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  1. Book ; Online: Addressing New Therapeutic Strategies Using Models

    Faustino, Ana / Oliveira, Paula A

    2023  

    Keywords Research & information: general ; Biology, life sciences ; spontaneous models ; induced models ; genetically engineered models ; acute kidney injury ; biomarkers ; coagulation ; ischemia-reperfusion injury ; shock ; newborn lamb ; multiple intestinal loop model ; 3R ; Cryptosporidium parvum ; yeast cell wall fractions ; fatty liver disease ; glucose ; imipramine ; insulin ; obesity ; renal impairment ; retinal injury ; xenograft ; ectopic ; orthotopic ; hIBC ; cIMC ; whole-body ischemia ; cardiopulmonary resuscitation ; drug-induced hypothermia ; spinal motor neuron ; inflammation ; paraplegia ; virucidal drugs ; IBV ; chickens ; Coronaviridae ; silver nanoparticles ; artificial ribonuclease ; monoglyceride lauryl acid ; spinal cord hemisection ; Macaca radiata ; predegenerated nerve transplantation ; locomotor recovery ; Cornu Ammonis 1 ; glutaminergic synapse ; memory function ; oligodendrocyte ; pyramidal cells ; animal model ; trichotillomania ; hair-pulling ; body-focused repetitive disorder ; transitional cell carcinoma ; urothelial carcinoma ; histology ; therapeutic marker ; prognosis ; mandibular growth ; mandibular posterior displacement ; mandibular length ; condylar growth ; rat ; class III malocclusion ; orthodontic treatment ; antebrachial growth deformity ; dog ; osteotomy ; patient-specific instrumentation ; 3-D ; n/a
    Language English
    Size 1 electronic resource (246 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030375483
    ISBN 9783036570822 ; 3036570829
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Prostate Cancer

    Faustino, Ana / Oliveira, Paula A

    2023  

    Keywords Research & information: general ; Biology, life sciences ; neurotoxicity ; testosterone ; androgen-deprivation therapy ; cognitive function ; sleep ; depression ; prostate cancer ; long noncoding RNA ; NEAT1 ; laser capture microdissection ; diagnostic algorithm ; prostate health index ; biopsy ; Gleason score ; magnetic resonance ; positron emission tomography ; diagnosis ; imaging ; prostate-specific membrane antigen ; radical prostatectomy ; pelvic lymph node dissection ; lymph node invasion ; preoperative nomogram ; bone metastasis ; lymph node metastasis ; liver metastasis ; gene expression ; meta-analysis ; focal adhesion ; protein filament ; androgen receptor signaling ; biomarker ; circulating tumor cells ; Wnt ; β-catenin ; Wnt5A ; breast cancer ; DKK1 ; radiomic features ; classification ; risk stratification ; computed tomography ; prostate ; cancer ; urine ; PUR ; PUR-4 ; Gleason pattern 4 ; STEAP1 ; DNA methylation ; histone deacetylation ; bioinformatics ; Circulating Tumor Cell (CTC) ; prostate cancer (PCa) ; liquid biopsy ; cancer recurrence
    Language English
    Size 1 electronic resource (150 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030722289
    ISBN 9783036570846 ; 3036570845
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Pectus excavatum with right ventricular compression-induced ventricular arrhythmias.

    Ferraz, Lisa / Carvalho, Diana / Carvalho, Simāo / Pacheco, Adriana / Faustino, Ana / Neves, Ana

    The British journal of cardiology

    2023  Volume 30, Issue 1, Page(s) 4

    Abstract: A 33-year-old woman, with palpitations since the age of 15, was referred to a cardiology consultation due to very frequent ventricular extrasystoles with morphology of left bundle branch block, inferior frontal axis, late precordial transition, rS in V1, ...

    Abstract A 33-year-old woman, with palpitations since the age of 15, was referred to a cardiology consultation due to very frequent ventricular extrasystoles with morphology of left bundle branch block, inferior frontal axis, late precordial transition, rS in V1, R in V6 and rS in DI. She had pectus excavatum. The cardiac magnetic resonance showed severe pectus excavatum associated with exaggerated cardiac levoposition, compression and deformation of the right cardiac chambers. However, the patient became pregnant, and follow-up was delayed.
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Case Reports
    ZDB-ID 1354589-9
    ISSN 1753-4313 ; 0969-6113
    ISSN (online) 1753-4313
    ISSN 0969-6113
    DOI 10.5837/bjc.2023.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Spontaneous splenic rupture due to falciparum malaria successfully treated with a conservative approach

    Dias, Lúcia Ribeiro / Caldas, João Paulo / Teixeira, João Pedro Araújo / Gomes, Virgília / Babo, Alexandra / Faustino, Ana Sofia / Baptista, Ricardo / Valdoleiros, Sofia R. / Santos, Lurdes

    Parasitology International. 2023 Feb. 05, p.102736-

    2023  , Page(s) 102736–

    Abstract: Malaria is frequently associated with splenomegaly. However, spontaneous splenic rupture is a rare and life-threatening complication. It is mostly seen in acute infection in non-immune adults and Plasmodium vivax and Plasmodium falciparum have been ... ...

    Abstract Malaria is frequently associated with splenomegaly. However, spontaneous splenic rupture is a rare and life-threatening complication. It is mostly seen in acute infection in non-immune adults and Plasmodium vivax and Plasmodium falciparum have been associated with the majority of cases. We describe a case of splenic rupture in an adult with complicated malaria by Plasmodium falciparum in which a conservative approach was used.
    Keywords Plasmodium falciparum ; Plasmodium vivax ; adults ; falciparum malaria ; parasitology ; splenomegaly ; Malaria ; splenic rupture ; malaria complication ; conservative treatment
    Language English
    Dates of publication 2023-0205
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 1363151-2
    ISSN 1383-5769
    ISSN 1383-5769
    DOI 10.1016/j.parint.2023.102736
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2322: Show issues Location:
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  5. Article: Extra Corporeal Membrane Oxygenation in the Treatment of Human Immunodeficiency Virus-Related

    Lacerda Pereira, Sara / Branco, Elsa / Faustino, Ana Sofia / Figueiredo, Paulo / Sarmento, António / Santos, Lurdes

    Infectious disease reports

    2021  Volume 13, Issue 4, Page(s) 1009–1017

    Abstract: Despite the undeniable complexity one may encounter while managing critically ill patients with human immunodeficiency virus infection (HIV), intensive care unit-related mortality has declined in recent years, not only because of more efficacious ... ...

    Abstract Despite the undeniable complexity one may encounter while managing critically ill patients with human immunodeficiency virus infection (HIV), intensive care unit-related mortality has declined in recent years, not only because of more efficacious antiretroviral therapy (ART) but also due to the advances in critical support. However, the use of extracorporeal membrane oxygenation (ECMO) in these patients remains controversial. We report four cases of HIV-infected patients with
    Language English
    Publishing date 2021-12-02
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr13040092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Septic shock due to co-infection with

    Caldas, João Paulo / Silva-Pinto, André / Faustino, Ana Sofia / Figueiredo, Paulo / Sarmento, António / Santos, Lurdes

    IDCases

    2021  Volume 27, Page(s) e01369

    Abstract: Septic shock is the most dreaded presentation of an infection, carrying a reserved prognosis. Appropriate antimicrobial therapy is therefore the mainstay of treatment, alongside organ support as needed. Legionnaires' disease is mainly due ... ...

    Abstract Septic shock is the most dreaded presentation of an infection, carrying a reserved prognosis. Appropriate antimicrobial therapy is therefore the mainstay of treatment, alongside organ support as needed. Legionnaires' disease is mainly due to
    Language English
    Publishing date 2021-12-20
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Studying and Analyzing Humane Endpoints in the Fructose-Fed and Streptozotocin-Injected Rat Model of Diabetes

    Silva-Reis, Rita / Rocha Faustino, Ana Isabel / Silva, Jéssica / Valada, Abigaël / Azevedo, Tiago / Anjos, Lara / Gonçalves, Lio / Pinto, Maria de Lurdes / Ferreira, Rita / Silva, Artur M. S. / Cardoso, Susana M. / Oliveira, Paula A.

    Animals. 2023 Apr. 18, v. 13, no. 8

    2023  

    Abstract: This work aimed to define a humane endpoint scoring system able to objectively identify signs of animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced group. The induced animals drink a 10% ... ...

    Abstract This work aimed to define a humane endpoint scoring system able to objectively identify signs of animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced group. The induced animals drink a 10% fructose solution for 14 days. Then, received an administration of streptozotocin (40 mg/kg). Animals’ body weight, water and food consumption were recorded weekly. To evaluate animal welfare, a score sheet with 14 parameters was employed. Blood glucose levels were measured at three time points. After seven weeks of initiating the protocol, the rats were euthanized. The induced animals showed weight loss, polyuria, polyphagia, and polydipsia. According to our humane endpoints table, changes in animal welfare became noticeable after the STZ administration. None of the animals hit the critical score limit (four). Data showed that the most effective parameters to assess welfare in this type 2 diabetes rat induction model were dehydration, grooming, posture, abdominal visualization, and stool appearance. The glycemia was significantly higher in the induced group when compared to the controls (p < 0.01). Induced animals’ murinometric and nutritional parameters were significantly lower than the controls (p < 0.01). Our findings suggest that in this rat model of type 2 diabetes with STZ-induced following fructose consumption, our list of humane endpoints is suitable for monitoring the animals’ welfare.
    Keywords animal models ; animal welfare ; blood glucose ; body weight ; food consumption ; fructose ; humane endpoints ; males ; noninsulin-dependent diabetes mellitus ; overeating ; posture ; rats ; streptozotocin ; weight loss
    Language English
    Dates of publication 2023-0418
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13081397
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: The Impact of Resveratrol-Enriched Bread on Cardiac Remodeling in a Preclinical Model of Diabetes

    Silva, Andreia F. R. / Silva-Reis, Rita / Ferreira, Rita / Oliveira, Paula A. / Rocha Faustino, Ana Isabel / Pinto, Maria de Lurdes / Coimbra, Manuel A. / Silva, Artur M. S. / Cardoso, Susana M.

    Antioxidants. 2023 May 09, v. 12, no. 5

    2023  

    Abstract: The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it ... ...

    Abstract The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate the effect of RSV-enriched bread in preventing early type 2 diabetes cardiomyopathy in vivo. Male Sprague Dawley rats (3 weeks old) were divided into four groups: controls with plain bread (CB) and RSV bread (CBR), and diabetics with plain bread (DB) and RSV bread (DBR). Type 2 diabetes was induced by adding fructose to the drinking water for two weeks followed by an injection of streptozotocin (STZ) (40 mg/kg). Then, plain bread and RSV bread (10 mg RSV/kg body weight) were included in the rats’ diet for four weeks. Cardiac function, anthropometric, and systemic biochemical parameters were monitored, as well as the histology of the heart and molecular markers of regeneration, metabolism, and oxidative stress. Data showed that an RSV bread diet decreased the polydipsia and body weight loss observed in the early stages of the disease. At the cardiac level, an RSV bread diet diminished fibrosis but did not counteract the dysfunction and metabolic changes seen in fructose-fed STZ-injected rats.
    Keywords World Health Organization ; body weight changes ; breads ; cardiac output ; cardiomyopathy ; diet ; fibrosis ; fructose ; heart ; histology ; males ; metabolism ; models ; noninsulin-dependent diabetes mellitus ; oxidative stress ; resveratrol ; streptozotocin
    Language English
    Dates of publication 2023-0509
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12051066
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Subclavian crush syndrome AND subcutaneous ICD in primary prevention patients.

    Paiva, Luis / Providencia, Rui / Faustino, Ana / Nascimento, Jose

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2017  Volume 18, Issue 9, Page(s) 717–718

    MeSH term(s) Atrioventricular Block/complications ; Atrioventricular Block/therapy ; Cardiac Pacing, Artificial/adverse effects ; Defibrillators, Implantable/adverse effects ; Equipment Failure ; Fluoroscopy ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Primary Prevention ; Radiography, Thoracic ; Subclavian Vein/diagnostic imaging ; Subclavian Vein/injuries ; Vascular System Injuries/diagnostic imaging ; Vascular System Injuries/etiology
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0b013e32835ffbde
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5210: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 559: Show issues

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  10. Article ; Online: Mechanisms of social buffering of fear in zebrafish.

    Faustino, Ana I / Tacão-Monteiro, André / Oliveira, Rui F

    Scientific reports

    2017  Volume 7, Page(s) 44329

    Abstract: Some humans thrive whereas others resign when exposed to threatening situations throughout life. Social support has been identified as an important modulator of these discrepancies in human behaviour, and other social animals also exhibit phenomena in ... ...

    Abstract Some humans thrive whereas others resign when exposed to threatening situations throughout life. Social support has been identified as an important modulator of these discrepancies in human behaviour, and other social animals also exhibit phenomena in which individuals recover better from aversive events when conspecifics are present - aka social buffering. Here we studied social buffering in zebrafish, by exposing focal fish to an aversive stimulus (alarm substance - AS) either in the absence or presence of conspecific cues. When exposed to AS in the presence of both olfactory (shoal water) and visual (sight of shoal) conspecific cues, focal fish exhibited a lower fear response than when tested alone, demonstrating social buffering in zebrafish. When separately testing each cue's effectiveness, we verified that the visual cue was more effective than the olfactory in reducing freezing in a persistent threat scenario. Finally, we verified that social buffering was independent of shoal size and coincided with a distinct pattern of co-activation of brain regions known to be involved in mammalian social buffering. Thus, this study suggests a shared evolutionary origin for social buffering in vertebrates, bringing new evidence on the behavioural, sensory and neural mechanisms underlying this phenomenon.
    MeSH term(s) Animals ; Conditioning, Classical/physiology ; Fear/physiology ; Freezing Reaction, Cataleptic/physiology ; Male ; Social Environment ; Video Recording ; Zebrafish/physiology
    Language English
    Publishing date 2017-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep44329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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