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  1. Article ; Online: Lymphomas and Amyloid in the Gastrointestinal Tract.

    Ware, Alisha D / Wake, Laura M / Fedoriw, Yuri

    Surgical pathology clinics

    2023  Volume 16, Issue 4, Page(s) 719–743

    Abstract: Lymphoproliferative disorders are a heterogeneous group of neoplasms with varying clinical, morphologic, immunophenotypic, and genetic characteristics. A subset of lymphomas have a proclivity for the gastrointestinal tract, although this region may also ... ...

    Abstract Lymphoproliferative disorders are a heterogeneous group of neoplasms with varying clinical, morphologic, immunophenotypic, and genetic characteristics. A subset of lymphomas have a proclivity for the gastrointestinal tract, although this region may also be involved by systemic lymphomas. In addition, a number of indolent lymphoproliferative disorders of the gastrointestinal tract have been defined over the past decade, and it is important to accurately differentiate these neoplasms to ensure that patients receive the proper management. Here, the authors review lymphoid neoplasms that show frequent gastrointestinal involvement and provide updates from the recent hematolymphoid neoplasm classification systems.
    MeSH term(s) Humans ; Lymphoma/diagnosis ; Lymphoma/pathology ; Gastrointestinal Tract/pathology ; Lymphoproliferative Disorders/pathology
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2023.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Preface.

    Fedoriw, Yuri

    Surgical pathology clinics

    2016  Volume 9, Issue 1, Page(s) xi

    MeSH term(s) Biomarkers/analysis ; Diagnostic Tests, Routine ; Humans ; Pathology, Clinical/methods ; Pathology, Clinical/trends ; Review Literature as Topic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Editorial
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2016.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Epstein-Barr virus mucocutaneous ulcer followed by Hodgkin lymphoma in multiple myeloma patient.

    Forster, Moriah / Fedoriw, Yuri / Tuchman, Sascha / Grover, Natalie

    Clinical case reports

    2022  Volume 10, Issue 3, Page(s) e05528

    Abstract: Epstein-Barr virus mucocutaneous ulcers (EBV MCU) are B-cell lymphoproliferative disorders associated with immunosuppression. We report EBV MCU in a multiple myeloma patient on lenalidomide maintenance after stem cell transplant that resolved with ... ...

    Abstract Epstein-Barr virus mucocutaneous ulcers (EBV MCU) are B-cell lymphoproliferative disorders associated with immunosuppression. We report EBV MCU in a multiple myeloma patient on lenalidomide maintenance after stem cell transplant that resolved with decreased immunosuppression. Furthermore, the subsequent development of classical Hodgkin lymphoma suggests an underlying predisposition to EBV-driven lymphoproliferative disorders.
    Language English
    Publishing date 2022-03-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.5528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The role of telepathology in improving cancer diagnostic and research capacity in sub-Saharan Africa.

    Razzano, Dana / Puranam, Kaushik / Tomoka, Tamiwe / Fedoriw, Yuri

    Frontiers in medicine

    2022  Volume 9, Page(s) 978245

    Abstract: Non-communicable disease (NCD), including cancer, disproportionately affect Low- and Middle-Income Countries (LMICs). This inequity is in part due to limitations of pathology services, both human and infrastructural. While significant improvements have ... ...

    Abstract Non-communicable disease (NCD), including cancer, disproportionately affect Low- and Middle-Income Countries (LMICs). This inequity is in part due to limitations of pathology services, both human and infrastructural. While significant improvements have been made to address these gaps, creative approaches that are mindful of regional priorities, cultural differences, and unique local challenges are needed. In this perspective, we will describe the implementation of telepathology services in sub-Saharan Africa (SSA) that serve as cornerstones for direct patient care, multi-disciplinary care coordination, research programs, and building human capacity through training. Models and challenges of system implementation, sustainability, and pathologist engagement will be discussed. Using disease and site-specific examples, we will suggest metrics for quality control and improvement initiatives that are critical for providing high-quality cancer registry data and necessary for future implementation of therapeutic and interventional clinical trials.
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.978245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human Immunodeficiency Virus-Associated Lymphoproliferative Disorders.

    Lilly, Amy J / Fedoriw, Yuri

    Surgical pathology clinics

    2019  Volume 12, Issue 3, Page(s) 771–782

    Abstract: HIV infection is associated with an increased risk for developing B-cell lymphoproliferative disorders. The spectrum of disease differs in HIV-infected versus HIV-uninfected persons, with aggressive B-cell non-Hodgkin lymphomas constituting a higher ... ...

    Abstract HIV infection is associated with an increased risk for developing B-cell lymphoproliferative disorders. The spectrum of disease differs in HIV-infected versus HIV-uninfected persons, with aggressive B-cell non-Hodgkin lymphomas constituting a higher proportion of all lymphoproliferative disorders in the HIV-positive population. Although antiretroviral therapy (ART) has significantly changed the landscape of lymphomas arising in HIV-infected persons, population growth and aging are reflected in the steady increase in non-AIDS-defining cancers. In the ART era, outcomes for HIV-infected lymphoma patients are similar to those of HIV-negative patients. This article reviews the diagnostic features and summarizes current biologic understanding of HIV-associated lymphomas.
    MeSH term(s) Anti-HIV Agents/therapeutic use ; Burkitt Lymphoma/pathology ; Burkitt Lymphoma/virology ; Diagnosis, Differential ; HIV Infections/drug therapy ; HIV Infections/pathology ; Hodgkin Disease/pathology ; Hodgkin Disease/virology ; Humans ; Lymphoma, AIDS-Related/pathology ; Lymphoma, B-Cell/pathology ; Lymphoma, B-Cell/virology ; Lymphoma, Primary Effusion/pathology ; Lymphoma, Primary Effusion/virology ; Plasmablastic Lymphoma/pathology ; Plasmablastic Lymphoma/virology
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2019-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2019.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pathology and diagnosis of follicular lymphoma and related entities.

    Randall, Cara / Fedoriw, Yuri

    Pathology

    2019  Volume 52, Issue 1, Page(s) 30–39

    Abstract: Follicular lymphoma (FL) is an indolent, mature B-cell neoplasm classically characterised by the t(14;18)(q32;q21) with constitutive overexpression of the anti-apoptotic protein, BCL2. Most cases present in older adults with slowly progressive ... ...

    Abstract Follicular lymphoma (FL) is an indolent, mature B-cell neoplasm classically characterised by the t(14;18)(q32;q21) with constitutive overexpression of the anti-apoptotic protein, BCL2. Most cases present in older adults with slowly progressive lymphadenopathy and follow an indolent clinical course. Typical morphology shows an expansile follicular proliferation with tumour expression of germinal centre markers, and bone marrow involvement at diagnosis is frequent. However, in the recent past, efforts to understand the biological and clinical heterogeneity of FL has effected significant change to the diagnostic approach. While morphological grade, assessed by enumerating large 'centroblasts' in the neoplastic follicles, generally correlates with outcome in systemic nodal FL, variants with high-grade morphology but indolent clinical behaviour have been identified. Given the clinical implications of these FL variants, knowledge of their clinical and histopathological defining features is of paramount importance to the pathologist. Furthermore, as with many areas of diagnostic oncology, precursors to FL have been identified and described with measurable rates of progression to bona fide lymphoma. Accurate diagnosis of these early lesions can often prevent unnecessary therapy and guide appropriate monitoring for disease progression. This review aims to summarise these key pathological and diagnostic features of FL. We further highlight the biological underpinnings of FL that will likely affect the classification, diagnosis, and treatment of patients with lymphoma.
    MeSH term(s) B-Lymphocytes/pathology ; Diagnosis, Differential ; Germinal Center/pathology ; Humans ; Immunophenotyping ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/pathology ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/pathology
    Language English
    Publishing date 2019-11-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2019.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Hematopathology

    Fedoriw, Yuri / Hornick, Jason L

    (Surgical pathology clinics, ; volume 9, number 1)

    2016  

    Author's details editor, Yuri Fedoriw ; consulting editor, Jason L. Hornick
    Series title Surgical pathology clinics, ; volume 9, number 1
    MeSH term(s) Hematologic Diseases/pathology ; Hematologic Diseases/diagnosis ; Hematologic Tests/methods
    Language English
    Size ix, 187 pages :, illustrations, portrait.
    Document type Book
    ISBN 9780323416672 ; 0323416675
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Author Correction: An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.

    Souroullas, George P / Jeck, William R / Parker, Joel S / Simon, Jeremy M / Liu, Jie-Yu / Paulk, Joshiawa / Xiong, Jessie / Clark, Kelly S / Fedoriw, Yuri / Qi, Jun / Burd, Christin E / Bradner, James E / Sharpless, Norman E

    Nature medicine

    2024  

    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02867-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  9. Article ; Online: Safety, efficacy, and affordability of ABVD for Hodgkin lymphoma in Malawi: a prospective cohort study.

    Mponda, Marriam / Kudowa, Evaristar / Craven, Dalton M / Eastburg, Luke C / Chikasema, Maria / Kasonkanji, Edwards / Tomoka, Tamiwe / Roush, Sophie Maharry / Simwinga, Lusayo / Mumba, Noel / Gopal, Satish / Fedoriw, Yuri / Painschab, Matthew S

    EClinicalMedicine

    2024  Volume 69, Page(s) 102480

    Abstract: Background: ABVD (doxorubicin, bleomycin, vinblastine, and dexamethasone) is a proven, curative regimen for Hodgkin lymphoma (HL). Prospective data describing HL treatment in sub-Saharan Africa are limited. We aimed to fill this knowledge gap, using ... ...

    Abstract Background: ABVD (doxorubicin, bleomycin, vinblastine, and dexamethasone) is a proven, curative regimen for Hodgkin lymphoma (HL). Prospective data describing HL treatment in sub-Saharan Africa are limited. We aimed to fill this knowledge gap, using data from Malawi.
    Methods: We report a prospective observational cohort of HL (aged
    Findings: We enrolled 38 patients with a median age of 27 years (interquartile range 19-46); eleven (28%) were HIV-positive. Of 35 patients treated with ABVD, 24 (71%) had stage III/IV, nine (26%) unfavourable limited stage, and two (6%) favourable limited stage. Among HIV-infected individuals, mean CD4 count at HL diagnosis was 179 cells/uL and ten (91%) had HIV RNA < 400 copies/mL. Grade 3/4 neutropenia occurred in 24 (68%) patients and caused treatment delay in 16 (46%). Of ten deaths, seven were due to HL, two possible treatment-related toxicity, and one uncertain. 2-year overall survival was 82% (95% CI 70-96%) and 2-year progression-free survival was 64% (95% CI 50-83%). PFS appeared better for HIV-positive patients (HR 0.23 (95% CI 0.05-1.02)) after controlling for stage and performance status (p = 0.05). We estimated $2708 (2022 USD) for HL diagnosis, treatment, and follow-up in our cohort.
    Interpretation: Our findings suggest that treatment with ABVD is safe, efficacious, and affordable for HL in Malawi. Outcomes are worse than in high-income countries due to HL progression. Future studies are needed to understand outcome inequities and to assess efficacy of therapies for patients with relapsed or refractory HL in Malawi.
    Funding: National Institutes of Health, Lineberger Comprehensive Cancer Center.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2024.102480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Expanding Spectrum of Follicular Lymphoma.

    Fedoriw, Yuri / Dogan, Ahmet

    Surgical pathology clinics

    2016  Volume 9, Issue 1, Page(s) 29–40

    Abstract: Follicular lymphoma is a far more heterogeneous entity than originally appreciated. Clinical and biological variants are increasingly more granularly defined, expanding the spectrum of disease. Some variants associate with age, whereas others with ... ...

    Abstract Follicular lymphoma is a far more heterogeneous entity than originally appreciated. Clinical and biological variants are increasingly more granularly defined, expanding the spectrum of disease. Some variants associate with age, whereas others with anatomic site. Identification of these biologically distinct diseases has real prognostic and predictive value for patients today and likely will be more relevant in the future. Understanding of follicular lymphoma precursors has also made their identification both scientifically and clinically relevant. This review summarizes the features and understanding of follicular lymphoma, variants, and precursor lesions.
    MeSH term(s) Age Factors ; Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/pathology ; Neoplasm Grading ; Precancerous Conditions/diagnosis ; Precancerous Conditions/pathology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2015.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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