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Article ; Online: System-based integrated metabolomics and microRNA analysis identifies potential molecular alterations in human X-linked cerebral adrenoleukodystrophy brain.

Poisson, Laila M / Kaur, Navtej / Felicella, Michelle M / Singh, Jaspreet

2023 Volume 32, Issue 23, Page(s) 3249–3262

Abstract: X-linked adrenoleukodystrophy is a severe demyelinating neurodegenerative disease mainly affecting males. The severe cerebral adrenoleukodystrophy (cALD) phenotype has a poor prognosis and underlying mechanism of onset and progression of neuropathology ... ...

Abstract	X-linked adrenoleukodystrophy is a severe demyelinating neurodegenerative disease mainly affecting males. The severe cerebral adrenoleukodystrophy (cALD) phenotype has a poor prognosis and underlying mechanism of onset and progression of neuropathology remains poorly understood. In this study we aim to integrate metabolomic and microRNA (miRNA) datasets to identify variances associated with cALD. Postmortem brain tissue samples from five healthy controls (CTL) and five cALD patients were utilized in this study. White matter from ALD patients was obtained from normal-appearing areas, away from lesions (NLA) and from the periphery of lesions- plaque shadow (PLS). Metabolomics was performed by gas chromatography coupled with time-of-flight mass spectrometry and miRNA expression analysis was performed by next generation sequencing (RNAseq). Principal component analysis revealed that among the three sample groups (CTL, NLA and PLS) there were 19 miRNA, including several novel miRNA, of which 17 were increased with disease severity and 2 were decreased. Untargeted metabolomics revealed 13 metabolites with disease severity-related patterns with 7 increased and 6 decreased with disease severity. Ingenuity pathway analysis of differentially altered metabolites and miRNA comparing CTL with NLA and NLA with PLS, identified several hubs of metabolite and signaling molecules and their upstream regulation by miRNA. The transomic approach to map the crosstalk between miRNA and metabolomics suggests involvement of specific molecular and metabolic pathways in cALD and offers opportunity to understand the complex underlying mechanism of disease severity in cALD.
MeSH term(s)	Male ; Humans ; Adrenoleukodystrophy/genetics ; Adrenoleukodystrophy/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neurodegenerative Diseases/metabolism ; Brain/metabolism ; Phenotype ; Metabolomics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddad144
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Zs.A 3469: Show issues

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Article ; Online: Awake resection of recurrent astroblastoma with intraoperative 5-ALA-induced fluorescence: illustrative case.

Price, Anthony / O'Leary, Sean / Malkova, Kseniia / D'Souza, Preston / Ogasawara, Christian / Felicella, Michelle M / Karas, Patrick J

Journal of neurosurgery. Case lessons

2023 Volume 6, Issue 18

Abstract: Background: Astroblastoma is a rare neoplasm characterized as a circumscribed glial neoplasm most often arising in the frontoparietal cerebral hemispheres in older children.: Observations: We report an intriguing case of an astroblastoma recurrence ... ...

Abstract	Background: Astroblastoma is a rare neoplasm characterized as a circumscribed glial neoplasm most often arising in the frontoparietal cerebral hemispheres in older children. Observations: We report an intriguing case of an astroblastoma recurrence 21 years after gross-total resection and radiation. A 32-year-old right-handed female presented to the emergency department for a generalized tonic-clonic seizure. She had a history of bipolar disorder, intractable migraines, and prior seizures linked to an astroblastoma previously resected three times. Magnetic resonance imaging on the current visit showed growth of the recurrent lesion to a 3.8-cm maximal diameter. Left-sided awake craniotomy was performed to remove the tumor while using speech mapping and 5-aminolevulinic acid (5-ALA). Targeted next-generation sequencing of the tumor revealed in-frame MN1::BEND2 fusion transcripts. Lessons: We found that 5-ALA can be used in astroblastoma patients to assist in gross-total resection, which is important for long-term survival. Our astroblastoma case demonstrated classic astroblastoma morphology, with typical perivascular astroblastic rosettes, and was brightly fluorescent after 5-ALA administration.
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE23526
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Article ; Online: Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding.

Valdes, Pablo A / Yu, Chih-Chieh Jay / Aronson, Jenna / Ghosh, Debarati / Zhao, Yongxin / An, Bobae / Bernstock, Joshua D / Bhere, Deepak / Felicella, Michelle M / Viapiano, Mariano S / Shah, Khalid / Chiocca, E Antonio / Boyden, Edward S

Science translational medicine

2024 Volume 16, Issue 732, Page(s) eabo0049

Abstract: Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving antibody access to epitopes. Here, we ... ...

Abstract	Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving antibody access to epitopes. Here, we present an ExM variant, decrowding expansion pathology (dExPath), that can expand proteins away from each other in human brain pathology specimens, including formalin-fixed paraffin-embedded (FFPE) clinical specimens. Immunostaining of dExPath-expanded specimens reveals, with nanoscale precision, previously unobserved cellular structures, as well as more continuous patterns of staining. This enhanced molecular staining results in observation of previously invisible disease marker-positive cell populations in human glioma specimens, with potential implications for tumor aggressiveness. dExPath results in improved fluorescence signals even as it eliminates lipofuscin-associated autofluorescence. Thus, this form of expansion-mediated protein decrowding may, through improved epitope access for antibodies, render immunohistochemistry more powerful in clinical science and, perhaps, diagnosis.
MeSH term(s)	Humans ; Immunohistochemistry ; Brain ; Antibodies, Monoclonal ; Epitopes ; Nanostructures ; Formaldehyde
Chemical Substances	Antibodies, Monoclonal ; Epitopes ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.abo0049
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Zs.A 6941: Show issues

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Article ; Online: Recent Advances in the Classification and Treatment of Ependymomas.

Leeper, Heather / Felicella, Michelle M / Walbert, Tobias

Current treatment options in oncology

2017 Volume 18, Issue 9, Page(s) 55

Abstract: Opinion statement: Ependymomas are a subgroup of ependymal glia-derived neoplasms that affect children as well as adults. Arising within any CNS compartment, symptoms at presentation can range from acute onset due to increased intracranial pressure to ... ...

Abstract	Opinion statement: Ependymomas are a subgroup of ependymal glia-derived neoplasms that affect children as well as adults. Arising within any CNS compartment, symptoms at presentation can range from acute onset due to increased intracranial pressure to insidious myelopathy. The overall survival (OS) outcomes in adult patients across the subgroups is heterogeneous with subependymoma having an excellent prognosis often even in the absence of any treatment, whereas supratentorial ependymomas tend to be higher grade in nature and may have an OS of 5 years despite gross total resection and adjuvant radiation. The rarity of ependymal tumors, together still only representing 1.8% of all primary CNS tumors, has been a long-standing challenge in defining optimal treatment guidelines via prospective randomized trials. Retrospective studies have supported maximal safe resection, ideally gross total resection, as the optimal treatment with adjuvant radiation therapy proffering additional tumor control. The evidence for efficacy of chemotherapy and targeted agents in adult ependymomas is minimal. Recent investigations of the molecular, genetic, and DNA methylation profiles of ependymal tumors across all age groups and CNS compartments have identified distinct oncogenic gene products as well as nine molecular subgroups correlating with similar outcomes. The 2016 World Health Organization of Tumors of the Central Nervous System update addresses some of these findings, although their clinical significance has not yet been fully validated. There are inconsistent survival outcomes in retrospective studies for ependymomas graded as II versus III, bringing into question the validity of histologic grading which is subject to high interobserver variability in part due to inconsistent application of mitotic count parameters.
Language	English
Publishing date	2017-08-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-017-0496-7
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Zs.A 5523: Show issues

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Article ; Online: Necrotizing plasma cell-rich aortitis and sudden cardiac death: Late sequelae of COVID-19?

Boor, Paul J / Srinivasan, Mukund / Stevenson, Heather L / Gong, Bin / Nyong, Emmanuel / Dong, Jianli / Popov, Vsevolod / Sherman, Michael / Bopp, Nathen / Felicella, Michelle M / Zhao, Bihong / Buja, Maximilian / Nickels, Jaclyn / Aronson, Judith F

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

2023 Volume 66, Page(s) 107558

Abstract: The ongoing epidemic caused by the coronavirus SARS-CoV-2 is characterized by a variety of pathologic processes within the syndrome of COVID-19. Usually beginning as an upper respiratory infection with potential progression to a pneumonitis, many cases ... ...

Abstract	The ongoing epidemic caused by the coronavirus SARS-CoV-2 is characterized by a variety of pathologic processes within the syndrome of COVID-19. Usually beginning as an upper respiratory infection with potential progression to a pneumonitis, many cases of COVID-19 that show minimal signs or symptoms initially may develop adverse systemic sequelae later, such as widespread thrombo-embolic phenomena, systemic inflammatory disorders (especially in children), or vasculitis. Here, we present a patient who suffered a sudden cardiac death following persistent SARS-CoV-2 viral positivity for four-and-one-half months after a mild clinical viral course. At routine autopsy, a remarkable plasma cell-rich necrotizing aortitis was uncovered. The aortic intima displayed diffuse, circumferential ongoing chronic intimal edema, inflammation, and neo-vascularization. The plasma cell-rich inflammatory process also involved the origin of the left main coronary artery (LM) causing a coronary arteritis accompanied by subacute, stenosing intimal vascular smooth muscle cell (VSMC) proliferation resulting in acute myocardial necrosis as a cause of death. A similar vasculitis and plaque were noted during the routine autopsy at the ostium of the celiac artery; vasculitis was not found systemically or in smaller caliber vessels. Through a variety of techniques including extensive histopathologic and immunohistochemical characterization, immunostaining localization of viral antigen, and transmission electron microscopy we present highly suggestive evidence that this unique necrotizing, plasma cell-rich aortitis is a rare sequela of COVID-19.
MeSH term(s)	Child ; Humans ; Aortitis/pathology ; COVID-19/complications ; Plasma Cells/pathology ; SARS-CoV-2 ; Death, Sudden, Cardiac/etiology ; Disease Progression
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1134600-0
ISSN	1879-1336 ; 1054-8807
ISSN (online)	1879-1336
ISSN	1054-8807
DOI	10.1016/j.carpath.2023.107558
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Zs.A 3572: Show issues

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Article: A Fatal Fungal Infection:

Nielsen, Marisa C / Peterson, Joshua M / Shine, Billie / Hornak, J Patrik / Esechie, Aimalohi / Bhatt, Sandeep / Desai, Kinjal / Dabi, Alok / Felicella, Michelle M / Ren, Ping

Open forum infectious diseases

2022 Volume 9, Issue 7, Page(s) ofac236

Abstract: Cryptococcus ... ...

Abstract	Cryptococcus gattii
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofac236
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Article ; Online: Multifocal Intradural Extramedullary Pilocytic Astrocytomas of the Spinal Cord: A Case Report and Review of the Literature.

Basheer, Azam / Rammo, Richard / Kalkanis, Steven / Felicella, Michelle M / Chedid, Mokbel

Neurosurgery

2017 Volume 80, Issue 2, Page(s) E178–E184

Abstract: Background and importance: Pilocytic astrocytoma (PA) is among the most common of the central nervous system gliomas in the pediatric population; however, it is uncommon in adults. PAs of the spinal cord in adults are even rarer, with only a few cases ... ...

Abstract	Background and importance: Pilocytic astrocytoma (PA) is among the most common of the central nervous system gliomas in the pediatric population; however, it is uncommon in adults. PAs of the spinal cord in adults are even rarer, with only a few cases found in the literature. We report here the first case in the literature of multifocal intradural extramedullary spinal cord PAs in an adult. Clinical presentation: Our patient is a 56-yr-old female who presented with loss of balance and an ataxic gait. Multiple extramedullary spinal cord tumors were identified intraoperatively, the lesions completely resected, and all diagnosed as PAs. Conclusion: This case illustrates a unique instance of multifocal intradural extramedullary spinal cord PAs in an adult with no previous history of PA during childhood, no known familial syndromes, and no brain involvement.
MeSH term(s)	Adult ; Astrocytoma ; Female ; Humans ; Middle Aged ; Spinal Cord Neoplasms
Language	English
Publishing date	2017-02-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1093/neuros/nyw029
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 539: Show issues

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Article ; Online: Interdural course of the ophthalmic artery in the optic canal.

Tayebi Meybodi, Ali / Borba Moreira, Leandro / Lawton, Michael T / Eschbacher, Jennifer M / Belykh, Evgenii G / Felicella, Michelle M / Preul, Mark C

Journal of neurosurgery

2019 Volume 132, Issue 1, Page(s) 277–283

Abstract: Objective: In the current neurosurgical and anatomical literature, the intracanalicular segment of the ophthalmic artery (OphA) is usually described to be within the optic nerve dural sheath (ONDS), implying direct contact between the nerve and the ... ...

Abstract	Objective: In the current neurosurgical and anatomical literature, the intracanalicular segment of the ophthalmic artery (OphA) is usually described to be within the optic nerve dural sheath (ONDS), implying direct contact between the nerve and the artery inside the optic canal. In the present study, the authors sought to clarify the exact relationship between the OphA and ONDS. Methods: Ten cadaveric heads were subjected to endoscopic endonasal and transcranial exposures of the OphA in the optic canal (5 for each approach). The relationship between the OphA and ONDS was assessed. Histological examination of one specimen of the optic nerve and the accompanying OphA was also performed to confirm the relationship with the ONDS. Results: In all specimens, the OphA coursed between the two layers of the dura (endosteal and meningeal) and was not in direct contact with the optic nerve, except for the first few millimeters of the proximal optic canal before it pierced the ONDS. Upon reaching the orbit, the two layers of the dura separated and allowed the OphA to literally float within the orbital fat. The meningeal dura continued as the ONDS, whereas the endosteal dura became the periorbita. Conclusions: This study clarifies the interdural course of the OphA within the optic canal. This anatomical nuance has important neurosurgical implications regarding safe exposure and manipulation of the OphA.
MeSH term(s)	Carotid Artery, Internal/anatomy & histology ; Dura Mater/anatomy & histology ; Endoscopy ; Humans ; Ophthalmic Artery/anatomy & histology ; Optic Nerve/anatomy & histology
Language	English
Publishing date	2019-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2018.6.JNS18856
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Article ; Online: Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase.

Singh, Jaspreet / Olle, Brittany / Suhail, Hamid / Felicella, Michelle M / Giri, Shailendra

Journal of neurochemistry

2016 Volume 138, Issue 1, Page(s) 86–100

Abstract: X-linked adrenoleukodystrophy (X-ALD) is a progressive neurometabolic disease caused by mutations/deletions in the Abcd1 gene. Similar mutations/deletions in the Abcd1 gene often result in diagonally opposing phenotypes of mild adrenomyeloneuropathy and ... ...

Abstract	X-linked adrenoleukodystrophy (X-ALD) is a progressive neurometabolic disease caused by mutations/deletions in the Abcd1 gene. Similar mutations/deletions in the Abcd1 gene often result in diagonally opposing phenotypes of mild adrenomyeloneuropathy and severe neuroinflammatory cerebral adrenoleukodystrophy (ALD), which suggests involvement of downstream modifier genes. We recently documented the first evidence of loss of AMP-activated protein kinase α1 (AMPKα1) in ALD patient-derived cells. Here, we report the novel loss of AMPKα1 in postmortem brain white matter of patients with ALD phenotype. Pharmacological activation of AMPK can rescue the mitochondrial dysfunction and inhibit the pro-inflammatory response. The FDA approved anti-diabetic drug Metformin, a well-known AMPK activator, induces mitochondrial biogenesis and is documented for its anti-inflammatory role. We observed a dose-dependent activation of AMPKα1 in metformin-treated X-ALD patient-derived fibroblasts. Metformin also induced mitochondrial oxidative phosphorylation and ATP levels in X-ALD patient-derived fibroblasts. Metformin treatment decreased very long chain fatty acid levels and pro-inflammatory cytokine gene expressions in X-ALD patient-derived cells. Abcd2 [adrenoleukodystrophy protein-related protein] levels were increased in metformin-treated X-ALD patient-derived fibroblasts and Abcd1-KO mice primary mixed glial cells. Abcd2 induction was AMPKα1-dependent since metformin failed to induce Abcd2 levels in AMPKα1-KO mice-derived primary mixed glial cells. In vivo metformin (100 mg/Kg) in drinking water for 60 days induced Abcd2 levels and mitochondrial oxidative phosphorylation protein levels in the brain and spinal cord of Abcd1-KO mice. Taken together, these results provide proof-of-principle for therapeutic potential of metformin as a useful strategy for correcting the metabolic and inflammatory derangements in X-ALD by targeting AMPK. There is no effective therapy for inherited peroxisomal disorder X-linked adrenoleukodystrophy (X-ALD). We document the therapeutic potential of FDA approved drug, Metformin, for X-ALD by targeting AMPK. Metformin induced peroxisomal Abcd2 levels in vitro and in vivo. Metformin lowered VLCFA levels, improved mitochondrial function and ameliorated inflammatory gene expression in X-ALD patient-derived cells. Metformin-induced Abcd2 levels were dependent on AMPKα1, a metabolic and anti-inflammatory gene, recently documented by our laboratory to play a putative role in X-ALD pathology. Read the Editorial Highlight for this article on page 10.
MeSH term(s)	AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; ATP Binding Cassette Transporter, Sub-Family D ; ATP Binding Cassette Transporter, Sub-Family D, Member 1 ; ATP-Binding Cassette Transporters/deficiency ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Adrenoleukodystrophy/enzymology ; Adrenoleukodystrophy/genetics ; Adrenoleukodystrophy/pathology ; Animals ; Animals, Newborn ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Humans ; Hypoglycemic Agents/pharmacology ; Metformin/pharmacology ; Mice ; Mice, Knockout ; Mitochondria/drug effects ; Mitochondria/genetics ; Nitric Oxide Synthase Type II/metabolism ; Oxidation-Reduction/drug effects ; Oxygen Consumption/drug effects ; Oxygen Consumption/genetics ; Phosphorylation/drug effects ; Phosphorylation/genetics ; Time Factors ; Up-Regulation/drug effects ; Up-Regulation/genetics
Chemical Substances	ABCD2 protein, human ; ATP Binding Cassette Transporter, Sub-Family D ; ATP Binding Cassette Transporter, Sub-Family D, Member 1 ; Abcd1 protein, mouse ; Hypoglycemic Agents ; Metformin (9100L32L2N) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; AMPK alpha1 subunit, mouse (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.13562
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Article ; Online: A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.

Chen, Joshua C / Kan, Peter / Yu, Zhanghao / Alrashdan, Fatima / Garcia, Roberto / Singer, Amanda / Lai, C S Edwin / Avants, Ben / Crosby, Scott / Li, Zhongxi / Wang, Boshuo / Felicella, Michelle M / Robledo, Ariadna / Peterchev, Angel V / Goetz, Stefan M / Hartgerink, Jeffrey D / Sheth, Sunil A / Yang, Kaiyuan / Robinson, Jacob T

Nature biomedical engineering

2022 Volume 6, Issue 6, Page(s) 706–716

Abstract: Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation ...

Abstract	Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals' sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.
MeSH term(s)	Animals ; Electric Power Supplies ; Proof of Concept Study ; Prostheses and Implants ; Rats ; Sciatic Nerve ; Swine ; Wireless Technology
Language	English
Publishing date	2022-03-31
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-022-00873-7
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