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  1. Book ; Thesis: Morphologische und funktionelle Aspekte der dynamischen Doxorubicinaufnahme in malignen Gliomzellen

    Felsberg, Jörg

    1997  

    Author's details vorgelegt von Jörg Felsberg
    Language German
    Size II, 112, 19 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT008400003
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 MB 592 order for loan Magazin

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  2. Book ; Thesis: Morphologische und funktionelle Aspekte der dynamischen Doxorubicinaufnahme in malignen Gliomzellen

    Felsberg, Jörg

    1997  

    Author's details vorgelegt von Jörg Felsberg
    Language German
    Size II, 112, 19 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 1997
    HBZ-ID HT008173922
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    98 E 1012 order for loan Magazin

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  3. Book ; Online ; Thesis: Die Bedeutung der Wachoperation und des intraoperativen Neuromonitoring bei Glioblastomen: Funktionelles Outcome und Grad der Resektion

    Hibbe, Helena [Verfasser] / Felsberg, Jörg [Gutachter]

    2022  

    Author's details Helena Hibbe ; Gutachter: Jörg Felsberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  4. Article: Elevated Level of CXCL13 in Nonenhancing Diffuse Primary Lymphoma of the Brainstem.

    Sturm, Dietrich / Tosch, Marco / Felsberg, Jörg / Haupt, Cornel / Kitzrow, Martin

    Innovations in clinical neuroscience

    2022  Volume 18, Issue 10-12, Page(s) 8

    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675366-2
    ISSN 2158-8341 ; 2158-8333
    ISSN (online) 2158-8341
    ISSN 2158-8333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Droplet digital PCR-based analyses for robust, rapid, and sensitive molecular diagnostics of gliomas.

    Wolter, Marietta / Felsberg, Jörg / Malzkorn, Bastian / Kaulich, Kerstin / Reifenberger, Guido

    Acta neuropathologica communications

    2022  Volume 10, Issue 1, Page(s) 42

    Abstract: Classification of gliomas involves the combination of histological features with molecular biomarkers to establish an integrated histomolecular diagnosis. Here, we report on the application and validation of a set of molecular assays for glioma ... ...

    Abstract Classification of gliomas involves the combination of histological features with molecular biomarkers to establish an integrated histomolecular diagnosis. Here, we report on the application and validation of a set of molecular assays for glioma diagnostics based on digital PCR technology using the QX200™ Droplet Digital™ PCR (ddPCR) system. The investigated ddPCR-based assays enable the detection of diagnostically relevant glioma-associated mutations in the IDH1, IDH2, H3-3A, BRAF, and PRKCA genes, as well as in the TERT promoter. In addition, ddPCR-based assays assessing diagnostically relevant copy number alterations were studied, including 1p/19q codeletion, gain of chromosome 7 and loss of chromosome 10 (+ 7/-10), EGFR amplification, duplication of the BRAF locus, and CDKN2A homozygous deletion. Results obtained by ddPCR were validated by other methods, including immunohistochemistry, Sanger sequencing, pyrosequencing, microsatellite analyses for loss of heterozygosity, as well as real-time PCR- or microarray-based copy number assays. Particular strengths of the ddPCR approach are (1) its high analytical sensitivity allowing for reliable detection of mutations even with low mutant allele frequencies, (2) its quantitative determination of mutant allele frequencies and copy number changes, and (3) its rapid generation of results within a single day. Thus, in line with other recent studies our findings support ddPCR analysis as a valuable approach for molecular glioma diagnostics in a fast, quantitative and highly sensitive manner.
    MeSH term(s) Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Glioma/diagnosis ; Glioma/genetics ; Glioma/pathology ; Homozygote ; Humans ; Isocitrate Dehydrogenase/genetics ; Pathology, Molecular ; Real-Time Polymerase Chain Reaction ; Sequence Deletion
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2022-03-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2715589-4
    ISSN 2051-5960 ; 2051-5960
    ISSN (online) 2051-5960
    ISSN 2051-5960
    DOI 10.1186/s40478-022-01335-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Preclinical evaluation of HDAC inhibitors for epigenetic therapy of primary brain tumors

    Marquardt, Viktoria [Verfasser] / Kurz, Thomas [Gutachter] / Felsberg, Jörg [Gutachter]

    2022  

    Author's details Viktoria Marquardt ; Gutachter: Thomas Kurz, Jörg Felsberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  7. Book ; Online ; Thesis: Die Rolle temporärer Blockade des Hinterstrang-Ganglions via PRT für die DRG-Stimulation

    Sievert, Hanna [Verfasser] / Slotty, Philipp Jörg [Gutachter] / Felsberg, Jörg [Gutachter]

    2021  

    Author's details Hanna Sievert ; Gutachter: Philipp Jörg Slotty, Jörg Felsberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  8. Book ; Online ; Thesis: Komplette Resektion um jeden Preis? Einfluss des molekularen Tumorstatus bei Glioblastompatienten mit postoperativem, residualem Tumor.

    Ehrmann, Julia Melanie [Verfasser] / Rapp, Marion [Gutachter] / Felsberg, Jörg [Gutachter]

    2021  

    Author's details Julia Melanie Ehrmann ; Gutachter: Marion Rapp, Jörg Felsberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  9. Book ; Online ; Thesis: Klinische Ergebnisse bei der Behandlung der lumbalen Spinalkanalstenose nach mikrochirurgischer Dekompressionsoperation in Kombination mit paraspinöser Stabilisierung

    Weber, Marc [Verfasser] / Floeth, Frank [Gutachter] / Felsberg, Jörg [Gutachter]

    2021  

    Author's details Marc Weber ; Gutachter: Frank Floeth, Jörg Felsberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma.

    Weller, Michael / Felsberg, Jörg / Hentschel, Bettina / Gramatzki, Dorothee / Kubon, Nadezhda / Wolter, Marietta / Reusche, Matthias / Roth, Patrick / Krex, Dietmar / Herrlinger, Ulrich / Westphal, Manfred / Tonn, Joerg C / Regli, Luca / Maurage, Claude-Alain / von Deimling, Andreas / Pietsch, Torsten / Le Rhun, Emilie / Reifenberger, Guido

    Acta neuropathologica

    2024  Volume 147, Issue 1, Page(s) 11

    Abstract: Prognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease characteristics, prognostic markers, and outcome in patients with this newly ... ...

    Abstract Prognostic factors and standards of care for astrocytoma, isocitrate dehydrogenase (IDH)-mutant, CNS WHO grade 4, remain poorly defined. Here we sought to explore disease characteristics, prognostic markers, and outcome in patients with this newly defined tumor type. We determined molecular biomarkers and assembled clinical and outcome data in patients with IDH-mutant astrocytomas confirmed by central pathology review. Patients were identified in the German Glioma Network cohort study; additional cohorts of patients with CNS WHO grade 4 tumors were identified retrospectively at two sites. In total, 258 patients with IDH-mutant astrocytomas (114 CNS WHO grade 2, 73 CNS WHO grade 3, 71 CNS WHO grade 4) were studied. The median age at diagnosis was similar for all grades. Karnofsky performance status at diagnosis inversely correlated with CNS WHO grade (p < 0.001). Despite more intensive treatment upfront with higher grade, CNS WHO grade was strongly prognostic: median overall survival was not reached for grade 2 (median follow-up 10.4 years), 8.1 years (95% CI 5.4-10.8) for grade 3, and 4.7 years (95% CI 3.4-6.0) for grade 4. Among patients with CNS WHO grade 4 astrocytoma, median overall survival was 5.5 years (95% CI 4.3-6.7) without (n = 58) versus 1.8 years (95% CI 0-4.1) with (n = 12) homozygous CDKN2A deletion. Lower levels of global DNA methylation as detected by LINE-1 methylation analysis were strongly associated with CNS WHO grade 4 (p < 0.001) and poor outcome. MGMT promoter methylation status was not prognostic for overall survival. Histomolecular stratification based on CNS WHO grade, LINE-1 methylation level, and CDKN2A status revealed four subgroups of patients with significantly different outcomes. In conclusion, CNS WHO grade, global DNA methylation status, and CDKN2A homozygous deletion are prognostic in patients with IDH-mutant astrocytoma. Combination of these parameters allows for improved prediction of outcome. These data aid in designing upcoming trials using IDH inhibitors.
    MeSH term(s) Humans ; Astrocytoma/genetics ; Astrocytoma/therapy ; Cohort Studies ; Homozygote ; Isocitrate Dehydrogenase/genetics ; Prognosis ; Retrospective Studies ; Sequence Deletion
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
    Language English
    Publishing date 2024-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-023-02662-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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