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  1. Article ; Online: Ethnomedicinal herbs in African traditional medicine with potential activity for the prevention, treatment, and management of coronavirus disease 2019.

    Adeleye, Olutayo Ademola / Femi-Oyewo, Mbang Nyong / Bamiro, Oluyemisi Adebowale / Bakre, Lateef Gbenga / Alabi, Akinyinka / Ashidi, Joseph Senu / Balogun-Agbaje, Olalekan Adeyinka / Hassan, Oluwakemi Mary / Fakoya, Gbemisola

    Future journal of pharmaceutical sciences

    2021  Volume 7, Issue 1, Page(s) 72

    Abstract: Background: Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed from it. ...

    Abstract Background: Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been discovered and developed from it.
    Main text: The deadly coronavirus disease 2019 (COVID-19) caused by a novel coronavirus known as SARS-CoV-2 has widely spread globally with high mortality and morbidity. Its prevention, treatment and management still pose a serious challenge. A drug for the cure of this disease is yet to be developed. The clinical management at present is based on symptomatic treatment as presented by individuals infected and this is by combination of more than two drugs such as antioxidants, anti-inflammatory, anti-pyretic, and anti-microbials. Literature search was performed through electronic searches of PubMed, Google Scholar, and several research reports including WHO technical documents and monographs.
    Conclusion: Drug discovery from herbs is essential and should be exploited for the discovery of drugs for the management of COVID-19. This review is aimed at identifying ethnomedicinal herbs available in Africa that could be used for the discovery and development of a drug for the prevention, treatment, and management of the novel coronavirus disease 2019.
    Language English
    Publishing date 2021-03-20
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2834845-X
    ISSN 2314-7253 ; 2314-7253
    ISSN (online) 2314-7253
    ISSN 2314-7253
    DOI 10.1186/s43094-021-00223-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The effect of processing variables on the mechanical and release properties of tramadol matrix tablets incorporating Cissus populnea gum as controlled release excipient.

    Adeleye, Olutayo Ademola / Femi-Oyewo, Mbang Nyong / Odeniyi, Michael Ayodele

    Polimery w medycynie

    2014  Volume 44, Issue 4, Page(s) 209–220

    Abstract: Background: Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics.: Objectives: To evaluate different methods of gum ... ...

    Abstract Background: Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics.
    Objectives: To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matrix tablets incorporating cissus gum as controlled release polymer.
    Material and methods: Water (CW) and acetone (CA) extracts of cissus gum were obtained from Cissus populea stem and two methods - wet granulation and direct compression - were used to compress the tablet and compare it with xanthan gum (X) formulations. Crushing strength and friability were used to assess mechanical properties while dissolution rate were used to assess release properties. Data were analysed using t-test and ANOVA at p < 0.05.
    Results: The crushing strength of tramadol tablets has increased together with the increase in polymer concentration in all formulations, while friability has decreased for both methods. Tablets made by wet granulation had higher crushing strength than those made by direct compression method. The release mechanism for both direct compression and wet granulation methods was Fickian and non-Fickian respectively. The rank order for t25, t50 and t75 for all formulations was X > CA > CW. Generally, wet granulation method decreased the rate of tramadol release more than direct compression method, indicating a higher drug retarding ability.
    Conclusions: Incorporation of cissus gum controlled the release of tramadol hydrochloride from the matrix tablets. Extraction method and formulation variables influenced mechanical and release properties of the tablets. Cissus gum acetone extract had comparable release properties with xanthan gum and could serve as a cheaper alternative in controlled release tablet formulations.
    MeSH term(s) Administration, Oral ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/chemistry ; Analgesics, Opioid/pharmacokinetics ; Analysis of Variance ; Chemistry, Pharmaceutical ; Cissus ; Delayed-Action Preparations ; Excipients/administration & dosage ; Excipients/chemistry ; Excipients/pharmacokinetics ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/pharmacokinetics ; Plant Gums/administration & dosage ; Plant Gums/chemistry ; Plant Gums/pharmacokinetics ; Solubility ; Tablets ; Tramadol/administration & dosage ; Tramadol/chemistry ; Tramadol/pharmacokinetics
    Chemical Substances Analgesics, Opioid ; Delayed-Action Preparations ; Excipients ; Plant Extracts ; Plant Gums ; Tablets ; Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2014-10
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 193157-x
    ISSN 0370-0747
    ISSN 0370-0747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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