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Article: Secondary Hyperparathyroidism and Cognitive Decline.

Crepeau, Philip / Fedorova, Tatiana / Morris-Wiseman, Lilah F / Mathur, Aarti

Current transplantation reports

2023 Volume 10, Issue 2, Page(s) 60–68

Abstract: Purpose of review: Secondary hyperparathyroidism (SHPT) likely contributes to the high prevalence of cognitive decline found among individuals with end-stage kidney disease (ESKD). Our objective is to critically evaluate the recent literature regarding ... ...

Abstract	Purpose of review: Secondary hyperparathyroidism (SHPT) likely contributes to the high prevalence of cognitive decline found among individuals with end-stage kidney disease (ESKD). Our objective is to critically evaluate the recent literature regarding the association between SHPT and cognitive decline and identify potential mechanisms. Recent findings: Nine studies assessing the relationship between SHPT and cognition have been published in the last two decades, each showing that elevated parathyroid hormone (PTH) levels were associated with cognitive decline. One also found structural changes within the brain related to SHPT. Additionally, two found that SHPT treatment decreases the risk of cognitive decline in ESKD patients. Summary: SHPT is associated with cognitive impairment. However, the severity of SHPT associated with these changes and the specific cognitive domains affected remain unclear. Future studies are needed to focus on specific cognitive domains, the trajectory of cognitive decline, and optimal treatment strategies including the impact of kidney transplant and tertiary hyperparathyroidism.
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2196-3029
ISSN	2196-3029
DOI	10.1007/s40472-023-00394-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Normohormonal Primary Hyperparathyroidism; a surgical dilemma pre and intra-operatively.

Fedorova, Tatiana / Hagglund, Karen / Hawasli, Abdelkader

American journal of surgery

2022 Volume 223, Issue 3, Page(s) 589–591

Abstract: Introduction: Normohormonal Primary Hyperparathyroidism (NPHPT), poses a dilemma for surgeons; first in deciding when to operate where the PTH is normal and second at what level should the drop in intra-operative PTH (ioPTH) be considered a successful ... ...

Abstract	Introduction: Normohormonal Primary Hyperparathyroidism (NPHPT), poses a dilemma for surgeons; first in deciding when to operate where the PTH is normal and second at what level should the drop in intra-operative PTH (ioPTH) be considered a successful operation. Materials & methods: A retrospective evaluation of all parathyroidectomies performed by a single surgeon from 2009 to 2019 was conducted. Results: In 33 of 349 (9%) parathyroidectomies the indication was NPHPT. Negative pre-operative nuclear localization was found in 17(52%) patients. Intra-operative findings were: 27(82%) single-adenoma, 3(9%) double-adenomas and 3(9%) hyperplasia. In patients with single-adenomas the ioPTH dropped from 57 ± 8 to 23 ± 10 pg./ml. The average size of the adenomas was 403 ± 360 mg. Conclusion: NPHPT is uncommon where the disease is diagnosed in its early stages. Over 50% has negative pre-operative nuclear localization test requiring 4-gland surgical exploration. The intra-operative drop in PTH below 30 pg./ml can be utilized as an indicator of a successful operation.
MeSH term(s)	Adenoma/surgery ; Humans ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/surgery ; Monitoring, Intraoperative ; Parathyroid Hormone ; Parathyroidectomy ; Retrospective Studies
Chemical Substances	Parathyroid Hormone
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2022.01.002
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Article ; Online: Assessing the innovative capacity of the scientific-industrial complex

Gorbachev Andrey / Fedorova Tatiana

SHS Web of Conferences, Vol 55, p

2018 Volume 01016

Abstract: One of the most effective structures on release of innovative products is the scientific-industrial complex today. To make innovative products for the establishment of capability of scientific-industrial complex and to perform competitive activity, such ... ...

Abstract	One of the most effective structures on release of innovative products is the scientific-industrial complex today. To make innovative products for the establishment of capability of scientific-industrial complex and to perform competitive activity, such characteristic of the enterprise as its innovative potential having three following components is estimated: the volume of the resources of the enterprise used for performance of works, an opportunity to perform profitable works and to perform investing activities by means of implementation of orders with remote financial result. Efficiency of activity of scientific-industrial complex depends on capability of the enterprise competently to distribute the potential between different job groups, providing financial result, both today and in the future.
Keywords	Social Sciences ; H
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Changing profile of infective endocarditis during a 20-year observation period.

Tazina, Serafima / Fedorova, Tatiana / Semenenko, Natalya / Ilina, Yuliya / Mamonov, Alexander / Pavlov, Chavdar

Bratislavske lekarske listy

2023 Volume 124, Issue 8, Page(s) 622–629

Abstract: Background: Infective endocarditis (IE) is most often caused by bacteria.: Objectives: The aim of this work is the research of the dynamics of the clinical laboratory and instrumental methods of the diagnostics during the period of two decades.: ... ...

Abstract	Background: Infective endocarditis (IE) is most often caused by bacteria. Objectives: The aim of this work is the research of the dynamics of the clinical laboratory and instrumental methods of the diagnostics during the period of two decades. Methods: The data of 241 patients with infective endocarditis (IE) who were treated at the State Clinical Hospital named after Botkin S.P. was included in the research. 121 patients were observed from 2011 till 2020 (the first group) and 120 patients - from 1997 to 2004 (the second test group). These data included age and social structure of pathology, peculiarities of clinical picture, laboratory, and instrumental methods of research, as well as the outcome of the disease. We studied the concentrations of procalcitonin and presepsin in patients hospitalized after 2011. We observed pathomorphism of the modern IE. Results: To discover the bacteriological origin of the disease, we found the diagnostic evaluation of inflammation, procalcitonin, and presepsin activities, using C-reactive protein, important. We observed decrease in the number of general and hospital deaths. Conclusions: The knowledge of the IE peculiarities during the IE progression is essential for timely diagnosis and more accurate pathology prediction (Fig. 5, Ref. 38). Text in PDF www.elis.sk Keywords: infectious endocarditis, valve apparatus disease, thromboembolic complications, immunocomplex complications, procalcitonin, presepsin.
MeSH term(s)	Humans ; Procalcitonin ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/complications ; Endocarditis/diagnosis ; Endocarditis/complications ; Endocarditis/therapy ; C-Reactive Protein/analysis ; Retrospective Studies ; Peptide Fragments ; Lipopolysaccharide Receptors
Chemical Substances	Procalcitonin ; C-Reactive Protein (9007-41-4) ; presepsin protein, human ; Peptide Fragments ; Lipopolysaccharide Receptors
Language	English
Publishing date	2023-05-23
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	127421-1
ISSN	0006-9248
ISSN	0006-9248
DOI	10.4149/BLL_2023_097
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Article ; Online: Neuroprotective Efficacy of a Nanomicellar Complex of Carnosine and Lipoic Acid in a Rat Model of Rotenone-Induced Parkinson’s Disease

Kulikova, Olga / Troshev, Dmitry / Berezhnoy, Daniil / Stvolinsky, Sergey / Timoshina, Yulia / Abaimov, Denis / Muzychuk, Olga / Latanov, Alexander / Fedorova, Tatiana

Antioxidants. 2023 June 04, v. 12, no. 6

2023

Abstract: Oxidative stress, accompanied by mitochondrial dysfunction, is a key mechanism involved in the pathogenesis of Parkinson’s disease (PD). Both carnosine and lipoic acid are potent antioxidants, the applicability of which in therapy is hindered by their ... ...

Abstract	Oxidative stress, accompanied by mitochondrial dysfunction, is a key mechanism involved in the pathogenesis of Parkinson’s disease (PD). Both carnosine and lipoic acid are potent antioxidants, the applicability of which in therapy is hindered by their limited bioavailability. This study aimed to evaluate the neuroprotective properties of a nanomicellar complex of carnosine and lipoic acid (CLA) in a rotenone-induced rat model of PD. Parkinsonism was induced via the administration of 2 mg/kg rotenone over the course of 18 days. Two doses of intraperitoneal CLA (25 mg/kg and 50 mg/kg) were administered alongside rotenone to assess its neuroprotective effect. At 25 mg/kg CLA decreased muscle rigidity and partially restored locomotor activity in animals that received rotenone. Furthermore, it caused an overall increase in brain tissue antioxidant activity, accompanied by a 19% increase in neuron density in the substantia nigra and increased dopamine levels in the striatum relative to animals that only received rotenone. Based on the acquired results, it may be concluded that CLA have neuroprotective properties and could potentially be beneficial in PD treatment when used in conjunction with the base therapy.
Keywords	Parkinson disease ; animal models ; antioxidant activity ; bioavailability ; brain ; carnosine ; dopamine ; lipoic acid ; locomotion ; mitochondria ; muscles ; neurons ; neuroprotective effect ; oxidative stress ; pathogenesis ; rotenone ; therapeutics
Language	English
Dates of publication	2023-0604
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061215
Database	NAL-Catalogue (AGRICOLA)

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Article: Time Course of Neurobehavioral Disruptions and Regional Brain Metabolism Changes in the Rotenone Mice Model of Parkinson's Disease.

Troshev, Dmitry / Voronkov, Dmitry / Pavlova, Anastasia / Abaimov, Denis / Latanov, Alexander / Fedorova, Tatiana / Berezhnoy, Daniil

Biomedicines

2022 Volume 10, Issue 2

Abstract: Parkinson's disease (PD) is characterized by slow progression with a long prodromal stage and the gradual evolution of both neuropsychological symptoms and subtle motor changes, preceding motor dysfunction. Thus, in order for animal models of PD to be ... ...

Abstract	Parkinson's disease (PD) is characterized by slow progression with a long prodromal stage and the gradual evolution of both neuropsychological symptoms and subtle motor changes, preceding motor dysfunction. Thus, in order for animal models of PD to be valid, they should reproduce these characteristics of the disease. One of such models, in which neuropathology is induced by chronic injections of low doses of mitochondrial toxin rotenone, is well established in rats. However, data on this model adapted to mice remain controversial. We have designed the study to describe the timecourse of motor and non-motor symptoms during chronic subcutaneous administration of rotenone (4 mg/kg daily for 35 days) in C57BL/6 mice. We characterize the underlying neuropathological processes (dopaminergic neuron degeneration, regional brain metabolism, monoamine neurotransmitter and lipid peroxidation changes) at different timepoints: 1 day, 2 weeks and 5 weeks of daily rotenone exposure. Based on the behavioral data, we can describe three stages of pathology: cognitive changes from week 2 of rotenone exposure, subtle motor changes in week 3-4 and motor dysfunction starting roughly from week 4. Neuropathological changes in this model include a general decrease in COX activity in different areas of the brain (acute effect of rotenone) and a more specific decrease in midbrain (chronic effect), followed by significant neurodegeneration in SNpc but not VTA by the 5th week of rotenone exposure. However, we were unable to find changes in the level of monoamine neurotransmitters neither in the striatum nor in the cortex, nor in the level of lipid peroxidation in the brainstem. Thus, the gradual progression of pathology in this model is linked with metabolic changes, rather than with oxidative stress or tonic neurotransmitter release levels. Overall, this study supports the idea that a low-dose rotenone mouse model can also reproduce different stages of PD as well as rats.
Language	English
Publishing date	2022-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10020466
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Article: Neuroprotective Efficacy of a Nanomicellar Complex of Carnosine and Lipoic Acid in a Rat Model of Rotenone-Induced Parkinson's Disease.

Kulikova, Olga / Troshev, Dmitry / Berezhnoy, Daniil / Stvolinsky, Sergey / Timoshina, Yulia / Abaimov, Denis / Muzychuk, Olga / Latanov, Alexander / Fedorova, Tatiana

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Oxidative stress, accompanied by mitochondrial dysfunction, is a key mechanism involved in the pathogenesis of Parkinson's disease (PD). Both carnosine and lipoic acid are potent antioxidants, the applicability of which in therapy is hindered by their ... ...

Abstract	Oxidative stress, accompanied by mitochondrial dysfunction, is a key mechanism involved in the pathogenesis of Parkinson's disease (PD). Both carnosine and lipoic acid are potent antioxidants, the applicability of which in therapy is hindered by their limited bioavailability. This study aimed to evaluate the neuroprotective properties of a nanomicellar complex of carnosine and lipoic acid (CLA) in a rotenone-induced rat model of PD. Parkinsonism was induced via the administration of 2 mg/kg rotenone over the course of 18 days. Two doses of intraperitoneal CLA (25 mg/kg and 50 mg/kg) were administered alongside rotenone to assess its neuroprotective effect. At 25 mg/kg CLA decreased muscle rigidity and partially restored locomotor activity in animals that received rotenone. Furthermore, it caused an overall increase in brain tissue antioxidant activity, accompanied by a 19% increase in neuron density in the substantia nigra and increased dopamine levels in the striatum relative to animals that only received rotenone. Based on the acquired results, it may be concluded that CLA have neuroprotective properties and could potentially be beneficial in PD treatment when used in conjunction with the base therapy.
Language	English
Publishing date	2023-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12061215
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Article ; Online: Impact of manganese accumulation on Na,K-ATPase expression and function in the cerebellum and striatum of C57Bl/6 mice.

Smolyaninova, Larisa V / Timoshina, Yulia A / Berezhnoy, Daniil S / Fedorova, Tatiana N / Mikheev, Ivan V / Seregina, Irina F / Loginova, Nadezhda A / Dobretsov, Maxim G

Neurotoxicology

2023 Volume 98, Page(s) 86–97

Abstract: Overexposure to Mn causes a neurological disorder-manganism-with motor symptoms that overlap closely with disorders associated with haploinsufficiency in the gene encoding for ... ...

Abstract	Overexposure to Mn causes a neurological disorder-manganism-with motor symptoms that overlap closely with disorders associated with haploinsufficiency in the gene encoding for α
MeSH term(s)	Animals ; Mice ; Manganese/toxicity ; Sodium-Potassium-Exchanging ATPase/genetics ; Corpus Striatum ; Cerebellum ; Manganese Poisoning ; Mice, Inbred C57BL
Chemical Substances	Manganese (42Z2K6ZL8P) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2023-08-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	800820-6
ISSN	1872-9711 ; 0161-813X
ISSN (online)	1872-9711
ISSN	0161-813X
DOI	10.1016/j.neuro.2023.08.002
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Book ; Thesis: Entwicklung einer neuen Nickelbasis-Superlegierung auf Basis von Alloy 718

Fedorova, Tatiana

2013

Title variant	siebenhundertachtzehn sieben-eins-acht
Author's details	von Tatiana Fedorova
Language	German
Size	246 S., Ill., graph. Darst.
Edition	1. Aufl.
Publisher	Cuvillier
Publishing place	Göttingen
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Techn. Univ., Diss.--Braunschweig, 2013
ISBN	9783954044795 ; 395404479X
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: An assessment of the transport mechanism and intraneuronal stability of L-carnosine

Lopachev, Alexander V. / Abaimov, Denis A. / Filimonov, Ivan S. / Kulichenkova, Kseniya N. / Fedorova, Tatiana N.

Amino acids. 2022 Aug., v. 54, no. 8

2022

Abstract: L-Carnosine (β-alanyl-L-histidine) is a well-known antioxidant and neuroprotector in various models on animals and cell cultures. However, while there is a plethora of data demonstrating its efficiency as a neuroprotector, there is a distinct lack of ... ...

Abstract	L-Carnosine (β-alanyl-L-histidine) is a well-known antioxidant and neuroprotector in various models on animals and cell cultures. However, while there is a plethora of data demonstrating its efficiency as a neuroprotector, there is a distinct lack of data regarding the mechanism of its take up by neurons. According to literature, cultures of rat astrocytes, SKPT cells and rat choroid plexus epithelial cells take up carnosine via the H⁺-coupled PEPT2 membrane transporter. We’ve assessed the effectiveness and mechanism of carnosine transport, and its stability in primary rat cortical culture neurons. We demonstrated that neurons take up carnosine via active transport with Km = 119 μM and a maximum velocity of 0.289 nmol/mg (prot)/min. Passive transport speed constituted 0.21∙10–⁴ nmol/mg (prot)/min (with 119 μM concentration in the medium)—significantly less than active transport speed. However, carnosine concentrations over 12.5 mM led to passive transport speed becoming greater than active transport speed. Using PEPT2 inhibitor zofenopril, we demonstrated that PEPT2-dependent transport is one of the main modes of carnosine take up by neurons. Our experiments demonstrated that incubation with carnosine does not affect PEPT2 amount present in culture. At the same time, after removing carnosine from the medium, its elimination speed by culture cells reached 0.035 nmol/mg (prot)/min, which led to a decrease in carnosine quantity to control levels in culture within 1 h. Thus, carnosine is taken up by neurons with an effectiveness comparable to that of other PEPT2 substrates, but its elimination rate suggests that for effective use as a neuroprotector it’s necessary to either maintain a high concentration in brain tissue, or increase the effectiveness of glial cell synthesis of endogenous carnosine and its shuttling into neurons, or use more stable chemical modifications of carnosine.
Keywords	active transport ; antioxidants ; astrocytes ; brain ; carnosine ; choroid plexus ; epithelium ; rats
Language	English
Dates of publication	2022-08
Size	p. 1115-1122.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-021-03094-5
Database	NAL-Catalogue (AGRICOLA)

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