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  1. Article ; Online: Functions of RNAi Pathways in Ribosomal RNA Regulation.

    Shatskikh, Aleksei S / Fefelova, Elena A / Klenov, Mikhail S

    Non-coding RNA

    2024  Volume 10, Issue 2

    Abstract: Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and genome protection through RNA interference (RNAi)-related mechanisms. Ribosomal RNAs (rRNAs), encoded by repeated rDNA units, constitute the core of the ribosome being ... ...

    Abstract Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and genome protection through RNA interference (RNAi)-related mechanisms. Ribosomal RNAs (rRNAs), encoded by repeated rDNA units, constitute the core of the ribosome being the most abundant cellular transcripts. rDNA clusters also serve as sources of small RNAs, which are loaded into Argonaute proteins and are able to regulate rDNA itself or affect other gene targets. In this review, we consider the impact of small RNA pathways, specifically siRNAs and piRNAs, on rRNA gene regulation. Data from diverse eukaryotic organisms suggest the potential involvement of small RNAs in various molecular processes related to the rDNA transcription and rRNA fate. Endogenous siRNAs are integral to the chromatin-based silencing of rDNA loci in plants and have been shown to repress rDNA transcription in animals. Small RNAs also play a role in maintaining the integrity of rDNA clusters and may function in the cellular response to rDNA damage. Studies on the impact of RNAi and small RNAs on rRNA provide vast opportunities for future exploration.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna10020019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanical Tensions Regulate Gene Expression in the

    Eroshkin, Fedor M / Fefelova, Elena A / Bredov, Denis V / Orlov, Eugeny E / Kolyupanova, Nataliya M / Mazur, Alexander M / Sokolov, Alexey S / Zhigalova, Nadezhda A / Prokhortchouk, Egor B / Nesterenko, Alexey M / Zaraisky, Andrey G

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: During gastrulation and neurulation, the chordamesoderm and overlying neuroectoderm of vertebrate embryos converge under the control of a specific genetic programme to the dorsal midline, simultaneously extending along it. However, whether mechanical ... ...

    Abstract During gastrulation and neurulation, the chordamesoderm and overlying neuroectoderm of vertebrate embryos converge under the control of a specific genetic programme to the dorsal midline, simultaneously extending along it. However, whether mechanical tensions resulting from these morphogenetic movements play a role in long-range feedback signaling that in turn regulates gene expression in the chordamesoderm and neuroectoderm is unclear. In the present work, by using a model of artificially stretched explants of
    MeSH term(s) Animals ; Stress, Mechanical ; Xenopus laevis/genetics ; 4-Butyrolactone ; Gene Expression
    Chemical Substances A-factor (Streptomyces) (51311-41-2) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon.

    Fefelova, Elena A / Pleshakova, Irina M / Mikhaleva, Elena A / Pirogov, Sergei A / Poltorachenko, Valentin A / Abramov, Yuri A / Romashin, Daniil D / Shatskikh, Aleksei S / Blokh, Roman S / Gvozdev, Vladimir A / Klenov, Mikhail S

    Nucleic acids research

    2021  Volume 50, Issue 2, Page(s) 867–884

    Abstract: Eukaryotic genomes harbor hundreds of rRNA genes, many of which are transcriptionally silent. However, little is known about selective regulation of individual rDNA units. In Drosophila melanogaster, some rDNA repeats contain insertions of the R2 ... ...

    Abstract Eukaryotic genomes harbor hundreds of rRNA genes, many of which are transcriptionally silent. However, little is known about selective regulation of individual rDNA units. In Drosophila melanogaster, some rDNA repeats contain insertions of the R2 retrotransposon, which is capable to be transcribed only as part of pre-rRNA molecules. rDNA units with R2 insertions are usually inactivated, although R2 expression may be beneficial in cells with decreased rDNA copy number. Here we found that R2-inserted rDNA units are enriched with HP1a and H3K9me3 repressive mark, whereas disruption of the heterochromatin components slightly affects their silencing in ovarian germ cells. Surprisingly, we observed a dramatic upregulation of R2-inserted rRNA genes in ovaries lacking Udd (Under-developed) or other subunits (TAF1b and TAF1c-like) of the SL1-like complex, which is homologues to mammalian Selective factor 1 (SL1) involved in rDNA transcription initiation. Derepression of rRNA genes with R2 insertions was accompanied by a reduction of H3K9me3 and HP1a enrichment. We suggest that the impairment of the SL1-like complex affects a mechanism of selective activation of intact rDNA units which competes with heterochromatin formation. We also propose that R2 derepression may serve as an adaptive response to compromised rRNA synthesis.
    MeSH term(s) Animals ; DNA, Ribosomal/metabolism ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Heterochromatin/metabolism ; Nuclear Proteins/metabolism ; Retroelements ; Ribosomes/metabolism ; Transcription Factors/metabolism ; Transcription, Genetic
    Chemical Substances DNA, Ribosomal ; Drosophila Proteins ; Heterochromatin ; Nuclear Proteins ; Retroelements ; TAF1B protein, Drosophila ; Transcription Factors ; Udd protein, Drosophila
    Language English
    Publishing date 2021-12-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkab1276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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