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  1. Article ; Online: Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep.

    Scorsato, Paulo Sérgio / Rahal, Sheila Canevese / Cestari, Tania Mary / Mamprim, Maria Jaqueline / Doiche, Danuta Pulz / Teixeira, Daniel de Bortoli / Siqueira, Rafael Cerântola / Felix, Marcílio

    Acta cirurgica brasileira

    2022  Volume 37, Issue 4, Page(s) e370405

    Abstract: Purpose: To evaluate in-vivo degradation of two bioabsorbable interference screws.: Methods: Twenty-two crossbred Santa Inês ewes were used. A poly-DL-lactide (PDLLA) screw (70%/30%) was inserted in the right pelvic limb, and a PDLLA screw (70%) + β- ... ...

    Abstract Purpose: To evaluate in-vivo degradation of two bioabsorbable interference screws.
    Methods: Twenty-two crossbred Santa Inês ewes were used. A poly-DL-lactide (PDLLA) screw (70%/30%) was inserted in the right pelvic limb, and a PDLLA screw (70%) + β-tri-calcium phosphate (β-TCP) (30%) in the left pelvic limb. Animals were euthanized at one, four, seven and a half and 18 months after surgery. Plain radiography, computed tomography (CT), microCT, and histological analysis were accomplished.
    Results: PDLLA screw was hypodense at all evaluation moments, but with progressive density increase along the central axis, whereas PDLLA/β-TCP was initially hyperdense and progressively lost this characteristic. No adverse reactions were observed on histological evaluation.
    Conclusions: The inclusion of β-TCP favors screw degradation since the PDLLA/β-TCP screws evidenced a more intense degradation process than the PDLLA screws at the last evaluation. PDLLA screws showed higher bone production, evident around the screw thread, inside the lateral perforations, and in the central canal, whereas the PDLLA/β-TCP screws presented less bone tissue at the implantation site.
    MeSH term(s) Absorbable Implants ; Animals ; Bone Screws ; Female ; Polyesters ; Sheep ; Tomography, X-Ray Computed
    Chemical Substances Polyesters
    Language English
    Publishing date 2022-06-27
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2012156-8
    ISSN 1678-2674 ; 1678-2674
    ISSN (online) 1678-2674
    ISSN 1678-2674
    DOI 10.1590/acb370405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer-Koch Modeling.

    da Silva, Thamires Santos / Horvath-Pereira, Bianca de Oliveira / da Silva-Júnior, Leandro Norberto / Tenório Fireman, João Víctor Barbosa / Mattar, Michel / Félix, Marcílio / Buchaim, Rogerio Leone / Carreira, Ana Claudia Oliveira / Miglino, Maria Angelica / Soares, Marcelo Melo

    Polymers

    2023  Volume 15, Issue 21

    Abstract: Accurately printing customizable scaffolds is a challenging task because of the complexity of bone tissue composition, organization, and mechanical behavior. Graphene oxide (GO) and poly-L-lactic acid (PLLA) have drawn attention in the field of bone ... ...

    Abstract Accurately printing customizable scaffolds is a challenging task because of the complexity of bone tissue composition, organization, and mechanical behavior. Graphene oxide (GO) and poly-L-lactic acid (PLLA) have drawn attention in the field of bone regeneration. However, as far as we know, the Fischer-Koch model of the GO/PLLA association for three-dimensional (3D) printing was not previously reported. This study characterizes the properties of GO/PLLA-printed scaffolds in order to achieve reproducibility of the trabecula, from virtual planning to the printed piece, as well as its response to a cell viability assay. Fourier-transform infrared and Raman spectroscopy were performed to evaluate the physicochemical properties of the nanocomposites. Cellular adhesion, proliferation, and growth on the nanocomposites were evaluated using scanning electron microscopy. Cell viability tests revealed no significant differences among different trabeculae and cell types, indicating that these nanocomposites were not cytotoxic. The Fischer Koch modeling yielded satisfactory results and can thus be used in studies directed at diverse medical applications, including bone tissue engineering and implants.
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15214213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Serological survey and DNA screening of Leptospira spp. in free-living adult tufted capuchin monkeys (Cebus apella nigritus) in a forest reserve Southeast São Paulo State, Brazil.

    Girio, Raul José Silva / de Andrade-Cruvinel, Tatiana Morosini / Vasconcellos, Silvio Arruda / Repetti, Cláudia Sampaio Fonseca / Friolani, Milena / Bueno, Patrícia Cincotto Dos Santos / Felix, Marcílio / Teixeira, Daniel De Bortoli

    Journal of medical primatology

    2020  Volume 50, Issue 1, Page(s) 3–8

    Abstract: Background: Leptospirosis is an important anthropozoonosis. The study investigated the presence of anti-Leptospira antibodies and detection of Leptospira spp DNA in the urine as well as the biochemical profile in Neotropical wild primates living in a ... ...

    Abstract Background: Leptospirosis is an important anthropozoonosis. The study investigated the presence of anti-Leptospira antibodies and detection of Leptospira spp DNA in the urine as well as the biochemical profile in Neotropical wild primates living in a forest reserve from Southeast São Paulo State, Brazil.
    Methods: Blood samples were obtained from 50 adult tufted capuchin monkeys (Cebus apella nigritus). Urine samples were obtained only from male primates. The screening for antibodies against Leptospira spp was evaluated by microscopic agglutination test (MAT). Leptospira DNA in the urine was evaluated by polymerase chain reaction (PCR) considering the target gene LipL32. Biochemical profile was evaluated by using a spectrophotometer.
    Results: The MAT results included 39 (78%) serum reactive animals with the proportions of 28/39 males and 11/39 females. The most frequent reactive serogroups were Icterohemorrhagiae, Canicola, and Autumnalis. All urine samples were negative for leptospiral DNA. There were no significant differences between sexes for aspartate aminotransferase (AST) and alkaline phosphatase values, but alanine aminotransferase (ALT), creatinine, glucose, and urea were significantly higher in males.
    Conclusions: Tufted capuchin monkeys were sera reactive against leptospirosis. Prevalence was similar for the 2 sexes. Leptospiral DNA was not detected in the urine of sera reactive primates tested by the MAT method. ALT, creatinine, glucose, and urea values were higher in male animals.
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Brazil/epidemiology ; Cebinae ; DNA, Bacterial/urine ; Kidney/microbiology ; Kidney/pathology ; Leptospira/isolation & purification ; Leptospirosis/epidemiology ; Leptospirosis/microbiology ; Leptospirosis/veterinary ; Liver/microbiology ; Liver/pathology ; Male ; Monkey Diseases/epidemiology ; Monkey Diseases/microbiology
    Chemical Substances Antibodies, Bacterial ; DNA, Bacterial
    Language English
    Publishing date 2020-09-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 121206-0
    ISSN 1600-0684 ; 0047-2565
    ISSN (online) 1600-0684
    ISSN 0047-2565
    DOI 10.1111/jmp.12493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 819: Show issues Location:
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  4. Article: Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing.

    Iatecola, Amilton / Longhitano, Guilherme Arthur / Antunes, Luiz Henrique Martinez / Jardini, André Luiz / Miguel, Emilio de Castro / Béreš, Miloslav / Lambert, Carlos Salles / Andrade, Tiago Neves / Buchaim, Rogério Leone / Buchaim, Daniela Vieira / Pomini, Karina Torres / Dias, Jefferson Aparecido / Spressão, Daniele Raineri Mesquita Serva / Felix, Marcílio / Cardoso, Guinea Brasil Camargo / da Cunha, Marcelo Rodrigues

    Pharmaceutics

    2021  Volume 13, Issue 5

    Abstract: Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. ... ...

    Abstract Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.
    Language English
    Publishing date 2021-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13050724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Radiographic determination of pelvic limb orthopaedic measurements in maned wolf (Chrysocyon brachyurus).

    Siqueira, Rafael C / Rahal, Sheila C / Inamassu, Leticia R / Mamprim, Maria J / Teixeira, Rodrigo H F / Teixeira, Carlos R / Rassy, Fabricio B / Mesquita, Luciane R / Monteiro, Frederico O B / Felix, Marcilio / Melchert, Alessandra

    Anatomia, histologia, embryologia

    2018  Volume 47, Issue 6, Page(s) 527–536

    Abstract: The aim of this study was to determine some radiographic reference values for hip joint, femur and patella in maned wolves. Ten maned wolves (Chrysocyon brachyurus), five live (G1) and five cadavers (G2), were used. There were no statistically ... ...

    Abstract The aim of this study was to determine some radiographic reference values for hip joint, femur and patella in maned wolves. Ten maned wolves (Chrysocyon brachyurus), five live (G1) and five cadavers (G2), were used. There were no statistically significant differences in the radiological measurements between right and left pelvic limbs of the G1 and G2, except for mechanical lateral proximal femoral angle (mLPFA) in both Groups. The comparison of the measurements between Groups showed difference only for mechanical lateral distal femoral angle (mLDFA). Norberg angle values were 113.1° and 112.9° for G1 and G2. The values of femoral angle of inclination by Hauptman A and Hauptman B methods were 139.7° and 128.6° for G1, and 139.3° and 128.7° for G2. Femoral varus angle values were 5.5° for G1 and 3.9° for G2. The values of anatomic lateral distal femoral angle and anatomic lateral proximal femoral angle were 96.8° and 95.2° for G1, and 95.0° and 95.6° for G2. The values of mLDFA for G1 and G2 were 96.5° and 95.7°. The values of mLPFA were 95.8 (right) and 93.5 (left) for G1, and 95.7 (right) and 93.8 (left) for G2. The values of patellar ligament length, patellar length and L:P ratio were 4.6, 2.4 cm and 1.9 for G1, and 4.4, 2.3 cm and 1.8 for G2. In conclusion, the radiographic reference values described for the hip joint, the femur and the patella, may be useful in the diagnosis of diseases and deformities in maned wolves.
    MeSH term(s) Animals ; Canidae/anatomy & histology ; Female ; Femur/anatomy & histology ; Hindlimb/anatomy & histology ; Hip Joint/anatomy & histology ; Lower Extremity/anatomy & histology ; Male ; Patella/anatomy & histology ; Pelvis/anatomy & histology ; Radiography/veterinary
    Language English
    Publishing date 2018-07-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 537922-2
    ISSN 1439-0264 ; 0340-2096 ; 0044-4294
    ISSN (online) 1439-0264
    ISSN 0340-2096 ; 0044-4294
    DOI 10.1111/ahe.12393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1221: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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