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  1. Article ; Online: Publisher Correction: The blue hue of einsteinium.

    Natrajan, Louise S / Faulkner, Stephen

    Nature chemistry

    2021  Volume 13, Issue 7, Page(s) 715

    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-021-00743-w
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  2. Article ; Online: The blue hue of einsteinium.

    Natrajan, Louise S / Faulkner, Stephen

    Nature chemistry

    2021  Volume 13, Issue 5, Page(s) 393–395

    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-021-00693-3
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  3. Article ; Online: Isolation of the elusive [Ru(bipy)

    Horsewill, Samuel J / Cao, Chengyang / Dabney, Noah / Yang, Eric S / Faulkner, Stephen / Scott, Daniel J

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 99, Page(s) 14665–14668

    Abstract: Photoredox catalysis has flourished in recent years, but due to its widespread utility applications have grown faster than mechanistic understanding. In this report we help to address this deficit by isolating and characterising one of the intermediates ... ...

    Abstract Photoredox catalysis has flourished in recent years, but due to its widespread utility applications have grown faster than mechanistic understanding. In this report we help to address this deficit by isolating and characterising one of the intermediates of the iconic photocatalyst [Ru(bipy)
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04375d
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  4. Article ; Online: Two Color Imaging of Different Hypoxia Levels in Cancer Cells.

    Wallabregue, Antoine L D / Bolland, Hannah / Faulkner, Stephen / Hammond, Ester M / Conway, Stuart J

    Journal of the American Chemical Society

    2023  Volume 145, Issue 4, Page(s) 2572–2583

    Abstract: Hypoxia (low oxygen levels) occurs in a range of biological contexts, including plants, bacterial biofilms, and solid tumors; it elicits responses from these biological systems that impact their survival. For example, conditions of low oxygen make ... ...

    Abstract Hypoxia (low oxygen levels) occurs in a range of biological contexts, including plants, bacterial biofilms, and solid tumors; it elicits responses from these biological systems that impact their survival. For example, conditions of low oxygen make treating tumors more difficult and have a negative impact on patient prognosis. Therefore, chemical probes that enable the study of biological hypoxia are valuable tools to increase the understanding of disease-related conditions that involve low oxygen levels, ultimately leading to improved diagnosis and treatment. While small-molecule hypoxia-sensing probes exist, the majority of these image only very severe hypoxia (<1% O
    MeSH term(s) Humans ; Hypoxia ; Neoplasms/diagnostic imaging ; Oxygen/analysis ; Fluorescent Dyes/chemistry ; Cell Hypoxia
    Chemical Substances Oxygen (S88TT14065) ; Fluorescent Dyes
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c12493
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  5. Article: Heterometallic lanthanide complexes with site-specific binding that enable simultaneous visible and NIR-emission.

    Thornton, Matthew E / Hemsworth, Jake / Hay, Sam / Parkinson, Patrick / Faulkner, Stephen / Natrajan, Louise S

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1232690

    Abstract: Macrocyclic lanthanide complexes have become widely developed due to their distinctive luminescence characteristics and wide range of applications in biological imaging. However, systems with sufficient brightness and metal selectivity can be difficult ... ...

    Abstract Macrocyclic lanthanide complexes have become widely developed due to their distinctive luminescence characteristics and wide range of applications in biological imaging. However, systems with sufficient brightness and metal selectivity can be difficult to produce on a molecular scale. Presented herein is the stepwise introduction of differing lanthanide ions in a bis-DO3A/DTPA scaffold to afford three trinuclear bimetallic [Ln
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1232690
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  6. Article ; Online: Multimetallic Lanthanide Complexes: Using Kinetic Control To Define Complex Multimetallic Arrays.

    Sørensen, Thomas Just / Faulkner, Stephen

    Accounts of chemical research

    2018  Volume 51, Issue 10, Page(s) 2493–2501

    Abstract: Kinetically inert lanthanide complexes are proving to be highly effective building blocks for the preparation of complex heterometallic architectures, allowing complete control of metal ion domains, which cannot be achieved under thermodynamic control. ... ...

    Abstract Kinetically inert lanthanide complexes are proving to be highly effective building blocks for the preparation of complex heterometallic architectures, allowing complete control of metal ion domains, which cannot be achieved under thermodynamic control. Kinetic stability may render perceivable labile coordination bonds more durable than several types of covalent interactions. For complexes in clinical use, the significance of kinetic stability cannot be overstated, and this Account treats the topic accordingly. Kinetically inert complexes can be used as building blocks for elaborate synthesis. For instance, it is now possible to prepare heterometallic lanthanide complexes containing two or more different lanthanide ions by linking kinetically robust complexes together. This approach can yield bimetallic (f-f' or d-f) and trimetallic (f-f'-f″) lanthanide complexes. In this Account, we describe our studies exploiting the slow dissociation of lanthanide complexes derived from 1,4,7,10-tetraazadodecane-1,4,7,10-tetraacetic acid (DOTA) related ligands to link complexes together through synthetic manipulation of pendent groups on the ligand skeleton or through coordination of bridging donor groups to a d-block metal center. In the course of this work, we have developed a variety of such methods, ranging from peptide coupling and diazotization to Ugi and click chemistry and have also explored the use of alternative strategies that combine orthogonal protecting group chemistry with sequential complexation of different lanthanide ions or that use self-assembly to deliver well-defined multimetallic systems. These well-defined bimetallic systems also have considerable scope for exploitation. Since the earliest studies, it has been clear that there is potential for application in the burgeoning field of molecular imaging. Heterometallic lanthanide complexes can be used as single-molecule bimodal imaging agents through incorporation of MRI active and luminescent components. Alternatively, conventional luminescence methods can be exploited in conjunction with lanthanide luminescence. In the simplest cases, a single lanthanide can be used to achieve a switchable response in combination with a transition metal complex. Bimetallic f-f' complexes allow the full potential of the approach to be realized in systems in which one lanthanide responds to changes in the concentration of an analyte, while a second lanthanide center can be used to define the concentration of the probe itself. This offers a new solution to the old dichotomy of ratiometric imaging that can potentially be applied widely.
    Language English
    Publishing date 2018-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.8b00205
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  7. Article: Chelating chloride using binuclear lanthanide complexes in water.

    Alexander, Carlson / Thom, James A / Kenwright, Alan M / Christensen, Kirsten E / Sørensen, Thomas Just / Faulkner, Stephen

    Chemical science

    2022  Volume 14, Issue 5, Page(s) 1194–1204

    Abstract: Halide recognition by supramolecular receptors and coordination complexes in water is a long-standing challenge. In this work, we report chloride binding in water and in competing media by pre-organised binuclear kinetically inert lanthanide complexes, ... ...

    Abstract Halide recognition by supramolecular receptors and coordination complexes in water is a long-standing challenge. In this work, we report chloride binding in water and in competing media by pre-organised binuclear kinetically inert lanthanide complexes, bridged by flexible -(CH
    Language English
    Publishing date 2022-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc05417e
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  8. Article ; Online: Boronic ester functionalised 1,8-diboryl-naphthalene scaffolds: fluoride

    Booth, Anna C / Vasko, Petra / Fuentes, M Ángeles / Cornelissen, Bart / Faulkner, Stephen / Aldridge, Simon

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 41, Page(s) 15783–15791

    Abstract: 1,8-Bis(boronic ester) derivatives of naphthalene, 1,8- ... ...

    Abstract 1,8-Bis(boronic ester) derivatives of naphthalene, 1,8-C
    MeSH term(s) Boron/chemistry ; Fluorides/chemistry ; Esters ; Oxides ; Chelating Agents/chemistry ; Naphthalenes ; Catechols ; Anhydrides
    Chemical Substances Boron (N9E3X5056Q) ; Fluorides (Q80VPU408O) ; Esters ; Oxides ; Chelating Agents ; Naphthalenes ; Catechols ; Anhydrides
    Language English
    Publishing date 2022-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt02888c
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  9. Article ; Online: Understanding catalytic synergy in dinuclear polymerization catalysts for sustainable polymers.

    Fiorentini, Francesca / Diment, Wilfred T / Deacy, Arron C / Kerr, Ryan W F / Faulkner, Stephen / Williams, Charlotte K

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4783

    Abstract: Understanding the chemistry underpinning intermetallic synergy and the discovery of generally applicable structure-performances relationships are major challenges in catalysis. Additionally, high-performance catalysts using earth-abundant, non-toxic and ... ...

    Abstract Understanding the chemistry underpinning intermetallic synergy and the discovery of generally applicable structure-performances relationships are major challenges in catalysis. Additionally, high-performance catalysts using earth-abundant, non-toxic and inexpensive elements must be prioritised. Here, a series of heterodinuclear catalysts of the form Co(III)M(I/II), where M(I/II) = Na(I), K(I), Ca(II), Sr(II), Ba(II) are evaluated for three different polymerizations, by assessment of rate constants, turn over frequencies, polymer selectivity and control. This allows for comparisons of performances both within and between catalysts containing Group I and II metals for CO
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-40284-z
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  10. Article ; Online: A Model System to Explore the Detection Limits of Antibody-Based Immuno-SPECT Imaging of Exclusively Intranuclear Epitopes.

    Veal, Mathew / Dias, Gemma / Kersemans, Veerle / Sneddon, Deborah / Faulkner, Stephen / Cornelissen, Bart

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 62, Issue 11, Page(s) 1537–1544

    Abstract: Imaging of intranuclear epitopes using antibodies tagged to cell-penetrating peptides has great potential given its versatility, specificity, and sensitivity. However, this process is technically challenging because of the location of the target. ... ...

    Abstract Imaging of intranuclear epitopes using antibodies tagged to cell-penetrating peptides has great potential given its versatility, specificity, and sensitivity. However, this process is technically challenging because of the location of the target. Previous research has demonstrated a variety of intranuclear epitopes that can be targeted with antibody-based radioimmunoconjugates. Here, we developed a controlled-expression model of nucleus-localized green fluorescent protein (GFP) to interrogate the technical limitations of intranuclear SPECT using radioimmunoconjugates, notably the lower target-abundance detection threshold.
    MeSH term(s) Green Fluorescent Proteins ; Limit of Detection ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances enhanced green fluorescent protein ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.251173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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