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  1. Article ; Online: Physiologic oxygen responses to smoking opioids: an observational study using continuous pulse oximetry at overdose prevention services in British Columbia, Canada.

    Moe, Jessica / Buxton, Jane A / Wang, Yueqiao Elle / Chavez, Tamara / Feldman-Kiss, Damian / Marr, Charotte / Purssell, Roy A / Otterstatter, Michael

    Harm reduction journal

    2024  Volume 21, Issue 1, Page(s) 89

    Abstract: Background: In British Columbia, Canada, smoking is the most common modality of drug use among people who die of opioid toxicity. We aimed to assess oxygen saturation (SpO: Methods: This was an observational cohort study, using a participatory design. ...

    Abstract Background: In British Columbia, Canada, smoking is the most common modality of drug use among people who die of opioid toxicity. We aimed to assess oxygen saturation (SpO
    Methods: This was an observational cohort study, using a participatory design. We implemented our monitoring protocol from March to August 2021 at four OPS. We included adults (≥ 18 years) presenting to smoke opioids. A sensor taped to participants' fingers transmitted real-time SpO
    Results: We recorded 599 smoking events; 72.8% (436/599) had analyzable SpO
    Conclusions: Continuous pulse oximetry SpO
    MeSH term(s) Humans ; Male ; Female ; Oximetry ; British Columbia/epidemiology ; Adult ; Analgesics, Opioid ; Middle Aged ; Drug Overdose/prevention & control ; Oxygen Saturation ; Pilot Projects ; Smoking/epidemiology ; Cohort Studies ; Oxygen/blood ; Harm Reduction
    Chemical Substances Analgesics, Opioid ; Oxygen (S88TT14065)
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146691-9
    ISSN 1477-7517 ; 1477-7517
    ISSN (online) 1477-7517
    ISSN 1477-7517
    DOI 10.1186/s12954-024-01011-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Feeling safer: effectiveness, feasibility, and acceptability of continuous pulse oximetry for people who smoke opioids at overdose prevention services in British Columbia, Canada.

    Moe, Jessica / Chavez, Tamara / Marr, Charotte / Cameron, Fred / Feldman-Kiss, Damian / Wang, Yueqiao Elle / Xavier, Jessica C / Mamdani, Zahra / Purssell, Roy A / Salmon, Amy / Buxton, Jane A

    Harm reduction journal

    2024  Volume 21, Issue 1, Page(s) 45

    Abstract: Background: Smoking is the most common mode of unregulated opioid consumption overall and implicated in fatal overdoses in British Columbia (BC). In part, perception of decreased risk (e.g., fewer who smoke carry naloxone kits) and limited smoking- ... ...

    Abstract Background: Smoking is the most common mode of unregulated opioid consumption overall and implicated in fatal overdoses in British Columbia (BC). In part, perception of decreased risk (e.g., fewer who smoke carry naloxone kits) and limited smoking-specific harm reduction services contribute to overdose deaths. Overdose prevention services (OPS) offer supervised settings for drug use. Continuous pulse oximetry, common in acute care, allows real-time, remote oxygen monitoring. We evaluated the effectiveness of a novel continuous pulse oximetry protocol aimed at allowing physical distancing (as required by COVID-19, secluded spaces, and to avoid staff exposure to vaporized opioids), its feasibility, and acceptability at OPS for people who smoke opioids.
    Methods: This was a mixed methods survey study. We developed a continuous pulse oximetry protocol in collaboration with clinical experts and people with lived/living experience of substance use. We implemented our protocol from March to August 2021 at four OPS in BC permitting smoking. We included adults (≥ 18 years) presenting to OPS to smoke opioids. Peer researchers collected demographic, health, and substance use information, and conducted structured observations. OPS clients participating in our study, OPS staff, and peer researchers completed post-monitoring surveys. We analyzed responses using a thematic inductive approach and validated themes with peer researchers.
    Results: We included 599 smoking events. OPS clients participating in our study had a mean age of 38.5 years; 73% were male. Most (98%) reported using "down", heroin, or fentanyl; 48% concurrently used other substances (32% of whom reported stimulants); 76% reported smoking alone in the last 3 days; and 36% reported an overdose while smoking. Respondents reported that the protocol facilitated physical distancing, was easy to use, high satisfaction, improved confidence, improved sense of safety, and that they would use it again.
    Conclusions: Continuous pulse oximetry allowed safe physical distancing, was feasible, and acceptable in monitoring people who smoke opioids at OPS.
    MeSH term(s) Adult ; Male ; Humans ; Female ; Analgesics, Opioid/therapeutic use ; British Columbia ; Feasibility Studies ; Drug Overdose/prevention & control ; Drug Overdose/drug therapy ; Substance-Related Disorders/drug therapy ; Oximetry ; Smoking
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2146691-9
    ISSN 1477-7517 ; 1477-7517
    ISSN (online) 1477-7517
    ISSN 1477-7517
    DOI 10.1186/s12954-024-00963-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices.

    Feldman-Kiss, Damian / Li, Dailin / Cleve, Richard / Sinclair, Graham / Dubland, Joshua A / Wang, Li

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 37, Issue 6, Page(s) 1347–1353

    Abstract: Background: The presence of ketone bodies (KBs) can interfere with creatinine (Cr) measurement in both enzymatic and Jaffe methods. Since a high proportion of children hospitalized for diabetic ketoacidosis (DKA) develop acute kidney injury (AKI), here ... ...

    Abstract Background: The presence of ketone bodies (KBs) can interfere with creatinine (Cr) measurement in both enzymatic and Jaffe methods. Since a high proportion of children hospitalized for diabetic ketoacidosis (DKA) develop acute kidney injury (AKI), here we investigate whether KB interferences affect the accuracy of pediatric Cr measurement.
    Methods: Residual patient plasma samples were pooled to make three Cr levels (~ 50, 100, and 250 μM). KBs (acetone, acetoacetate, and β-hydroxybutyrate) were used to spike the pooled samples. All samples were measured for Cr by two enzymatic methods (E1 and E2), two Jaffe methods (J1 and J2), and LC-MS/MS. LC-MS/MS was considered the gold standard, and the % difference in Cr concentration was calculated for each method.
    Results: E1 and E2 were unaffected by the presence of all three KBs. J1 and J2 were unaffected by the presence of β-hydroxybutyrate. The presence of acetone resulted in dose-dependent positive interference in both Jaffe methods, whereas the presence of acetoacetate resulted in dose-dependent positive and negative interference in J1 and J2, respectively.
    Conclusions: Compared to the enzymatic methods, the Jaffe methods were much more susceptible to interference by acetone and acetoacetate, especially at lower Cr values which are commonly seen in pediatrics. Interpretation of changes in Cr concentration between different hospitals when transferring patients can become ambiguous and true kidney function unclear if different methods are used without awareness of method-specific biases. To improve DKA patient care, we recommend standardizing all of the Cr methods to an enzymatic method. A higher resolution version of the Graphical abstract is available as Supplementary information.
    MeSH term(s) 3-Hydroxybutyric Acid ; Acetoacetates ; Acetone ; Child ; Chromatography, Liquid/methods ; Creatinine ; Diabetic Ketoacidosis/diagnosis ; Humans ; Ketone Bodies ; Tandem Mass Spectrometry
    Chemical Substances Acetoacetates ; Ketone Bodies ; Acetone (1364PS73AF) ; Creatinine (AYI8EX34EU) ; 3-Hydroxybutyric Acid (TZP1275679)
    Language English
    Publishing date 2021-11-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05324-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Core competencies of peer workers who use pulse oximeters to supplement their overdose response in British Columbia.

    Mamdani, Zahra / Feldman-Kiss, Damian / McKenzie, Sophie / Knott, Mike / Cameron, Fred / Voyer, Rayne / van Norren, Jessica / Scott, Tracy / Pauly, Bernie / Buxton, Jane A

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0273744

    Abstract: Introduction: Peer workers (those with lived/living experience of substance use) are at the forefront of overdose response initiatives in British Columbia, Canada. The onset of the coronavirus disease pandemic has significantly compounded the impact of ... ...

    Abstract Introduction: Peer workers (those with lived/living experience of substance use) are at the forefront of overdose response initiatives in British Columbia, Canada. The onset of the coronavirus disease pandemic has significantly compounded the impact of the overdose crisis. Peer workers are integral in supporting people who use substances. However, despite the important work they do, peer workers often lack formalized credibility and do not have the same resources available to them as service providers without lived experience. The peer-led project titled the Peer2Peer Project implemented several support programs for peer workers, including providing pulse oximeters to peer workers to supplement their overdose response procedures.
    Materials and methods: This study was a component of a larger evaluation of the pulse oximeter program at two organizations in BC. The study aims to highlight the competencies of peer workers who use pulse oximeters. Telephone interviews were conducted with seven peer workers who were given pulse oximeters. The transcripts were thematically coded using Covert et al.'s framework of core competencies of community health workers to compare our sample with other widely recognized professions.
    Findings: We found that peer workers who used pulse oximeters described several core competencies in their work and these were aligned with Covert et al.'s core competencies for community health workers, including assessment, community health practice, communication, diversity and inclusion, professional practice, and disease prevention and management.
    Conclusion: By aligning peer workers' skills to those of community health workers, we create awareness on the competencies of peer workers in using oximeters to supplement overdose response and advocate for them to receive more recognition and respect within the workplace. Further, our findings act as groundwork for future research in identifying the professional proficiencies of peer workers.
    MeSH term(s) British Columbia ; Drug Overdose ; Humans ; Oximetry ; Oxygen ; Peer Group
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving

    Musso, Pierre-Yves / Junca, Pierre / Jelen, Meghan / Feldman-Kiss, Damian / Zhang, Han / Chan, Rachel Cw / Gordon, Michael D

    eLife

    2019  Volume 8

    Abstract: Manipulating feeding circuits in freely moving animals is challenging, in part because the timing of sensory inputs is affected by the animal's behavior. To address this challenge ... ...

    Abstract Manipulating feeding circuits in freely moving animals is challenging, in part because the timing of sensory inputs is affected by the animal's behavior. To address this challenge in
    MeSH term(s) Animals ; Drosophila/physiology ; Entomology/methods ; Feeding Behavior ; Nerve Net/physiology ; Optogenetics/methods
    Language English
    Publishing date 2019-07-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.45636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A complex peripheral code for salt taste in

    Jaeger, Alexandria H / Stanley, Molly / Weiss, Zachary F / Musso, Pierre-Yves / Chan, Rachel Cw / Zhang, Han / Feldman-Kiss, Damian / Gordon, Michael D

    eLife

    2018  Volume 7

    Abstract: Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding ... ...

    Abstract Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in
    MeSH term(s) Animals ; Avoidance Learning/drug effects ; Calcium/metabolism ; Drosophila melanogaster/anatomy & histology ; Drosophila melanogaster/physiology ; Models, Biological ; Pheromones/pharmacology ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Sodium Chloride/pharmacology ; Taste/physiology ; Tetanus Toxin/pharmacology
    Chemical Substances Pheromones ; Tetanus Toxin ; Sodium Chloride (451W47IQ8X) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-10-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.37167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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