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  1. Article ; Online: Occurrence and distribution of extended-spectrum β-lactamase in clinical

    Deku, John G / Duedu, Kwabena O / Ativi, Emmanuel / Kpene, Godsway E / Feglo, Patrick K

    Ghana medical journal

    2022  Volume 55, Issue 4, Page(s) 298–307

    Abstract: Objective: This study determined the occurrence and distribution of Extended Spectrum β-Lactamase (ESBL) genotypes of : Design: A cross-sectional study.: Setting: A single centre study was conducted at Ho Teaching Hospital of Ghana.: ... ...

    Abstract Objective: This study determined the occurrence and distribution of Extended Spectrum β-Lactamase (ESBL) genotypes of
    Design: A cross-sectional study.
    Setting: A single centre study was conducted at Ho Teaching Hospital of Ghana.
    Participants: Patients who visited Ho Teaching Hospital Laboratory with the request for culture and susceptibility testing.
    Main outcome measure: Escherichia coli
    Results: Of the 135 isolates, 56(41.5%,95% CI: 33.1% - 50.3%) were ESBL producers. More males, 14(58.3%), produced ESBL than females, 42(37.8%). The ESBL prevalence was highest among the elderly who were 80 years and above 3(100.0%), with the least prevalence among patients within 50-59 years and 0-9 years age bracket, representing 4(25.0%) and 3(27.3%), respectively. The total prevalence of ESBL was marginally higher among out-patients (41.8% 95% CI: 31.9% - 52.2%) compared to in-patients [40.5% 95% CI: 24.8% - 57.9]. BlaTEM-1 was the predominant ESBL genotype obtained from 83.9% (47/56) of the confirmed ESBL producing isolates, with the least being TOHO-1 4(7.1%). The co-existence of 2 different ESBL genes occurred in 19(33.9%) of the isolates. The single and quadruple carriage were 16(28.6%) and 3(5.4%), respectively. The highest co-existence of the ESBL genotypes was recorded for blaTEM-1 and blaCTXM-1 15(26.8%), followed by blaTEM-1, blaCTXM-1 and blaSHV-73 [12(21.4%)].
    Conclusion: The high prevalence of ESBL-producing
    Funding: This research received no external funding.
    MeSH term(s) Aged ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Escherichia coli/genetics ; Escherichia coli Infections/epidemiology ; Female ; Ghana/epidemiology ; Hospitals, Teaching ; Humans ; Male ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-07-31
    Publishing country Ghana
    Document type Journal Article
    ZDB-ID 2259233-7
    ISSN 2616-163X ; 2616-163X
    ISSN (online) 2616-163X
    ISSN 2616-163X
    DOI 10.4314/gmj.v55i4.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genotypic characterization of extended-spectrum β-lactamase producing urinary isolates among pregnant women in Ho municipality, Ghana

    Adedze-Kpodo, Robert K. / Feglo, Patrick K. / Agboli, Eric / Asmah, Richard H. / Kwadzokpui, Precious K.

    Heliyon. 2022 Dec., v. 8, no. 12 p.e12513-

    2022  

    Abstract: The case of antibiotic resistance has become a major global concern and Extended Spectrum β-lactamase (ESBL) producing organisms have so far remained the biggest culprit. The consequences of urinary tract infection (UTI) and antibiotic resistance among ... ...

    Abstract The case of antibiotic resistance has become a major global concern and Extended Spectrum β-lactamase (ESBL) producing organisms have so far remained the biggest culprit. The consequences of urinary tract infection (UTI) and antibiotic resistance among pregnant women cannot be underestimated. We investigated UTI and ESBL production among urinary pathogens isolated from pregnant women. We obtained non-repeat, clean catch midstream urine samples from 1345 pregnant women suspected of having UTI for bacterial identification at the Ho Teaching Hospital Laboratory between June 2013 and March 2015. The isolates were taken through relevant biochemical testing for identification and then subjected to antimicrobial agents for susceptibility testing using the disc diffusion method. We tested for ESBL production by the combined disc method and ESBL positive (+ESBL) phenotype isolates were genotyped for BlaTEM, BlaSHV, and BlaCTX₋M using polymerase chain reaction (PCR). Data were analyzed using SPSS v24 and p-values < 0.05 were considered statistically significant. Of the 1345 urine samples tested, 230 (17.1%, 95% CI: 15.1%–19.1%) yielded significant bacteriuria. The most common bacterium isolated was Staphylococcus aureus (29.6%) followed closely by Escherichia coli (28.7%) both of which were highest during the second trimester of gestation. We isolated 152 gram-negative isolates with 41.4% (63/230) being + ESBL. Of the 63 + ESBL, 45 (71.4%) possessed blaTEM, 42 (66.7%) had blaCTX₋M and 2 (3.2%) possessed blaSHV genes; 38 possessed multiple ESBL genes comprising 2 with both SHV and TEM genes and 36 with both CTX-M and TEM genes. High prevalence of UTI and persistent transmission of ESBLs among pregnant women in the Ho Municipality is worrying and a course for public health concern. We recommend urine culture during pregnancy as a routine laboratory investigation to avoid birth-related complications.
    Keywords Escherichia coli ; Staphylococcus aureus ; antibiotic resistance ; bacteria ; genotyping ; hospitals ; phenotype ; polymerase chain reaction ; pregnancy ; public health ; urinary tract diseases ; urine ; Ghana ; Extended spectrum β-lactamase ; Antimicrobial ; Urinary bacteria ; Antenatal clinic
    Language English
    Dates of publication 2022-12
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e12513
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Cryptosporidium Infection and Associated Risk Factors among Cattle in the Central Region of Ghana.

    Dankwa, Kwabena / Feglo, Patrick K / Nuvor, Samuel V / Aggrey-Korsah, Michael / Mutocheluh, Mohamed

    Journal of parasitology research

    2021  Volume 2021, Page(s) 6625117

    Abstract: ... ...

    Abstract Cryptosporidium
    Language English
    Publishing date 2021-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2563542-6
    ISSN 2090-0031 ; 2090-0023
    ISSN (online) 2090-0031
    ISSN 2090-0023
    DOI 10.1155/2021/6625117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Estimated Burden of Serious Fungal Infections in Ghana.

    Ocansey, Bright K / Pesewu, George A / Codjoe, Francis S / Osei-Djarbeng, Samuel / Feglo, Patrick K / Denning, David W

    Journal of fungi (Basel, Switzerland)

    2019  Volume 5, Issue 2

    Abstract: Fungal infections are increasingly becoming common and yet often neglected in developing countries. Information on the burden of these infections is important for improved patient outcomes. The burden of serious fungal infections in Ghana is unknown. We ... ...

    Abstract Fungal infections are increasingly becoming common and yet often neglected in developing countries. Information on the burden of these infections is important for improved patient outcomes. The burden of serious fungal infections in Ghana is unknown. We aimed to estimate this burden. Using local, regional, or global data and estimates of population and at-risk groups, deterministic modelling was employed to estimate national incidence or prevalence. Our study revealed that about 4% of Ghanaians suffer from serious fungal infections yearly, with over 35,000 affected by life-threatening invasive fungal infections. Incidence of cryptococcal meningitis,
    Language English
    Publishing date 2019-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof5020038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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