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  1. Book ; Online ; E-Book: Integrative approaches in environmental health and exposome research

    Giroux, Élodie / Merlin, Francesca / Fayet, Yohan

    epistemological and practical issues

    2023  

    Author's details Élodie Giroux, Francesca Merlin, Yohan Fayet, editors
    Language English
    Size 1 Online-Ressource (xvii, 271 Seiten), Illustrationen
    Publisher Springer International Publishing AG
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030349550
    ISBN 978-3-031-28432-8 ; 9783031284311 ; 3-031-28432-1 ; 3031284313
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: L’Exposome - Tensions entre holisme et réductionnisme.

    Giroux, Élodie / Fayet, Yohan / Serviant-Fine, Thibaut

    Medecine sciences : M/S

    2021  Volume 37, Issue 8-9, Page(s) 774–778

    Abstract: In a post-genomics context, the concept of the exposome was introduced by Christopher Wild to advance a unified approach of exposures and consolidate different disciplinary fields of environmental health research. The exposome approach is characterized ... ...

    Title translation The exposome: Tensions between holism and reductionism.
    Abstract In a post-genomics context, the concept of the exposome was introduced by Christopher Wild to advance a unified approach of exposures and consolidate different disciplinary fields of environmental health research. The exposome approach is characterized by the will to develop an integrative, longitudinal and more precise analysis of exposures, through the identification of biomarkers. The application of this plastic concept constitutes a privileged field of exploration of current issues and tensions, notably between holism and reductionism. This article analyses this concept and the associated promises. Improving the integration of biological, environmental and social data, the exposome concept supports practical interactions in the field of environmental health research and the advent of novel crosswise concepts to understand aetiology, such as 'embodiment' or 'sociomarkers'.
    MeSH term(s) Causality ; Environmental Exposure/analysis ; Environmental Health ; Exposome ; Genomics ; Humans
    Language French
    Publishing date 2021-09-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: La RCP-SHS : un dispositif à l’interface de la recherche et du soin.

    Fayet, Yohan / Chanel, Emilie / Roussel, Rémi / Besle, Sylvain / Christophe, Véronique

    Bulletin du cancer

    2022  Volume 110, Issue 1, Page(s) 136–137

    Title translation The RCP-SHS: A device at the interface of research and care.
    Language French
    Publishing date 2022-11-10
    Publishing country France
    Document type Letter
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2022.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Beyond the map: evidencing the spatial dimension of health inequalities.

    Fayet, Yohan / Praud, Delphine / Fervers, Béatrice / Ray-Coquard, Isabelle / Blay, Jean-Yves / Ducimetiere, Françoise / Fagherazzi, Guy / Faure, Elodie

    International journal of health geographics

    2021  Volume 20, Issue 1, Page(s) 1

    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Published Erratum
    ISSN 1476-072X
    ISSN (online) 1476-072X
    DOI 10.1186/s12942-020-00255-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Beyond the map

    Fayet Yohan / Praud Delphine / Fervers Béatrice / Ray-Coquard Isabelle / Blay Jean-Yves / Ducimetiere Françoise / Fagherazzi Guy / Faure Elodie

    International Journal of Health Geographics, Vol 19, Iss 1, Pp 1-

    evidencing the spatial dimension of health inequalities

    2020  Volume 11

    Abstract: Abstract Background Spatial inequalities in health result from different exposures to health risk factors according to the features of geographical contexts, in terms of physical environment, social deprivation, and health care accessibility. Using a ... ...

    Abstract Abstract Background Spatial inequalities in health result from different exposures to health risk factors according to the features of geographical contexts, in terms of physical environment, social deprivation, and health care accessibility. Using a common geographical referential, which combines indices measuring these contextual features, could improve the comparability of studies and the understanding of the spatial dimension of health inequalities. Methods We developed the Geographical Classification for Health studies (GeoClasH) to distinguish French municipalities according to their ability to influence health outcomes. Ten contextual scores measuring physical and social environment as well as spatial accessibility of health care have been computed and combined to classify French municipalities through a K-means clustering. Age-standardized mortality rates according to the clusters of this classification have been calculated to assess its effectiveness. Results Significant lower mortality rates compared to the mainland France population were found in the Wealthy Metropolitan Areas (SMR = 0.868, 95% CI 0.863–0.873) and in the Residential Outskirts (SMR = 0.971, 95% CI 0.964–0.978), while significant excess mortality were found for Precarious Population Districts (SMR = 1.037, 95% CI 1.035–1.039), Agricultural and Industrial Plains (SMR = 1.066, 95% CI 1.063–1.070) and Rural Margins (SMR = 1.042, 95% CI 1.037–1.047). Conclusions Our results evidence the comprehensive contribution of the geographical context in the constitution of health inequalities. To our knowledge, GeoClasH is the first nationwide classification that combines social, environmental and health care access scores at the municipality scale. It can therefore be used as a proxy to assess the geographical context of the individuals in public health studies.
    Keywords Health inequalities ; Environment ; Social deprivation ; Health care access ; Geography ; Public health ; Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 910
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Beyond the map: evidencing the spatial dimension of health inequalities.

    Fayet, Yohan / Praud, Delphine / Fervers, Béatrice / Ray-Coquard, Isabelle / Blay, Jean-Yves / Ducimetiere, Françoise / Fagherazzi, Guy / Faure, Elodie

    International journal of health geographics

    2020  Volume 19, Issue 1, Page(s) 46

    Abstract: Background: Spatial inequalities in health result from different exposures to health risk factors according to the features of geographical contexts, in terms of physical environment, social deprivation, and health care accessibility. Using a common ... ...

    Abstract Background: Spatial inequalities in health result from different exposures to health risk factors according to the features of geographical contexts, in terms of physical environment, social deprivation, and health care accessibility. Using a common geographical referential, which combines indices measuring these contextual features, could improve the comparability of studies and the understanding of the spatial dimension of health inequalities.
    Methods: We developed the Geographical Classification for Health studies (GeoClasH) to distinguish French municipalities according to their ability to influence health outcomes. Ten contextual scores measuring physical and social environment as well as spatial accessibility of health care have been computed and combined to classify French municipalities through a K-means clustering. Age-standardized mortality rates according to the clusters of this classification have been calculated to assess its effectiveness.
    Results: Significant lower mortality rates compared to the mainland France population were found in the Wealthy Metropolitan Areas (SMR = 0.868, 95% CI 0.863-0.873) and in the Residential Outskirts (SMR = 0.971, 95% CI 0.964-0.978), while significant excess mortality were found for Precarious Population Districts (SMR = 1.037, 95% CI 1.035-1.039), Agricultural and Industrial Plains (SMR = 1.066, 95% CI 1.063-1.070) and Rural Margins (SMR = 1.042, 95% CI 1.037-1.047).
    Conclusions: Our results evidence the comprehensive contribution of the geographical context in the constitution of health inequalities. To our knowledge, GeoClasH is the first nationwide classification that combines social, environmental and health care access scores at the municipality scale. It can therefore be used as a proxy to assess the geographical context of the individuals in public health studies.
    MeSH term(s) Cities ; France/epidemiology ; Health Status Disparities ; Humans ; Risk Factors ; Rural Population ; Socioeconomic Factors
    Language English
    Publishing date 2020-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1476-072X
    ISSN (online) 1476-072X
    DOI 10.1186/s12942-020-00242-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Structural and Socio-Spatial Determinants Influencing Care and Survival of Patients with a Pancreatic Adenocarcinoma: Results of the PANDAURA Cohort.

    Roth, Gaël S / Fayet, Yohan / Benmameche-Medjahed, Sakina / Ducimetière, Françoise / Charreton, Amandine / Cropet, Claire / Chabaud, Sylvie / Marion-Audibert, Anne-Marie / Berthelet, Olivier / Walter, Thomas / Adham, Mustapha / Baconnier, Mathieu / Tavan, David / Williet, Nicolas / Artru, Pascal / Huet-Penz, Floriane / Ray-Coquard, Isabelle / Farsi, Fadila / Labrosse, Hélène /
    de la Fouchardière, Christelle

    Cancers

    2022  Volume 14, Issue 21

    Abstract: Background and aims: Pancreatic cancer is highly lethal and often diagnosed at an advanced stage. This cohort study analyzes the impact of care pathways, delays, and socio-spatial determinants on pancreatic cancer patients’ diagnosis, treatment, and ... ...

    Abstract Background and aims: Pancreatic cancer is highly lethal and often diagnosed at an advanced stage. This cohort study analyzes the impact of care pathways, delays, and socio-spatial determinants on pancreatic cancer patients’ diagnosis, treatment, and prognosis. Method: Patients with pancreatic adenocarcinoma newly diagnosed at all stages between January and June 2016 in the AuRA French region were included. The influence on survival of delays of care, healthcare centers’ expertise, and socio-spatial determinants was evaluated. Results: Here, 538 patients were included in 76 centers including 116 patients (21.8%) with resectable, 64 (12.0%) borderline-resectable, 147 (27.6%) locally-advanced tumors, and 205 (38.5%) with metastatic disease. A delay between first symptoms and CT scans did not statistically influence overall survival (OS). In resected patients, OS was significantly higher in centers with more than 20 surgeries (HR<5 surgeries/year = 2.236 and HR5-20 surgeries/year = 1.215 versus centers with > 20 surgeries/year p = 0.0081). Regarding socio-spatial determinants, patients living in municipalities with greater access to a general practitioner (HR = 1.673, p = 0.0153) or with a population density below 795.1 people/km2 (HR = 1.881, p = 0.0057) were significantly more often resectable. Conclusion: This cohort study supports the pivotal role of general practitioner in cancer care and the importance of the centralization of pancreatic surgery to optimize pancreatic cancer patients’ care and outcomes. However, delays of care did not impact patient survival.
    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215413
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  8. Article: Management of Patients with Pancreatic Ductal Adenocarcinoma in the Real-Life Setting: Lessons from the French National Hospital Database.

    de la Fouchardière, Christelle / Adham, Mustapha / Marion-Audibert, Anne-Marie / Duclos, Antoine / Darcha, Claude / Berthelet, Olivier / Hervieu, Valérie / Artru, Pascal / Labrosse, Hélène / Fayet, Yohan / Ferroud-Plattet, Bruno / Aublet-Cuvellier, Bruno / Chambon, Georges / Baconnier, Mathieu / Rebischung, Christine / Farsi, Fadila / Ray-Coquard, Isabelle / Mastier, Charles / Ternamian, Pierre-Jean /
    Williet, Nicolas / Buc, Emmanuel / Walter, Thomas / Herr, Andrée-Laure

    Cancers

    2021  Volume 13, Issue 14

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a major public health challenge, and faces disparities and delays in the diagnosis and access to care. Our purposes were to describe the medical path of PDAC patients in the real-life setting and evaluate ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a major public health challenge, and faces disparities and delays in the diagnosis and access to care. Our purposes were to describe the medical path of PDAC patients in the real-life setting and evaluate the overall survival at 1 year. We used the national hospital discharge summaries database system to analyze the management of patients with newly diagnosed PDAC over the year 2016 in Auvergne-Rhône-Alpes region (AuRA) (France). A total of 1872 patients met inclusion criteria corresponding to an incidence of 22.6 per 100,000 person-year. Within the follow-up period, 353 (18.9%) were operated with a curative intent, 743 (39.7%) underwent chemo- and/or radiotherapy, and 776 (41.4%) did not receive any of these treatments. Less than half of patients were operated in a high-volume center, defined by more than 20 PDAC resections performed annually, mainly university hospitals. The 1-year survival rate was 47% in the overall population. This study highlights that a significant number of patients with PDAC are still operated in low-volume centers or do not receive any specific oncological treatment. A detailed analysis of the medical pathways is necessary in order to identify the medical and territorial determinants and their impact on the patient's outcome.
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13143515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Geographical Accessibility of the Referral Networks in France. Intermediate Results from the IGéAS Research Program.

    Fayet, Yohan / Coindre, Jean-Michel / Dalban, Cécile / Gouin, François / De Pinieux, Gonzague / Farsi, Fadila / Ducimetière, Françoise / Chemin-Airiau, Claire / Jean-Denis, Myriam / Chabaud, Sylvie / Blay, Jean-Yves / Ray-Coquard, Isabelle

    International journal of environmental research and public health

    2018  Volume 15, Issue 10

    Abstract: Rare cancer patients face lower survival and experience delays in diagnosis and therapeutic mismanagement. Considering the specificities of rare cancers, referral networks have been implemented in France to improve the management and survival of patients. ...

    Abstract Rare cancer patients face lower survival and experience delays in diagnosis and therapeutic mismanagement. Considering the specificities of rare cancers, referral networks have been implemented in France to improve the management and survival of patients. The IGéAS research program aims to assess the networks' ability to reduce inequalities. Data analysis of the IGéAS cohort (
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; France ; Geography ; Health Services Accessibility ; Humans ; Infant ; Infant, Newborn ; Male ; Medical Oncology ; Middle Aged ; Referral and Consultation ; Sarcoma/therapy ; Socioeconomic Factors ; Specialization ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2018-10-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph15102204
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  10. Article ; Online: Compliance to regional recommendations for molecular analyses and management of advanced lung cancer patients.

    Swalduz, Aurélie / Souquet, Pierre-Jean / Pérol, Maurice / Moro-Sibilot, Denis / Schiffler, Camille / Chabaud, Sylvie / Fayet, Yohan / Rogasik, Muriel / Labrosse, Hélène / Farsi, Fadila / Brun, Philippe / Decroisette, Chantal / Bombaron, Pierre / Bringuier, Pierre-Paul / Haddad, Véronique / Forest, Fabien / Peoc'h, Michel / Lantuejoul, Sylvie / de Fraipont, Florence /
    Ray-Coquard, Isabelle / Fournel, Pierre

    Future oncology (London, England)

    2019  Volume 15, Issue 18, Page(s) 2139–2149

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Carcinoma, Non-Small-Cell Lung/etiology ; Carcinoma, Non-Small-Cell Lung/therapy ; Clinical Audit ; Disease Management ; Female ; France ; Genes, erbB-1 ; Geography ; Guideline Adherence ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Molecular Targeted Therapy ; Mutation ; Neoplasm Metastasis ; Neoplasm Staging ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Retrospective Studies ; Survival Analysis
    Chemical Substances Biomarkers, Tumor ; Protein Kinase Inhibitors
    Language English
    Publishing date 2019-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2018-0943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6478: Show issues Location:
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