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  1. Article ; Online: An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice.

    Hu, Pan / Yan, Xin / Zeng, Yijia / Jiang, Zherui / Liu, Juan / Feng, Wu-Wen

    Journal of pharmaceutical and biomedical analysis

    2023  Volume 235, Page(s) 115585

    Abstract: Botanic polysaccharides can be metabolized by gut microbiota into short-chain fatty acids (SCFAs) to exert extensive bioactivities, yet targeted analysis of the effect of botanic polysaccharides on other gut microbial metabolites is scarcely seen. ... ...

    Abstract Botanic polysaccharides can be metabolized by gut microbiota into short-chain fatty acids (SCFAs) to exert extensive bioactivities, yet targeted analysis of the effect of botanic polysaccharides on other gut microbial metabolites is scarcely seen. Tryptophan metabolites such as indole and indole derivatives play import roles in health and disease development. Using polysaccharides from Atractylodes macrocephala Koidz. (AMP) in treating ulcerative colitis as the example, we checked the effects of AMP on tryptophan metabolites. After examination of pharmacological effects of AMP, we established an ultra-performance liquid chromatography coupled with mass spectrometry/mass spectrometry (UPLC-MS/MS) method to simultaneously determinate the levels of 30 tryptophan metabolites and used the method to determine the levels of these metabolites in feces and plasma. The detection results showed that 12 metabolites in feces can be detected, and 17 metabolites can be detected in plasma samples. In addition, we found out that total levels of aryl hydrocarbon receptor ligands were decreased in colitis model whereas AMP treatment can increase the levels of total ligands in both feces and plasma. The results indicated that the therapeutical effect of AMP on colitis was associated with modulation of fecal and host tryptophan metabolism. This study provides new insight into the molecular mechanisms of polysaccharides that the beneficial effects of polysaccharides can be achieved by modulating microbial tryptophan metabolism in addition to SCFAs.
    MeSH term(s) Animals ; Mice ; Colitis, Ulcerative/drug therapy ; Atractylodes/chemistry ; Tryptophan/metabolism ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Ligands ; Tandem Mass Spectrometry ; Colitis ; Polysaccharides/chemistry
    Chemical Substances Tryptophan (8DUH1N11BX) ; Ligands ; Polysaccharides
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2023.115585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Integration of Gut Microbiota and Metabolomics for Chinese Medicine Research: Opportunities and Challenges.

    Feng, Wu-Wen / Liu, Juan / Cheng, Hao / Peng, Cheng

    Chinese journal of integrative medicine

    2021  Volume 28, Issue 11, Page(s) 1032–1039

    Abstract: Chinese medicines (CM) are gaining more attentions from all over the world. However, there are a large body of questions to be answered because of the chemical complexity of CM and intricate molecular reactions within human body. In recent years, gut ... ...

    Abstract Chinese medicines (CM) are gaining more attentions from all over the world. However, there are a large body of questions to be answered because of the chemical complexity of CM and intricate molecular reactions within human body. In recent years, gut microbiota and metabolomics have emerged as two cynosures in deciphering the mechanisms of how our body is functioning. Since gut microbiota and host is a closely interrelated system, paying attention only to gut microbiota or metabolites may omit the interplays among CM, gut microbiota, and hosts. To systemically study these interplays, a network understanding of CM components, gut microbiota, metabolites of gut microbiota, metabolites in human body is necessary. Although there are some obstacles impeding the application of this integrative approach, the potential areas for implementation of the integrative approach is vast. These areas include, but not limited to, elucidating the mechanisms of CM at system level, screening bioactive compounds in CM, and guiding quality control of CM.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Medicine, Chinese Traditional ; Metabolomics
    Language English
    Publishing date 2021-11-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-021-3305-x
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  3. Article: Anti-obesity and Gut Microbiota Modulation Effect of Astragalus Polysaccharides Combined with Berberine on High-Fat Diet-Fed Obese Mice.

    Yue, Shi-Jun / Wang, Wen-Xiao / Zhang, Lei / Liu, Juan / Feng, Wu-Wen / Gao, Huan / Tang, Yu-Ping / Yan, Dan

    Chinese journal of integrative medicine

    2021  Volume 29, Issue 7, Page(s) 617–625

    Abstract: Objective: To investigate whether astragalus polysaccharides (APS) combined with berberine (BBR) can reduce high-fat diet (HFD)-induced obesity in mice.: Methods: Except for normal mice, 32 HFD-induced obese mice were randomized into HFD, APS (1,000 ... ...

    Abstract Objective: To investigate whether astragalus polysaccharides (APS) combined with berberine (BBR) can reduce high-fat diet (HFD)-induced obesity in mice.
    Methods: Except for normal mice, 32 HFD-induced obese mice were randomized into HFD, APS (1,000 mg/kg APS), BBR (200 mg/kg BBR), and APS plus BBR (1,000 mg/kg APS plus 200 mg/kg BBR) groups, respectively. After 6-week treatment (once daily by gavage), the obesity phenotype and pharmacodynamic effects were evaluated by histopathological examination of epididymal fat, liver, and colon using hematoxylin-eosin staining and serum biochemical analyses by an automated chemistry analyzer. The feces were collected at the 12 th week, and taxonomic and functional profiles of gut microbiota were analyzed by 16S ribosomal ribonucleic acid (16S rRNA) sequencing.
    Results: Compared with HFD group, the average body weight of APS plus BBR group was decreased (P<0.01), accompanied with the reduced fat accumulation, enhanced colonic integrity, insulin sensitivity and glucose homeostasis (P<0.05 or P<0.01). Importantly, APS combined with BBR treatment was more effective than APS or BBR alone in improving HFD-induced insulin resistance (P<0.05 or P<0.01). 16S rRNA sequence-based analysis of fecal samples demonstrated that APS combined with BBR treatment exhibited a better impact on HFD-induced gut microbiota dysbiosis, exclusively via the enriched abundances of Bacteroides, which corresponded to the large increase of predicted bacterial genes involved in carbohydrate metabolism.
    Conclusion: APS combined with BBR may synergistically reduce obesity and modulate the gut microbiota in HFD-fed mice.
    MeSH term(s) Mice ; Animals ; Diet, High-Fat ; Berberine/pharmacology ; Berberine/therapeutic use ; Mice, Obese ; RNA, Ribosomal, 16S/genetics ; Gastrointestinal Microbiome ; Obesity/drug therapy ; Insulin Resistance ; Mice, Inbred C57BL
    Chemical Substances Berberine (0I8Y3P32UF) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-12-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-021-3303-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

    Xie, Yun-Fei / Feng, Wu-Wen / Liu, Mei-Chen / Xie, Jun / Yu, Lei / Gong, Xiao-Hong / Li, Yun-Xia / Peng, Cheng

    Evidence-based complementary and alternative medicine : eCAM

    2019  Volume 2019, Page(s) 9864841

    Abstract: Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in ... ...

    Abstract Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1
    Language English
    Publishing date 2019-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/9864841
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  5. Article: UPLC-QTOF/MS

    Yang, Zhi-Rui / Wang, Zi-Hao / Tang, Jin-Fa / Yan, Yan / Yue, Shi-Jun / Feng, Wu-Wen / Shi, Zheng-Yuan / Meng, Xin-Tong / Peng, Cheng / Wang, Chang-Yun / Meng, Da-Li / Yan, Dan

    Frontiers in pharmacology

    2018  Volume 9, Page(s) 633

    Abstract: Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted ... ...

    Abstract Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from
    Language English
    Publishing date 2018-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2018.00633
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  6. Article ; Online: Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin.

    Feng, Wu-Wen / Kuang, Shuang-Yu / Tu, Can / Ma, Zhi-Jie / Pang, Jing-Yao / Wang, Yan-Hui / Zang, Qing-Ce / Liu, Ta-Si / Zhao, Yan-Ling / Xiao, Xiao-He / Wang, Jia-Bo

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2018  Volume 99, Page(s) 325–333

    Abstract: Studies have shown that satins and herbal products have potential to treat non-alcohol fatty liver disease (NAFLD) in clinic. However, no study has compared their effects, and their mechanisms remain unresolved. Here, we choose lovastatin and two herbal ... ...

    Abstract Studies have shown that satins and herbal products have potential to treat non-alcohol fatty liver disease (NAFLD) in clinic. However, no study has compared their effects, and their mechanisms remain unresolved. Here, we choose lovastatin and two herbal products including berberine and curcumin to compare their effects in treating NAFLD. NAFLD model was established by high fat food, and rats were administrated with lovastatin, berberine, curcumin, berberine + curcumin at the dosage of 100, 100, 100, 50 + 50 mg/kg bw, respectively. The body weight, visceral fat gain, histological inspection and serum parameters were studied to exam the curative effects. In addition, mediators including SREBP-1c, caveolin-1, pERK, NF-κB, TNF-α, and pJNK were studied. Results showed that berberine + curcumin group exhibited lower body and fat weigh compared with lovastatin group. Biochemical assays showed that LDL-c, ALT, AST, ALP, MDA, LSP level were lower in berberine + curcumin group compared with lovastatin group. Lower expression of SREBP-1c, pERK, TNF-α, and pJNK were also observed in berberine + curcumin group. We conclude that combination of curcumin and berberine exhibited better ameliorative effects in treating NAFLD than lovastatin, and this enhanced effect is associated with oxidative stress, hepatic inflammation and lipid metabolism.
    MeSH term(s) Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Animals ; Aspartate Aminotransferases/blood ; Berberine/chemistry ; Berberine/pharmacology ; Berberine/therapeutic use ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Blood Glucose/metabolism ; Body Weight/drug effects ; Curcumin/chemistry ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Gene Expression Regulation/drug effects ; Inflammation/genetics ; Insulin/blood ; Intra-Abdominal Fat/drug effects ; Lipid Metabolism/genetics ; Lipids/blood ; Lipopolysaccharides/metabolism ; Liver/metabolism ; Liver/pathology ; Lovastatin/pharmacology ; Lovastatin/therapeutic use ; Male ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/enzymology ; Non-alcoholic Fatty Liver Disease/pathology ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley
    Chemical Substances Biological Products ; Blood Glucose ; Insulin ; Lipids ; Lipopolysaccharides ; Berberine (0I8Y3P32UF) ; Lovastatin (9LHU78OQFD) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2018-01-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2018.01.071
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  7. Article: [Uniformity of Coptidis Rhizoma decoction pieces dispensing based on effective constituent equivalence].

    Dong, Qin / Wang, Jia-bo / Zhang, Ding-kun / Feng, Wu-wen / Zhang, Cong-en / Niu, Ming / Dong, Xiao-ping / Xiao, Xiao-he

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2015  Volume 40, Issue 20, Page(s) 3981–3986

    Abstract: Traditional Chinese medicine (TCM) dispensing is the final step of TCM used for clinical treatment, the stability of TCM dispensing is the guarantee of good clinical effect. Establishment of effect-constituent equivalence for Chinese herbal pieces based ... ...

    Abstract Traditional Chinese medicine (TCM) dispensing is the final step of TCM used for clinical treatment, the stability of TCM dispensing is the guarantee of good clinical effect. Establishment of effect-constituent equivalence for Chinese herbal pieces based on clinical efficacy, can not only guarantee the stability of TCM dispensing, but also relate to the precision of clinical effect. This study chose Coptidis Rhizoma as the model, established effect-constituent equivalence of Coptidis Rhizoma, based on the effect-constituent index already established by our research group, and taking into consideration of homogeneity of clinical dosage and compliance of decoction, the uniformity of dispensing for different specification of Coptidis Rhizoma decoction pieces was studied. This research model was then applied to guide the specification-optimization of Coptidis Rhizoma and its clinical dispensing. The result indicated, effective constituent equivalence could reflect the fluctuation of specification, dosage and decoction to the fluctuation of efficacy; Optimized Coptidis Rhizoma decoction pieces had the characteristic of high homogeneity as for clinical dispensing, good compliance as for decoction, and high effective constituent equivalence. In conclusion, effective constituent equivalence could improve relevance of methods of TCM dispensing control to clinical effect. Preparated Superior-standard Decoction Pieces based on effective constituent equivalence was featured by good quality and a good practice of adjustable dosage, which could promote the development of TCM decoction pieces toward precision medicine.
    MeSH term(s) Chemistry, Pharmaceutical/methods ; Coptis/chemistry ; Drugs, Chinese Herbal/chemistry ; Quality Control ; Rhizome/chemistry ; Therapeutic Equivalency
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2015-10
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: System Pharmacology-Based Dissection of the Synergistic Mechanism of Huangqi and Huanglian for Diabetes Mellitus.

    Yue, Shi-Jun / Liu, Juan / Feng, Wu-Wen / Zhang, Fei-Long / Chen, Jian-Xin / Xin, Lan-Ting / Peng, Cheng / Guan, Hua-Shi / Wang, Chang-Yun / Yan, Dan

    Frontiers in pharmacology

    2017  Volume 8, Page(s) 694

    Abstract: The rapidly increasing diabetes mellitus (DM) is becoming a major global public health issue. Traditional Chinese medicine (TCM) has a long history of the treatment of DM with good efficacy. Huangqi and Huanglian are one of the most frequently prescribed ...

    Abstract The rapidly increasing diabetes mellitus (DM) is becoming a major global public health issue. Traditional Chinese medicine (TCM) has a long history of the treatment of DM with good efficacy. Huangqi and Huanglian are one of the most frequently prescribed herbs for DM, and the combination of them occurs frequently in antidiabetic formulae. However, the synergistic mechanism of Huangqi (
    Language English
    Publishing date 2017-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2017.00694
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  9. Article: Idiosyncratic drug-induced liver injury linked to Polygonum multiflorum: A case study by pharmacognosy.

    Li, Chun-Yu / He, Qin / Gao, Dan / Li, Rui-Yu / Zhu, Yun / Li, Hui-Fang / Feng, Wu-Wen / Yang, Mei-Hua / Xiao, Xiao-He / Wang, Jia-Bo

    Chinese journal of integrative medicine

    2017  Volume 23, Issue 8, Page(s) 625–630

    MeSH term(s) Adult ; Chemical and Drug Induced Liver Injury/etiology ; Fallopia multiflora/adverse effects ; Humans ; Male ; Pharmacognosy
    Language English
    Publishing date 2017-05-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-017-2543-9
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  10. Article: [Influence of specification on chemical composition of dissolution and hepatocytes toxicity of Polygonum multiflorum].

    lI, Yu-Meng / Li, Rui-Yu / Niu, Ming / Li, Chun-Yu / Bai, Zhao-Fang / Feng, Wu-Wen / Zhang, Cong-En / Tan, Peng / Huang, Zhi-Pu / Ma, Wei-Guang / Wang, Jia-Bo / Xiao, Xiao-He

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2016  Volume 41, Issue 6, Page(s) 1033–1039

    Abstract: According to different toxicities of various aqueous extracts of Polygonum multiflorum on hepatocyte, the impacts of chemical composition on the safety of P. multiforum was studied. In this study, 8 main chemical compositions in aqueous extracts of P. ... ...

    Abstract According to different toxicities of various aqueous extracts of Polygonum multiflorum on hepatocyte, the impacts of chemical composition on the safety of P. multiforum was studied. In this study, 8 main chemical compositions in aqueous extracts of P. multiflorum were determined by the established HPLC method; at the same time, the inhibition ratios of different aqueous extracts of P. multiflorum on L02 cell were determined. Afterwards, the potential compounds related to the toxicity of P. multiforum were tentatively found through a multiple correlation analysis. The results showed that P. multiforum with different chemical compositions exhibited great differences in dissolution. The hepatocyte toxicity of P. multiflorum powder was much greater than P. multiflorum lumps. In addition, three constituents closely related to toxicity of P. multiflorum were found by multiple correlation analysis. The study revealed that chemical composition of P. multiflorum is closely related to the hepatotoxicity, and the hepatotoxicity of P. multiflorum powder is greater than that of other dosage forms. This study indicates that P. multiflorum with different chemical compositions show varying toxicity, which therefore shall be given high attention.
    MeSH term(s) Cell Line, Tumor ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/toxicity ; Fallopia multiflora/chemistry ; Fallopia multiflora/toxicity ; Hepatocytes/drug effects ; Humans ; Solubility
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2016-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.4268/cjcmm20160610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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