Article ; Online: Walnut Kernel Oil and Defatted Extracts Enhance Mesenchymal Stem Cell Stemness and Delay Senescence.
Molecules (Basel, Switzerland)
2023 Volume 28, Issue 17
Abstract: Decreased stemness and increased cellular senescence impair the ability of mesenchymal stem cells (MSCs) to renew themselves, change into different cell types, and contribute to regenerative medicine. There is an urgent need to discover new compounds ... ...
| Abstract | Decreased stemness and increased cellular senescence impair the ability of mesenchymal stem cells (MSCs) to renew themselves, change into different cell types, and contribute to regenerative medicine. There is an urgent need to discover new compounds that can boost MSCs' stemness and delay senescence. Therefore, this study aimed to investigate the impact of walnut kernel oil (WKO) and defatted (WKD) extracts on bone marrow (BM)-MSC stemness and senescence. Premature senescence and inflammation were induced in BM-MSCs using H |
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| MeSH term(s) | Animals ; Rats ; AMP-Activated Protein Kinases ; Antioxidants/pharmacology ; Hydrogen Peroxide ; Juglans ; Sirtuin 1/genetics ; Tumor Suppressor Protein p53 | |||||
| Chemical Substances | AMP-Activated Protein Kinases (EC 2.7.11.31) ; Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Sirtuin 1 (EC 3.5.1.-) ; Tumor Suppressor Protein p53 | |||||
| Language | English | |||||
| Publishing date | 2023-08-28 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1413402-0 | |||||
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 | |||||
| ISSN (online) | 1420-3049 | |||||
| ISSN | 1431-5165 ; 1420-3049 | |||||
| DOI | 10.3390/molecules28176281 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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