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  1. Article ; Online: Editorial: Special Issue "Addressing New Therapeutic Strategies Using Models".

    Faustino-Rocha, Ana I / Oliveira, Paula A

    Veterinary sciences

    2023  Volume 10, Issue 3

    Abstract: A disease model displays pathological processes observed in human or animal diseases [ ... ]. ...

    Abstract A disease model displays pathological processes observed in human or animal diseases [...].
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10030230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter to the Editor.

    Murkin, Jake / Faustino-Rocha, Ana I / Oliveira, Paula A

    Comparative medicine

    2023  Volume 73, Issue 2, Page(s) 107

    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2006425-1
    ISSN 2769-819X ; 0023-6764 ; 1532-0820
    ISSN (online) 2769-819X
    ISSN 0023-6764 ; 1532-0820
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 601: Show issues Location:
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  3. Article ; Online: Current views on

    Ferreira, Tiago / Azevedo, Tiago / Silva, Jessica / Faustino-Rocha, Ana I / Oliveira, Paula A

    Expert opinion on drug discovery

    2024  Volume 19, Issue 2, Page(s) 189–207

    Abstract: Introduction: Animal models play a crucial role in breast cancer research, in particular mice and rats, who develop mammary tumors that closely resemble their human counterparts. These models allow the study of mechanisms behind breast carcinogenesis, ... ...

    Abstract Introduction: Animal models play a crucial role in breast cancer research, in particular mice and rats, who develop mammary tumors that closely resemble their human counterparts. These models allow the study of mechanisms behind breast carcinogenesis, as well as the efficacy and safety of new, and potentially more effective and advantageous therapeutic approaches. Understanding the advantages and disadvantages of each model is crucial to select the most appropriate one for the research purpose.
    Area covered: This review provides a concise overview of the animal models available for breast cancer research, discussing the advantages and disadvantages of each one for searching new and more effective approaches to treatments for this type of cancer.
    Expert opinion: Rodent models provide valuable information on the genetic alterations of the disease, the tumor microenvironment, and allow the evaluation of the efficacy of chemotherapeutic agents. However,
    MeSH term(s) Mice ; Rats ; Humans ; Animals ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Disease Models, Animal ; Drug Development ; Tumor Microenvironment
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2023.2293152
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6388: Show issues Location:
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  4. Article: Realistic aspects behind the application of the rat model of chemically-induced mammary cancer: Practical guidelines to obtain the best results.

    Silva, Jéssica / Faustino-Rocha, Ana I / Duarte, José Alberto / Oliveira, Paula A

    Veterinary world

    2023  Volume 16, Issue 6, Page(s) 1222–1230

    Abstract: Cancer is one of the most important public health problems worldwide. Despite the great contribution ... ...

    Abstract Cancer is one of the most important public health problems worldwide. Despite the great contribution of
    Language English
    Publishing date 2023-06-05
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2456277-4
    ISSN 2231-0916 ; 0972-8988
    ISSN (online) 2231-0916
    ISSN 0972-8988
    DOI 10.14202/vetworld.2023.1222-1230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Equine influenza: a comprehensive review from etiology to treatment.

    Dionísio, Luís / Medeiros, Francisco / Pequito, Manuel / Faustino-Rocha, Ana I

    Animal health research reviews

    2021  Volume 22, Issue 1, Page(s) 56–71

    Abstract: Influenza is an extremely contagious respiratory disease, which predominantly affects the upper respiratory tract. There are four types of influenza virus, and pigs and chickens are considered two key reservoirs of this virus. Equine influenza (EI) virus ...

    Abstract Influenza is an extremely contagious respiratory disease, which predominantly affects the upper respiratory tract. There are four types of influenza virus, and pigs and chickens are considered two key reservoirs of this virus. Equine influenza (EI) virus was first identified in horses in 1956, in Prague. The influenza A viruses responsible for EI are H7N7 and H3N8. Outbreaks of EI are characterized by their visible and rapid spread, and it has been possible to isolate and characterize H3N8 outbreaks in several countries. The clinical diagnosis of this disease is based on the clinical signs presented by the infected animals, which can be confirmed by performing complementary diagnostic tests. In the diagnosis of EI, in the field, rapid antigen detection tests can be used for a first approach. Treatment is based on the management of the disease and rest for the animal. Regarding the prognosis, it will depend on several factors, such as the animal's vaccination status. One of the important points in this disease is its prevention, which can be done through vaccination. In addition to decreasing the severity of clinical signs and morbidity during outbreaks, vaccination ensures immunity for the animals, reducing the economic impact of this disease.
    MeSH term(s) Animals ; Disease Outbreaks/prevention & control ; Disease Outbreaks/veterinary ; Horse Diseases/epidemiology ; Horse Diseases/prevention & control ; Horses ; Humans ; Influenza A Virus, H3N8 Subtype ; Influenza A Virus, H7N7 Subtype ; Influenza, Human ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/prevention & control ; Orthomyxoviridae Infections/veterinary
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2072117-1
    ISSN 1475-2654 ; 1466-2523
    ISSN (online) 1475-2654
    ISSN 1466-2523
    DOI 10.1017/S1466252321000050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Animal Models in Pharmacology: A Brief History Awarding the Nobel Prizes for Physiology or Medicine.

    Jota Baptista, Catarina V / Faustino-Rocha, Ana I / Oliveira, Paula A

    Pharmacology

    2021  Volume 106, Issue 7-8, Page(s) 356–368

    Abstract: Background: The Nobel Prize of Physiology or Medicine (NPPM) has recognized the work of 222 scientists from different nationalities, from 1901 until 2020. From the total, 186 award researchers used animal models in their projects, and 21 were attributed ...

    Abstract Background: The Nobel Prize of Physiology or Medicine (NPPM) has recognized the work of 222 scientists from different nationalities, from 1901 until 2020. From the total, 186 award researchers used animal models in their projects, and 21 were attributed to scientists and projects directly related to Pharmacology. In the most recent years, genetics is a dominant scientific area, while at the beginning of the 20th century, most of the studies were more related to anatomy, cytology, and physiology.
    Summary: Mammalian models were used in 144 NPPM projects, being rodents the most used group of species. Moreover, 92 researchers included domestic species in their work. The criteria used to choose the species, the number of animals used and the experimental protocol is always debatable and dependent on the scientific area of the study; however, the 3R's principle can be applied to most scientific fields. Independently of the species, the animal model can be classified in different types and criteria, depending on their ecology, genetics, and mode of action. Key-Messages: The use of animal models in NPPM awarded projects, namely in Pharmacology, illustrates their importance, need and benefit to improve scientific knowledge and create solutions. In the future, with the contribute of technology, it might be possible to refine the use of animal models in pharmacology studies.
    MeSH term(s) Animals ; History, 20th Century ; History, 21st Century ; Humans ; Mammals ; Models, Animal ; Nobel Prize ; Pharmacology/history ; Research/history ; Research Design ; Rodentia
    Language English
    Publishing date 2021-05-21
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000516240
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    Zs.A 332: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Canine and feline papillomaviruses: an update.

    Medeiros-Fonseca, Beatriz / Faustino-Rocha, Ana I / Medeiros, Rui / Oliveira, Paula A / Gil da Costa, Rui M

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1174673

    Abstract: Papillomaviruses are small viruses able to cause disease not only in mammalians, but also in birds and reptiles. In recent years, a rising number of papillomaviruses have been identified in dogs and cats, totaling 24 canine papillomavirus (CPV) and six ... ...

    Abstract Papillomaviruses are small viruses able to cause disease not only in mammalians, but also in birds and reptiles. In recent years, a rising number of papillomaviruses have been identified in dogs and cats, totaling 24 canine papillomavirus (CPV) and six feline papillomavirus (FcaPV). The canine and feline papillomaviruses (CPVs and FcaPVs, respectively) are responsible for multiple lesions in these domestic species but the potential pathological relevance of some recently identified types remains to be determined. CPVs are associated with oral papillomatosis, cutaneous papillomas and viral pigmented plaques, and have been rarely associated with the development of oral and cutaneous squamous cell carcinomas in their canine hosts. FcaPVs are associated with oral papillomas, viral plaques, and Bowenoid
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1174673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage

    Neto, Tiago / Faustino-Rocha, Ana I / Gil da Costa, Rui M / Medeiros, Rui / Oliveira, Paula A

    Laboratory animals. 2022 Apr., v. 56, no. 2

    2022  

    Abstract: Oral administration of medication to experimental animals is a cause of significant stress. When coupled to animals who are already under strenuous circumstances due to the disease being modelled, there is a significant risk for increased morbidity and ... ...

    Abstract Oral administration of medication to experimental animals is a cause of significant stress. When coupled to animals who are already under strenuous circumstances due to the disease being modelled, there is a significant risk for increased morbidity and mortality, thus influencing the results. Faced with these constraints, a low-intensity method for oral administration was developed, based solely on the natural behaviour of the animals and minimal conditioning, in which precise doses of medication were administered in a locally available, standard wheat cookie fragment, providing both a palatable vehicle and an absorbent matrix for the medication. Fast administration to large numbers of animals was thus achieved, safeguarding the animals’ welfare and ensuring ease of handling. This method is a promising alternative to oral gavage in pre-clinical drug studies with laboratory mice.
    Keywords absorbents ; cookies ; drugs ; laboratories ; morbidity ; mortality ; oral administration ; risk ; wheat
    Language English
    Dates of publication 2022-04
    Size p. 185-190.
    Publishing place SAGE Publications
    Document type Article
    ZDB-ID 391008-8
    ISSN 1758-1117 ; 0023-6772
    ISSN (online) 1758-1117
    ISSN 0023-6772
    DOI 10.1177/00236772211035250
    Database NAL-Catalogue (AGRICOLA)

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    Zs.B 1951: Show issues Location:
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  9. Article: Equine influenza: a comprehensive review from etiology to treatment

    Dionísio, Luís / Medeiros, Francisco / Pequito, Manuel / Faustino-Rocha, Ana I.

    Animal health research reviews. 2021 June, v. 22, no. 1

    2021  

    Abstract: Influenza is an extremely contagious respiratory disease, which predominantly affects the upper respiratory tract. There are four types of influenza virus, and pigs and chickens are considered two key reservoirs of this virus. Equine influenza (EI) virus ...

    Abstract Influenza is an extremely contagious respiratory disease, which predominantly affects the upper respiratory tract. There are four types of influenza virus, and pigs and chickens are considered two key reservoirs of this virus. Equine influenza (EI) virus was first identified in horses in 1956, in Prague. The influenza A viruses responsible for EI are H7N7 and H3N8. Outbreaks of EI are characterized by their visible and rapid spread, and it has been possible to isolate and characterize H3N8 outbreaks in several countries. The clinical diagnosis of this disease is based on the clinical signs presented by the infected animals, which can be confirmed by performing complementary diagnostic tests. In the diagnosis of EI, in the field, rapid antigen detection tests can be used for a first approach. Treatment is based on the management of the disease and rest for the animal. Regarding the prognosis, it will depend on several factors, such as the animal's vaccination status. One of the important points in this disease is its prevention, which can be done through vaccination. In addition to decreasing the severity of clinical signs and morbidity during outbreaks, vaccination ensures immunity for the animals, reducing the economic impact of this disease.
    Keywords animal health ; antigen detection ; economic impact ; equine influenza ; immunity ; morbidity ; prognosis ; research ; respiratory system ; vaccination ; viruses
    Language English
    Dates of publication 2021-06
    Size p. 56-71.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 2072117-1
    ISSN 1475-2654 ; 1466-2523
    ISSN (online) 1475-2654
    ISSN 1466-2523
    DOI 10.1017/S1466252321000050
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  10. Article: Studying humane endpoints in a rat model of mammary carcinogenesis.

    Faustino-Rocha, Ana I / Ginja, Mário / Ferreira, Rita / Oliveira, Paula A

    Iranian journal of basic medical sciences

    2019  Volume 22, Issue 6, Page(s) 643–649

    Abstract: Objectives: The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats.: Materials and methods: Animals were observed twice a day; all parameters were registered once a ... ...

    Abstract Objectives: The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats.
    Materials and methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/distress during an experimental assay of chemically-induced mammary carcinogenesis in female rats.
    Results: Fourteen animals developed at least one mammary tumor with a diameter >35 mm. No animals exhibited alterations in the remaining parameters that implied their early sacrifice. Statistically significant changes were not observed in the quantitative parameters like the hematocrit and urine specific gravity among groups, not being valuable for the assessment of the health status of animals included in an assay of mammary carcinogenesis for 18 weeks. The remaining humane endpoints seemed to be helpful to monitor the animals' health status.
    Conclusion: The alteration in only one humane endpoint (mammary tumor dimensions) does not imply the animals' sacrifice; the endpoints should be evaluated in conjunction, in order to define the most adequate time in which the animals should be sacrificed.
    Language English
    Publishing date 2019-06-11
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2500485-2
    ISSN 2008-3874 ; 2008-3866
    ISSN (online) 2008-3874
    ISSN 2008-3866
    DOI 10.22038/ijbms.2019.33331.7957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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