controls while Group 2 had 67(60.3%) diabetic patients. Elevated levels of mean serum ferritin (233.11±43.84 ng/ml), insulin (29.94±2.19), homeostasis model of insulin resistance (10.23±0.89) and high-sensitivity C-reactive protein (5.29±0.80 mg/L) with low serum iron levels (1.07± 0.115 ?g/dl) were found in Group 2. There was positive correlation of homeostasis model of insulin resistance with fasting blood sugar (r=0.596; p<0.001), serum ferritin (r=0.306; p<0.008), insulin (r=0.866; p<0.001), and total iron-binding capacity (r=0.302; p<0.009). There was negative correlation with serum iron (r=-0.280; p<0.016) and transferrin saturation (r=-0.316; p<0.006).
    Conclusion: Elevated ferritin levels without evident iron overload may affect glucose homeostasis, leading to insulin resistance in conjunction with inflammatory changes as seen by elevated C-reactive protein levels.
    MeSH term(s) Adolescent ; Adult ; Aged ; C-Reactive Protein/analysis ; Case-Control Studies ; Diabetes Mellitus, Type 2/blood ; Female ; Ferritins/blood ; Humans ; Insulin Resistance/physiology ; Male ; Middle Aged ; Young Adult
    Chemical Substances C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2)
    Language English
    Publishing date 2014-12
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  5. Article ; Online: Are patients on oral anticoagulation therapy aware of its effects? A cross-sectional study from Karachi, Pakistan.

    Zahid, Ibrahim / Ul Hassan, Syed Wajih / Bhurya, Nida Sehar / Alam, Sheena Nadeem / Hasan, Choudhary Ahmed / Shah, Bakht Hussain / Fatima, Fasiha Bakhtawar / Ahmed, Ayesha / Ul Hassan, Syed Sabih / Hayat, Javeria / Zulfiqar, Aqsa / Sheikh, Rija / Aziz, Momin / Siddiqi, Rabbia / Fatima, Kaneez / Khan, Muhammad Shahzeb

    BMC research notes

    2020  Volume 13, Issue 1, Page(s) 279

    Abstract: Objective: Oral anticoagulants are one of the most frequently used medications. However, these drugs have a range of side effects including potential life-threatening complications. Little is known regarding the awareness of its side effect profile ... ...

    Abstract Objective: Oral anticoagulants are one of the most frequently used medications. However, these drugs have a range of side effects including potential life-threatening complications. Little is known regarding the awareness of its side effect profile amongst the patients in Pakistan. Therefore, the aim of this study was to assess the knowledge of oral anticoagulant therapy and its side effects among its users.
    Results: The mean age was 48.9 ± 15.2 years. Median scores of the participants for knowledge regarding oral anticoagulants and warfarin were 48.7 (8.3-91.7) and 10.3 (0.0-70.0) respectively. Of 207 patients, most notably, 65.7% did not know what side effects to be wary of or how to reduce their occurrence; and most patients were unaware of the interaction between oral anticoagulant drugs and over-the-counter substances such as aspirin, herbal medicines and alcohol. Knowledge of international normalised ratio (INR) was extremely poor with more than 75% of the population not being aware of the target INR range during warfarin therapy. Higher level of education was significantly associated with better knowledge scores. Overall, knowledge of oral anticoagulant therapy and INR monitoring is extremely poor among oral anticoagulant users.
    MeSH term(s) Administration, Oral ; Adult ; Aged ; Anticoagulants/administration & dosage ; Anticoagulants/pharmacology ; Cross-Sectional Studies ; Drug Interactions ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; International Normalized Ratio ; Male ; Middle Aged ; Pakistan ; Warfarin/administration & dosage ; Warfarin/pharmacology
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-020-05119-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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