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  1. Article ; Online: Copper-catalyzed dehydrogenative cyclization/alkenylation towards dihydroquinolinones.

    Pari, Keerthana / Fazlur-Rahman, Nawaz Khan

    Organic & biomolecular chemistry

    2024  

    Abstract: An efficient copper-catalyzed one-pot sequential synthesis of alkenylated quinolinyl dihydroquinolinones is reported, utilizing ketones, 1,3-cyclohexanediones, and benzyl ... ...

    Abstract An efficient copper-catalyzed one-pot sequential synthesis of alkenylated quinolinyl dihydroquinolinones is reported, utilizing ketones, 1,3-cyclohexanediones, and benzyl alcohols
    Language English
    Publishing date 2024-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d4ob00134f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Choline Chloride-Based Deep Eutectic Systems in Sequential Friedländer Reaction and Palladium-Catalyzed sp3 CH Functionalization of Methyl Ketones

    Chitrala Teja / Fazlur Rahman Nawaz Khan

    ACS Omega, Vol 4, Iss 5, Pp 8046-

    2019  Volume 8055

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Water mediated catalyst-free efficient domino synthesis of 9-(quinolin-2(1H)-one)-xanthene-1,8(5H,9H)-diones using parallel synthesizer

    Krishnakumar, Varadhan / Badal Kumar Mandal / Euh Duck Jeong / Fazlur-Rahman Nawaz Khan

    Tetrahedron letters. 2014 July 02, v. 55, no. 27

    2014  

    Abstract: A facile and efficient method for the preparation of 3,4,6,7-tetrahydro-9-(1,2-dihydro-2-oxoquinolin-3-yl)-2H-xanthene-1,8(5H,9H)-diones from substituted 2-chloro-3-formylquinoline and 1,3-cyclohexanedione or dimedone in water at 90°C using parallel ... ...

    Abstract A facile and efficient method for the preparation of 3,4,6,7-tetrahydro-9-(1,2-dihydro-2-oxoquinolin-3-yl)-2H-xanthene-1,8(5H,9H)-diones from substituted 2-chloro-3-formylquinoline and 1,3-cyclohexanedione or dimedone in water at 90°C using parallel synthesizer is reported. The present methodology offers a tandem-cascade methodology, high yield, and operational simplicity.
    Keywords chemical reactions ; chemical structure ; organic compounds
    Language English
    Dates of publication 2014-0702
    Size p. 3717-3720.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.05.015
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Regioselective synthesis of 3,4,6,7-tetrahydro-3,3-dimethyl-9-phenyl-2H-xanthene-1,8(5H,9H)-diones through ascorbic acid catalyzed three-component domino reaction

    Napoleon, Ayyakannu Arumugam / Euh Duck Jeong / Eun Hyuk Chung / Fazlur-Rahman Nawaz Khan

    Tetrahedron letters. 2014 Oct. 08, v. 55, no. 41

    2014  

    Abstract: An efficient, three-component domino reaction of dimedone 1, aromatic aldehydes (2a–o), and 1,3-cyclohexanedione 1a in the regio-selective synthesis of 3,3-dimethyl-9-phenyl-2H-xanthene-1,8(5H,9H)-diones (3a–o) is reported. The desired product, 3 is ... ...

    Abstract An efficient, three-component domino reaction of dimedone 1, aromatic aldehydes (2a–o), and 1,3-cyclohexanedione 1a in the regio-selective synthesis of 3,3-dimethyl-9-phenyl-2H-xanthene-1,8(5H,9H)-diones (3a–o) is reported. The desired product, 3 is efficiently promoted by ascorbic acid as an organo catalyst.
    Keywords aldehydes ; ascorbic acid ; catalysts ; chemical reactions ; chemical structure ; regioselectivity
    Language English
    Dates of publication 2014-1008
    Size p. 5656-5659.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.08.040
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Efficient one pot multi-component domino Aldol condensation–Michael addition–Suzuki coupling reaction for the highly functionalized quinolines

    Ubba, Eethamukkala / C. Dasaradhan / Euh Duck Jeong / Eun Hyuk Chung / Fazlur-Rahman Nawaz Khan / Y. Suneel Kumar

    Tetrahedron letters. 2015 Aug. 12, v. 56, no. 33

    2015  

    Abstract: A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation–Michael addition–Suzuki coupling approach for a variety of 2,3-disubstituted highly functionalized quinolines. The domino reactions of 2- ... ...

    Abstract A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation–Michael addition–Suzuki coupling approach for a variety of 2,3-disubstituted highly functionalized quinolines. The domino reactions of 2-chloro-3-formylquinolines, 1 acetophenones, 2 and distinctive boronic acids, 3 were carried out utilizing PdCl2(PPh3)2/tripotassium phosphate/ethanol–water system. At 80°C they gave diversified functionalized quinolines in good yields.
    Keywords acetophenones ; boronic acids ; chemical reactions ; chemical structure ; quinolines
    Language English
    Dates of publication 2015-0812
    Size p. 4744-4748.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2015.06.040
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Efficient copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling in the preparation of 3′-hydroxycorfin and gymnopalynes A analogues

    Dasaradhan, Changalaraya / Euh Duck Jeong / Eun Hyuk Chung / Fazlur-Rahman Nawaz Khan / Yadavalli Suneel Kumar

    Tetrahedron letters. 2015 Jan. 01, v. 56, no. 1

    2015  

    Abstract: An efficient method involving copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling strategy for a variety of 3-alkynyl isochromen-1-ones has been developed. Sonogashira coupling in the presence of catalytic system—Pd(OAc)2/Ruphos, Et3N base, and ... ...

    Abstract An efficient method involving copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling strategy for a variety of 3-alkynyl isochromen-1-ones has been developed. Sonogashira coupling in the presence of catalytic system—Pd(OAc)2/Ruphos, Et3N base, and tetrahydrofuran solvent under aqueous and room temperature conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones in excellent yields. The methodology has also been extended toward natural isochromen-1-one–3′-hydroxycorfin and gymnopalynes A analogues.
    Keywords ambient temperature ; chemical reactions ; chemical structure ; solvents ; tetrahydrofuran ; trimethylamine
    Language English
    Dates of publication 2015-0101
    Size p. 187-191.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.11.059
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Efficient and convenient copper-free Pd(OAc)2/Ruphos-catalyzed Sonogashira coupling in the preparation of corfin analogues

    Dasaradhan, Changalaraya / Euh Duck Jeong / Eun Hyuk Chung / Fazlur-Rahman Nawaz Khan / Kamalakannan Prabakaran / Yadavalli Suneel Kumar

    Tetrahedron letters. 2015 Feb. 04, v. 56, no. 6

    2015  

    Abstract: The Sonogashira coupling reaction of 3-chloro-1H-isochromen-1-one and terminal alkynes, in the presence of catalytic system-Pd(OAc)2/Ruphos, Et3N base, and tetrahydrofuran solvent under aqueous conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones ... ...

    Abstract The Sonogashira coupling reaction of 3-chloro-1H-isochromen-1-one and terminal alkynes, in the presence of catalytic system-Pd(OAc)2/Ruphos, Et3N base, and tetrahydrofuran solvent under aqueous conditions, provided novel 3-(alkynyl)-1H-isochromen-1-ones in excellent yields. The methodology has also been extended toward natural isochromen-1-ones—corfin analogues.
    Keywords alkynes ; chemical reactions ; chemical structure ; solvents ; tetrahydrofuran ; trimethylamine
    Language English
    Dates of publication 2015-0204
    Size p. 784-788.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.12.059
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones

    Varadhan Krishnakumar / Kesarla Mohan Kumar / Badal Kumar Mandal / Fazlur-Rahman Nawaz Khan

    The Scientific World Journal, Vol

    2012  Volume 2012

    Abstract: The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C–N bond formation ...

    Abstract The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C–N bond formation from the lactone in the presence of 10 mol% zinc oxide nanoparticles (ZnO NPs) (<150 nm) afforded the desired bis-isoquinolinones in high yield and purity. The synthesized compounds were then characterized using FTIR, 1H NMR, 13C NMR, and HRMS techniques.
    Keywords Technology ; T ; Medicine ; R ; Science ; Q
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Palladium catalyzed Suzuki Miyaura cross coupling of 3-chloroisochromen-1-one: synthesis of glomellin and reticulol analogues

    Kumar, Yadavalli Suneel / Changalaraya Dasaradhan / Euh Duck Jeong / Eun Hyuk Chung / Fazlur-Rahman Nawaz Khan / Kamalakannan Prabakaran / Pitchai Manivel

    Tetrahedron letters. 2015 Feb. 11, v. 56, no. 7

    2015  

    Abstract: A facile protocol has been developed for a series of 3-substituted isochromen-1-ones utilizing Suzuki coupling strategy. The reaction of 3-chloroisochromen-1one, 1 with different boronic acids utilizing PdCl2(PPh3)2-Ruphos catalytic system gave ... ...

    Abstract A facile protocol has been developed for a series of 3-substituted isochromen-1-ones utilizing Suzuki coupling strategy. The reaction of 3-chloroisochromen-1one, 1 with different boronic acids utilizing PdCl2(PPh3)2-Ruphos catalytic system gave diversified 3-substituted isochromen-1-ones in excellent yields. The methodology has been utilized in the synthesis of glomellin and reticulol analogues.
    Keywords boronic acids ; catalytic activity ; chemical structure ; organic compounds ; palladium ; protocols ; Suzuki reaction
    Language English
    Dates of publication 2015-0211
    Size p. 941-945.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2014.12.114
    Database NAL-Catalogue (AGRICOLA)

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