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  1. Article: Acromicric dysplasia caused by a mutation of fibrillin 1 in a family: A case report.

    Shen, Ren / Feng, Jian-Hua / Yang, Shan-Pu

    World journal of clinical cases

    2023  Volume 11, Issue 9, Page(s) 2036–2042

    Abstract: Background: Acromicric dysplasia (AD) is a rare skeletal dysplasia. Its incidence is < 1/1000000, and only approximately 60 cases are reported worldwide. It is a disease characterized by severe short stature, short hands and feet, facial abnormalities, ... ...

    Abstract Background: Acromicric dysplasia (AD) is a rare skeletal dysplasia. Its incidence is < 1/1000000, and only approximately 60 cases are reported worldwide. It is a disease characterized by severe short stature, short hands and feet, facial abnormalities, normal intelligence, and bone abnormalities. Unlike other skeletal dysplasia, AD has a mild clinical phenotype, mainly characterized by short stature. Extensive endocrine examination has not revealed a potential cause. The clinical effect of growth hormone therapy is still uncertain.
    Case summary: We report a clinical phenotype of AD associated with mutations in the fibrillin 1 (
    Conclusion: FBN1
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i9.2036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coexistence of medullary thyroid carcinoma and gastric carcinoma: A case report and literature review.

    Gan, Xiao-Xiong / Feng, Jian-Hua / Cai, Wen-Song / Xu, Bo

    Asian journal of surgery

    2023  Volume 47, Issue 4, Page(s) 1829–1830

    MeSH term(s) Humans ; Carcinoma, Neuroendocrine/complications ; Carcinoma, Neuroendocrine/surgery ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology
    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  3. Article: [Advances in research on childhood neutropenia].

    Feng, Jian-Hua / Qian, Yan

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2017  Volume 19, Issue 4, Page(s) 484–489

    Abstract: Neutrophils, an important type of human immune cells, are involved in host defense against infections. Neutropenia refers to a group of diseases manifesting as a reduction in the absolute value of mature neutrophils and is often accompanied by an ... ...

    Abstract Neutrophils, an important type of human immune cells, are involved in host defense against infections. Neutropenia refers to a group of diseases manifesting as a reduction in the absolute value of mature neutrophils and is often accompanied by an increased risk of bacterial infection. According to etiology and pathogenesis, neutropenia is classified into congenital and acquired neutropenia. This article reviews the current research status and advances in the etiology of neutropenia in children. A deep understanding of the etiology of neutropenia helps to improve the diagnosis and treatment of this disease.
    MeSH term(s) Biomedical Research ; Child ; Humans ; Neutropenia/classification ; Neutropenia/etiology ; Neutropenia/therapy
    Language Chinese
    Publishing date 2017-05-01
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1008-8830
    ISSN 1008-8830
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  4. Article: Design and development of a new type of phimosis dilatation retractor for children.

    Yue, You-Wei / Chen, Yi-Wen / Deng, Li-Ping / Zhu, Han-Liang / Feng, Jian-Hua

    World journal of clinical cases

    2021  Volume 9, Issue 17, Page(s) 4159–4165

    Abstract: Background: Phimosis is one of the most common diseases in children. Early selection of appropriate treatment for phimosis in children is beneficial to the development of their reproductive organs and significantly improves the prognosis of phimosis in ... ...

    Abstract Background: Phimosis is one of the most common diseases in children. Early selection of appropriate treatment for phimosis in children is beneficial to the development of their reproductive organs and significantly improves the prognosis of phimosis in children. Although traditional circumcision is the most widely used, it has many disadvantages, including postoperative bleeding and incision infection, pain, obvious scars on the surgical incision, and unsatisfactory appearance. In addition, there is much controversy regarding treatment options and timing at home and abroad. Surgical procedures such as circumcision and cerclage for children with excessively long foreskin will greatly affect the normal life of children after the operation. Young children need general anesthesia, but this anesthesia carries a great risk.
    Aim: To design a new children phimosis dilatation retractor for children phimosis.
    Methods: The children phimosis was dilated with an elastic dilation frame, in order to expand the foreskin mouth and expose the penis head, and after that, the phimosis was cured.
    Results: A new type of phimosis dilatation retractor was designed, which can gently dilate the prepuce at multiple angles and in multiple directions at the same time. It has obtained the national patent for clinical application.
    Conclusion: The phimosis dilatation retractor based on the principle of elastically expanding the prepuce can achieve the purpose of expanding the phimosis. The clinical application shows that the effect of the children phimosis retractor is significant, which is worth promoting.
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i17.4159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Network Pharmacology to Explore the Molecular Mechanisms of

    Gan, Xiao-Xiong / Zhong, Lin-Kun / Shen, Fei / Feng, Jian-Hua / Li, Ya-Yi / Li, Si-Jing / Cai, Wen-Song / Xu, Bo

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 700896

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.700896
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  6. Article ; Online: Interaction between CD9 and PI3K‑p85 activates the PI3K/AKT signaling pathway in B‑lineage acute lymphoblastic leukemia.

    Shi, Yi-Fen / Huang, Zi-Yang / Huang, Yi-Sha / Dong, Ru-Jiao / Xing, Chong-Yun / Yu, Kang / Leung, Kam Tong / Feng, Jian-Hua

    Oncology reports

    2021  Volume 46, Issue 1

    Abstract: Our previous study has shown ... ...

    Abstract Our previous study has shown that
    MeSH term(s) Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Chromones/pharmacology ; Disease Progression ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Morpholines/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Tetraspanin 29/genetics ; Tetraspanin 29/metabolism
    Chemical Substances CD9 protein, human ; Chromones ; Morpholines ; Tetraspanin 29 ; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-05-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2021.8091
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4213: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: The prognostic value of soluble Klotho in patients with haemodialysis: a systematic review and meta-analysis.

    Liu, Qi-Feng / Li, Sha-Sha / Yu, Li-Xia / Feng, Jian-Hua / Xue, Li-Li / Lu, Guo-Yuan

    Therapeutic advances in chronic disease

    2020  Volume 11, Page(s) 2040622320940176

    Abstract: Aim: The correlation between soluble Klotho (sKlotho) levels and clinical outcomes remains inconclusive for patients undergoing maintenance haemodialysis (MHD). We aimed to evaluate the potential predictive significance of sKlotho in this population by ... ...

    Abstract Aim: The correlation between soluble Klotho (sKlotho) levels and clinical outcomes remains inconclusive for patients undergoing maintenance haemodialysis (MHD). We aimed to evaluate the potential predictive significance of sKlotho in this population by conducting a meta-analysis.
    Methods: PubMed, Embase, Web of Science and Cochrane Library were comprehensively searched for studies concerning the association between sKlotho level and clinical outcomes including cardiovascular (CV) events and all-cause mortality. The pooled hazard ratios (HR) and 95% confidence intervals (CI) were generated using either random or fixed effects models. Sensitivity and subgroup analyses were used to explore heterogeneity sources.
    Results: Eight prospective studies with 992 MHD participants were included and reduced sKlotho levels predicted more adverse outcomes in this meta-analysis. The pooled HRs and 95% CIs related to CV events, mortality, or composite outcomes were 1.73 (95% CI 1.08-2.76,
    Conclusion: Lower sKlotho levels were associated with more CV events and all-cause mortality, suggesting that sKlotho may have predictive value in CKD patients receiving haemodialysis.
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622320940176
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  8. Article: MicroRNA-3690 promotes cell proliferation and cell cycle progression by altering DKK3 expression in human thyroid cancer.

    Shen, Fei / Gan, Xiao-Xiong / Deng, Xing-Yan / Feng, Jian-Hua / Cai, Wen-Song / Shen, Liang / Xiao, Huan-Qing / Xu, Bo

    Oncology letters

    2020  Volume 20, Issue 5, Page(s) 223

    Abstract: An increasing amount of evidence has demonstrated the importance of microRNAs (miRNAs/miRs) in the tumorigenesis of malignant types of cancer, and data retrieved from The Cancer Genome Atlas database revealed that miR-3690 was upregulated in thyroid ... ...

    Abstract An increasing amount of evidence has demonstrated the importance of microRNAs (miRNAs/miRs) in the tumorigenesis of malignant types of cancer, and data retrieved from The Cancer Genome Atlas database revealed that miR-3690 was upregulated in thyroid cancer (TC). The present study focused on the biological function and mechanism of miR-3690 in TC, demonstrating that miR-3690 expression was significantly elevated in TC cells and clinical tissues. Functional studies indicated that miR-3690 acted as an oncogene in TC by promoting cell proliferation, colony formation and cell cycle progression in association with the increased expression of cyclin E and c-myc. Mechanistically, prediction software indicated that Dickkopf-related protein 3 (DKK3) was a target of miR-3690, which was confirmed by the results of luciferase reporter assays and western blotting. DKK3 silencing abrogated the functions of miR-3690-in on TC cell proliferation. Collectively, the findings of the present study demonstrated that miR-3690 promoted TC cell proliferation and indicated miR-3690 as a potential biomarker and therapeutic target for TC.
    Language English
    Publishing date 2020-09-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2020.12086
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  9. Article: Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.

    Lou, Yu-Ting / Li, Xiao-Long / Wang, Ye / Ji, Gong-Jun / Zang, Yu-Feng / Wang, Jue / Feng, Jian-Hua

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 543049

    Abstract: Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging ... ...

    Abstract Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventional frequency band (0.01-0.08 Hz) in TS. No published studies have reported abnormalities of local synchronization across different frequency bands. We estimated the alterations of local synchronization across five bands ranging from 0 to 0.25 Hz. Seventy-nine children with TS and 63 age-, sex-, and handedness-matched healthy children were recruited. Frequency-specific regional homogeneity (ReHo) and independent component analysis were used to identify functional alterations between TS and healthy children. TS patients showed significantly increased ReHo in the left precentral gyrus and decreased ReHo in the right operculum. Abnormal ReHo alterations of the superior frontal gyrus, superior parietal gyrus, anterior cingulate gyrus, putamen, superior temporal gyrus, and operculum were observed in different frequency bands. TS patients showed increased connectivity of the right superior frontal gyrus within the left executive control network. In addition, a significantly negative correlation was found between Yale Global Tic Severity Scale (YGTSS) vocal score and ReHo values of the right operculum in the highest frequency bands (0.198-0.25 Hz), while a significant positive correlation was found between YGTSS motor score and altered connectivity of the right superior frontal gyrus. The present study revealed frequency-specific abnormal alterations of ReHo in the whole brain and altered connectivity within the executive control network of TS children. Its neural importance and clinical practicability require further investigation.
    Language English
    Publishing date 2020-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.543049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of Soluble Klotho Level with Adverse Outcomes in Patients on Maintenance Hemodialysis.

    Yu, Li-Xia / Liu, Qi-Feng / Feng, Jian-Hua / Li, Sha-Sha / Gu, Xiao-Xia / Xiong, Yan / Qiang-Sun / Ye, Jian-Ming

    Disease markers

    2020  Volume 2020, Page(s) 4923970

    Abstract: Background: The predictive value of soluble Klotho (sKlotho) for adverse outcomes in patients on maintenance hemodialysis (MHD) is controversial. In this study, we aimed to clarify the potential association of sKlotho levels with adverse outcomes in ... ...

    Abstract Background: The predictive value of soluble Klotho (sKlotho) for adverse outcomes in patients on maintenance hemodialysis (MHD) is controversial. In this study, we aimed to clarify the potential association of sKlotho levels with adverse outcomes in this patient population.
    Materials: A total of 211 patients on MHD were identified and stratified according to the median sKlotho level. Patients were followed up for adverse outcomes including cardiovascular (CV) morbidity and all-cause mortality.
    Results: During the 36-month follow-up, 75 patients [51 CV events (including 16 CV deaths) and 40 deaths] experienced adverse outcomes. After stratification according to median sKlotho level, patients with a lower sKlotho level had a greater risk of CV events (38.2% vs. 19.5%,
    Conclusions: The sKlotho level was an independent predictive factor of adverse outcomes including CV morbidity and mortality in patients on MHD.
    MeSH term(s) Adult ; Aged ; Biomarkers/metabolism ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Down-Regulation ; Female ; Glucuronidase/metabolism ; Humans ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Klotho Proteins ; Male ; Middle Aged ; Morbidity ; Mortality ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Renal Dialysis/methods
    Chemical Substances Biomarkers ; Glucuronidase (EC 3.2.1.31) ; Klotho Proteins (EC 3.2.1.31)
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2020/4923970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1856: Show issues Location:
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    Einzelsignatur: Show issues

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