Article ; Online: Serum levels of Selenium and C-reactive protein in comatose patients with severe traumatic brain injury during the first week of hospitalization
The Pan African Medical Journal, Vol 29, Iss
case-control study
2018 Volume 36
Abstract: INTRODUCTION: mortality and morbidity related to traumatic brain injuries still remain high in patients. Many authors reported the importance of Selenium in maintaining the integrity of brain functions. This fact is supported by clinical evidence that ... ...
| Abstract | INTRODUCTION: mortality and morbidity related to traumatic brain injuries still remain high in patients. Many authors reported the importance of Selenium in maintaining the integrity of brain functions. This fact is supported by clinical evidence that therapy with selenium supplementation could help patients suffering from brain disorders like neurodegenerative diseases. The aim of our study was to assess the relationship between Selenium concentration in serum and evolution of comatose patients with severe traumatic brain injury, in the first week of admission, and the correlation between selenium and C-reactive protein. METHODS: this case-control study was conducted with 64 comatose patients with TBI,in the Department of Anesthesiology and Reanimation, IbnSina University Hospital and Hospital of specialties in Rabat-Morocco, and healthy volunteers recruited in Blood transfusion center of Rabat. Blood sampling was collected from TBI patients, in the first week (3h after admission and each 48h during one week), and from healthy volunteers one time. Concentration of Se in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann,Whitney U test. A P-value 0.05 was considered to be statistically significant. RESULTS: comparison selenium concentration in the first day (D0), third day (D2) and fifth day according to the death and survival statue in patients did not show statistical significance (p[0.05). Selenium concentration of D0 in patients and Selenium concentration in control group also did not show statistical significance (p=0.05). Similarly, we did not report a correlation between selenium and C-reactive protein. CONCLUSION: according to our data selenium and CRP may not play a role in progression of coma state in patients with severe traumatic brain injury. |
|---|---|
| Keywords | severe brain injury ; selenium ; coma ; c-reactive protein ; comatose patients ; serum selenium ; serum c-reactive protein ; Medicine ; R |
| Subject code | 616 ; 610 |
| Language | English |
| Publishing date | 2018-01-01T00:00:00Z |
| Publisher | The Pan African Medical Journal |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Full text online
More links
Kategorien
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.