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  1. Article ; Online: Receptor-binding Domain Severe Acute Respiratory Syndrome Coronavirus 2-specific Antibodies in Human Milk From Mothers With Coronavirus Disease 2019 Polymerase Chain Reaction or With Symptoms Suggestive of Coronavirus Disease 2019.

    Demers-Mathieu, Veronique / DaPra, Ciera / Fels, Shawn / Medo, Elena

    Journal of pediatric gastroenterology and nutrition

    2021  Volume 73, Issue 1, Page(s) 125–128

    Abstract: Abstract: This study aims to compare the receptor-binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody titers in human milk between mothers with a confirmed coronavirus disease 2019 (COVID-19) polymerase ... ...

    Abstract Abstract: This study aims to compare the receptor-binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody titers in human milk between mothers with a confirmed coronavirus disease 2019 (COVID-19) polymerase chain reaction (PCR) test and mothers with viral symptoms suggestive of COVID-19. The area under the curve (AUC) for RBD SARS-CoV-2-specific secretory immunoglobulin A (SIgA)/immunoglobulin A (IgA), secretory immunoglobulin M (SIgM)/immunoglobulin M (IgM), immunoglobulin G (IgG), and free secretory components (fSC) in milk samples from eight mothers with a confirmed COVID-19 PCR, eight mothers with viral symptoms (no PCR testing), and six unexposed mothers (pre-pandemic 2018). AUCs of RBD SARS-CoV-2-specific SIgA/IgA, SIgM/IgM, IgG, and fSC in milk samples were comparable between mothers with confirmed COVID-19 PCR and mothers with viral symptoms of suggestive COVID-19. AUCs of RBD-specific SIgA/IgA, IgG, and fSC were higher in the COVID-19-exposed group than in the unexposed group, and SIgM/IgM tended to be higher in the exposed mothers. In conclusion, women with viral symptoms suggestive of COVID-19 could secrete antibodies and fSC specific to SARS-CoV-2 in human milk.
    MeSH term(s) Antibodies, Viral/analysis ; COVID-19 ; Female ; Humans ; Immunoglobulin M ; Milk, Human/immunology ; Mothers ; Polymerase Chain Reaction ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin M
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000003158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Influence of Previous COVID-19 and Mastitis Infections on the Secretion of Brain-Derived Neurotrophic Factor and Nerve Growth Factor in Human Milk.

    Demers-Mathieu, Veronique / Hines, Dustin J / Hines, Rochelle M / Lavangnananda, Sirima / Fels, Shawn / Medo, Elena

    International journal of molecular sciences

    2021  Volume 22, Issue 8

    Abstract: Background: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) play a critical role in neurodevelopment, where breast milk is a significant dietary source. The impact of previous COVID-19 infection and mastitis on the concentration ... ...

    Abstract Background: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) play a critical role in neurodevelopment, where breast milk is a significant dietary source. The impact of previous COVID-19 infection and mastitis on the concentration of BDNF and NGF in human milk was investigated.
    Methods: Concentrations of BDNF and NGF were measured via ELISA in human milk samples collected from 12 mothers with a confirmed COVID-19 PCR, 13 mothers with viral symptoms suggestive of COVID-19, and 22 unexposed mothers (pre-pandemic Ctl-2018). These neurotrophins were also determined in 12 mothers with previous mastitis and 18 mothers without mastitis.
    Results: The NGF concentration in human milk was lower in the COVID-19 PCR and viral symptoms groups than in the unexposed group, but BDNF did not differ significantly. Within the COVID-19 group, BDNF was higher in mothers who reported headaches or loss of smell/taste when compared with mothers without the respective symptom. BDNF was lower in mothers with mastitis than in mothers without mastitis.
    Conclusions: Previous COVID-19 and mastitis infections changed differently the secretion of NGF and BDNF in human milk. Whether the changes in NGF and BDNF levels in milk from mothers with infection influence their infant's development remains to be investigated.
    MeSH term(s) Adult ; Bodily Secretions/chemistry ; Brain-Derived Neurotrophic Factor/analysis ; Brain-Derived Neurotrophic Factor/metabolism ; COVID-19/complications ; COVID-19/metabolism ; Female ; Humans ; Mastitis/complications ; Mastitis/metabolism ; Milk, Human/chemistry ; Mothers ; Nerve Growth Factor/analysis ; Nerve Growth Factor/metabolism
    Chemical Substances Brain-Derived Neurotrophic Factor ; NGF protein, human ; BDNF protein, human (7171WSG8A2) ; Nerve Growth Factor (9061-61-4)
    Language English
    Publishing date 2021-04-08
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22083846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women.

    Demers-Mathieu, Veronique / Hakansson, Anders P / Hall, Stephanie / Lavangnananda, Sirima / Fels, Shawn / Medo, Elena

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2021  Volume 17, Issue 2, Page(s) 163–172

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Antibodies, Viral/immunology ; Breast Feeding ; COVID-19/immunology ; COVID-19 Vaccines ; Female ; Humans ; Milk, Human/immunology ; Mutation ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2021.0232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of vaccination during pregnancy and staphylococci concentration on the presence of Bacillus cereus in raw human milk.

    Demers-Mathieu, Veronique / Mathijssen, Gabrielle / Fels, Shawn / Chace, Donald H / Medo, Elena

    Journal of perinatology : official journal of the California Perinatal Association

    2020  Volume 40, Issue 9, Page(s) 1323–1330

    Abstract: Objective: This study aimed to determine whether vaccination during pregnancy, prematurity, and staphylococci concentration influenced the presence of B. cereus or staphylococcal enterotoxins (SEs) in raw human milk from healthy mothers.: Study design! ...

    Abstract Objective: This study aimed to determine whether vaccination during pregnancy, prematurity, and staphylococci concentration influenced the presence of B. cereus or staphylococcal enterotoxins (SEs) in raw human milk from healthy mothers.
    Study design: Human milk samples were collected from 152 healthy women. B. cereus, S. aureus and coagulase-negative staphylococci (CNS) were enumerated using selective agar culture media. The detection of B. cereus spores and SEs were determined using ELISA.
    Results: CNS and B. cereus concentrations in milk from non-vaccinated mothers were higher than that from mothers vaccinated during pregnancy, but S. aureus did not differ. Prematurity did not affect B. cereus or staphylococci in human milk. S. aureus and CNS concentrations in human milk with the presence of B. cereus were higher than that with the absence of B. cereus. Viable B. cereus was present in 9.2% of raw human milk samples whereas SEs were not detected in any samples.
    Conclusions: Vaccination during pregnancy and low concentration of staphylococci could reduce the risk of B. cereus in raw human milk. The screening of B. cereus in raw human milk must be performed before pasteurization to reduce the risk of B. cereus infection in preterm infants.
    MeSH term(s) Animals ; Bacillus cereus ; Female ; Food Microbiology ; Humans ; Infant, Newborn ; Infant, Premature ; Milk ; Milk, Human ; Pregnancy ; Staphylococcus ; Staphylococcus aureus ; Vaccination
    Keywords covid19
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-019-0586-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2412: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Human Milk Antibodies Against S1 and S2 Subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E in Mothers with A Confirmed COVID-19 PCR, Viral SYMPTOMS, and Unexposed Mothers.

    Demers-Mathieu, Veronique / DaPra, Ciera / Mathijssen, Gabrielle / A Sela, David / M Jarvinen, Kirsi / Seppo, Antti / Fels, Shawn / Medo, Elena

    International journal of molecular sciences

    2021  Volume 22, Issue 4

    Abstract: Background: Preexisting immunity to SARS-CoV-2 could be related to cross-reactive antibodies to common human-coronaviruses (HCoVs). This study aimed to evaluate whether human milk antibodies against to S1 and S2 subunits SARS-CoV-2 are cross-reactive to ...

    Abstract Background: Preexisting immunity to SARS-CoV-2 could be related to cross-reactive antibodies to common human-coronaviruses (HCoVs). This study aimed to evaluate whether human milk antibodies against to S1 and S2 subunits SARS-CoV-2 are cross-reactive to S1 and S2 subunits HCoV-OC43 and HCoV-229E in mothers with a confirmed COVID-19 PCR test, in mothers with previous viral symptoms during COVID-19 pandemic, and in unexposed mothers; Methods: The levels of secretory IgA (SIgA)/IgA, secretory IgM (SIgM)/IgM, and IgG specific to S1 and S2 SARS-CoV-2, and reactive to S1 + S2 HCoV-OC43, and HCoV-229E were measured in milk from 7 mothers with a confirmed COVID-19 PCR test, 20 mothers with viral symptoms, and unexposed mothers (6 Ctl1-2018 and 16 Ctl2-2018) using ELISA; Results: The S2 SARS-CoV-2 IgG levels were higher in the COVID-19 PCR (
    MeSH term(s) Adult ; Antibodies, Viral/immunology ; Antigen-Antibody Reactions ; COVID-19/pathology ; COVID-19/virology ; Coronavirus 229E, Human/metabolism ; Coronavirus OC43, Human/metabolism ; Cross Reactions ; Female ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Immunoglobulin M/immunology ; Milk, Human/metabolism ; Mothers ; Polymerase Chain Reaction ; RNA, Viral/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M ; RNA, Viral ; Spike Glycoprotein, Coronavirus ; secretory IgM ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22041749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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