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  1. Article ; Online: Ectopic thyroid of the pancreatic head: A case report.

    Hou, Gui-Min / Qin, Fang-Yin / He, Yong-Jie / Feng, Xie-Lin

    Asian journal of surgery

    2023  Volume 46, Issue 7, Page(s) 2970–2971

    MeSH term(s) Humans ; Thyroid Dysgenesis/diagnostic imaging ; Thyroid Dysgenesis/surgery
    Language English
    Publishing date 2023-03-09
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.02.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  2. Article: [Resection of liver caudate lobe hepatocellular carcinoma via right-side approach to dissect the third hepatic hilum].

    Feng, Xie-lin / Peng, Jun-ping / Li, Ge

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2008  Volume 30, Issue 10, Page(s) 796–797

    MeSH term(s) Aged ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Hepatectomy/methods ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Tomography, X-Ray Computed
    Language Chinese
    Publishing date 2008-10
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2277: Show issues Location:
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    Zs.MO 321: Show issues

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  3. Article ; Online: Pemigatinib in previously treated Chinese patients with locally advanced or metastatic cholangiocarcinoma carrying FGFR2 fusions or rearrangements: A phase II study.

    Shi, Guo-Ming / Huang, Xiao-Yong / Wen, Tian-Fu / Song, Tian-Qiang / Kuang, Ming / Mou, Hai-Bo / Bao, Le-Qun / Zhao, Hai-Tao / Zhao, Hong / Feng, Xie-Lin / Zhang, Bi-Xiang / Peng, Tao / Zhang, Yu-Bao / Li, Xiang-Cheng / Yu, Hong-Sheng / Cao, Yu / Liu, Lian-Xin / Zhang, Ti / Wang, Wei-Lin /
    Ran, Jiang-Hua / Liu, Ying-Bin / Gong, Wei / Chen, Ming-Xia / Cao, Lian / Luo, Yang / Wang, Yan / Zhou, Hui / Yang, Guo-Huan / Fan, Jia / Zhou, Jian

    Cancer medicine

    2022  Volume 12, Issue 4, Page(s) 4137–4146

    Abstract: Objective: This study evaluated the antitumor activity and safety of pemigatinib in previously treated Chinese patients with advanced cholangiocarcinoma and fibroblast growth factor receptor 2 (FGFR2) fusions or rearrangements.: Background: ... ...

    Abstract Objective: This study evaluated the antitumor activity and safety of pemigatinib in previously treated Chinese patients with advanced cholangiocarcinoma and fibroblast growth factor receptor 2 (FGFR2) fusions or rearrangements.
    Background: Pemigatinib provided clinical benefits for previously treated patients with cholangiocarcinoma carrying FGFR2 fusions or rearrangements and was approved for this indication in multiple countries.
    Methods: In this ongoing, multicenter, single-arm, phase II study, adult patients with locally advanced or metastatic cholangiocarcinoma carrying centrally confirmed FGFR2 fusions or rearrangements who had progressed on ≥1 systemic therapy received 13.5 mg oral pemigatinib once daily (3-week cycle; 2 weeks on, 1 week off) until disease progression, unacceptable toxicity, or consent withdrawal. The primary endpoint was objective response rate (ORR) assessed by an independent radiology review committee.
    Results: As of January 29, 2021, 31 patients were enrolled. The median follow-up was 5.1 months (range, 1.5-9.3). Among 30 patients with FGFR2 fusions or rearrangements evaluated for efficacy, 15 patients achieved partial response (ORR, 50.0%; 95% confidence interval [CI], 31.3-68.7); 15 achieved stable disease, contributing to a disease control rate of 100% (95% CI, 88.4-100). The median time to response was 1.4 months (95% CI, 1.3-1.4), the median duration of response was not reached, and the median progression-free survival was 6.3 months (95% CI, 4.9-not estimable [NE]). Eight (25.8%) of 31 patients had ≥grade 3 treatment-emergent adverse events. Hyperphosphatemia, hypophosphatasemia, nail toxicities, and ocular disorders were mostly <grade 3, except for 2 events ≥grade 3.<br />Conclusions: The encouraging antitumor activity and favorable safety profile support the use of pemigatinib as a treatment in previously treated Chinese patients with cholangiocarcinoma and FGFR2 rearrangements.
    MeSH term(s) Adult ; Humans ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/genetics ; Bile Ducts, Intrahepatic/pathology ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/genetics ; East Asian People ; Receptor, Fibroblast Growth Factor, Type 2/genetics
    Chemical Substances Antineoplastic Agents ; FGFR2 protein, human (EC 2.7.10.1) ; pemigatinib (Y6BX7BL23K) ; Receptor, Fibroblast Growth Factor, Type 2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Clinical Trial, Phase II ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [The effects of transferring DPC4-adenovirus on pancreatic adenocarcinoma cells].

    Feng, Xie-lin / Zhang, Zhao-da / Tian, Lin / Wei, Yu-quan

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2004  Volume 35, Issue 5, Page(s) 607–611

    Abstract: Objective: To observe the effect of transferring DPC4-adenovirus on pancreatic cells.: Methods: The recombined wild DPC4 gene and replication-deficiency adenovirus was transfected into cultured pancreatic adenocarcinoma cells and exograft pancreatic ... ...

    Abstract Objective: To observe the effect of transferring DPC4-adenovirus on pancreatic cells.
    Methods: The recombined wild DPC4 gene and replication-deficiency adenovirus was transfected into cultured pancreatic adenocarcinoma cells and exograft pancreatic adenocarcinoma at the axillary flank of nude mice. The expression of objective gene was evaluated by flow cytometry and immunohistological chemistry assay. The cell cycle was also measured by flow cytometry. The related data were collected and analyzed with statistical methods.
    Results: in viro, the suppression rate of transferring DPC4-adenovirus on cultured pancreatic adenocarcinoma cells was 30% on the fourth day. The fluorescence intensity of PD cells, P cells, HD cells, PA (Pc-3-Adenovirus) cells was higher than that of HS766T cells and HA cells (P<0.05). After transfection, PD cells proliferated most slowly, while H and HA proliferated most quickly (P<0.05). Significant difference was seen between the volume of exograft tumor of the controlled group and that of the treatment group (P<0.05). After transfection, the proliferation of cultured pancreatic adenocarcinoma cells was suppressed, the cells of G1 phase increased obviously (P<0.05) while the cells of S phase decreased (P<0.05), although no obvious increase of apoptosic cell number was observed.
    Conclusion: The DPC4-adenovirus can be transfected into pancreatic adenocarcinoma cells effectively. It could suppress the proliferation of pancreatic adenocarcinoma cells in vivo and in vitro.
    MeSH term(s) Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenoviridae/genetics ; Animals ; Cell Division ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Genes, Tumor Suppressor ; Genetic Therapy ; Humans ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Signal Transduction ; Smad4 Protein ; Trans-Activators/biosynthesis ; Trans-Activators/genetics ; Transfection ; Tumor Cells, Cultured
    Chemical Substances DNA-Binding Proteins ; SMAD4 protein, human ; Smad4 Protein ; Trans-Activators
    Language Chinese
    Publishing date 2004-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2708: Show issues Location:
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  5. Article: Modified techniques of heterotopic total small intestinal transplantation in rats.

    Wu, Xiao-Ting / Li, Jie-Shou / Zhao, Xiao-Fei / Zhuang, Wen / Feng, Xie-Lin

    World journal of gastroenterology

    2002  Volume 8, Issue 4, Page(s) 758–762

    Abstract: Aim: To establish a successful model of heterotopic total small intestinal transplantation (SIT) in rats in order to reduce the complications and increase the survival rate.: Methods: A total of 196 Wistar rats underwent heterotopic SIT with ... ...

    Abstract Aim: To establish a successful model of heterotopic total small intestinal transplantation (SIT) in rats in order to reduce the complications and increase the survival rate.
    Methods: A total of 196 Wistar rats underwent heterotopic SIT with microsurgical technique. Technical modifications included shortening fasting time and supplying energy before surgery, administering optimal volume of crystalloid fluid to the donor and recipient during surgical procedures, reducing mechanical and ischemic injuries to donor intestine, revascularizing small intestinal graft with a combination of conventional aorta to aorta anastomosis and a cuffed portal vein to left renal vein anastomosis which resulted in an acceptably short warm ischemic time, and also an adequate blood supply and drainage of the graft.
    Results: The average time for the donor surgery was 86 min +/- 20 min, the mean operative time for the recipient was 115 min +/-20 min and warm ischemia time was shortened to 40 min +/- 5 min. There was a shorter revascularizing time of the graft, the abdominal aorta (AA) to AA anastomosis being 21 min +/- 10 min, and the cuffed portal vein (PV) to the renal vein anastomosis being 5 min +/- 5 min. The one-week survival rate of 98 rats with SIT was 88.78% (87/98), without thrombosis and stenosis of anastomosis. The longest survival time of recipient rats was more than 389 days after SIT, the rats were maintaining normal weight, with perfect intestinal function and intact intestinal histology.
    Conclusion: These modified techniques for SIT would remarkably reduce the complications and improve survival rate in rats, which provided a potentially more consistent and practical model for experimental and clinical studies.
    MeSH term(s) Animals ; Fasting ; Intestine, Small/transplantation ; Male ; Methods ; Microsurgery ; Models, Animal ; Postoperative Complications/prevention & control ; Rats ; Rats, Wistar ; Shock/prevention & control ; Time Factors
    Language English
    Publishing date 2002-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v8.i4.758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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