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Article ; Online: Domestic sources of ‘mild’ positions on international cooperation

Federica Genovese

Italian Political Science, Vol 15, Iss

Italy and global climate policy

2020 Volume 1

Abstract: This paper investigates Italy's position on global climate change politics in order to explore the larger question of why this country, like similar middle powers, may adopt ambiguous positions on global public policy issues. I start from the observation ...

Abstract	This paper investigates Italy's position on global climate change politics in order to explore the larger question of why this country, like similar middle powers, may adopt ambiguous positions on global public policy issues. I start from the observation that in recent history Italy has taken a rather mild posi-tion on international climate cooperation and climate policy more broadly. To explain this, I propose an argument in divergence with those who claim Italy has low salience in the issue or lack of interest in international climate leadership. I put forward a political economy perspective and claim that different salient concerns motivate the domestic actors that shape the country’s international position. I main-tain that these different concerns offset each other, resulting in overall mild preferences. I present support for my theory, zooming in on the motivations of two domestic sources of international posi-tions: economic sectors and public opinion. The empirical data largely corroborates the theory.
Keywords	italy ; international cooperation ; climate change ; political economy ; domestic politics ; Political science (General) ; JA1-92 ; Political theory ; JC11-607
Subject code	300
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Università degli Studi di Catania
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Quantifying peripheral modulation of olfaction by trigeminal agonists.

Federica, Genovese / Jiang, Xu / Marco, Tizzano / Johannes, Reisert

bioRxiv : the preprint server for biology

2023

Abstract: In the mammalian nose, two chemosensory systems, the trigeminal and the olfactory mediate the detection of volatile chemicals. Most odorants in fact are able to activate the trigeminal system, and vice versa, most trigeminal agonists activate the ... ...

Abstract	In the mammalian nose, two chemosensory systems, the trigeminal and the olfactory mediate the detection of volatile chemicals. Most odorants in fact are able to activate the trigeminal system, and vice versa, most trigeminal agonists activate the olfactory system as well. Although these two systems constitute two separate sensory modalities, trigeminal activation modulates the neural representation of an odor. The mechanisms behind the modulation of olfactory response by trigeminal activation are still poorly understood. In this study, we addressed this question by looking at the olfactory epithelium, where olfactory sensory neurons and trigeminal sensory fibers co-localize and where the olfactory signal is generated. We characterize the trigeminal activation in response to five different odorants by measuring intracellular Ca
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.13.532477
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: [No title information]

Federica Genovese

Research & Politics, Vol

Religious authority and the Pope in modern international relations

2015 Volume 2

Abstract: Political scientists are increasingly interested in the impact of religious authority on modern politics. However, little attention has been paid to the conditions under which religious leaders are more likely to speak politically. Tackling this question, ...

Abstract	Political scientists are increasingly interested in the impact of religious authority on modern politics. However, little attention has been paid to the conditions under which religious leaders are more likely to speak politically. Tackling this question, this article argues that religious authorities should issue political statements at the outbreak of international crises, when secular institutions are unwilling or incapable of taking clear political positions. I test this argument focusing on the Roman Vatican through a quantitative text analysis of the papal encyclicals from 1958 until today. Latent topic models indicate that political themes systematically emerge in the papal documents and that the timing of the more political encyclicals correlate with years in which international crises break out. The findings have implications for the understanding of the modern relations between state and church and the political mobilization of religion today.
Keywords	Political science ; J
Language	English
Publishing date	2015-10-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases

Alexander L. Reese-Petersen / Federica Genovese / Lei Zhao / Glen Banks / David A. Gordon / Morten A. Karsdal

Frontiers in Molecular Biosciences, Vol

2023 Volume 10

Abstract: Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated ... ...

Abstract	Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated to an increased risk of adverse outcome in heart failure with preserved ejection fraction (HFpEF). Here we show that the stimulation of human cardiac fibroblasts by endotrophin upregulates the synthesis of type I collagen, the main interstitial collagen that accumulates in the myocardium during fibrogenesis. These data provide a possible mechanistic explanation for the relation between circulating endotrophin levels and risk of outcome in HFpEF.
Keywords	fibrosis ; biomarkers ; heart failure ; collagen ; ECM ; extracellular matrix ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy

Michaela Neprasova / Dita Maixnerova / Nadja Sparding / Federica Genovese / Morten Asser Karsdal / Helena Koprivova / Marek Kollar / Miloslav Suchanek / Zdenka Hruskova / Vladimir Tesar

International Journal of Molecular Sciences, Vol 24, Iss 2064, p

2023 Volume 2064

Abstract: We evaluated biomarkers related to kidney fibrosis for the outcome of patients with IgA nephropathy (IgAN). Clinical parameters (estimated glomerular filtration rate, hypertension, proteinuria) and histological findings were assessed in 134 patients with ...

Abstract	We evaluated biomarkers related to kidney fibrosis for the outcome of patients with IgA nephropathy (IgAN). Clinical parameters (estimated glomerular filtration rate, hypertension, proteinuria) and histological findings were assessed in 134 patients with IgAN at the time of diagnosis and followed up prospectively (mean follow-up time, 56.5 months). We measured biomarkers of collagen and laminin turnover in serum and urine collected at the time of kidney biopsy using a novel enzyme-linked immunosorbent assay. Linear discriminant analysis and logistic regression models were used to predict the patient’s kidney outcome. Five serum and urine biomarkers of laminin and collagen turnover (sLG1M, sPRO-C3, sPRO-C6, uPRO-C6/Cr, uC3M/Cr) could significantly differentiae IgAN patients with a worse prognosis. Clinical parameters (glomerular filtration rate (GFR), proteinuria) distinguished patients at risk of IgAN progression with a specificity of 87.3% and a sensitivity of 45.2% (area under the curve-AUC 0.751). The addition of the biomarkers significantly increased the prognostic ability with a specificity of 85.1% and a sensitivity of 73.3% (AUC 0.905). We have identified three serum (sLG1M, sPRO-C3, sPRO-C6) and two urinary markers (uPRO-C6/Cr, u-C3M /Cr) that significantly improve the prognostic ability of markers of kidney function to identify an IgAN patient’s risk of progressing to ESKD.
Keywords	IgA nephropathy ; biomarkers ; PRO-C6 ; PRO-C3 ; LG1M ; C3M ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nitisinone Treatment Affects Biomarkers of Bone and Cartilage Remodelling in Alkaptonuria Patients

Federica Genovese / Peder Frederiksen / Anne-Christine Bay-Jensen / Morten A. Karsdal / Anna M. Milan / Birgitta Olsson / Mattias Rudebeck / James A. Gallagher / Lakshminarayan R. Ranganath

International Journal of Molecular Sciences, Vol 24, Iss 10996, p

2023 Volume 10996

Abstract: Nitisinone has been approved for treatment of alkaptonuria (AKU). Non-invasive biomarkers of joint tissue remodelling could aid in understanding the molecular changes in AKU pathogenesis and how these can be affected by treatment. Serological and urinary ...

Abstract	Nitisinone has been approved for treatment of alkaptonuria (AKU). Non-invasive biomarkers of joint tissue remodelling could aid in understanding the molecular changes in AKU pathogenesis and how these can be affected by treatment. Serological and urinary biomarkers of type I collagen and II collagen in AKU were investigated in patients enrolled in the randomized SONIA 2 (NCT01916382) clinical study at baseline and yearly until the end of the study (Year 4). The trajectories of the biomarkers over time were observed. After treatment with nitisinone, the biomarkers of type I collagen remodelling increased at Year 1 (19% and 40% increase in CTX-I and PRO-C1, respectively), which was potentially reflected in the higher degree of mobility seen following treatment. The biomarkers of type II collagen remodelling decreased over time in the nitisinone group: C2M showed a 9.7% decline at Year 1, and levels then remained stable over the following visits; CTX-II showed a 26% decline at Year 3 and 4 in the nitisinone-treated patients. Nitisinone treatment induced changes in biomarkers of bone and cartilage remodelling. These biomarkers can aid patient management and deepen our knowledge of the molecular mechanisms of this rare disease.
Keywords	alkaptonuria ; biomarkers ; collagen ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria.

Christina Gjerlev Poulsen / Daniel G K Rasmussen / Federica Genovese / Tine W Hansen / Signe Holm Nielsen / Henrik Reinhard / Bernt Johan von Scholten / Peter K Jacobsen / Hans-Henrik Parving / Morten Asser Karsdal / Peter Rossing / Marie Frimodt-Møller

PLoS ONE, Vol 18, Iss 3, p e

2023 Volume 0283296

Abstract: Background Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover of collagen type III is associated with development of kidney fibrosis. We investigated whether a degradation product of collagen type III (C3M) was a ... ...

Abstract	Background Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover of collagen type III is associated with development of kidney fibrosis. We investigated whether a degradation product of collagen type III (C3M) was a risk marker for progression of chronic kidney disease (CKD), occurrence of cardiovascular disease (CVD), and mortality during follow up in people with type 2 diabetes (T2D) and microalbuminuria. Moreover, we investigated whether C3M was correlated with markers of inflammation and endothelial dysfunction at baseline. Methods C3M was measured in serum (sC3M) and urine (uC3M) in 200 participants with T2D and microalbuminuria included in an observational, prospective study at Steno Diabetes Center Copenhagen in Denmark from 2007-2008. Baseline measurements included 12 markers of inflammation and endothelial dysfunction. The endpoints were CVD, mortality, and CKD progression (>30% decline in eGFR). Results Mean (SD) age was 59 (9) years, eGFR 90 (17) ml/min/1.73m2 and median (IQR) urine albumin excretion rate 102 (39-229) mg/24-h. At baseline all markers for inflammation were positively correlated with sC3M (p≤0.034). Some, but not all, markers for endothelial dysfunction were correlated with C3M. Median follow-up ranged from 4.9 to 6.3 years. Higher sC3M was associated with CKD progression (with mortality as competing risk) with a hazard ratio (per doubling) of 2.98 (95% CI: 1.41-6.26; p = 0.004) adjusted for traditional risk factors. uC3M was not associated with CKD progression. Neither sC3M or uC3M were associated with risk of CVD or mortality. Conclusions Higher sC3M was a risk factor for chronic kidney disease progression and was correlated with markers of inflammation.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adipose-derived stromal cells increase the formation of collagens through paracrine and juxtacrine mechanisms in a fibroblast co-culture model utilizing macromolecular crowding

Rebekka Harary Søndergaard / Lisbeth Drozd Højgaard / Alexander Lynge Reese-Petersen / Cecilie Hoeeg / Anders Bruun Mathiasen / Mandana Haack-Sørensen / Bjarke Follin / Federica Genovese / Jens Kastrup / Morten Juhl / Annette Ekblond

Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-

2022 Volume 12

Abstract: Abstract Background Adipose-derived stromal cells (ASCs) possess a multitude of regenerative capabilities, which include immunomodulation, angiogenesis, and stimulation of extracellular matrix (ECM) remodeling. However, the underlying mechanisms leading ... ...

Abstract	Abstract Background Adipose-derived stromal cells (ASCs) possess a multitude of regenerative capabilities, which include immunomodulation, angiogenesis, and stimulation of extracellular matrix (ECM) remodeling. However, the underlying mechanisms leading to ECM remodeling remain largely elusive and highlight the need for functional in vitro models for mode of action studies. Therefore, the purpose of this study was to develop an in vitro co-culture model to investigate the capabilities of ASCs to modulate fibroblasts and ECM. Methods An ECM in vitro model with ASCs and normal human dermal fibroblasts (NHDFs) was established utilizing macromolecular crowding, ascorbic acid, and TGF-β stimulation. Paracrine and juxtacrine co-cultures were created using transwell inserts and cell cultures with direct cell–cell contacts. The cultures were screened using RT2 PCR Profiler Arrays; the protein levels of myofibroblast differentiation marker alpha smooth muscle actin (αSMA) and ECM remodeling enzymes were analyzed using western blot on cell lysates; the formation of collagen type I, III, VI, and fibronectin was investigated using ELISA on culture supernatants; and the deposition of collagens was analyzed using immunocytochemistry. Results TGF-β stimulation of NHDF monocultures increased the expression of 18 transcripts relevant for ECM formation and remodeling, the protein levels of αSMA and matrix metalloproteinase-2 (MMP-2), the formation of collagen type I, III, VI, and fibronectin, and the deposition of collagen type I and VI and decreased the protein levels of MMP-14. Inclusion of ASCs in the ECM co-culture model increased the formation of collagen type I and III through paracrine mechanisms and the formation of collagen type VI through juxtacrine mechanisms. Conclusions The co-culture model provides effective stimulation of NHDF monocultures by TGF-β for enhanced formation and deposition of ECM. In the model, ASCs induce changes in ECM by increasing formation of collagen type I, III and VI. The obtained results could ...
Keywords	Adipose-derived stromal cells ; Extracellular matrix ; Metalloproteinases ; Macromolecular crowding ; Fibroblasts ; Paracrine and juxtacrine co-cultures ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of a Novel Enzyme-Linked Immunosorbent Assay Targeting a Neo-Epitope Generated by Cathepsin-Mediated Turnover of Type III Collagen and Its Application in Chronic Obstructive Pulmonary Disease.

Daniel Guldager Kring Rasmussen / Jannie Marie Bülow Sand / Morten Asser Karsdal / Federica Genovese

PLoS ONE, Vol 12, Iss 1, p e

2017 Volume 0170023

Abstract: A high level of extracellular matrix (ECM) turnover characterizes several lung diseases with fibrotic features. Type III collagen is one of the most abundant collagens in lung parenchyma, and cathepsins play a role in lung pathology, being responsible ... ...

Abstract	A high level of extracellular matrix (ECM) turnover characterizes several lung diseases with fibrotic features. Type III collagen is one of the most abundant collagens in lung parenchyma, and cathepsins play a role in lung pathology, being responsible for tissue remodeling. In this study, we explore the diagnostic features of neo-epitope fragments of type III collagen generated by cathepsins that could reflect the pathological tissue turnover in patients with different diseases. A novel enzyme-linked immunosorbent assay (ELISA) measuring cathepsins B, L, S and K -generated type III collagen fragments (C3C) was developed for assessment in serum and plasma. The assay was biologically validated in serum from patients with chronic obstructive pulmonary disease (COPD). Serological levels of C3C were significantly elevated in patients with COPD compared to healthy controls (p = 0.0006). Levels of C3C in serum and heparin plasma of COPD patients had a highly significant correlation (R2 = 0.86, p<0.0001). The data suggests that the C3C fragment is elevated in patients with COPD compared to healthy controls.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis

Federica Genovese / Zsolt S. Kàrpàti / Signe H. Nielsen / Morten A. Karsdal

Biomarker Insights, Vol 2016, Iss 11, Pp 77-

2016 Volume 84

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2016-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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