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  1. Article ; Online: Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging.

    Fay, Rachael / Holland, Jason P

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 15, Page(s) 4893–4897

    Abstract: Photochemistry provides a wide range of alternative reagents that hold potential for use in bimolecular functionalisation of proteins. Here, we report the synthesis and characterisation of metal ion binding chelates derivatised with disubstituted ... ...

    Abstract Photochemistry provides a wide range of alternative reagents that hold potential for use in bimolecular functionalisation of proteins. Here, we report the synthesis and characterisation of metal ion binding chelates derivatised with disubstituted tetrazoles for the photoradiochemical labelling of monoclonal antibodies (mAbs). The photophysical properties of tetrazoles featuring extended aromatic systems and auxochromic substituents to tune excitation toward longer wavelengths (365 and 395 nm) were studied. Two photoactivatable chelates based on desferrioxamine B (DFO) and the aza-macrocycle NODAGA were functionalised with a tetrazole and developed for protein labelling with
    MeSH term(s) Animals ; Cell Line, Tumor ; Mice ; Molecular Imaging ; Photochemistry ; Positron-Emission Tomography ; Tetrazoles ; Tissue Distribution ; Zirconium
    Chemical Substances Tetrazoles ; 1H-tetrazole (288-94-8) ; Zirconium (C6V6S92N3C)
    Language English
    Publishing date 2021-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202100061
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  2. Book ; Online ; E-Book: The mammalian auditory pathways

    Oliver, Douglas L. / Cant, Nell B. / Fay, Richard R. / Popper, Arthur N.

    synaptic organization and microcircuits

    (Springer handbook of auditory research ; 65)

    2018  

    Author's details Douglas L. Oliver, Nell B. Cant, Richard R. Fay, Arthur N. Popper editors
    Series title Springer handbook of auditory research ; 65
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 267 Seiten)), Illustrationen
    Publisher ASA Press ; Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019718933
    ISBN 978-3-319-71798-2 ; 9783319717968 ; 3-319-71798-7 ; 3319717960
    DOI 10.1007/978-3-319-71798-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Understanding the cochlea

    Manley, Geoffrey A. / Gummer, Anthony W. / Popper, Arthur N. / Fay, Richard R.

    (Springer handbook of auditory research ; 62)

    2017  

    Author's details Geoffrey A. Manley, Anthony W. Gummer, Arthut N. Popper, Richard R. Fay editors
    Series title Springer handbook of auditory research ; 62
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 351 Seiten)), Illustrationen
    Publisher ASA Press ; Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019718972
    ISBN 978-3-319-52073-5 ; 9783319520711 ; 3-319-52073-3 ; 3319520717
    DOI 10.1007/978-3-319-52073-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; E-Book: Vertebrate sound production and acoustic communication

    Suthers, Roderick A. / Fitch, William Tecumseh / Fay, Richard R. / Popper, Arthur N.

    (Springer handbook of auditory research ; 53)

    2016  

    Author's details Roderick A. Suthers, W. Tecumseh Fitch, Richard R. Fay, Arthur N. Popper editors
    Series title Springer handbook of auditory research ; 53
    Collection
    Keywords Medicine ; Neurosciences ; Otorhinolaryngology ; Neurobiology ; Vertebrates
    Subject code 612.8
    Language English
    Size 1 Online-Ressource (xvi, 328 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018996901
    ISBN 978-3-319-27721-9 ; 9783319277196 ; 3-319-27721-9 ; 3319277197
    DOI 10.1007/978-3-319-27721-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book ; Online ; E-Book: Translational research in audiology, neurotology, and the hearing sciences

    Le Prell, Colleen G. / Lobarinas, Edward / Fay, Richard R. / Popper, Arthur N.

    (Springer handbook of auditory research ; 58)

    2016  

    Author's details Colleen G. Le Prell, Edward Lobarinas, Arthur N. Popper, Richard R. Fay editors
    Series title Springer handbook of auditory research ; 58
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 265 Seiten), 24 Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019152384
    ISBN 978-3-319-40848-4 ; 9783319408460 ; 3-319-40848-8 ; 3319408461
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: The Impact of Emerging Bioconjugation Chemistries on Radiopharmaceuticals.

    Fay, Rachael / Holland, Jason P

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2019  Volume 60, Issue 5, Page(s) 587–591

    Abstract: The use of radiolabeled antibodies, immunoglobulin fragments, and other proteins are an increasingly important sector of research for diagnostic imaging and targeted radiotherapy in nuclear medicine. As with all radiopharmaceuticals, efficient ... ...

    Abstract The use of radiolabeled antibodies, immunoglobulin fragments, and other proteins are an increasingly important sector of research for diagnostic imaging and targeted radiotherapy in nuclear medicine. As with all radiopharmaceuticals, efficient radiochemistry is a prerequisite to clinical translation. For proteins, variations in the primary amino acid sequence, the secondary structures, and tertiary folds, as well as differences in the size, charge, polarity, lipophilicity, and the presence of posttranslational modifications, add complexity to the system. The choice of radionuclide or chelate, and its impact on the thermodynamic, kinetic, and metabolic stability of a radiotracer, has attracted much attention but the chemistry by which the radionuclide is conjugated to the protein scaffold is of equal importance. Recently, a wealth of creative advances in protein ligation methods based on chemical, photochemical, and enzyme-mediated processes has emerged. As radiochemists explore alternative bioconjugation strategies, this article considers their potential impact on radiotracer design.
    MeSH term(s) Drug Design ; Radioactive Tracers ; Radiochemistry/methods ; Radiopharmaceuticals/chemistry
    Chemical Substances Radioactive Tracers ; Radiopharmaceuticals
    Language English
    Publishing date 2019-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.118.220806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 328: Show issues

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  7. Article ; Online: Development of an Intraprofessional Scholarship Workgroup: Systematic Process for Creating and Disseminating Nursing Knowledge.

    Fay, Rebecca / Swint, Charlotte / Thrower, Eileen J B

    Nurse educator

    2021  Volume 46, Issue 2, Page(s) 65–68

    MeSH term(s) Fellowships and Scholarships ; Humans ; Nursing Education Research ; Nursing Research
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1034267-9
    ISSN 1538-9855 ; 0363-3624
    ISSN (online) 1538-9855
    ISSN 0363-3624
    DOI 10.1097/NNE.0000000000000880
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The impact of boldness on demographic rates and life-history outcomes in the wandering albatross.

    Van de Walle, Joanie / Sun, Ruijiao / Fay, Rémi / Patrick, Samantha C / Barbraud, Christophe / Delord, Karine / Weimerkirch, Henri / Jenouvrier, Stephanie

    The Journal of animal ecology

    2024  

    Abstract: Differences among individuals within a population are ubiquitous. Those differences are known to affect the entire life cycle with important consequences for all demographic rates and outcomes. One source of among-individual phenotypic variation that has ...

    Abstract Differences among individuals within a population are ubiquitous. Those differences are known to affect the entire life cycle with important consequences for all demographic rates and outcomes. One source of among-individual phenotypic variation that has received little attention from a demographic perspective is animal personality, which is defined as consistent and heritable behavioural differences between individuals. While many studies have shown that individual variation in individual personality can generate individual differences in survival and reproductive rates, the impact of personality on all demographic rates and outcomes remains to be assessed empirically. Here, we used a unique, long-term, dataset coupling demography and personality of wandering albatross (Diomedea exulans) in the Crozet Archipelago and a comprehensive analysis based on a suite of approaches (capture-mark-recapture statistical models, Markov chains models and structured matrix population models). We assessed the effect of boldness on annual demographic rates (survival, breeding probability, breeding success), life-history outcomes (life expectancy, lifetime reproductive outcome, occupancy times), and an integrative demographic outcome (population growth rate). We found that boldness had little impact on female demographic rates, but was very likely associated with lower breeding probabilities in males. By integrating the effects of boldness over the entire life cycle, we found that bolder males had slightly lower lifetime reproductive success compared to shyer males. Indeed, bolder males spent a greater proportion of their lifetime as non-breeders, which suggests longer inter-breeding intervals due to higher reproductive allocation. Our results reveal that the link between boldness and demography is more complex than anticipated by the pace-of-life literature and highlight the importance of considering the entire life cycle with a comprehensive approach when assessing the role of personality on individual performance and demography.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 3024-7
    ISSN 1365-2656 ; 0021-8790
    ISSN (online) 1365-2656
    ISSN 0021-8790
    DOI 10.1111/1365-2656.14077
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  9. Article ; Online: Distinguishing within- from between-individual effects: How to use the within-individual centring method for quadratic patterns.

    Fay, Rémi / Martin, Julien / Plard, Floriane

    The Journal of animal ecology

    2021  Volume 91, Issue 1, Page(s) 8–19

    Abstract: Any average pattern observed at the population level (cross-sectional analysis) may confound two different types of processes: some processes that occur among individuals and others that occur within individuals. Separating within- from among-individual ... ...

    Abstract Any average pattern observed at the population level (cross-sectional analysis) may confound two different types of processes: some processes that occur among individuals and others that occur within individuals. Separating within- from among-individual processes is critical for our understanding of ecological and evolutionary dynamics. The within-individual centring method allows distinguishing within- from among-individual processes and this method has been widely used in ecology to investigate both linear and quadratic patterns. Here we show that two alternative equations could be used for the investigation of quadratic within-individual patterns. We explain the different assumptions and constraints of both equations. Reviewing the literature, we found that mainly one of these two equations has been used in studies investigating quadratic patterns. Yet this equation might not be the most appropriate in all circumstances leading to bias and imprecision. We show that these two alternative equations make different assumptions about the shape of the within-individual pattern. One equation assumes that the within-individual effect is related to an absolute process whereas the other assumes the effect arises from an individual relative process. The choice of using one equation instead of the other should depend upon the biological process investigated. Using simulations, we showed that a mismatch between the assumptions made by the equation used to analyse the data and the biological process investigated might led to flawed inference affecting output of model selection and accuracy of estimates. We stress that the equation used should be chosen carefully. We provide step by step guidelines for choosing an equation when studying quadratic pattern with the within-individual centring approach. We encourage the use of the within-individual centring method, promoting its relevant application for nonlinear relationships.
    MeSH term(s) Animals ; Biological Evolution ; Cross-Sectional Studies
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 3024-7
    ISSN 1365-2656 ; 0021-8790
    ISSN (online) 1365-2656
    ISSN 0021-8790
    DOI 10.1111/1365-2656.13606
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    In stock of ZB MED Bonn / Germany

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  10. Book: The breakdown of capitalism

    Hansen, Fay R

    a history of the idea in Western Marxism, 1883-1983

    (Routledge library editions ; rhe history of economic thought ; volume 4)

    2017  

    Author's details F.R. Hansen
    Series title Routledge library editions
    rhe history of economic thought ; volume 4
    Keywords Capitalism ; Marxian economics
    Language English
    Dates of publication 2017-1985
    Size vi, 174 Seiten, 22 cm
    Publisher Routledge
    Publishing place London
    Document type Book
    Note First published in 1985 by Routledge & Kegan Paul plc
    ISBN 9781138229938 ; 9781315387475 ; 9781315387482 ; 9781315387482 ; 9781315387499 ; 9781315387505 ; 1138229938 ; 1315387476 ; 1315387484 ; 1315387484 ; 1315387492 ; 1315387506
    Database ECONomics Information System

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