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  1. Book ; Conference proceedings: The scientific basis of rheumatology

    Feldmann, Marc

    proceedings of a symposium held on 24 - 26 June 2002 in London, UK

    (Arthritis reseach ; 4, Suppl. 3)

    2002  

    Institution Conference The Scientific Basis of Rheumatology
    Author's details ed.: Marc Feldmann ... [Conference The Scientific Basis of Rheumatology]
    Series title Arthritis reseach ; 4, Suppl. 3
    Arthritis research
    Collection Arthritis research
    Language English
    Size S301, XXIX S. : Ill., graph. Darst.
    Publisher BioMed Central
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT014018875
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 5490 -4,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Treatment of Adults Hospitalized With COVID-19 Pneumonia.

    Mathew, Paul / Feldmann, Marc

    JAMA

    2023  Volume 330, Issue 21, Page(s) 2122–2123

    MeSH term(s) Adult ; Humans ; COVID-19/therapy ; Hospitalization ; Pneumonia/therapy ; SARS-CoV-2
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.20406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  3. Book: T-cells

    Feldmann, Marc

    (Cell biology ; 7 ; A Wiley-interscience publication)

    1989  

    Author's details ed. by Marc Feldmann
    Series title Cell biology ; 7
    A Wiley-interscience publication
    Collection
    Keywords T-Lymphocytes / immunology ; T-Lymphozyt
    Subject Thymus-Lymphozyt ; T-Zelle ; T-Lymphozyt ; Thymozyt
    Size XII, 424 S. : Ill., graph. Darst.
    Edition 1. [Dr.]
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003422748
    ISBN 0-471-89169-x ; 978-0-471-89169-x7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5016 order for loan Magazin

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  4. Article ; Online: Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors.

    Jensen, Lise Torp / Attfield, Kathrine E / Feldmann, Marc / Fugger, Lars

    EBioMedicine

    2023  Volume 97, Page(s) 104840

    Abstract: JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in treating complex diseases such as cancers and immune-mediated disorders. However, their broad reach also poses safety concerns, which have fuelled a demand for ... ...

    Abstract JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in treating complex diseases such as cancers and immune-mediated disorders. However, their broad reach also poses safety concerns, which have fuelled a demand for increasingly selective JAK inhibitors. Deucravacitinib, a first-in-class allosteric TYK2 inhibitor, represents a remarkable advancement in the field. Rather than competing at kinase domain catalytic sites as classical JAK1-3 inhibitors, deucravacitinib targets the regulatory pseudokinase domain of TYK2. It strikingly mirrors the functional effect of an evolutionary conserved naturally occurring TYK2 variant, P1104A, known to protect against multiple autoimmune diseases yet provide sufficient TYK2-mediated cytokine signalling required to prevent immune deficiency. The unprecedentedly high functional selectivity and efficacy-safety profile of deucravacitinib, initially demonstrated in psoriasis, combined with genetic support, and promising outcomes in early SLE clinical trials make this inhibitor ripe for exploration in other autoimmune diseases for which better, safe, and efficacious treatments are urgently needed.
    MeSH term(s) Humans ; Janus Kinase Inhibitors/pharmacology ; Janus Kinase Inhibitors/therapeutic use ; TYK2 Kinase/genetics ; Autoimmune Diseases/drug therapy ; Cytokines ; Psoriasis/drug therapy ; Janus Kinase 1/genetics ; Janus Kinase 1/metabolism
    Chemical Substances Janus Kinase Inhibitors ; TYK2 Kinase (EC 2.7.10.2) ; Cytokines ; TYK2 protein, human (EC 2.7.10.2) ; JAK1 protein, human (EC 2.7.10.2) ; Janus Kinase 1 (EC 2.7.10.2)
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  5. Book: Kollaboratives Filtern in latenten Datenräumen

    Feldmann, Marc

    Entwurf und prototypische Realisierung eines Empfehlungssystems unter Datenknappheit

    (Wirtschaftswissenschaftliches Forum der FOM ; Band 55)

    2018  

    Institution Shaker Verlag GmbH
    Author's details Marc Feldmann
    Series title Wirtschaftswissenschaftliches Forum der FOM ; Band 55
    Language German
    Size 147 Seiten, Illustrationen, 21 cm x 14.8 cm, 221 g
    Edition 1. Auflage
    Document type Book
    ISBN 3844061797 ; 9783844061796
    Database ECONomics Information System

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  6. Book ; Conference proceedings: Regulation of immune gene expression

    Feldmann, Marc

    [based on proceed. of a conference held at Trinity College, Oxford on Sept. 21 - 25, 1985]

    (Experimental biology and medicine ; [13])

    1986  

    Author's details ed. by Marc Feldmann
    Series title Experimental biology and medicine ; [13]
    Collection
    Keywords Gene Expression Regulation / congresses ; Genes, MHC Class II / congresses ; Immunreaktion ; Genregulation ; Immungenetik ; Regulierung
    Subject Marktregulierung ; Staatliche Regulierung ; Staat ; Regulation ; Staatliche Kontrolle ; Immunogenetik ; Genetische Regulation ; Transkription ; Genaktivität ; Abwehrreaktion ; Immunantwort ; Immunoreaktivität ; Immunabwehr
    Size XIII, 359 S. : Ill., graph. Darst.
    Publisher Humana Pr
    Publishing place Clifton, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT002867556
    ISBN 0-89603-104-7 ; 978-0-89603-104-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1987 A 76 order for loan Magazin

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  7. Article ; Online: A conversation with Marc Feldmann, Jacques Miller, and Max Cooper.

    Feldmann, Marc / Neill, Ushma S

    The Journal of clinical investigation

    2020  Volume 130, Issue 1, Page(s) 1–3

    MeSH term(s) Adaptive Immunity ; Allergy and Immunology ; Awards and Prizes ; B-Lymphocytes/immunology ; Humans ; T-Lymphocytes/immunology
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Interview ; Video-Audio Media
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI134899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.184: Show issues Location:
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  8. Book: Human T cell clones

    Feldmann, Marc

    a new approach to immune regulation ; [proc. of a conf. held at ... Oxford, on Sept. 22 - 26, 1984]

    (Experimental biology and medicine ; [9])

    1985  

    Author's details ed. by Marc Feldmann
    Series title Experimental biology and medicine ; [9]
    Collection
    Keywords Autoimmune Diseases / congresses ; Clone Cells / congresses ; HLA Antigens / congresses ; Immunity, Cellular / congresses ; Receptors, Antigen, T-Cell / congresses ; T-Lymphocytes / congresses ; T-Lymphozyt ; Klon ; Immunpathologie ; Mensch
    Subject Menschen ; Homo sapiens ; Thymus-Lymphozyt ; T-Zelle ; T-Lymphozyt ; Thymozyt ; Immunopathologie
    Size XV, 455 S. : graph. Darst.
    Publisher Humana Pr
    Publishing place Clifton, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT002831931
    ISBN 0-89603-084-9 ; 978-0-89603-084-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 3259 order for loan Magazin

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  9. Book ; Conference proceedings: Immune regulation

    Feldmann, Marc

    [based on papers pres. at a conference held in 1984 at Cambridge, England]

    (Experimental biology and medicine ; [8])

    1985  

    Author's details ed. by Marc Feldmann
    Series title Experimental biology and medicine ; [8]
    Collection
    Keywords Cell Differentiation / congresses ; Immunity, Cellular / congresses ; Lymphocytes / cytology / congresses ; Lymphocytes / immunology / congresses ; Immunsystem ; Regulation
    Subject Körpereigene Abwehr ; Körpereigene Abwehrkräfte ; Körpereigenes Abwehrsystem ; Abwehrkräfte
    Size XV, 391 S. : Ill., graph. Darst.
    Publisher Humana Pr
    Publishing place Clifton, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT002286911
    ISBN 0-89603-083-0 ; 978-0-89603-083-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1986 A 927 order for loan Magazin

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  10. Article ; Online: A conversation with Marc Feldmann. Interviewed by Ushma S. Neill.

    Feldmann, Marc

    The Journal of clinical investigation

    2014  Volume 124, Issue 1, Page(s) 1–2

    MeSH term(s) Allergy and Immunology/history ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Australia ; England ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2014-01-02
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Interview ; Portrait
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI71860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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