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  1. Article ; Online: Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?

    Sweed, Dina / Mohamady, Mohamed / Gouda, Marwa A / Fayed, Yahya / Saied, Sara A / Elhamed, Sara M Abd

    Parasitology research

    2023  Volume 123, Issue 1, Page(s) 22

    Abstract: Echinococcus granulosus (sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non- ... ...

    Abstract Echinococcus granulosus (sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; nevertheless, the mechanism of non-fertile CE cysts remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 + could be related to the induction of non-fertile CE cysts. A total of fifty-eight individuals diagnosed with visceral hydatid cysts were selected, and they were further divided according to cyst fertility into fertile and non-fertile. Immunohistochemistry for CD4, CD8, and GrB was done. According to the results, hydatid cysts are common in adults and have no gender preference. The same clinical and laboratory data were shared by patients with fertile and non-fertile cysts (p = 0.186). GrB expression was not impacted by the fibrous deposition inside the hydatid cyst wall (p = 0.85); however, GrB was significantly correlated with the inflammatory density (p = 0.005). GrB expression was also found to be significantly higher in non-fertile cysts (p = 0.04). GrB expression is positively correlated with CD4 and CD8 expression. In conclusion, the expression of GrB in hydatid cysts may exacerbate the inflammatory response and impede cyst fertility while not affecting the fibrous deposition in the cyst wall.
    MeSH term(s) Animals ; Humans ; Cysts ; Echinococcosis/epidemiology ; Echinococcus ; Echinococcus granulosus/physiology ; Fertility ; Fibrosis ; Granzymes ; Inflammation
    Chemical Substances Granzymes (EC 3.4.21.-) ; GZMB protein, human (EC 3.4.21.-)
    Language English
    Publishing date 2023-12-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-023-08056-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.124: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Lymphoepithelioma-like Hepatocellular Carcinoma: a Case Report and Review of Literature.

    Sweed, Dina / Sultan, Mervat M / Mosbeh, Asmaa / Fayed, Yahya A / Abdelsameea, Eman / Ehsan, Nermine A / Abdel-Rahman, Mohamed H / Waked, Imam

    Journal of gastrointestinal cancer

    2021  Volume 54, Issue 1, Page(s) 275–281

    Abstract: We report a case of hepatic lymphoepithelioma-like carcinoma-hepatocellular carcinoma subtype (LEL-HCC) in a 41-year-old man with chronic hepatitis C virus (HCV) infection. The patient presented with abdominal pain and further assessment revealed a ... ...

    Abstract We report a case of hepatic lymphoepithelioma-like carcinoma-hepatocellular carcinoma subtype (LEL-HCC) in a 41-year-old man with chronic hepatitis C virus (HCV) infection. The patient presented with abdominal pain and further assessment revealed a hypoechoic mass on ultrasonography. Serum alpha-fetoprotein (AFP) was 13·6 ng/dl. The patient was diagnosed as hepatocellular carcinoma based on the established triphasic computed tomography (TCT) diagnostic criteria and he underwent a surgical resection of the mass. Microscopic examination showed sheets and cords of malignant epithelial cells intermixed with heavy lymphoid infiltrate, with more than 100 tumor-infiltrating lymphocytes (TILs) per 10 high-power-field (HPF). Based on immunohistochemical studies, the malignant cells were positive for Hep Par 1 and glypican 3, focally positive for cytokeratin 7 (CK7), and negative for cytokeratin 20 (CK20). TILs were diffusely positive for cluster of differentiation 3 CD3 with an approximately equal CD4/CD8 ratio. The patient was recurrence free at 25 months after surgery, as evident by CT and serum alpha-fetoprotein level. LEL-HCC is a rare variant of HCC with a relatively better prognosis. Exploring the potential for immune modulator-based therapy in this subset of tumors is highly recommended.
    MeSH term(s) Male ; Humans ; Adult ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; alpha-Fetoproteins ; Hepatitis C, Chronic/complications
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2452514-5
    ISSN 1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
    ISSN (online) 1941-6636 ; 1559-0739
    ISSN 1941-6628 ; 1537-3649
    DOI 10.1007/s12029-021-00757-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt.

    Sweed, Dina / Sweed, Enas / Moaz, Inas / Mosbeh, Asmaa / Fayed, Yahya / Elhamed, Sara Mohamed Abd / Sweed, Eman / Macshut, Mahmoud / Abdelsattar, Shimaa / Kilany, Shimaa / Saied, Sara A / Badr, Reda / Abdallah, Mahmoud S / Ehsan, Nermine

    World journal of surgical oncology

    2022  Volume 20, Issue 1, Page(s) 298

    Abstract: Background: Hepatocellular carcinoma (HCC) remains a major health problem despite the emergence of several preventive and therapeutic modalities. HCC has heterogeneous and wide morpho-molecular patterns, resulting in unique clinical and prognostic ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) remains a major health problem despite the emergence of several preventive and therapeutic modalities. HCC has heterogeneous and wide morpho-molecular patterns, resulting in unique clinical and prognostic criteria. Therefore, we aimed to study the clinical and pathological criteria of HCC to update the morpho-molecular classifications and provide a guide to the diagnosis of this disease.
    Methods: Five hundred thirty pathologically analyzed HCC cases were included in this study. The clinical and survival data of these cases were collected.
    Results: Hepatitis C virus is still the dominant cause of HCC in Egypt. Post-direct-acting antiviral agent HCC showed an aggressive course compared to interferon-related HCC. Old age, male gender, elevated alpha-fetoprotein level, tumor size, and background liver were important prognostic parameters. Special HCC variants have characteristic clinical, laboratory, radiological, prognostic, and survival data. Tumor-infiltrating lymphocytes rather than neutrophil-rich HCC have an excellent prognosis.
    Conclusions: HCC is a heterogenous tumor with diverse clinical, pathological, and prognostic parameters. Incorporating the clinicopathological profile per specific subtype is essential in the treatment decision of patients with HCC.
    Trial registration: This was a retrospective study that included 530 HCC cases eligible for analysis. The cases were obtained from the archives of the Pathology Department, during the period between January 2010 and December 2019. Clinical and survival data were collected from the patients' medical records after approval by the institutional review board (IRB No. 246/2021) of Liver National Institute, Menoufia University. The research followed the guidelines outlined in the Declaration of Helsinki and registered on ClinicalTrials.gov (NCT05047146).
    MeSH term(s) Antiviral Agents/therapeutic use ; Carcinoma, Hepatocellular ; Egypt/epidemiology ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferons ; Liver Neoplasms ; Male ; Prognosis ; Retrospective Studies ; alpha-Fetoproteins
    Chemical Substances Antiviral Agents ; alpha-Fetoproteins ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-022-02764-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Post direct acting anti-viral agents associated primary hepatic Castleman's disease: A case report.

    Sweed, Dina / Abdelhalim, Heba / Fayed, Yahya / Mosbeh, Asmaa / Kilany, Shimaa / Ehsan, Nermine / El-Azab, Dina / Shalan, Mai / Helal, Thanaa

    Annals of medicine and surgery (2012)

    2020  Volume 58, Page(s) 37–40

    Abstract: Castleman's disease (CD) is a primary lymphoproliferative disorder of the lymph nodes with rare extra-nodal primary affection.: Presentation of case: Here we present a case of primary hepatic CD associated with hepatocellular carcinoma (HCC).: ... ...

    Abstract Castleman's disease (CD) is a primary lymphoproliferative disorder of the lymph nodes with rare extra-nodal primary affection.
    Presentation of case: Here we present a case of primary hepatic CD associated with hepatocellular carcinoma (HCC).
    Discussion: Sixty-two years old, male received direct-acting antiviral agents (DAAs) for HCV infection. Follow up revealed sustained virologic response; however, three hepatic focal lesions were accidently discovered. Triphasic CT confirmed the HCC nature of two masses while the other mass remained undiagnosed. Surgical intervention was the treatment of choice, and pathological examination showed a fairly circumscribed mass formed of angiolymphoid hyperplasia displayed atrophic germinal center, expanded mantle zone, and variable hyalinization. The radiological evaluation of lymph nodes was unremarkable. The patient is 40 months alive after resection, with no further management advised.
    Conclusion: The immune-modulatory effect of DAAs may induce hepatic CD development in a cirrhotic patient, necessitating further studies. A new radiologic finding was observed in the present case in the form of vessels traversing through the lesion with no attenuation or occlusion. Pathology remains the gold standard in the diagnosis of CD.
    Language English
    Publishing date 2020-08-23
    Publishing country England
    Document type Case Reports
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2020.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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