LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article: [Analysis of pre-operative factors affecting vault after posterior chamber phakic intraocular lens implantation].

    Li, X L / Xie, Y / Lin, L M / Feng, Q T / Liu, Q

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2024  Volume 60, Issue 2, Page(s) 168–175

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Male ; Female ; Young Adult ; Adult ; Lens Implantation, Intraocular/methods ; Retrospective Studies ; Anterior Chamber ; Phakic Intraocular Lenses ; Myopia/surgery
    Language Chinese
    Publishing date 2024-01-31
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-202300910-00091
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2482: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 267: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: α-SMA-Cre-mediated excision of PDK1 reveals an essential role of PDK1 in regulating morphology of cardiomyocyte and tumor progression in tissue microenvironment.

    Qian, X-J / Li, X-L / Xu, X / Wang, X / Feng, Q-T / Yang, C-J

    Pathologie-biologie

    2015  Volume 63, Issue 2, Page(s) 91–100

    Abstract: The phosphoinositide-3 kinase (PI3K) - phosphoinositide-dependent protein kinase 1 (PDK1)-Akt/protein kinase B (PKB) cascade plays a critical role in cardiovascular development and tumor genesis. But the role of PDK1 in the microenvironment of heart and ... ...

    Abstract The phosphoinositide-3 kinase (PI3K) - phosphoinositide-dependent protein kinase 1 (PDK1)-Akt/protein kinase B (PKB) cascade plays a critical role in cardiovascular development and tumor genesis. But the role of PDK1 in the microenvironment of heart and tumor remains unknown. To clarify the effects of PDK1 on tissue microenvironment in vivo, here, we created α-SMA-Cre-mediated excision of PDK1 mice. And the mice were injected subcutaneously with Lewis lung carcinoma (LLC) cells. We found PDK1-deficient mice had post-natal praecox dilated cardiomyopathy, decelerated tumor growth and severe tumor metastasis. Histopathological analysis revealed abnormality of vascular microenvironment in heart and primary tumor. In conclusion, PDK1 plays a pivotal role in regulating cardiac function and tumor metastasis by interfering with microenvironment.
    MeSH term(s) Actins/genetics ; Animals ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/pathology ; Cell Shape/genetics ; Disease Progression ; Female ; Gene Deletion ; Gene Knockout Techniques ; Integrases/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/physiology ; Neoplasm Metastasis ; Neoplasms/genetics ; Neoplasms/pathology ; Protein-Serine-Threonine Kinases/genetics ; Tumor Cells, Cultured ; Tumor Microenvironment/genetics
    Chemical Substances Actins ; alpha-smooth muscle actin, mouse ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; pyruvate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.2) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2015-04
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207652-4
    ISSN 1768-3114 ; 0369-8114
    ISSN (online) 1768-3114
    ISSN 0369-8114
    DOI 10.1016/j.patbio.2014.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 84/5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top