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  1. Article ; Online: Immunogenicity, safety and reactogenicity of heterologous (third dose) booster vaccination with a full or fractional dose of two different COVID-19 vaccines: A phase 4, single-blind, randomized controlled trial in adults.

    Costa Clemens, Sue Ann / Marchevsky, Natalie / Kelly, Sarah / Felle, Sally / Eldawi, Ahmed / Rajasingam, Rupetha / Mahmud, Rawan / Lambe, Teresa / Voysey, Merryn / Gonzalez, Isabela / Milan, Eveline Pipolo / Justino, Maria Cleonice / Bibi, Sagida / Aley, Parvinder / Clemens, Ralf / Pollard, Andrew J

    Human vaccines & immunotherapeutics

    2023  Volume 19, Issue 2, Page(s) 2233400

    Abstract: In this phase 4 study we assessed boosting with fractional doses of heterologous COVID-19 vaccines in Brazilian adults primed with two doses of CoronaVac (Sinovac/Butantan, São Paulo, Brazil) at least 4 months previously. Participants received either ... ...

    Abstract In this phase 4 study we assessed boosting with fractional doses of heterologous COVID-19 vaccines in Brazilian adults primed with two doses of CoronaVac (Sinovac/Butantan, São Paulo, Brazil) at least 4 months previously. Participants received either full-dose of ChAdOx1-S (Group 1,
    MeSH term(s) Adult ; Humans ; COVID-19 Vaccines/adverse effects ; BNT162 Vaccine ; Single-Blind Method ; Brazil ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; ChAdOx1 nCoV-19 ; Immunoglobulin G
    Chemical Substances sinovac COVID-19 vaccine ; COVID-19 Vaccines ; BNT162 Vaccine ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Immunoglobulin G
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Randomized Controlled Trial ; Clinical Trial, Phase IV ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2023.2233400
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  2. Article ; Online: An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females.

    Marchevsky, Natalie Gabrielle / Li, Grace / Aley, Parvinder / Costa Clemens, Sue Ann / Barrett, Jordan Richard / Belij-Rammerstorfer, Sandra / Bibi, Sagida / Clutterbuck, Elizabeth / Dold, Christina / Felle, Sally / Flaxman, Amy / Folegatti, Pedro / Jenkin, Daniel / Gilbert, Sarah / Kelly, Sarah / Lambe, Teresa / Plested, Emma / Ramasamy, Maheshi / Singh, Nisha /
    Smith, Holly / Taylor, Stephen / Weckx, Lily / Pollard, Andrew John / Voysey, Merryn

    EBioMedicine

    2022  Volume 81, Page(s) 104128

    Abstract: Background: There are known differences in vaccine reactogenicity and immunogenicity by sex. Females have been shown to report greater reactogenicity and generate higher humoral and cellular immune responses than males following vaccination with several ...

    Abstract Background: There are known differences in vaccine reactogenicity and immunogenicity by sex. Females have been shown to report greater reactogenicity and generate higher humoral and cellular immune responses than males following vaccination with several different vaccines. Whether this is also the case for COVID-19 vaccines is currently unknown, as COVID-19 vaccine study data disaggregated by sex are not routinely reported. Therefore, we have assessed the influence of sex on reactogenicity, immunogenicity and efficacy of COVID-19 vaccine ChAdOx1 nCoV-19.
    Methods: Vaccine efficacy was assessed in 15169 volunteers enrolled into single-blind randomised controlled trials of ChAdOx1 nCoV-19 in Brazil and the UK, with the primary endpoint defined as nucleic acid amplification test (NAAT)-positive symptomatic SARS-CoV-2 infection. All participants were electronically randomised to receive two standard doses of vaccine or the control product. Logistic regression models were fitted to explore the effect of age and sex on reactogenicity, and linear models fitted to log-transformed values for immunogenicity data. Reactogenicity data were taken from self-reported diaries of 788 trial participants. Pseudovirus neutralisation assay data were available from 748 participants and anti-SARS-CoV-2 spike IgG assay data from 1543 participants.
    Findings: 7619 participants received ChAdOx1 nCoV-19 and 7550 received the control. Vaccine efficacy in participants after two doses of ChAdOx1 nCoV-19 (4243 females and 3376 males) was 66.1% (95% CI 55.9-73.9%) in males and 59.9% (95% CI 49.8-67.9%) in females; with no evidence of a difference in efficacy between the sexes (vaccine by sex interaction term P=0.3359). A small, statistically significant difference in anti-spike IgG was observed (adjusted GMR 1.14; 95% CI 1.04-1.26), with higher titres in females than males, but there were no statistically significant differences in other immunological endpoints. Whilst the majority of individuals reported at least one systemic reaction following a first dose of ChAdOx1 nCoV-19, females were twice as likely as males to report any systemic reaction after a first dose (OR 1.95; 95% CI 1.37-2.77). Measured fever of 38°C or above was reported in 5% of females and 1% of males following first doses. Headache and fatigue were the most commonly reported reactions in both sexes.
    Interpretation: Our results show that there is no evidence of difference in efficacy of the COVID-19 vaccine ChAdOx1 nCoV-19 in males and females. Greater reactogenicity in females was not associated with any difference in vaccine efficacy.
    Funding: Studies were registered with ISRCTN 90906759 (COV002) and ISRCTN 89951424 (COV003) and follow-up is ongoing. Funding was received from the UK Research and Innovation, Engineering and Physical Sciences Research Council, National Institute for Health Research, Coalition for Epidemic Preparedness Innovations, National Institute for Health Research Oxford Biomedical Research Centre, Chinese Academy of Medical Sciences Innovation Fund for Medical Science, Thames Valley and South Midlands NIHR Clinical Research Network, the Lemann Foundation, Rede D'Or, the Brava and Telles Foundation, the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil, and AstraZeneca.
    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19 ; Female ; Humans ; Immunoglobulin G ; Male ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Single-Blind Method
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin G ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2022-06-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  3. Article ; Online: Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.

    Mentzer, Alexander J / O'Connor, Daniel / Bibi, Sagida / Chelysheva, Irina / Clutterbuck, Elizabeth A / Demissie, Tesfaye / Dinesh, Tanya / Edwards, Nick J / Felle, Sally / Feng, Shuo / Flaxman, Amy L / Karp-Tatham, Eleanor / Li, Grace / Liu, Xinxue / Marchevsky, Natalie / Godfrey, Leila / Makinson, Rebecca / Bull, Maireid B / Fowler, Jamie /
    Alamad, Bana / Malinauskas, Tomas / Chong, Amanda Y / Sanders, Katherine / Shaw, Robert H / Voysey, Merryn / Snape, Matthew D / Pollard, Andrew J / Lambe, Teresa / Knight, Julian C

    Nature medicine

    2022  Volume 29, Issue 1, Page(s) 147–157

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity varies between individuals, and immune responses correlate with vaccine efficacy. Using data from 1,076 participants enrolled in ChAdOx1 nCov-19 vaccine efficacy trials ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity varies between individuals, and immune responses correlate with vaccine efficacy. Using data from 1,076 participants enrolled in ChAdOx1 nCov-19 vaccine efficacy trials in the United Kingdom, we found that inter-individual variation in normalized antibody responses against SARS-CoV-2 spike and its receptor-binding domain (RBD) at 28 days after first vaccination shows genome-wide significant association with major histocompatibility complex (MHC) class II alleles. The most statistically significant association with higher levels of anti-RBD antibody was HLA-DQB1*06 (P = 3.2 × 10
    MeSH term(s) Humans ; Alleles ; Antibodies, Viral ; Breakthrough Infections ; ChAdOx1 nCoV-19 ; COVID-19/genetics ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Histocompatibility Antigens Class II ; Immunogenicity, Vaccine ; SARS-CoV-2 ; Vaccination
    Chemical Substances Antibodies, Viral ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; COVID-19 Vaccines ; Histocompatibility Antigens Class II
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-02078-6
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    Zs.A 4212: Show issues Location:
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  4. Article: A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

    Ahern, David J. / Ai, Zhichao / Ainsworth, Mark / Allan, Chris / Allcock, Alice / Angus, Brian / Ansari, M. Azim / Arancibia-Cárcamo, Carolina V. / Aschenbrenner, Dominik / Attar, Moustafa / Baillie, J. Kenneth / Barnes, Eleanor / Bashford-Rogers, Rachael / Bashyal, Archana / Beer, Sally / Berridge, Georgina / Beveridge, Amy / Bibi, Sagida / Bicanic, Tihana /
    Blackwell, Luke / Bowness, Paul / Brent, Andrew / Brown, Andrew / Broxholme, John / Buck, David / Burnham, Katie L. / Byrne, Helen / Camara, Susana / Candido Ferreira, Ivan / Charles, Philip / Chen, Wentao / Chen, Yi-Ling / Chong, Amanda / Clutterbuck, Elizabeth A. / Coles, Mark / Conlon, Christopher P. / Cornall, Richard / Cribbs, Adam P. / Curion, Fabiola / Davenport, Emma E. / Davidson, Neil / Davis, Simon / Dendrou, Calliope A. / Dequaire, Julie / Dib, Lea / Docker, James / Dold, Christina / Dong, Tao / Downes, Damien / Drakesmith, Hal / Dunachie, Susanna J. / Duncan, David A. / Eijsbouts, Chris / Esnouf, Robert / Espinosa, Alexis / Etherington, Rachel / Fairfax, Benjamin / Fairhead, Rory / Fang, Hai / Fassih, Shayan / Felle, Sally / Fernandez Mendoza, Maria / Ferreira, Ricardo / Fischer, Roman / Foord, Thomas / Forrow, Aden / Frater, John / Fries, Anastasia / Gallardo Sanchez, Veronica / Garner, Lucy C. / Geeves, Clementine / Georgiou, Dominique / Godfrey, Leila / Golubchik, Tanya / Gomez Vazquez, Maria / Green, Angie / Harper, Hong / Harrington, Heather A. / Heilig, Raphael / Hester, Svenja / Hill, Jennifer / Hinds, Charles / Hird, Clare / Ho, Ling-Pei / Hoekzema, Renee / Hollis, Benjamin / Hughes, Jim / Hutton, Paula / Jackson-Wood, Matthew A. / Jainarayanan, Ashwin / James-Bott, Anna / Jansen, Kathrin / Jeffery, Katie / Jones, Elizabeth / Jostins, Luke / Kerr, Georgina / Kim, David / Klenerman, Paul / Knight, Julian C. / Kumar, Vinod / Kumar Sharma, Piyush / Kurupati, Prathiba / Kwok, Andrew / Lee, Angela / Linder, Aline / Lockett, Teresa / Lonie, Lorne / Lopopolo, Maria / Lukoseviciute, Martyna / Luo, Jian / Marinou, Spyridoula / Marsden, Brian / Martinez, Jose / Matthews, Philippa C. / Mazurczyk, Michalina / McGowan, Simon / McKechnie, Stuart / Mead, Adam / Mentzer, Alexander J. / Mi, Yuxin / Monaco, Claudia / Montadon, Ruddy / Napolitani, Giorgio / Nassiri, Isar / Novak, Alex / O'Brien, Darragh P. / O'Connor, Daniel / O'Donnell, Denise / Ogg, Graham / Overend, Lauren / Park, Inhye / Pavord, Ian / Peng, Yanchun / Penkava, Frank / Pereira Pinho, Mariana / Perez, Elena / Pollard, Andrew J. / Powrie, Fiona / Psaila, Bethan / Quan, T. Phuong / Repapi, Emmanouela / Revale, Santiago / Silva-Reyes, Laura / Richard, Jean-Baptiste / Rich-Griffin, Charlotte / Ritter, Thomas / Rollier, Christine S. / Rowland, Matthew / Ruehle, Fabian / Salio, Mariolina / Sansom, Stephen Nicholas / Sanches Peres, Raphael / Santos Delgado, Alberto / Sauka-Spengler, Tatjana / Schwessinger, Ron / Scozzafava, Giuseppe / Screaton, Gavin / Seigal, Anna / Semple, Malcolm G. / Sergeant, Martin / Simoglou Karali, Christina / Sims, David / Skelly, Donal / Slawinski, Hubert / Sobrinodiaz, Alberto / Sousos, Nikolaos / Stafford, Lizzie / Stockdale, Lisa / Strickland, Marie / Sumray, Otto / Sun, Bo / Taylor, Chelsea / Taylor, Stephen / Taylor, Adan / Thongjuea, Supat / Thraves, Hannah / Todd, John A. / Tomic, Adriana / Tong, Orion / Trebes, Amy / Trzupek, Dominik / Tucci, Felicia Anna / Turtle, Lance / Udalova, Irina / Uhlig, Holm / van Grinsven, Erinke / Vendrell, Iolanda / Verheul, Marije / Voda, Alexandru / Wang, Guanlin / Wang, Lihui / Wang, Dapeng / Watkinson, Peter / Watson, Robert / Weinberger, Michael / Whalley, Justin / Witty, Lorna / Wray, Katherine / Xue, Luzheng / Yeung, Hing Yuen / Yin, Zixi / Young, Rebecca K. / Youngs, Jonathan / Zhang, Ping / Zurke, Yasemin-Xiomara

    Cell. 2022 Mar. 03, v. 185, no. 5

    2022  

    Abstract: Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated ... ...

    Institution COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium
    Abstract Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Systems-based integrative analyses including tensor and matrix decomposition of all modalities revealed feature groupings linked with severity and specificity compared to influenza and sepsis. Our approach and blood atlas will support future drug development, clinical trial design, and personalized medicine approaches for COVID-19.
    Keywords COVID-19 infection ; biomarkers ; clinical trials ; coagulation ; disease severity ; drug development ; influenza ; metabolism ; patients ; precision medicine ; proteome
    Language English
    Dates of publication 2022-0303
    Size p. 916-938.e58.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.01.012
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Performance characteristics of five immunoassays for SARS-CoV-2

    Ainsworth, Mark / Andersson, Monique / Auckland, Kathryn / Baillie, J Kenneth / Barnes, Eleanor / Beer, Sally / Beveridge, Amy / Bibi, Sagida / Blackwell, Luke / Borak, Martyna / Bown, Abbie / Brooks, Tim / Burgess-Brown, Nicola A / Camara, Susana / Catton, Matthew / Chau, Kevin K. / Christott, Thomas / Clutterbuck, Elizabeth / Coker, Jesse /
    Cornall, Richard J / Cox, Stuart / Crawford-Jones, David / Crook, Derrick W / D'Arcangelo, Silvia / Dejnirattsai, Wanwisa / Dequaire, Julie M M / Dimitriadis, Stavros / Dingle, Kate E / Doherty, George / Dold, Christina / Dong, Tao / Dunachie, Susanna J / Ebner, Daniel / Emmenegger, Marc / Espinosa, Alexis / Eyre, David W / Fairhead, Rory / Fassih, Shayan / Feehily, Conor / Felle, Sally / Fernandez-Cid, Alejandra / Fernandez Mendoza, Maria / Foord, Thomas H / Fordwoh, Thomas / Fox McKee, Deborah / Frater, John / Gallardo Sanchez, Veronica / Gent, Nick / Georgiou, Dominique / Groves, Christopher J / Hallis, Bassam / Hammond, Peter M / Hatch, Stephanie B. / Harvala, Heli J / Hill, Jennifer / Hoosdally, Sarah J / Horsington, Bryn / Howarth, Alison / James, Tim / Jeffery, Katie / Jones, Elizabeth / Justice, Anita / Karpe, Fredrik / Kavanagh, James / Kim, David S / Kirton, Richard / Klenerman, Paul / Knight, Julian C / Koukouflis, Leonidas / Kwok, Andrew / Leuschner, Ullrich / Levin, Robert / Linder, Aline / Lockett, Teresa / Lumley, Sheila F / Marinou, Spyridoula / Marsden, Brian D / Martinez, Jose / Martins Ferreira, Lucas / Mason, Lara / Matthews, Philippa C / Mentzer, Alexander J / Mobbs, Alexander / Mongkolsapaya, Juthathip / Morrow, Jordan / Mukhopadhyay, Shubhashish M M / Neville, Matthew J / Oakley, Sarah / Oliveira, Marta / Otter, Ashley / Paddon, Kevin / Pascoe, Jordan / Peng, Yanchun / Perez, Elena / Perumal, Prem K / Peto, Timothy E A / Pickford, Hayleah / Ploeg, Rutger J / Pollard, Andrew J / Richardson, Anastasia / Ritter, Thomas G / Roberts, David J / Rodger, Gillian / Rollier, Christine S / Rowe, Cathy / Rudkin, Justine K / Screaton, Gavin / Semple, Malcolm G / Sienkiewicz, Alex / Silva-Reyes, Laura / Skelly, Donal T / Sobrino Diaz, Alberto / Stafford, Lizzie / Stockdale, Lisa / Stoesser, Nicole / Street, Teresa / Stuart, David I / Sweed, Angela / Taylor, Adan / Thraves, Hannah / Tsang, Hoi P / Verheul, Marije K / Vipond, Richard / Walker, Timothy M / Wareing, Susan / Warren, Yolanda / Wells, Charlie / Wilson, Clare / Withycombe, Kate / Young, Rebecca K

    The Lancet Infectious Diseases ; ISSN 1473-3099

    a head-to-head benchmark comparison

    2020  

    Keywords Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/s1473-3099(20)30634-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

    The COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium / Ahern, David J / Ai, Zhichao / Ainsworth, Mark / Allan, Chris / Allcock, Alice / Ansari, Azim / Arancibia-Carcamo, Carolina V / Aschenbrenner, Dominik / Attar, Moustafa / Baillie, J. Kenneth / Barnes, Eleanor / Bashford-Rogers, Rachael / Bashyal, Archana / Beer, Sally / Berridge, Georgina / Beveridge, Amy / Bibi, Sagida / Bicanic, Tihana /
    Blackwell, Luke / Bowness, Paul / Brent, Andrew / Brown, Andrew / Broxholme, John / Buck, David / Burnham, Katie L / Byrne, Helen / Camara, Susana / Candido Ferreira, Ivan / Charles, Philip / Chen, Wentao / Chen, Yi-Ling / Chong, Amanda / Clutterbuck, Elizabeth / Coles, Mark / Conlon, Christopher P / Cornall, Richard / Cribbs, Adam P / Curion, Fabiola / Davenport, Emma E / Davidson, Neil / Davis, Simon / Dendrou, Calliope / Dequaire, Julie / Dib, Lea / Docker, James / Dold, Christina / Dong, Tao / Downes, Damien / Drakesmith, Alexander / Dunachie, Susanna J / Duncan, David A / Eijsbouts, Chris / Esnouf, Robert / Espinosa, Alexis / Etherington, Rachel / Fairfax, Benjamin / Fairhead, Rory / Fang, Hai / Fassih, Shayan / Felle, Sally / Fernandez Mendoza, Maria / Ferreira, Ricardo / Fischer, Roman / Foord, Thomas / Forrow, Aden / Frater, John / Fries, Anastasia / Gallardo Sanchez, Veronica / Garner, Lucy / Geeves, Clementine / Georgiou, Dominique / Godfrey, Leila / Golubchik, Tanya / Gomez Vazquez, Maria / Green, Angie / Harper, Hong / Harrington, Heather A / Heilig, Raphael / Hester, Svenja / Hill, Jennifer / Hinds, Charles / Hird, Clare / Ho, Ling-Pei / Hoekzema, Renee / Hollis, Benjamin / Hughes, Jim / Hutton, Paula / Jackson, Matthew / Jainarayanan, Ashwin / James-Bott, Anna / Jansen, Kathrin / Jeffery, Katie / Jones, Elizabeth / Jostins, Luke / Kerr, Georgina / Kim, David / Klenerman, Paul / Knight, Julian C / Kumar, Vinod / Kumar Sharma, Piyush / Kurupati, Prathiba / Kwok, Andrew / Lee, Angela / Linder, Aline / Lockett, Teresa / Lonie, Lorne / Lopopolo, Maria / Lukoseviciute, Martyna / Luo, Jian / Marinou, Spyridoula / Marsden, Brian / Martinez, Jose / Matthews, Philippa / Mazurczyk, Michalina / McGowan, Simon / McKechnie, Stuart / Mead, Adam / Mentzer, Alexander J / Mi, Yuxin / Monaco, Claudia / Montadon, Ruddy / Napolitani, Giorgio / Nassiri, Isar / Novak, Alex / O'Brien, Darragh / O'Connor, Daniel / O'Donnell, Denise / Ogg, Graham / Overend, Lauren / Park, Inhye / Pavord, Ian / Peng, Yanchun / Penkava, Frank / Pereira Pinho, Mariana / Perez, Elena / Pollard, Andrew J / Powrie, Fiona / Psaila, Bethan / Quan, T. Phuong / Repapi, Emmanouela / Revale, Santiago / Silva-Reyes, Laura / Richard, Jean-Baptiste / Rich-Griffin, Charlotte / Ritter, Thomas / Rollier, Christine S / Rowland, Matthew / Ruehle, Fabian / Salio, Mariolina / Sansom, Stephen N / Santos Delgado, Alberto / Sauka-Spengler, Tatjana / Schwessinger, Ron / Scozzafava, Giuseppe / Screaton, Gavin / Seigal, Anna / Semple, Malcolm G / Sergeant, Martin / Simoglou Karali, Christina / Sims, David / Skelly, Donal / Slawinski, Hubert / Sobrinodiaz, Alberto / Sousos, Nikolaos / Stafford, Lizzie / Stockdale, Lisa / Strickland, Marie / Sumray, Otto / Sun, Bo / Taylor, Chelsea / Taylor, Stephen / Taylor, Adan / Thongjuea, Supat / Thraves, Hannah / Todd, John A / Tomic, Adriana / Tong, Orion / Trebes, Amy / Trzupek, Dominik / Tucci, Felicia A / Turtle, Lance / Udalova, Irina / Uhlig, Holm / van Grinsven, Erinke / Vendrell, Iolanda / Verheul, Marije / Voda, Alexandru / Wang, Guanlin / Wang, Lihui / Wang, Dapeng / Watkinson, Peter / Watson, Robert / Weinberger, Michael / Whalley, Justin / Witty, Lorna / Wray, Katherine / Xue, Luzheng / Yeung, Hing Yuen / Yin, Zixi / Young, Rebecca K / Youngs, Jonathan / Zhang, Ping / Zurke, Yasemin-Xiomara

    medRxiv

    Abstract: Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete understanding of potentially druggable immune mediators of disease. To advance this, we present a comprehensive multi-omic blood atlas in patients with varying ... ...

    Abstract Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete understanding of potentially druggable immune mediators of disease. To advance this, we present a comprehensive multi-omic blood atlas in patients with varying COVID-19 severity and compare with influenza, sepsis and healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity revealed cells, their inflammatory mediators and networks as potential therapeutic targets, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Tensor and matrix decomposition of the overall dataset revealed feature groupings linked with disease severity and specificity. Our systems-based integrative approach and blood atlas will inform future drug development, clinical trial design and personalised medicine approaches for COVID-19.
    Keywords covid19
    Language English
    Publishing date 2021-05-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.05.11.21256877
    Database COVID19

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  7. Article ; Online: Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2

    Folegatti, Pedro M / Ewer, Katie J / Aley, Parvinder K / Angus, Brian / Becker, Stephan / Belij-Rammerstorfer, Sandra / Bellamy, Duncan / Bibi, Sagida / Bittaye, Mustapha / Clutterbuck, Elizabeth A / Dold, Christina / Faust, Saul N / Finn, Adam / Flaxman, Amy L / Hallis, Bassam / Heath, Paul / Jenkin, Daniel / Lazarus, Rajeka / Makinson, Rebecca /
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    The Lancet

    a preliminary report of a phase 1/2, single-blind, randomised controlled trial

    2020  Volume 396, Issue 10249, Page(s) 467–478

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31604-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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