LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Federica Piccioni"
  2. AU=Slinin Yelena
  3. AU=Guan Donghui
  4. AU="Petty, W"
  5. AU="Jordi Camps"
  6. AU="Correa, Marcia Cruz"
  7. AU="Sampson, M"
  8. AU=Dugerdil Adeline
  9. AU="Engebretsen, Lars F"
  10. AU="Wong, Edwin W"
  11. AU="Thelakkat, Mukundan"
  12. AU="Morales-Ruiz, Valeria"
  13. AU=Pilotto Andrea AU=Pilotto Andrea
  14. AU="Díaz, Bogar"
  15. AU="Bennett, Christopher P"
  16. AU=Chute Christopher G.
  17. AU="Lemon, Katherine P"
  18. AU="An-Ning Zhang"
  19. AU="Ingerson-Mahar, Joseph"
  20. AU="Marie-Anne Mawhin"
  21. AU=Rizzo J Douglas
  22. AU=Anstey A

Search results

Result 1 - 10 of total 20

Search options

  1. Article ; Online: Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

    Athea Vichas / Amanda K. Riley / Naomi T. Nkinsi / Shriya Kamlapurkar / Phoebe C. R. Parrish / April Lo / Fujiko Duke / Jennifer Chen / Iris Fung / Jacqueline Watson / Matthew Rees / Austin M. Gabel / James D. Thomas / Robert K. Bradley / John K. Lee / Emily M. Hatch / Marina K. Baine / Natasha Rekhtman / Marc Ladanyi /
    Federica Piccioni / Alice H. Berger

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 19

    Abstract: RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased ... ...

    Abstract RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.
    Keywords Science ; Q
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Kendall R. Sanson / Ruth E. Hanna / Mudra Hegde / Katherine F. Donovan / Christine Strand / Meagan E. Sullender / Emma W. Vaimberg / Amy Goodale / David E. Root / Federica Piccioni / John G. Doench

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, ... ...

    Abstract Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, respectively.
    Keywords Science ; Q
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

    Kendall R. Sanson / Ruth E. Hanna / Mudra Hegde / Katherine F. Donovan / Christine Strand / Meagan E. Sullender / Emma W. Vaimberg / Amy Goodale / David E. Root / Federica Piccioni / John G. Doench

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Volume 15

    Abstract: Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, ... ...

    Abstract Genome-wide libraries for CRISPR knockout, interference, and activation have allowed the systemic interrogation of gene function. Here, the authors evaluate the Brunello CRISPRko library and introduce Dolcetto and Calabrese for CRISPRi and CRISPRa, respectively.
    Keywords Science ; Q
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

    Peter G. Miller / Murugappan Sathappa / Jamie A. Moroco / Wei Jiang / Yue Qian / Sumaiya Iqbal / Qi Guo / Andrew O. Giacomelli / Subrata Shaw / Camille Vernier / Besnik Bajrami / Xiaoping Yang / Cerise Raffier / Adam S. Sperling / Christopher J. Gibson / Josephine Kahn / Cyrus Jin / Matthew Ranaghan / Alisha Caliman /
    Merissa Brousseau / Eric S. Fischer / Robert Lintner / Federica Piccioni / Arthur J. Campbell / David E. Root / Colin W. Garvie / Benjamin L. Ebert

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a ... ...

    Abstract In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conformationally inactive state, and explain the distribution of PPM1D activating mutations in cancer.
    Keywords Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

    Carla Eller / Laura Heydmann / Che C. Colpitts / Houssein El Saghire / Federica Piccioni / Frank Jühling / Karim Majzoub / Caroline Pons / Charlotte Bach / Julie Lucifora / Joachim Lupberger / Michael Nassal / Glenn S. Cowley / Naoto Fujiwara / Sen-Yung Hsieh / Yujin Hoshida / Emanuele Felli / Patrick Pessaux / Camille Sureau /
    Catherine Schuster / David E. Root / Eloi R. Verrier / Thomas F. Baumert

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 17

    Abstract: Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a ... ...

    Abstract Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

    Carla Eller / Laura Heydmann / Che C. Colpitts / Houssein El Saghire / Federica Piccioni / Frank Jühling / Karim Majzoub / Caroline Pons / Charlotte Bach / Julie Lucifora / Joachim Lupberger / Michael Nassal / Glenn S. Cowley / Naoto Fujiwara / Sen-Yung Hsieh / Yujin Hoshida / Emanuele Felli / Patrick Pessaux / Camille Sureau /
    Catherine Schuster / David E. Root / Eloi R. Verrier / Thomas F. Baumert

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 17

    Abstract: Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a ... ...

    Abstract Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer

    Roy Z. Granit / Hadas Masury / Reba Condiotti / Yaakov Fixler / Yael Gabai / Tzofia Glikman / Simona Dalin / Eitan Winter / Yuval Nevo / Einat Carmon / Tamar Sella / Amir Sonnenblick / Tamar Peretz / Ulrich Lehmann / Keren Paz / Federica Piccioni / Aviv Regev / David E. Root / Ittai Ben-Porath

    Cell Reports, Vol 24, Iss 12, Pp 3237-

    2018  Volume 3250

    Abstract: Summary: Differentiation events contribute to phenotypic cellular heterogeneity within tumors and influence disease progression and response to therapy. Here, we dissect mechanisms controlling intratumoral heterogeneity within triple-negative basal-like ... ...

    Abstract Summary: Differentiation events contribute to phenotypic cellular heterogeneity within tumors and influence disease progression and response to therapy. Here, we dissect mechanisms controlling intratumoral heterogeneity within triple-negative basal-like breast cancers. Tumor cells expressing the cytokeratin K14 possess a differentiation state that is associated with that of normal luminal progenitors, and K14-negative cells are in a state closer to that of mature luminal cells. We show that cells can transition between these states through asymmetric divisions, which produce one K14+ and one K14− daughter cell, and that these asymmetric divisions contribute to the generation of cellular heterogeneity. We identified several regulators that control the proportion of K14+ cells in the population. EZH2 and Notch increase the numbers of K14+ cells and their rates of symmetric divisions, and FOXA1 has an opposing effect. Our findings demonstrate that asymmetric divisions generate differentiation transitions and heterogeneity, and identify pathways that control breast cancer cellular composition. : Granit et al. study the sources of phenotypic cellular heterogeneity in triple-negative breast cancers. They find that cancer cells can undergo asymmetric divisions that produce K14+ and K14− daughters and thereby generate heterogeneity. K14+ cells possess a progenitor-associated, tumorigenic phenotype, and the authors identify regulators that control their relative numbers. Keywords: triple-negative breast cancer, basal-like breast cancer, tumor heterogeneity, asymmetric divisions, mammary progenitor cells, EZH2, Notch, FOXA1, NFIB, KLF5
    Keywords Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

    Colin W. Garvie / Xiaoyun Wu / Malvina Papanastasiou / Sooncheol Lee / James Fuller / Gavin R. Schnitzler / Steven W. Horner / Andrew Baker / Terry Zhang / James P. Mullahoo / Lindsay Westlake / Stephanie H. Hoyt / Marcus Toetzl / Matthew J. Ranaghan / Luc de Waal / Joseph McGaunn / Bethany Kaplan / Federica Piccioni / Xiaoping Yang /
    Martin Lange / Adrian Tersteegen / Donald Raymond / Timothy A. Lewis / Steven A. Carr / Andrew D. Cherniack / Christopher T. Lemke / Matthew Meyerson / Heidi Greulich

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 16

    Abstract: The small molecule DNMDP acts as a velcrin by inducing complex formation between phosphodiesterase PDE3A and SLFN12, which kills cancer cells that express sufficient levels of both proteins. Here, the authors present the cryo-EM structure of the DNMDP- ... ...

    Abstract The small molecule DNMDP acts as a velcrin by inducing complex formation between phosphodiesterase PDE3A and SLFN12, which kills cancer cells that express sufficient levels of both proteins. Here, the authors present the cryo-EM structure of the DNMDP-stabilized PDE3A-SLFN12 complex and show that SLFN12 is an RNase. PDE3A binding increases SLFN12 RNase activity, and SLFN12 RNase activity is required for DNMDP-mediated cancer cell killing.
    Keywords Science ; Q
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition

    Belinda Wang / Elsa Beyer Krall / Andrew James Aguirre / Miju Kim / Hans Ragnar Widlund / Mihir Bhavik Doshi / Ewa Sicinska / Rita Sulahian / Amy Goodale / Glenn Spencer Cowley / Federica Piccioni / John Gerard Doench / David Edward Root / William Chun Hahn

    Cell Reports, Vol 18, Iss 6, Pp 1543-

    2017  Volume 1557

    Abstract: Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome-scale CRISPR-Cas9 loss-of- ...

    Abstract Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome-scale CRISPR-Cas9 loss-of-function screens in two KRAS mutant pancreatic cancer cell lines treated with the MEK1/2 inhibitor trametinib. Loss of CIC, a transcriptional repressor of ETV1, ETV4, and ETV5, promoted survival in the setting of MAPKi in cancer cells derived from several lineages. ATXN1L deletion, which reduces CIC protein, or ectopic expression of ETV1, ETV4, or ETV5 also modulated sensitivity to trametinib. ATXN1L expression inversely correlates with response to MAPKi inhibition in clinical studies. These observations identify the ATXN1L-CIC-ETS transcription factor axis as a mediator of resistance to MAPKi.
    Keywords CIC ; ATXN1L ; ETS ; MEK ; MAPK ; trametinib ; KRAS ; resistance ; CRISPR-Cas9 ; cancer ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2017-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.

    Shantanu Singh / Xiaoyun Wu / Vebjorn Ljosa / Mark-Anthony Bray / Federica Piccioni / David E Root / John G Doench / Jesse S Boehm / Anne E Carpenter

    PLoS ONE, Vol 10, Iss 7, p e

    2015  Volume 0131370

    Abstract: RNA interference and morphological profiling-the measurement of thousands of phenotypes from individual cells by microscopy and image analysis-are a potentially powerful combination. We show that morphological profiles of RNAi-induced knockdown using the ...

    Abstract RNA interference and morphological profiling-the measurement of thousands of phenotypes from individual cells by microscopy and image analysis-are a potentially powerful combination. We show that morphological profiles of RNAi-induced knockdown using the Cell Painting assay are in fact highly sensitive and reproducible. However, we find that the magnitude and prevalence of off-target effects via the RNAi seed-based mechanism make morphological profiles of RNAi reagents targeting the same gene look no more similar than reagents targeting different genes. Pairs of RNAi reagents that share the same seed sequence produce image-based profiles that are much more similar to each other than profiles from pairs designed to target the same gene, a phenomenon previously observed in small-scale gene-expression profiling experiments. Various strategies have been used to enrich on-target versus off-target effects in the context of RNAi screening where a narrow set of phenotypes are measured, mostly based on comparing multiple sequences targeting the same gene; however, new approaches will be needed to make RNAi morphological profiling (that is, comparing multi-dimensional phenotypes) viable. We have shared our raw data and computational pipelines to facilitate research.
    Keywords Medicine ; R ; Science ; Q
    Subject code 612
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top