LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 481

Search options

  1. Article ; Online: Permeability evolution of Bentheim Sandstone at simulated georeservoir conditions.

    Fazio, Marco / Chandler, Michael R / Sauter, Martin

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16171

    Abstract: Bentheim Sandstone is considered a suitable conventional georeservoir rock even at great depth because of its mineral composition, homogeneity, micro- and macrostructure, and is also used as a reference material in rock deformation tests. However, a full ...

    Abstract Bentheim Sandstone is considered a suitable conventional georeservoir rock even at great depth because of its mineral composition, homogeneity, micro- and macrostructure, and is also used as a reference material in rock deformation tests. However, a full characterization of the permeability at representative depths has never been performed. Here we report new experimental data where the permeability of Bentheim Sandstone is measured both with a simultaneous variation and with a sequential variation of three different variables to simulate georeservoir conditions. The results indicate a decrease in permeability with simulated increasing depth until 2-3 km, followed by a partial permeability recovery until 4-5 km depth. During the exhumation path, initially, permeability is unaffected, but at shallow depths, a sharp increase in permeability is observed, likely due to microcracking. These variations are a consequence of a complex interaction between stress, pore pressure and temperature, highlighting the importance of experiments considering all three variables when studying the evolution of permeability at depth. These results will aid with the accurate estimation of permeability at different georeservoir conditions.
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42826-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Accuracy evaluation of orthodontic movements with aligners: a prospective observational study.

    Bilello, G / Fazio, M / Amato, E / Crivello, L / Galvano, A / Currò, G

    Progress in orthodontics

    2022  Volume 23, Issue 1, Page(s) 12

    Abstract: Background: Since their introduction in orthodontics, clear aligners have been appreciated by patients, including adults, for their comfort and low aesthetic impact. Despite the enormous mobilization of financial resources all over the world aimed at ... ...

    Abstract Background: Since their introduction in orthodontics, clear aligners have been appreciated by patients, including adults, for their comfort and low aesthetic impact. Despite the enormous mobilization of financial resources all over the world aimed at producing new product lines, few clinical studies or high-quality evidence have been produced regarding the real effectiveness of such treatment. Given the few limited kinds of research on the subject, this study aims to produce and critically evaluate other data, to establish the concrete reliability of clear aligners in orthodontic therapy.
    Results: Significant sample sizes were obtained for intrusion, vestibulo/lingual (V/L) crown tipping, and rotation. The overall accuracy for rotation resulted in 86%, ranging from 96% for maxillary central incisors to 70.4% for mandibular first premolars. The intrusion was registered only for anterior teeth; mean predictability was 92%, with the worst result being 86.7% for mandibular canines and the best being 98% for mandibular central incisors. V/L tipping was the most accurate movement: 93.1% of the prescribed movement was completed. Maxillary central incisors showed the lowest accuracy (80.7%), while mandibular central incisors were the highest (97.5%).
    Conclusions: The present study provided reassuring data in support of the accuracy of the Invisalign
    MeSH term(s) Cuspid ; Humans ; Incisor ; Orthodontic Appliance Design ; Orthodontic Appliances, Removable ; Reproducibility of Results ; Tooth Movement Techniques/methods
    Language English
    Publishing date 2022-04-11
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 2040711-7
    ISSN 2196-1042 ; 1600-9975 ; 1723-7785 ; 1399-7513
    ISSN (online) 2196-1042 ; 1600-9975
    ISSN 1723-7785 ; 1399-7513
    DOI 10.1186/s40510-022-00406-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Safety and efficacy of Levorag emulgel in the treatment of anal fissures using a validated scoring system.

    Tomasicchio, G / Dezi, A / Picciariello, A / Altomare, D F / Giove, C / Martines, G / De Fazio, M / Rinaldi, M

    Frontiers in surgery

    2023  Volume 10, Page(s) 1145170

    Abstract: Introduction: Anal fissure is one of the most common anal disease characterized by intense anal pain, and deterioration of patients quality of life. Treatment is mainly based on the topical administration of calcium antagonist or nitric oxide ointments, ...

    Abstract Introduction: Anal fissure is one of the most common anal disease characterized by intense anal pain, and deterioration of patients quality of life. Treatment is mainly based on the topical administration of calcium antagonist or nitric oxide ointments, and in cases refractory to medical treatment patients can undergo surgery. This study aims to assess the efficacy and safety of Levorag emulgel in the treatment of acute and chronic fissures using of a validated scoring system.
    Material and methods: A prospective observational study was carried out on patients with anal fissures between February and May 2022. The efficacy of the treatment was evaluated using the REALISE score, a new validated scoring system that rates VAS for pain, NSAID use, pain duration, bleeding, and quality of life (QoL), recorded after 10, 20 and 30 days from the beginning of treatment.
    Results: Forty patients (median age 46 years, IQR 29-57, 70% women) with acute (22, 55%) or chronic (18, 45%) anal fissures entered the study. The median anal pain score according to the VAS scale decreased significantly from 7 (IQR 4.7-8) at baseline to 1 (IQR 0-3.2,
    Conclusion: The use of Levorag® Emulgel may represent a safe and effective non-invasive first line treatment in patients affected by acute or chronic anal fissure.
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1145170
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: The management of low trans-sphincteric anal fistula during the COVID-19 pandemic: revisiting the role of the seton.

    Tomasicchio, G / Giove, C / Dezi, A / Picciariello, A / Lantone, V / Martines, G / De Fazio, M / Rinaldi, M

    Updates in surgery

    2023  Volume 76, Issue 1, Page(s) 163–167

    Abstract: The management of trans-sphincteric anal fistula (TAF) includes several surgical options; however, during the COVID-19 pandemic, the access to the operating rooms was severely limited, leaving only the choice of minimally invasive procedures. This study ... ...

    Abstract The management of trans-sphincteric anal fistula (TAF) includes several surgical options; however, during the COVID-19 pandemic, the access to the operating rooms was severely limited, leaving only the choice of minimally invasive procedures. This study aimed to evaluate the safety and effectiveness of the slow cutting seton technique for TAF performed in an outpatient setting during the COVID-19 pandemic.Patients treated for TAF between January 2020 and July 2022 and followed-up for at least 12 months were retrospectively evaluated. A vascular silicone tie used as seton was positioned in the fistula tract using a Lockhart-Mummery fistula probe. The seton was maintained in moderate tension until the sphincter muscle was passed. Percentage and time for healing, recurrence, SF-36, VAS and Vaizey's Score were recorded.Fifty-eight patients [36 male/22 female, median age 56.5 years (IQR 41.25-65.75) [with TAF were included. After a median time of 4 months, complete healing occurred in 53 cases (91.5%), the anal pain VAS decreased from 6 to 0, the anal incontinence scores did not change significantly and the QoL improved significantly in all the SF36 domains. No complications were recorded, but the fistula recurred in five cases (8.5%). Two of them had additional seton treatment, and three underwent other surgical procedures after the COVID-19 emergency.The slow cutting seton technique is a safe and effective treatment for outpatient procedure with minimal patient discomfort. This treatment option in healthcare delivery for TAF should be reconsidered, even outside the limited in-hospital access during the COVID-19 pandemic.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Quality of Life ; Pandemics ; COVID-19 ; Treatment Outcome ; Rectal Fistula/surgery ; Anal Canal/surgery
    Language English
    Publishing date 2023-12-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01713-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Ageing with sacral nerve modulation for fecal incontinence: how many patients get benefit after more than 10 years?

    Picciariello, A / Rinaldi, M / Dibra, R / Trigiante, G / Tomasicchio, G / Lantone, G / De Fazio, M

    Updates in surgery

    2022  Volume 74, Issue 1, Page(s) 185–191

    Abstract: Sacral nerve modulation (SNM) has represented a major advancement in the minimally invasive management of patients with fecal incontinence (FI). Although the success rate in the short-medium term has widely been demonstrated, the very long-term outcomes ... ...

    Abstract Sacral nerve modulation (SNM) has represented a major advancement in the minimally invasive management of patients with fecal incontinence (FI). Although the success rate in the short-medium term has widely been demonstrated, the very long-term outcomes are poorly investigated. This study aims to assess the effectiveness of SNM in a cohort of patients with a follow-up longer than 10 years. Clinical records of patients submitted to SNM for FI in our tertiary referral colorectal Unit between 1998 and 2010 were retrospectively reviewed looking for status of the implantable pulse generator (IPG), follow-up duration, severity of FI by the St Marks' score and quality of life. 58 patients fulfilled the entry criteria and 36 (58%, median follow-up, 12 years) accepted to take part to the telephone interview, while 22 (38%) were lost to the follow-up. Nineteen patients had their IPG removed (Group A) while 17 (27%) had the SNM still active after a median follow-up of 13 years (Group B). In the group A, the median baseline St Marks' score was 13 and did not change after the IPG removal. In group B, the median baseline St Marks' score was 14, at last IPG substitution, it was of 7 and at the last follow-up dropped to 4. In the group A, the median SF-12 physical and mental scores did not change significantly while they improved significantly in group B. A progressive deterioration of the success rate of SNM with the time has been documented after a very long-term follow-up.
    MeSH term(s) Aging ; Electric Stimulation Therapy ; Electrodes, Implanted ; Fecal Incontinence/therapy ; Humans ; Quality of Life ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-01-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01229-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Haploinsufficiency of PRRT2 Leading to Familial Hemiplegic Migraine in Chromosome 16p11.2 Deletion Syndrome.

    Sen, Kuntal / Genser, Ilyse / DiFazio, Marc / DiSabella, Marc

    Neuropediatrics

    2022  Volume 53, Issue 4, Page(s) 279–282

    Abstract: Microdeletion in the 16p11.2 loci lead to a distinct neurodevelopmental disorder with intellectual disability and autism spectrum disorder in addition to dysmorphia, macrocephaly, and increased body mass index. One of the deleted genes in this region ... ...

    Abstract Microdeletion in the 16p11.2 loci lead to a distinct neurodevelopmental disorder with intellectual disability and autism spectrum disorder in addition to dysmorphia, macrocephaly, and increased body mass index. One of the deleted genes in this region is
    MeSH term(s) Adolescent ; Autism Spectrum Disorder/genetics ; Autistic Disorder ; Chromosome Deletion ; Chromosome Disorders ; Chromosomes ; Chromosomes, Human, Pair 16 ; Dystonia ; Haploinsufficiency/genetics ; Humans ; Intellectual Disability/complications ; Intellectual Disability/genetics ; Ischemic Stroke ; Male ; Membrane Proteins/genetics ; Migraine with Aura/complications ; Migraine with Aura/genetics ; Mutation ; Nerve Tissue Proteins/genetics ; Pedigree
    Chemical Substances Membrane Proteins ; Nerve Tissue Proteins ; PRRT2 protein, human
    Language English
    Publishing date 2022-05-26
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/a-1863-1798
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Artificial intelligence in veterinary diagnostic imaging: A literature review.

    Hennessey, Erin / DiFazio, Matthew / Hennessey, Ryan / Cassel, Nicky

    Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

    2022  

    Abstract: Artificial intelligence in veterinary medicine is an emerging field. Machine learning, a subfield of artificial intelligence, allows computer programs to analyze large imaging datasets and learn to perform tasks relevant to veterinary diagnostic imaging. ...

    Abstract Artificial intelligence in veterinary medicine is an emerging field. Machine learning, a subfield of artificial intelligence, allows computer programs to analyze large imaging datasets and learn to perform tasks relevant to veterinary diagnostic imaging. This review summarizes the small, yet growing body of artificial intelligence literature in veterinary imaging, provides necessary background to understand these papers, and provides author commentary on the state of the field. To date, less than 40 peer-reviewed publications have utilized machine learning to perform imaging-associated tasks across multiple anatomic regions in veterinary clinical and biomedical research. Major challenges in this field include collection and cleaning of sufficient image data, selection of high-quality ground truth labels, formation of relationships between veterinary and machine learning professionals, and closure of the gap between academic uses of artificial intelligence and currently available commercial products. Further development of artificial intelligence has the potential to help meet the growing need for radiological services through applications in workflow, quality control, and image interpretation for both general practitioners and radiologists.
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2142058-0
    ISSN 1740-8261 ; 1058-8183
    ISSN (online) 1740-8261
    ISSN 1058-8183
    DOI 10.1111/vru.13163
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Isolated Unilateral Ptosis in a 5-year-old Boy.

    Markow, Mary Ball / Ren, Dennis / Andrews, Alex / DiFazio, Marc

    Pediatrics in review

    2022  Volume 43, Issue 12, Page(s) 721–723

    MeSH term(s) Child, Preschool ; Humans ; Male ; Eyelid Diseases
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2020-004176
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Automated chemotherapy compounding: Process optimization for the preparation of admixture containing high-dose of cyclophosphamide.

    Perego, Gianluca / Longobardo, Giorgia / Baldisserotto, Anna / Feliciani, Matteo / Fazio, Maria

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2022  , Page(s) 10781552221130012

    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/10781552221130012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: FAM19A4 and hsa-miR124-2 Double Methylation as Screening for ASC-H- and CIN1 HPV-Positive Women.

    Peronace, Cinzia / Cione, Erika / Abrego-Guandique, Diana Marisol / Fazio, Marco De / Panduri, Giuseppina / Caroleo, Maria Cristina / Cannataro, Roberto / Minchella, Pasquale

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: The DNA methylation levels of host cell genes increase with the severity of the cervical intraepithelial neoplasia (CIN) grade and are very high in cervical cancer. Our study aims to evaluate FAM19A4 and hsa-miR124-2 methylation in Atypical Squamous ... ...

    Abstract The DNA methylation levels of host cell genes increase with the severity of the cervical intraepithelial neoplasia (CIN) grade and are very high in cervical cancer. Our study aims to evaluate FAM19A4 and hsa-miR124-2 methylation in Atypical Squamous cells with high-grade squamous intraepithelial lesions (ASC-H) and in CIN1, defined as low-grade squamous intraepithelial lesions (LSILs) by the Bethesda classification, as possible early warning biomarkers for managing women with high-risk HPV infections (hrHPV). FAM19A4 and hsa-miR124-2 methylation tests were conducted on fifty-six cervical screening samples from a subset of women aged 30-64 years old. Specimens were collected into ThinPrep PreservCyt Solution. Their HrHPV genotype and cytology diagnosis were known. A Qiasure (Qiagen) was used for FAM19A4 and hsa-miR124-2 methylation testing on bisulfite-converted DNA, according to the manufacturer's specifications. The reported results were hypermethylation-positive or -negative. We found that FAM194A4 and hsa-miR124-2 methylation was detected in 75% of ASC-H cases with a persistent infection of hrHPV. A total of 60% of CIN1 lesions were found to be positive for methylation, and 83.3% were when the cytology was CIN2/3. In addition, as a novelty of this pilot study, we found that combined FAM19A4 and hsa-miR124-2 methylation positivity rates (both methylated) were associated with the HPV genotypes 16, 18, and 59 and covered 22 and 25% of ASC-H and CIN1 cases, respectively. The methylation of these two genes, in combination with HPV genotyping, can be used as an early warning biomarker in the management and follow-up of women with ASC-H and CIN1 to avoid their progression to cervical cancer.
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040312
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top