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  1. Article ; Online: Highlighting the Dystonic Phenotype Related to GNAO1.

    Wirth, Thomas / Garone, Giacomo / Kurian, Manju A / Piton, Amélie / Millan, Francisca / Telegrafi, Aida / Drouot, Nathalie / Rudolf, Gabrielle / Chelly, Jamel / Marks, Warren / Burglen, Lydie / Demailly, Diane / Coubes, Phillipe / Castro-Jimenez, Mayte / Joriot, Sylvie / Ghoumid, Jamal / Belin, Jérémie / Faucheux, Jean-Marc / Blumkin, Lubov /
    Hull, Mariam / Parnes, Mered / Ravelli, Claudia / Poulen, Gaëtan / Calmels, Nadège / Nemeth, Andrea H / Smith, Martin / Barnicoat, Angela / Ewenczyk, Claire / Méneret, Aurélie / Roze, Emmanuel / Keren, Boris / Mignot, Cyril / Beroud, Christophe / Acosta, Fernando / Nowak, Catherine / Wilson, William G / Steel, Dora / Capuano, Alessandro / Vidailhet, Marie / Lin, Jean-Pierre / Tranchant, Christine / Cif, Laura / Doummar, Diane / Anheim, Mathieu

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 7, Page(s) 1547–1554

    Abstract: Background: Most reported patients carrying GNAO1 mutations showed a severe phenotype characterized by early-onset epileptic encephalopathy and/or chorea.: Objective: The aim was to characterize the clinical and genetic features of patients with mild ...

    Abstract Background: Most reported patients carrying GNAO1 mutations showed a severe phenotype characterized by early-onset epileptic encephalopathy and/or chorea.
    Objective: The aim was to characterize the clinical and genetic features of patients with mild GNAO1-related phenotype with prominent movement disorders.
    Methods: We included patients diagnosed with GNAO1-related movement disorders of delayed onset (>2 years). Patients experiencing either severe or profound intellectual disability or early-onset epileptic encephalopathy were excluded.
    Results: Twenty-four patients and 1 asymptomatic subject were included. All patients showed dystonia as prominent movement disorder. Dystonia was focal in 1, segmental in 6, multifocal in 4, and generalized in 13. Six patients showed adolescence or adulthood-onset dystonia. Seven patients presented with parkinsonism and 3 with myoclonus. Dysarthria was observed in 19 patients. Mild and moderate ID were present in 10 and 2 patients, respectively.
    Conclusion: We highlighted a mild GNAO1-related phenotype, including adolescent-onset dystonia, broadening the clinical spectrum of this condition. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    MeSH term(s) Dystonia/genetics ; Dystonic Disorders/genetics ; GTP-Binding Protein alpha Subunits, Gi-Go/genetics ; Humans ; Movement Disorders/genetics ; Parkinsonian Disorders/genetics ; Phenotype
    Chemical Substances GNAO1 protein, human ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1)
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29074
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  2. Article: A de novo SPAST mutation leading to somatic mosaicism is associated with a later age at onset in HSP.

    Depienne, Christel / Fedirko, Estelle / Faucheux, Jean-Marc / Forlani, Sylvie / Bricka, Bernard / Goizet, Cyril / Lesourd, Sylvie / Stevanin, Giovanni / Ruberg, Merle / Durr, Alexandra / Brice, Alexis

    Neurogenetics

    2007  Volume 8, Issue 3, Page(s) 231–233

    Abstract: SPG4/SPAST, the gene-encoding spastin, is responsible for the most frequent form of autosomal dominant hereditary spastic paraplegia (HSP). SPG4-HSP is a heterogeneous disorder characterized by both interfamilial and intrafamilial variation, especially ... ...

    Abstract SPG4/SPAST, the gene-encoding spastin, is responsible for the most frequent form of autosomal dominant hereditary spastic paraplegia (HSP). SPG4-HSP is a heterogeneous disorder characterized by both interfamilial and intrafamilial variation, especially regarding the severity and the age at onset. In this study, we investigated the origin of the mutation and the factors involved in intra-familial heterogeneity in a family with a SPG4 mutation. We demonstrated that the mutation occurred de novo and show evidence of somatic mosaicism in the grandfather, who was the only affected member of six siblings. His disease began at age 55, much later than in his daughter, who had onset at age 18, and his grandson, in whom onset was at age 5. These observations indicate that de novo mutations can occur in SPG4, and that somatic mosaicism might account for intra-familial variation in SPG4-linked HSP.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Adolescent ; Age of Onset ; Child, Preschool ; Family ; Female ; Humans ; Male ; Middle Aged ; Mosaicism ; Paraplegia/genetics ; Pedigree ; Spastin
    Chemical Substances Adenosine Triphosphatases (EC 3.6.1.-) ; Spastin (EC 3.6.4.3) ; SPAST protein, human (EC 5.6.1.1)
    Language English
    Publishing date 2007-06-28
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1339887-8
    ISSN 1364-6753 ; 1364-6745
    ISSN (online) 1364-6753
    ISSN 1364-6745
    DOI 10.1007/s10048-007-0090-4
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  3. Article ; Online: Treating asymptomatic bacteriuria before immunosuppressive therapy during multiple sclerosis: Should we do it?

    Rouzaud, Claire / Hautecoeur, Patrick / Donze, Cécile / Heinzlef, Olivier / Dinh, Aurélien / Creange, Alain / Abdullatif, Alkhedr / Audouin, Bertrand / Tourbah, Ayman / Berger, Eric / Bourre, Bertrand / Brochet, Bruno / Mekies, Claude / Cabre, Philippe / Papeix, Caroline / Casez, Olivier / Brassat, David / Defer, Gilles / Derache, Nathalie /
    De Seze, Jérôme / Dive, Dominique / LePage, Emmanuelle / Fromont, Agnes / Gouider, Riadh / Edan, Gilles / Pelletier, Jean / Grimaud, Jérôme / Guennoc, Anne-Marie / Camdessanché, Jean-Philippe / Kwiatkowski, Arnaud / Laplaud, David / Lebrun, Christine / Debouverie, Marc / Coustans, Marc / Gout, Olivier / La Rochelle, Olivier Anne / Ouallet, Jean-Christophe / Cavelou, Pierre / Labauge, Pierre / Vermersch, Patrick / Wiertlewski, Sandrine / Vukusic, Sandra / Marignier, Romain / Schluep, Myriam / Seeldrayers, Pierrette / Slassi, Ilham / Stankoff, Bruno / Thaite, Frederic / Moreau, Thibault / Thouvenot, Eric / Zephir, Hélène / Ciron, Jonhatan / Collongues, Nicolas / Kerschen, Philippe / Cohen, Mikael / Gueguen, Antoine / Mathey, Guillaume / Carra, Clarisse / Bernady, Patricia / Faucheux, Jean Marc / Planque, Evelyne / Donze, Cecile / Ruet, Aurélie / Mouzawakh, Catherine / Pittion, Sophie

    Multiple sclerosis and related disorders

    2017  Volume 18, Page(s) 161–163

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteriuria/therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Multicenter Studies as Topic ; Multiple Sclerosis/complications ; Multiple Sclerosis/therapy
    Chemical Substances Anti-Bacterial Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2017-08-24
    Publishing country Netherlands
    Document type Letter
    ISSN 2211-0356
    ISSN (online) 2211-0356
    DOI 10.1016/j.msard.2017.08.009
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  4. Article ; Online: Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.

    Nguyen, Thanh N / Qureshi, Muhammad M / Klein, Piers / Yamagami, Hiroshi / Mikulik, Robert / Czlonkowska, Anna / Abdalkader, Mohamad / Sedova, Petra / Sathya, Anvitha / Lo, Hannah C / Mansour, Ossama Yassin / Vanguru, Husitha Reddy / Lesaine, Emilie / Tsivgoulis, Georgios / Loochtan, Aaron I / Demeestere, Jelle / Uchino, Ken / Inoa, Violiza / Goyal, Nitin /
    Charidimou, Andreas / Siegler, James E / Yaghi, Shadi / Aguiar de Sousa, Diana / Mohammaden, Mahmoud H / Haussen, Diogo C / Kristoffersen, Espen Saxhaug / Lereis, Virginia Pujol / Scollo, Sergio Daniel / Campbell, Bruce C V / Ma, Alice / Thomas, James Orton / Parsons, Mark W / Singhal, Shaloo / Slater, Lee-Anne / Tomazini Martins, Rodrigo / Enzinger, Chris / Gattringer, Thomas / Rahman, Aminur / Bonnet, Thomas / Ligot, Noemie / De Raedt, Sylvie / Lemmens, Robin / Vanacker, Peter / Vandervorst, Fenne / Conforto, Adriana Bastos / Hidalgo, Raquel C T / de Oliveira Neves, Luciana / Martins, Rodrigo Targa / Mora Cuervo, Daissy Liliana / Rebello, Leticia C / Santiago, Igor Bessa / Lameirinhas da Silva, Isabelle / Sakelarova, Teodora / Kalpachki, Rosen / Alexiev, Filip / Catanese, Luciana / Cora, Elena Adela / Goyal, Mayank / Hill, Michael D / Kelly, Michael E / Khosravani, Houman / Lavoie, Pascale / Peeling, Lissa / Pikula, Aleksandra / Rivera, Rodrigo / Chen, Hui-Sheng / Chen, Yimin / Huo, Xiaochuan / Miao, Zhongrong / Yang, Shuiquan / Bedekovic, Marina Roje / Bralic, Marina / Budincevic, Hrvoje / Corredor-Quintero, Angel Basilio / Lara-Sarabia, Osvaldo E / Cabal, Martin / Tenora, Dusan / Fibrich, Petr / Herzig, Roman / Hlaváčová, Helena / Hrabanovska, Emanuela / Hlinovsky, David / Jurak, Lubomir / Kadlcikova, Jana / Karpowicz, Igor / Klecka, Lukas / Kovar, Martin / Lauer, David / Neumann, Jiri / Palouskova, Hana / Reiser, Martin / Rekova, Petra / Rohan, Vladimir / Skoda, Ondrej / Škorňa, Miroslav / Sobotková, Lenka / Sramek, Martin / Zakova, Lenka / Christensen, Hanne / Drenck, Nicolas / Iversen, Helle Klingenberg / Truelsen, Thomas Clement / Wienecke, Troels / Sobh, Khalid / Ylikotila, Pauli / Alpay, Kemal / Strbian, Daniel / Bernady, Patricia / Casenave, Philippe / Dan, Maria / Faucheux, Jean-Marc / Gentric, Jean-Christophe / Magro, Elsa / Sabben, Candice / Reiner, Peggy / Rouanet, Francois / Bohmann, Ferdinand O / Boskamp, Stefan / Mbroh, Joshua / Nagel, Simon / Nolte, Christian H / Ringleb, Peter A / Rosenkranz, Michael / Poli, Sven / Thomalla, Götz / Karapanayiotides, Theodoros / Koutroulou, Ioanna / Kargiotis, Odysseas / Palaiodimou, Lina / Barrientos Guerra, Jose Dominguo / Huded, Vikram / Menon, Bindu / Nagendra, Shashank / Prajapati, Chintan / Sylaja, P N / Krishna Pramana, Nyoman Angga / Sani, Achmad Firdaus / Ghoreishi, Abdoreza / Farhoudi, Mehdi / Hokmabadi, Elyar Sadeghi / Raya, Tariq Abu / Kalmanovich, Shani Avnery / Ronen, Levite / Sabetay, Sergiu Ionut / Acampa, Maurizio / Adami, Alessandro / Castellan, Lucio / Longoni, Marco / Ornello, Raffaele / Renieri, Leonardo / Bigliani, Claudia Rolla / Romoli, Michele / Sacco, Simona / Salmaggi, Andrea / Sangalli, Davide / Zini, Andrea / Doijiri, Ryosuke / Fukuda, Hiroki / Fujinaka, Toshiyuki / Fujita, Kyohei / Imamura, Hirotoshi / Sakai, Nobuyuki / Kanamaru, Takuya / Kimura, Naoto / Kono, Ryuhei / Miyake, Kosuke / Sakaguchi, Manabu / Sakai, Kenichiro / Sonoda, Kazutaka / Todo, Kenichi / Miyashita, Fumio / Tokuda, Naoki / Matsumaru, Yuji / Matsumoto, Shoji / Ohara, Nobuyuki / Shindo, Seigo / Takenobu, Yohei / Yoshimoto, Takeshi / Toyoda, Kazunori / Uwatoko, Takeshi / Yagita, Yoshiki / Yamada, Takehiro / Yamamoto, Nobuaki / Yamamoto, Ryoo / Yazawa, Yukako / Sugiura, Yuri / Waweru, Peter Kuria / Baek, Jang-Hyun / Lee, Si Baek / Seo, Kwon-Duk / Sohn, Sung-Il / Arsovska, Anita Ante / Chan, Yong Chieh / Wan Zaidi, Wan Asyraf / Jaafar, Ainul Syahrilfazli / Gongora-Rivera, Fernando / Martinez-Marino, Manuel / Infante-Valenzuela, Adrian / Groppa, Stanislav / Leahu, Pavel / Coutinho, Jonathan M / Rinkel, Leon A / Dippel, Diederik W J / van Dam-Nolen, Dianne H K / Ranta, Annemarei / Wu, Teddy Y / Adebayo, Tajudeen Temitayo / Bello, Abiodun H / Nwazor, Ernest Okwundu / Sunmonu, Taofiki Ajao / Wahab, Kolawole Wasiu / Ronning, Ole Morten / Sandset, Else Charlotte / Al Hashmi, Amal M / Ahmad, Saima / Rashid, Umair / Rodriguez-Kadota, Liliana / Vences, Miguel Ángel / Yalung, Patrick Matic / Hao Dy, Jon Stewart / Pineda-Franks, Maria Carissa / Co, Christian Oliver / Brola, Waldemar / Debiec, Aleksander / Dorobek, Malgorzata / Karlinski, Michal Adam / Labuz-Roszak, Beata M / Lasek-Bal, Anetta / Sienkiewicz-Jarosz, Halina / Staszewski, Jacek / Sobolewski, Piotr / Wiacek, Marcin / Zielinska-Turek, Justyna / Araujo, Andre Pinho / Rocha, Mariana / Castro, Pedro / Cruz, Vitor Tedim / Ferreira, Paulo Venancio / Ferreira, Patricia / Nunes, Ana Paiva / Fonseca, Luisa / Marto, João Pedro / Pinho E Melo, Teresa / Rodrigues, Miguel / Silva, M Luis / Dimitriade, Adela / Falup-Pecurariu, Cristian / Hamid, May Adel / Venketasubramanian, Narayanaswamy / Krastev, Georgi / Mako, Miroslav / Ayo-Martin, Oscar / Hernández-Fernández, Francisco / Blasco, Jordi / Rodríguez-Vázquez, Alejandro / Cruz-Culebras, Antonio / Moniche, Francisco / Montaner, Joan / Perez-Sanchez, Soledad / García Sánchez, María Jesús / Guillán Rodríguez, Marta / Jood, Katarina / Nordanstig, Annika / Mazya, Michael V / Moreira, Tiago T P / Bernava, Gianmarco / Beyeler, Morin / Bolognese, Manuel / Carrera, Emmanuel / Dobrocky, Tomas / Karwacki, Grzegorz Marek / Keller, Emanuela / Hsieh, Chang Yang / Boonyakarnkul, Surawan / Churojana, Anchalee / Aykac, Ozlem / Ozdemir, Atilla Ã-Zcan / Bajrami, Arsida / Senadim, Songul / Hussain, Syed Irteza / John, Seby / Banerjee, Soma / Kwan, Joseph / Krishnan, Kailash / Lenthall, Robert / Matthews, Ashok / Wong, Ken / Zhang, Liqun / Altschul, Dorothea / Asif, Kaiz S / Bahiru, Zeelalem / Below, Kristine / Biller, José / Ruland, Sean / Chaudry, Saqib A / Chen, Michael / Chebl, Alex / Cibulka, Jackie / Cistrunk, Leon / Clark, Judith / Colasurdo, Marco / Czap, Alexandra / de Havenon, Adam / D'Amato, Salvatore / Dharmadhikari, Sushrut / Grimmett, Kasey B / Dmytriw, Adam A / Etherton, Mark R / Ezepue, Chizoba / Farooqui, Mudassir / Feske, Steven K / Fink, Lauren / Gasimova, Ulviyya / Guzik, Amy K / Hakemi, Maryam / Hovingh, Majesta / Khan, Muhib / Jillela, Dinesh / Kan, Peter T / Khatri, Rakesh / Khawaja, Ayaz M / Khoury, Naim N / Kiley, Nicole L / Kim, Benny S / Kolikonda, Murali K / Kuhn, Anna Luisa / Lara, Stephanie / Linares, Guillermo / Linfante, Italo / Lukovits, Timothy G / Lycan, Sarah / Male, Shailesh S / Maali, Laith / Mancin, John / Masoud, Hesham / Mohamed, Ghada A / Monteiro, Andre / Nahab, Fadi / Nalleballe, Krishna / Ortega-Gutierrez, Santiago / Puri, Ajit S / Radaideh, Yazan / Rahangdale, Rahul H / Rai, Ansaar / Ramakrishnan, Pankajavalli / Reddy, Aravind B / Rojas-Soto, Diana M / Romero, Jose Rafael / Rost, Natalia S / Rothstein, Aaron / Omran, Setareh Salehi / Sheth, Sunil A / Siddiqui, Adnan H / Starosciak, Amy K / Tarlov, Nicholas E / Taylor, Robert A / Wang, Michael J / Wolfe, Jared / Wong, Ka-Ho / Le, Huynh Vu / Nguyen, Quy Viet / Pham, Thong Nhu / Nguyen, Trung Thanh / Phan, Hoang Thi / Ton, Mai Duy / Fischer, Urs / Michel, Patrik / Strambo, Davide / Martins, Sheila O / Zaidat, Osama O / Nogueira, Raul G

    Neurology

    2022  Volume 100, Issue 4, Page(s) e408–e421

    Abstract: Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on ... ...

    Abstract Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).
    Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their
    Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9];
    Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.
    Trial registration information: This study is registered under NCT04934020.
    MeSH term(s) Humans ; Brain Ischemia/therapy ; COVID-19/epidemiology ; COVID-19/therapy ; Follow-Up Studies ; Intracranial Hemorrhages ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Stroke/epidemiology ; Stroke/therapy ; Stroke/diagnosis ; Stroke Volume ; Thrombectomy ; Thrombolytic Therapy/methods ; Treatment Outcome
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Clinical Study ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201426
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  5. Article ; Online: Global Impact of COVID-19 on Stroke Care and IV Thrombolysis.

    Nogueira, Raul G / Qureshi, Muhammad M / Abdalkader, Mohamad / Martins, Sheila Ouriques / Yamagami, Hiroshi / Qiu, Zhongming / Mansour, Ossama Yassin / Sathya, Anvitha / Czlonkowska, Anna / Tsivgoulis, Georgios / Aguiar de Sousa, Diana / Demeestere, Jelle / Mikulik, Robert / Vanacker, Peter / Siegler, James E / Kõrv, Janika / Biller, Jose / Liang, Conrad W / Sangha, Navdeep S /
    Zha, Alicia M / Czap, Alexandra L / Holmstedt, Christine Anne / Turan, Tanya N / Ntaios, George / Malhotra, Konark / Tayal, Ashis / Loochtan, Aaron / Ranta, Annamarei / Mistry, Eva A / Alexandrov, Anne W / Huang, David Y / Yaghi, Shadi / Raz, Eytan / Sheth, Sunil A / Mohammaden, Mahmoud H / Frankel, Michael / Bila Lamou, Eric Guemekane / Aref, Hany M / Elbassiouny, Ahmed / Hassan, Farouk / Menecie, Tarek / Mustafa, Wessam / Shokri, Hossam M / Roushdy, Tamer / Sarfo, Fred S / Alabi, Tolulope Oyetunde / Arabambi, Babawale / Nwazor, Ernest O / Sunmonu, Taofiki Ajao / Wahab, Kolawole / Yaria, Joseph / Mohammed, Haytham Hussein / Adebayo, Philip B / Riahi, Anis D / Sassi, Samia Ben / Gwaunza, Lenon / Ngwende, Gift Wilson / Sahakyan, David / Rahman, Aminur / Ai, Zhibing / Bai, Fanghui / Duan, Zhenhui / Hao, Yonggang / Huang, Wenguo / Li, Guangwen / Li, Wei / Liu, Ganzhe / Luo, Jun / Shang, Xianjin / Sui, Yi / Tian, Ling / Wen, Hongbin / Wu, Bo / Yan, Yuying / Yuan, Zhengzhou / Zhang, Hao / Zhang, Jun / Zhao, Wenlong / Zi, Wenjie / Leung, Thomas W / Chugh, Chandril / Huded, Vikram / Menon, Bindu / Pandian, Jeyaraj Durai / Sylaja, P N / Usman, Fritz Sumantri / Farhoudi, Mehdi / Hokmabadi, Elyar Sadeghi / Horev, Anat / Reznik, Anna / Sivan Hoffmann, Rotem / Ohara, Nobuyuki / Sakai, Nobuyuki / Watanabe, Daisuke / Yamamoto, Ryoo / Doijiri, Ryosuke / Tokuda, Naoki / Yamada, Takehiro / Terasaki, Tadashi / Yazawa, Yukako / Uwatoko, Takeshi / Dembo, Tomohisa / Shimizu, Hisao / Sugiura, Yuri / Miyashita, Fumio / Fukuda, Hiroki / Miyake, Kosuke / Shimbo, Junsuke / Sugimura, Yusuke / Yagita, Yoshiki / Takenobu, Yohei / Matsumaru, Yuji / Yamada, Satoshi / Kono, Ryuhei / Kanamaru, Takuya / Yamazaki, Hidekazu / Sakaguchi, Manabu / Todo, Kenichi / Yamamoto, Nobuaki / Sonoda, Kazutaka / Yoshida, Tomoko / Hashimoto, Hiroyuki / Nakahara, Ichiro / Kondybayeva, Aida / Faizullina, Kamila / Kamenova, Saltanat / Zhanuzakov, Murat / Baek, Jang-Hyun / Hwang, Yangha / Lee, Jin Soo / Lee, Si Baek / Moon, Jusun / Park, Hyungjong / Seo, Jung Hwa / Seo, Kwon-Duk / Sohn, Sung Il / Young, Chang Jun / Ahdab, Rechdi / Wan Zaidi, Wan Asyraf / Aziz, Zariah Abdul / Basri, Hamidon Bin / Chung, Law Wan / Ibrahim, Aznita Binti / Ibrahim, Khairul Azmi / Looi, Irene / Tan, Wee Yong / Yahya, Nafisah Wan / Groppa, Stanislav / Leahu, Pavel / Al Hashmi, Amal M / Imam, Yahia Zakaria / Akhtar, Naveed / Pineda-Franks, Maria Carissa / Co, Christian Oliver / Kandyba, Dmitriy / Alhazzani, Adel / Al-Jehani, Hosam / Tham, Carol Huilian / Mamauag, Marlie Jane / Venketasubramanian, Narayanaswamy / Chen, Chih-Hao / Tang, Sung-Chun / Churojana, Anchalee / Akil, Esref / Aykaç, Özlem / Ozdemir, Atilla Ozcan / Giray, Semih / Hussain, Syed Irteza / John, Seby / Le Vu, Huynh / Tran, Anh Duc / Nguyen, Huy Hoang / Nhu Pham, Thong / Nguyen, Thang Huy / Nguyen, Trung Quoc / Gattringer, Thomas / Enzinger, Christian / Killer-Oberpfalzer, Monika / Bellante, Flavio / De Blauwe, Sofie / Vanhooren, Geert / De Raedt, Sylvie / Dusart, Anne / Lemmens, Robin / Ligot, Noemie / Pierre Rutgers, Matthieu / Yperzeele, Laetitia / Alexiev, Filip / Sakelarova, Teodora / Bedeković, Marina Roje / Budincevic, Hrvoje / Cindric, Igor / Hucika, Zlatko / Ozretic, David / Saric, Majda Seferovic / Pfeifer, František / Karpowic, Igor / Cernik, David / Sramek, Martin / Skoda, Miroslav / Hlavacova, Helena / Klecka, Lukas / Koutny, Martin / Vaclavik, Daniel / Skoda, Ondrej / Fiksa, Jan / Hanelova, Katerina / Nevsimalova, Miroslava / Rezek, Robert / Prochazka, Petr / Krejstova, Gabriela / Neumann, Jiri / Vachova, Marta / Brzezanski, Henryk / Hlinovsky, David / Tenora, Dusan / Jura, Rene / Jurák, Lubomír / Novak, Jan / Novak, Ales / Topinka, Zdenek / Fibrich, Petr / Sobolova, Helena / Volny, Ondrej / Krarup Christensen, Hanne / Drenck, Nicolas / Klingenberg Iversen, Helle / Simonsen, Claus Z / Truelsen, Thomas Clement / Wienecke, Troels / Vibo, Riina / Gross-Paju, Katrin / Toomsoo, Toomas / Antsov, Katrin / Caparros, Francois / Cordonnier, Charlotte / Dan, Maria / Faucheux, Jean-Marc / Mechtouff, Laura / Eker, Omer / Lesaine, Emilie / Ondze, Basile / Peres, Roxane / Pico, Fernando / Piotin, Michel / Pop, Raoul / Rouanet, Francois / Gubeladze, Tatuli / Khinikadze, Mirza / Lobjanidze, Nino / Tsiskaridze, Alexander / Nagel, Simon / Ringleb, Peter Arthur / Rosenkranz, Michael / Schmidt, Holger / Sedghi, Annahita / Siepmann, Timo / Szabo, Kristina / Thomalla, Götz / Palaiodimou, Lina / Sagris, Dimitrios / Kargiotis, Odysseas / Klivenyi, Peter / Szapary, Laszlo / Tarkanyi, Gabor / Adami, Alessandro / Bandini, Fabio / Calabresi, Paolo / Frisullo, Giovanni / Renieri, Leonardo / Sangalli, Davide / Pirson, Anne / Uyttenboogaart, Maarten / van den Wijngaard, Ido / Kristoffersen, Espen Saxhaug / Brola, Waldemar / Fudala, Małgorzata / Horoch-Lyszczarek, Ewa / Karlinski, Michal / Kazmierski, Radoslaw / Kram, Pawel / Rogoziewicz, Marcin / Kaczorowski, Rafal / Luchowski, Piotr / Sienkiewicz-Jarosz, Halina / Sobolewski, Piotr / Fryze, Waldemar / Wisniewska, Anna / Wiszniewska, Malgorzata / Ferreira, Patricia / Ferreira, Paulo / Fonseca, Luisa / Marto, João Pedro / Pinho E Melo, Teresa / Nunes, Ana Paiva / Rodrigues, Miguel / Tedim Cruz, Vítor / Falup-Pecurariu, Cristian / Krastev, Georgi / Mako, Miroslav / de Leciñana, María Alonso / Arenillas, Juan F / Ayo-Martin, Oscar / Cruz Culebras, Antonio / Tejedor, Exuperio Diez / Montaner, Joan / Pérez-Sánchez, Soledad / Tola Arribas, Miguel Angel / Rodriguez Vasquez, Alejandro / Mayza, Michael / Bernava, Gianmarco / Brehm, Alex / Machi, Paolo / Fischer, Urs / Gralla, Jan / Michel, Patrik L / Psychogios, Marios-Nikos / Strambo, Davide / Banerjee, Soma / Krishnan, Kailash / Kwan, Joseph / Butt, Asif / Catanese, Luciana / Demchuk, Andrew M / Field, Thalia / Haynes, Jennifer / Hill, Michael D / Khosravani, Houman / Mackey, Ariane / Pikula, Aleksandra / Saposnik, Gustavo / Scott, Courtney Anne / Shoamanesh, Ashkan / Shuaib, Ashfaq / Yip, Samuel / Barboza, Miguel A / 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Jane G / Multani, Sumeet S / Nahab, Fadi / Nalleballe, Krishna / Nguyen, Claude B / Novakovic-White, Roberta / Ortega-Gutierrez, Santiago / Rahangdale, Rahul H / Ramakrishnan, Pankajavalli / Romero, Jose Rafael / Rost, Natalia / Rothstein, Aaron / Ruland, Sean / Shah, Ruchir / Sharma, Malveeka / Silver, Brian / Simmons, Marc / Singh, Abhishek / Starosciak, Amy K / Strasser, Sheryl L / Szeder, Viktor / Teleb, Mohamed / Tsai, Jenny P / Voetsch, Barbara / Balaguera, Oscar / Pujol Lereis, Virginia A / Luraschi, Adriana / Almeida, Marcele Schettini / Cardoso, Fabricio Buchdid / Conforto, Adriana / De Deus Silva, Leonardo / Varrone Giacomini, Luidia / Oliveira Lima, Fabricio / Longo, Alexandre L / Magalhães, Pedro S C / Martins, Rodrigo Targa / Mont'alverne, Francisco / Mora Cuervo, Daissy Liliana / Costa Rebello, Leticia / Valler, Lenise / Zetola, Viviane Flumignan / Lavados, Pablo M / Navia, Victor / Olavarría, Verónica V / Almeida Toro, Juan Manuel / Amaya, Pablo Felipe Ricardo / Bayona, 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    Neurology

    2021  Volume 96, Issue 23, Page(s) e2824–e2838

    Abstract: Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.!# ...

    Abstract Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.
    Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.
    Results: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3,
    Conclusions: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Hospitalization ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Stroke/drug therapy ; Stroke/epidemiology ; Thrombolytic Therapy
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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