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Article ; Online: A prediction model for differentiating recurrent Kawasaki disease from other febrile illnesses.

Yang, Penghui / Zhang, Jing / Feng, Siqi / Yi, Qijian

2024

Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2024.03.020
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Article ; Online: Serum levels of PDGF-CC as a potential biomarker for the diagnosis of Kawasaki disease.

Zhang, Jing / Yang, Penghui / Liu, Yihao / Chen, Zhuo / Wu, Jinhui / Feng, Siqi / Yi, Qijian

Italian journal of pediatrics

2024 Volume 50, Issue 1, Page(s) 16

Abstract: Background: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with ... ...

Abstract	Background: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with angiogenic properties that has been amply demonstrated to play a critical role in the cardiovascular system. This study aimed to investigate the serum expression of PDGF-CC in children with KD and to evaluate the ability of PDGF-CC to diagnose KD. Methods: A total of 96 subjects, including 59 KD patients, 17 febrile controls (FC), and 20 healthy controls (HC), were enrolled. Serum levels of PDGF-CC were measured via enzyme-linked immunosorbent assay. The associations between PDGF-CC and clinical laboratory parameters were investigated by correlation analysis. The diagnostic performance was assessed by receiver operating characteristic (ROC) curve analysis. Results: Serum PDGF-CC levels in the KD group were significantly higher than in the FC and HC groups. Serum PDGF-CC levels in the KD group were positively correlated with white blood cell counts, percentage of neutrophils, IL-2, IL-12p70, TNF-α, and IL-1β levels, and negatively correlated with the percentage of lymphocytes. In the analysis of ROC curves, the area under the curve was 0.796 (95% confidence interval 0.688-0.880; P < 0.0001) for PDGF-CC and increased to 0.900 (95% confidence interval 0.808-0.957; P < 0.0001) in combination with white blood cell counts and C-reactive protein. Conclusions: PDGF-CC is a potential biomarker for KD diagnosis, and the combination with white blood cell counts and C-reactive protein can further improve diagnostic performance.
MeSH term(s)	Child ; Humans ; Mucocutaneous Lymph Node Syndrome/diagnosis ; C-Reactive Protein/analysis ; Biomarkers ; Platelet-Derived Growth Factor ; Fever ; Lymphokines
Chemical Substances	platelet-derived growth factor C ; C-Reactive Protein (9007-41-4) ; Biomarkers ; Platelet-Derived Growth Factor ; Lymphokines
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-024-01580-6
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Zs.A 1961: Show issues

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Article ; Online: Prediction of Coronary Artery Lesions in Patients With Recurrent Kawasaki Disease.

Yang, Penghui / Zhang, Jing / Liu, Yihao / Feng, Siqi / Yi, Qijian

The Pediatric infectious disease journal

2023

Abstract: Background: A subset of patients with Kawasaki disease (KD) will suffer recurrence. However, there is still a lack of accurate prediction models for coronary artery lesions (CAL) in recurrent KD patients. It is necessary to establish a new nomogram ... ...

Abstract	Background: A subset of patients with Kawasaki disease (KD) will suffer recurrence. However, there is still a lack of accurate prediction models for coronary artery lesions (CAL) in recurrent KD patients. It is necessary to establish a new nomogram model for predicting CAL in patients with recurrent KD. Methods: Data from patients with recurrent KD between 2015 and 2021 were retrospectively reviewed. After splitting the patients into training and validation cohorts, the least absolute shrinkage and selection operator was used to select the predictors of CAL and multivariate logistic regression was used to construct a nomogram based on the selected predictors. The application of area under the receiver operating characteristic curve (AUC), calibration curves, Hosmer-Lemeshow test, Brier score and decision curve analysis were used to assess the model performance. Results: A total of 159 recurrent KD patients were enrolled, 66 (41.5%) of whom had CAL. Hemoglobin levels, CAL at the first episode, and intravenous immunoglobulin resistance at recurrence were identified by the least absolute shrinkage and selection operator regression analysis as significant predictors. The model incorporating these predictors showed good discrimination (AUC, 0.777) and calibration capacities (Hosmer-Lemeshow P value, 0.418; Brier score, 0.190) in the training cohort. Application of the model to the validation cohort yielded an AUC of 0.741, a Hosmer-Lemeshow P value of 0.623 and a Brier score of 0.190. The decision curve analysis demonstrated that the nomogram model was clinically useful. Conclusions: The proposed nomogram model could help clinicians assess the risk of CAL in patients with recurrent KD.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004146
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Zs.A 1852: Show issues

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Article ; Online: The relationship between tumor metabolism and 5-fluorouracil resistance.

Hu, Jingyi / Li, Anqi / Guo, Yueyang / Ma, Ting / Feng, Siqi

Biochemical pharmacology

2023 Volume 218, Page(s) 115902

MeSH term(s)	Humans ; Fluorouracil/pharmacology ; Neoplasms/drug therapy ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Drug Resistance, Neoplasm ; Cell Line, Tumor
Chemical Substances	Fluorouracil (U3P01618RT) ; Antimetabolites, Antineoplastic
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2023.115902
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Article ; Online: Epigenetic Modifications as Therapeutic Targets.

Zheng, Yi-Chao / Feng, Si-Qi

Current drug targets

2020 Volume 21, Issue 11, Page(s) 1046

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Drug Approval ; Epigenesis, Genetic/drug effects ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2020-09-17
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/138945012111200727122724
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Zs.A 5578: Show issues

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Article ; Online: Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancers.

Ma, Ting / Song, Qianqian / Cheng, Bing / Guo, Enhui / Wang, Xiaoru / Li, Meng / Dai, Mengge / Li, Shaotong / Feng, Siqi / Yu, Bin

Bioorganic chemistry

2024 Volume 144, Page(s) 107142

Abstract: The abnormal activation of Cullin RING E3 Ligases (CRLs) is closely associated with the occurrence and development of various cancers. Targeting the neddylation pathway represents an effective approach for cancer treatment. In this work, we reported that ...

Abstract	The abnormal activation of Cullin RING E3 Ligases (CRLs) is closely associated with the occurrence and development of various cancers. Targeting the neddylation pathway represents an effective approach for cancer treatment. In this work, we reported that WS-299, structurally featuring a coumarin moiety attached to the triazolopyrimidine, exhibited excellent anti-proliferative activity in MGC-803 and HGC-27 cells. WS-299 exerted potent anticancer effects by inhibiting clone formation, EdU incorporation and inducing cell cycle arrest. WS-299 inhibited CUL3/5 neddylation and caused an obvious accumulation of Nrf2 and NOXA, substrates of CRL3 and CRL5, respectively. Biochemical studies showed that WS-299 inhibited CUL3 neddylation by inhibiting RBX1-UBE2M interaction. The anti-proliferative effect of WS-299 was mainly induced by NOXA-mediated apoptosis. Of note, Nrf2 attenuated WS-299-induced reactive oxygen species (ROS) levels. Furthermore, Nrf2 accumulation also had an antagonistic effect on NOXA-induced apoptosis. Therefore, WS-299 and siNrf2 synergistically increased ROS levels, apoptotic cells and suppressed tumor growth in vivo. Taken together, our research clarified the anti-cancer mechanisms of WS-299 through targeting the RBX1-UBE2M protein-protein interaction and inhibiting the neddylation modification of CUL3 and CUL5. More importantly, our studies also demonstrated that combination of WS-299 with shNrf2 could be an effective strategy for treating gastric cancers.
MeSH term(s)	Humans ; NF-E2-Related Factor 2/metabolism ; Stomach Neoplasms/drug therapy ; Reactive Oxygen Species/metabolism ; Cell Cycle Checkpoints ; Oxidative Stress ; Carrier Proteins/metabolism ; Cullin Proteins/metabolism ; Ubiquitin-Conjugating Enzymes/metabolism
Chemical Substances	NF-E2-Related Factor 2 ; Reactive Oxygen Species ; RBX1 protein, human ; Carrier Proteins ; CUL5 protein, human ; Cullin Proteins ; UBE2M protein, human (EC 6.3.2.-) ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23)
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2024.107142
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Zs.A 4207: Show issues

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Article ; Online: Discovery of WS-384, a first-in-class dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor for the treatment of non-small cell lung cancer.

Li, Anqi / Ma, Ting / Wang, Shuai / Guo, Yueyang / Song, Qianqian / Liu, Hongmin / Yu, Bin / Feng, Siqi

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116240

Abstract: Abnormally high expression of lysine-specific demethylase 1 A (LSD1) and DCN1 plays a vital role in the occurrence, development, and poor prognosis of non-small cell lung cancer (NSCLC). Accumulating evidence has shown that the development of small- ... ...

Abstract	Abnormally high expression of lysine-specific demethylase 1 A (LSD1) and DCN1 plays a vital role in the occurrence, development, and poor prognosis of non-small cell lung cancer (NSCLC). Accumulating evidence has shown that the development of small-molecule inhibitors dually targeting LSD1 and the DCN1-UBC12 interaction probably have therapeutic promise for cancer therapy. This work reported that WS-384 dually targeted LSD1 and DCN1-UBC12 interactions and evaluated its antitumor effects in vitro and in vivo. Specifically, WS-384 inhibited A549 and H1975 cells viability and decreased colony formation and EdU incorporation. WS-384 could also trigger cell cycle arrest, DNA damage, and apoptosis. Moreover, WS-384 significantly decreased tumor weight and volume in A549 xenograft mice. Mechanistically, WS-384 increased the gene and protein level of p21 by suppressing the neddylation of cullin 1 and decreasing H3K4 demethylation at the CDKN1A promoter. The synergetic upregulation of p21 contributed to cell cycle arrest and the proapoptotic effect of WS-384 in NSCLC cells. Taken together, our proof of concept studies demonstrated the therapeutic potential of dual inhibition of LSD1 and the DCN1-UBC12 interaction for the treatment of NSCLC. WS-384 could be used as a lead compound to develop new dual LSD1/DCN1 inhibitors for the treatment of human diseases in which LSD1 and DCN1 are dysregulated.
MeSH term(s)	Humans ; Animals ; Mice ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Intracellular Signaling Peptides and Proteins ; Ubiquitin-Conjugating Enzymes/metabolism ; Lung Neoplasms/drug therapy ; Histone Demethylases ; Cell Line, Tumor
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2024-02-23
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116240
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Article: Unveiling significance of Ca2+ ion for start-up of aerobic granular sludge reactor by distinguishing its effects on physicochemical property and bioactivity of sludge

Guo, Yuan / Zhang, Bing / Feng, Siqi / Wang, Dongqi / Li, Jiake / Shi, Wenxin

Environmental research. 2022 Sept., v. 212

2022

Abstract: Almost all of the aerobic granular sludge (AGS) reactors were fed on certain amounts of Ca²⁺ ion, but whether and why it was necessary for reactor start-up remain unknown. Herein, this study conducted a set of comparative experiments in three AGS ... ...

Abstract	Almost all of the aerobic granular sludge (AGS) reactors were fed on certain amounts of Ca²⁺ ion, but whether and why it was necessary for reactor start-up remain unknown. Herein, this study conducted a set of comparative experiments in three AGS reactors, which were operated in parallel with Ca²⁺ addition in R3, hydroxyapatite (HAP) addition in R1, and without any forms of Ca addition in R2. Results showed that R3 not only achieved the complete granulation of sludge, but exhibited superior performance of COD and nutrient removal. In contrast, R1 had a slightly quicker granulation rate than R3 (R1: 0.07 day⁻¹; R3: 0.06 day⁻¹), but the formed granules could not efficiently degrade pollutants. In R2, both sludge granulation and pollutants removal did not proceed normally. Further investigations found that the Ca²⁺ ion acted in three ways: (1) it increased inorganic composition of sludge to promote granulation; (2) the transformed HAP strengthened stability of granular structure; (3) it ensured bioactivity of granules by driving enrichment of functional microbes and synthesis of metabolism enzymes. Overall, this study systemically proved significance of Ca²⁺ ion for the start-up of AGS reactors and its influencing mechanisms on different properties of granules.
Keywords	bioactive properties ; calcium ; hydroxyapatite ; metabolism ; research ; sludge
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113299
Database	NAL-Catalogue (AGRICOLA)

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Article: Features of Lymph Node Metastasis and Structural Recurrence in Papillary Thyroid Carcinoma Located in the Upper Portion of the Thyroid: A Retrospective Cohort Study.

Heng, Yu / Feng, Siqi / Yang, Zheyu / Cai, Wei / Qiu, Weihua / Tao, Lei

Frontiers in endocrinology

2022 Volume 12, Page(s) 793997

Abstract: Background: This study aims to reveal the features of lymph node metastasis (LNM) and recurrence in papillary thyroid carcinoma (PTC) tumors located in the upper portion of the thyroid.: Methods: A total of 1075 PTC patients were retrospectively ... ...

Abstract	Background: This study aims to reveal the features of lymph node metastasis (LNM) and recurrence in papillary thyroid carcinoma (PTC) tumors located in the upper portion of the thyroid. Methods: A total of 1075 PTC patients were retrospectively reviewed, including 314 patients with a tumor in the upper portion of the thyroid. Another 103 PTC patients with upper portion diagonsis from three clinical centers were included for external validation. Results: The results showed no difference between the patients with a tumor in the upper portion of the thyroid and those with a tumor in the non-upper portion in terms of overall LNM rates. However, patients with a tumor in the upper portion were significantly more prone to LLNM and exhibited a significantly worse recurrence outcome than those with a tumor in other subregions. Multivariate analysis showed that four factors-age no more than 40, maximum tumor diameter no less than1.0 cm, the presence of thyroid capsular invasion, and tumor with ipsilateral nodular goiter-were independent risk factors for LLNM of the tumor in the upper thyroid. A predictive risk-scoring model was established based on these factors. Conclusions: Patients with PTC located in the upper portion may have an exclusive lymphatic drainage pathway to the lateral neck region and are more prone to suffer from LLNM and tumor recurrence than those with a tumor located in other subregions. A new postoperative strategy selection flow chart was established based on our newly created risk-scoring model that can effectively predict the individualized possibility of LLNM for PTC patients with a tumor in the upper portion.
MeSH term(s)	Adult ; Age Factors ; Cohort Studies ; Disease-Free Survival ; Female ; Goiter, Nodular/epidemiology ; Goiter, Nodular/pathology ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Multivariate Analysis ; Neck Dissection ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Thyroid Cancer, Papillary/epidemiology ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/pathology ; Thyroidectomy ; Tumor Burden
Language	English
Publishing date	2022-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.793997
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Article ; Online: Unveiling significance of Ca

Guo, Yuan / Zhang, Bing / Feng, Siqi / Wang, Dongqi / Li, Jiake / Shi, Wenxin

Environmental research

2022 Volume 212, Issue Pt B, Page(s) 113299

Abstract: Almost all of the aerobic granular sludge (AGS) reactors were fed on certain amounts of ... ...

Abstract	Almost all of the aerobic granular sludge (AGS) reactors were fed on certain amounts of Ca
MeSH term(s)	Aerobiosis ; Bioreactors ; Environmental Pollutants ; Sewage/chemistry ; Waste Disposal, Fluid/methods
Chemical Substances	Environmental Pollutants ; Sewage
Language	English
Publishing date	2022-04-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113299
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