LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article: Rarγ -Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer.

    Felice, Dario De / Alaimo, Alessandro / Bressan, Davide / Genovesi, Sacha / Marmocchi, Elisa / Annesi, Nicole / Beccaceci, Giulia / Dalfovo, Davide / Cutrupi, Federico / Foletto, Veronica / Lorenzoni, Marco / Gandolfi, Francesco / Kannan, Srinivasaraghavan / Verma, Chandra S / Vasciaveo, Alessandro / Shen, Michael M / Romanel, Alessandro / Chiacchiera, Fulvio / Cambuli, Francesco /
    Lunardi, Andrea

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial roles in directing body axis orientation and tissue differentiation, including in the reproductive system. However, a mechanistic understanding of how RA signaling ... ...

    Abstract Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial roles in directing body axis orientation and tissue differentiation, including in the reproductive system. However, a mechanistic understanding of how RA signaling promotes cell lineage identity in different tissues is often missing. Here, leveraging prostate organoid technology, we demonstrated that RA signaling orchestrates the commitment of adult mouse prostate progenitors to glandular identity, epithelial barrier integrity, and ultimately, proper specification of the prostatic lumen. Mechanistically, RA-dependent RARγ activation promotes the expression of the pioneer factor Foxa1, which synergizes with the androgen pathway for proper luminal expansion, cytoarchitecture and function.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.06.583256
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: The organoid era permits the development of new applications to study glioblastoma

    Andreatta, Francesco / Beccaceci, Giulia / Fortuna, Nicolò / Celotti, Martina / Felice, Dario De / Lorenzoni, Marco / Foletto, Veronica / Genovesi, Sacha / Rubert, Josep / Alaimo, Alessandro

    Cancers

    2020  Volume 12, Issue 11

    Abstract: Glioblastoma (GB) is the most frequent and aggressive type of glioma. The lack of reliable GB models, together with its considerable clinical heterogeneity, has impaired a comprehensive investigation of the mechanisms that lead to tumorigenesis, cancer ... ...

    Abstract Glioblastoma (GB) is the most frequent and aggressive type of glioma. The lack of reliable GB models, together with its considerable clinical heterogeneity, has impaired a comprehensive investigation of the mechanisms that lead to tumorigenesis, cancer progression, and response to treatments. Recently, 3D cultures have opened the possibility to overcome these challenges and cerebral organoids are emerging as a leading-edge tool in GB research. The opportunity to easily engineer brain organoids via gene editing and to perform co-cultures with patient-derived tumor spheroids has enabled the analysis of cancer development in a context that better mimics brain tissue architecture. Moreover, the establishment of biobanks from GB patient-derived organoids represents a crucial starting point to improve precision medicine therapies. This review exemplifies relevant aspects of 3D models of glioblastoma, with a specific focus on organoids and their involvement in basic and translational research.
    Keywords Glioblastoma ; Organoids ; Precision medicine ; Preclinical cancer models ; Stem cells ; Translational research ; Tumoroids
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top